Research Topics
Genomes and GenesSpecies | Suzanne D VernonSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
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Publications
Correlation of psycho-neuroendocrine-immune (PNI) gene expression with symptoms of acute infectious mononucleosisSuzanne D Vernon
Viral Exanthems and Herpesvirus Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road MSA15, Atlanta, GA 30333, USA
Brain Res 1068:1-6. 2006..Thus, investigation of the PNI response in peripheral blood may provide novel insights into the complex pathophysiology of centrally mediated disease states...- Microarray technology for use in molecular epidemiologySuzanne D Vernon
Division of Viral and Rickettsial Diseases, National Centers for Infectious Diseases, Center for Disease Control and Prevention, Atlanta, GA, USA
Methods Mol Biol 382:97-113. 2007..This reproducible and reliable approach for using microarrays should be applicable to any biological questions asked... - Challenges for molecular profiling of chronic fatigue syndromeSuzanne D Vernon
Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, National Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Pharmacogenomics 7:211-8. 2006..Successful molecular profiling of CFS will require the integration of genetic, genomic and proteomic data with environmental and behavioral data to define the heterogeneity in order to optimize intervention... 
Analysis of 16S rRNA gene sequences and circulating cell-free DNA from plasma of chronic fatigue syndrome and non-fatigued subjectsSuzanne D Vernon
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
BMC Microbiol 2:39. 2002..Plasma DNA from 34 CFS and 55 non-fatigued subjects was assessed to determine plasma DNA concentration and the presence of bacterial 16S ribosomal DNA (rDNA) sequences...- Utility of the blood for gene expression profiling and biomarker discovery in chronic fatigue syndromeSuzanne D Vernon
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
Dis Markers 18:193-9. 2002..These results successfully demonstrate the utility of the blood for gene expression profiling to distinguish subjects with CFS from healthy controls and for identifying genes that could serve as CFS biomarkers... - Bioelectronic DNA detection of human papillomaviruses using eSensor: a model system for detection of multiple pathogensSuzanne D Vernon
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
BMC Infect Dis 3:12. 2003..We used human papillomaviruses (HPV) as a model system to evaluate the utility of a nucleic acid, hybridization-based bioelectronic DNA detection platform (eSensor) in identifying multiple pathogens... - Preliminary evidence of mitochondrial dysfunction associated with post-infective fatigue after acute infection with Epstein Barr virusSuzanne D Vernon
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
BMC Infect Dis 6:15. 2006..The objective of this pilot study was to determine the gene expression correlates of post-infective fatigue following acute Epstein Barr virus (EBV) infection... - Evaluation of RNA markers for early detection of cervical neoplasia in exfoliated cervical cellsMartin Steinau
Division of Viral and Rickettsial Disease, Viral Exanthems and Herpesvirus Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 41, Atlanta, GA 30333, USA
Cancer Epidemiol Biomarkers Prev 16:295-301. 2007.... - Gene expression profile of cervical tissue compared to exfoliated cells: impact on biomarker discoveryMartin Steinau
Centers for Disease Control and Prevention, Atlanta, GA, USA
BMC Genomics 6:64. 2005..However, because of keratinization and terminal differentiation it is not clear that these cells have an mRNA profile representative of cervical tissue, and that the profile can distinguish the lesions targeted for early detection... - Epidemiologic and viral factors associated with cervical neoplasia in HPV-16-positive womenMangalathu S Rajeevan
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Int J Cancer 115:114-20. 2005..Cellular proliferation and differentiation pathways affected by HPV should be investigated as biomarkers for cervical cancer screening... - Gene expression profiling of dysplastic differentiation in cervical epithelial cells harboring human papillomavirus 16Daya G Ranamukhaarachchi
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service/US DHHS, Atlanta, GA 30333, USA
Genomics 85:727-38. 2005..Some of the genes with altered expression identified in this model of dysplastic differentiation may be useful biomarkers for early detection of cervical neoplasia and other HPV-associated oropharyngeal and anogenital cancers... 
Impact of acute psychosocial stress on peripheral blood gene expression pathways in healthy menUrs M Nater
Chronic Viral Diseases Branch, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS G41, Atlanta, GA 30329, USA
Biol Psychol 82:125-32. 2009..These results have relevance for understanding molecular mechanisms of the physiological stress response, and might be used to further study adverse health outcomes of psychosocial stress...- Genetic evaluation of the serotonergic system in chronic fatigue syndromeAlicia K Smith
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MSG41, Atlanta, GA 30333, USA
Psychoneuroendocrinology 33:188-97. 2008..These data indicate that sequence variation in HTR2A, potentially resulting in its enhanced activity, may be involved in the pathophysiology of CFS... - The challenge of integrating disparate high-content data: epidemiological, clinical and laboratory data collected during an in-hospital study of chronic fatigue syndromeSuzanne D Vernon
Centers for Disease Control and Prevention, National Center for Infectious Diseases, Atlanta, GA, USA
Pharmacogenomics 7:345-54. 2006.... - Global amplification of sense RNA: a novel method to replicate and archive mRNA for gene expression analysisMangalathu S Rajeevan
Viral Exanthems and Herpesvirus Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, GA 30333, USA
Genomics 82:491-7. 2003..00001-0.1%). This reflects the high fidelity of sRNA synthesis for mRNA as low as 0.3 copies/cell. sRNA is amplified synthetic mRNA in the 5'-->3' direction; the appropriate template for any gene expression analysis... - Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolutionWilliam C Reeves
Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
BMC Health Serv Res 3:25. 2003..Difficulties with accurate case ascertainment contribute to this ignorance... - Chronic fatigue syndrome--a clinically empirical approach to its definition and studyWilliam C Reeves
Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
BMC Med 3:19. 2005..The lack of standardized criteria for defining chronic fatigue syndrome (CFS) has constrained research. The objective of this study was to apply the 1994 CFS criteria by standardized reproducible criteria... - Exercise responsive genes measured in peripheral blood of women with chronic fatigue syndrome and matched control subjectsToni Whistler
Viral Exanthems and Herpesvirus Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
BMC Physiol 5:5. 2005..To search for markers of CFS-associated post-exertional fatigue, we measured peripheral blood gene expression profiles of women with CFS and matched controls before and after exercise challenge... - Molecular markers for early detection of cervical neoplasiaElizabeth R Unger
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, GA 30333, USA
Dis Markers 20:103-16. 2004 - Exploration of neuroendocrine and immune gene expression in peripheral blood mononuclear cellsAinsley C Nicholson
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
Brain Res Mol Brain Res 129:193-7. 2004.... - Differential-display PCR of peripheral blood for biomarker discovery in chronic fatigue syndromeMartin Steinau
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, MSG-41, Atlanta, GA 30333, USA
J Mol Med 82:750-5. 2004..The real-time reverse-transcription PCR assays that we developed for assay of these biomarkers will facilitate high-throughput testing of these additional samples... - Transcriptional control of complement activation in an exercise model of chronic fatigue syndromeBristol Sorensen
Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, United States of America
Mol Med 15:34-42. 2009..MASP2 down-regulation may act as an antiinflammatory acute-phase response in healthy subjects, whereas its elevated level may account for increased C4a and inflammation-mediated postexertional malaise in CFS subjects... - Molecular quality of exfoliated cervical cells: implications for molecular epidemiology and biomarker discoveryAngelique H Habis
Centers for Disease Control and Prevention, U.S. Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA, USA
Cancer Epidemiol Biomarkers Prev 13:492-6. 2004..However, with a sensitive gold particle-based detection method, reproducible microarray results were obtained using this RNA... - Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistabilityShakti Gupta
Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Theor Biol Med Model 4:8. 2007..The HPA axis responds to physical and mental challenge to maintain homeostasis in part by controlling the body's cortisol level. Dysregulation of the HPA axis is implicated in numerous stress-related diseases... - Comparison of target labeling methods for use with Affymetrix GeneChipsWilliam Lonergan
Chronic Viral Diseases Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA
BMC Biotechnol 7:24. 2007.... - Two optimized combination assays to examine apoptosis pathways in clinical samplesMark Hollier
Chronic Viral Diseases Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA
Cytometry A 71:675-85. 2007..This hinders studies on clinical samples that have limited cell numbers. Our objective was to combine and optimize assays that target specific stages of apoptosis for use in a typical clinical blood sample... - Assessment of normal variability in peripheral blood gene expressionCatherine Campbell
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
Dis Markers 18:201-6. 2002..These results suggest that observed variation was due to experimental variability... - Molecular characterization of human papillomaviruses by PCR and in situ hybridizationSuzanne D Vernon
Centers of Disease Control and Prevention, Atlanta, GA, USA
Methods Mol Med 97:159-80. 2004 - Impaired immune function in Gulf War IllnessToni Whistler
Chronic Viral Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA
BMC Med Genomics 2:12. 2009..Our results do not necessarily elucidate the cause of GWI, but they do reveal a role for immune cell dysfunction in sustaining illness... - Live sequence charts to model medical informationEric Aslakson
Poiema, LLC, 375 Chelsea Cir NE, Atlanta, GA 30307, USA
Theor Biol Med Model 9:22. 2012..The purpose of this study was to develop an object modeling technique as a first step towards a formal database of medical records... - A method for improving SELDI-TOF mass spectrometry data qualityToni Whistler
Chronic Viral Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd, G41, Atlanta, Georgia, 30329, USA
Proteome Sci 5:14. 2007..However, the events that occur between the first and last sample run are likely to introduce technical variation in the results... - Modifying differential display polymerase chain reaction to detect relative changes in gene expression profilesDaya G Ranamukhaarachchi
Viral Exanthems and Herpesvirus Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA 30333, USA
Anal Biochem 306:343-6. 2002 - Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort studyIan Hickie
Brain and Mind Research Institute, Sydney University, Sydney, NSW 2050, Australia
BMJ 333:575. 2006..Post-infective fatigue syndrome is a valid illness model for investigating one pathophysiological pathway to chronic fatigue syndrome... - Impact of RNA extraction from limited samples on microarray resultsHanna Ojaniemi
Karolinska Institutet at Huddinge University Hospital, Royal Institute of Technology, Stockholm, Sweden
Biotechniques 35:968-73. 2003..These experiments illustrate that microarray technology holds great promise for the use of limited clinical samples in the diagnostic setting... - Absence of Mycoplasma species DNA in chronic fatigue syndromeSuzanne D Vernon
J Med Microbiol 52:1027-8. 2003