Research Topics
Genomes and Genes | Venkatachalam UdhayakumarSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
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Publications
Plasma levels of angiopoietin-1 and -2 predict cerebral malaria outcome in Central IndiaVidhan Jain
Regional Medical Research Center for Tribals ICMR, Nagpur Road, Garha, 482003 Jabalpur, Madhya Pradesh, India
Malar J 10:383. 2011....
Longitudinal study of natural immune responses to the Plasmodium falciparum apical membrane antigen (AMA-1) in a holoendemic region of malaria in western Kenya: Asembo Bay Cohort Project VIIIV Udhayakumar
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Atlanta, Georgia, USA
Am J Trop Med Hyg 65:100-7. 2001..009). Responses to AMA-1 T-cell epitopes were short lived, and antibody responses were relatively stable...- Plasma IP-10, apoptotic and angiogenic factors associated with fatal cerebral malaria in IndiaVidhan Jain
National Institute of Malaria Research ICMR, Jabalpur, India
Malar J 7:83. 2008.... - Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populationsSankar Sridaran
Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Mail Stop D 67 Atlanta, GA, 30333, USA
Malar J 9:247. 2010..This meta-analysis attempts to: 1) summarize genotype frequency data that are critical for molecular surveillance of anti-folate resistance and 2) identify the specific challenges facing the development of future molecular databases... - Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian childrenHenry B Armah
Morehouse School of Medicine, Department of Microbiology, Biochemistry and Immunology, Atlanta, Georgia, USA
Malar J 6:147. 2007..Identification of prognostic markers that can predict CM severity will enable development of better intervention... - Burden of malaria in pregnancy in Jharkhand State, IndiaDavidson H Hamer
Center for Global Health and Development, Boston University School of Public Health, Boston, MA 02118, USA
Malar J 8:210. 2009..Given the large population at risk, a cross sectional study was conducted in order to better define the burden of malaria in pregnancy in Jharkhand, a malaria-endemic state in central-east India... - Evaluation of three PCR-based diagnostic assays for detecting mixed Plasmodium infectionTonya Mixson-Hayden
Malaria Branch, Division of Parasitic Diseases, National Center for Zoonotic Vector Borne and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
BMC Res Notes 3:88. 2010..To our knowledge, no one has reported whether the two multiplex methods are better at detecting mixed Plasmodium infections compared to the nested assay using known quantities of DNA in experimentally mixed cocktails... - Availability and utilization of malaria prevention strategies in pregnancy in eastern IndiaBlair J Wylie
Center for Global Health and Development, Boston University School of Public Health, Boston, MA, USA
BMC Public Health 10:557. 2010..It is not known whether prevention and treatment strategies for malaria in pregnancy (case management, insecticide-treated bednets, intermittent preventive therapy) are widely utilized in India... - Evidence of selective sweeps in genes conferring resistance to chloroquine and pyrimethamine in Plasmodium falciparum isolates in IndiaTonya Mixson-Hayden
Malaria Branch, Division of Parasitic Diseases, Centers for Disease Control and Prevention, 4770 Buford Highway, MS F 12, Chamblee, GA 30341, USA
Antimicrob Agents Chemother 54:997-1006. 2010..Microsatellites surrounding pfcrt indicate that the resistant genotypes (SVMNT) were most similar to those found in Papua New Guinea... - Differences in selective pressure on dhps and dhfr drug resistant mutations in western KenyaAndrea M McCollum
Program in Population Biology, Ecology, and Evolution, Emory University, Atlanta, GA, USA
Malar J 11:77. 2012..Importantly, the study is based on longitudinal data, which allows for a comprehensive analysis that contrasts with previous cross-sectional studies carried out in other endemic regions... - Origin and evolution of sulfadoxine resistant Plasmodium falciparumSumiti Vinayak
Atlanta Research and Education Foundation, Atlanta, Georgia, United States of America
PLoS Pathog 6:e1000830. 2010..Comparative analysis of the microsatellite haplotypes flanking dhps alleles from Cambodia, Kenya, Cameroon and Venezuela revealed an independent origin of sulfadoxine resistant alleles in each of these regions... - Selective sweeps and genetic lineages of Plasmodium falciparum drug -resistant alleles in GhanaMd Tauqeer Alam
Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA
J Infect Dis 203:220-7. 2011..A comprehensive study of the drug-resistance-associated mutations and their genetic lineages will lead to a better understanding of the evolution of antimalarial drug resistance in this region... - South American Plasmodium falciparum after the malaria eradication era: clonal population expansion and survival of the fittest hybridsSean M Griffing
Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
PLoS ONE 6:e23486. 2011..Understanding the population substructure of P. falciparum has implications for vaccine, drug, and epidemiologic studies, including monitoring malaria during and after the elimination phase... - pfmdr1 amplification and fixation of pfcrt chloroquine resistance alleles in Plasmodium falciparum in VenezuelaSean Griffing
Emory University, Atlanta, Georgia, USA
Antimicrob Agents Chemother 54:1572-9. 2010..falciparum in Sifontes, Venezuela, and multidrug resistance genotypes are present. This population could be targeted for malaria elimination programs to prevent the possible spread of multidrug-resistant parasites... - Levels of macrophage inflammatory protein 1 alpha (MIP-1 alpha) and MIP-1 beta in intervillous blood plasma samples from women with placental malaria and human immunodeficiency virus infectionSujittra Chaisavaneeyakorn
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA
Clin Diagn Lab Immunol 10:631-6. 2003..In summary, an elevated level of MIP-1 beta was associated with PM. HIV infection did not significantly alter these two chemokine levels in IVB plasma... 
Effect of placental malaria and HIV infection on the antibody responses to Plasmodium falciparum in infantsRenee M Ned
Malaria Branch, Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Chamblee, GA 30341, USA
J Infect Dis 198:1609-19. 2008..We studied the effects of PM and HIV infection on the antimalarial antibody responses and morbidity outcomes of infants throughout the first year of life...- Tracking origins and spread of sulfadoxine-resistant Plasmodium falciparum dhps alleles in ThailandMd Tauqeer Alam
Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Antimicrob Agents Chemother 55:155-64. 2011..In summary, this study suggests multiple and independent origins of resistant dhps alleles in Thailand... - Hitchhiking and selective sweeps of Plasmodium falciparum sulfadoxine and pyrimethamine resistance alleles in a population from central AfricaAndrea M McCollum
Program in Population Biology, Ecology, and Evolution, Emory University, Atlanta, Georgia, USA
Antimicrob Agents Chemother 52:4089-97. 2008.... - Antifolate resistance in Plasmodium falciparum: multiple origins and identification of novel dhfr allelesAndrea M McCollum
Emory University, Program in Population Biology, Ecology, and Evolution, Atlanta, GA, USA
J Infect Dis 194:189-97. 2006..CONCLUSIONS: These findings highlight the importance of local characterization of alleles before molecular surveillance of drug-resistant alleles is considered in different endemic settings and populations... - Decline in sulfadoxine-pyrimethamine-resistant alleles after change in drug policy in the Amazon region of PeruZhiyong Zhou
Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Antimicrob Agents Chemother 52:739-41. 2008..Microsatellite analysis showed that the dhfr and dhps alleles are of common origin... - Dihydrofolate reductase I164L mutations in Plasmodium falciparum isolates: clinical outcome of 14 Kenyan adults infected with parasites harbouring the I164L mutationMary J Hamel
Centers for Disease Control and Prevention, Division of Parasitic Diseases, Malaria Branch, Atlanta, GA, USA
Trans R Soc Trop Med Hyg 102:338-45. 2008..Surveillance to monitor spread of I164L is critical, especially among children and pregnant women, who are potentially a source for I164L amplification... - Relationship between plasma Interleukin-12 (IL-12) and IL-18 levels and severe malarial anemia in an area of holoendemicity in western KenyaSujittra Chaisavaneeyakorn
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Atlanta, Georgia 30333, USA
Clin Diagn Lab Immunol 10:362-6. 2003..In summary, the results from this study support the hypothesis that impairment of IL-12 and/or IL-18 response may contribute to the development of severe malarial anemia in areas of holoendemicity for malaria... - Increased efficacy of sulfadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria among children with sickle cell trait in Western KenyaDianne J Terlouw
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
J Infect Dis 186:1661-8. 2002..02) or in parasitologic treatment failure on day 7 (RR, 0.51; 95% CI, 0.36-0.71; P<.0001). These results suggest that the HbAS phenotype should be included among factors that determine sulfadoxine-pyrimethamine treatment outcome... - Placental malaria diminishes development of antibody responses to Plasmodium falciparum epitopes in infants residing in an area of western Kenya where P. falciparum is endemicPhillip Cullison Bonner
Malaria Branch, Division of Parasitic Diseases, NCID, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA, USA
Clin Diagn Lab Immunol 12:375-9. 2005..0035). These findings suggest that PM can negatively influence the development of immune responses to malaria in infants... - Immunohistological characterization of macrophage migration inhibitory factor expression in Plasmodium falciparum-infected placentasSujittra Chaisavaneeyakorn
Centers for Disease Control and Prevention, 4770 Buford Highway, Mail Stop F-12, Chamblee, GA 30341, USA
Infect Immun 73:3287-93. 2005..These findings suggest that placental malaria modulates MIF expression in different placental compartments... - Applied genomics: data mining reveals species-specific malaria diagnostic targets more sensitive than 18S rRNAAllison Demas
Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30602, USA
J Clin Microbiol 49:2411-8. 2011..These novel targets provide a powerful alternative molecular diagnostic method for the detection of P. falciparum and P. vivax in conventional or multiplex PCR platforms... - Preliminary observations on the efficacy of a recombinant multistage Plasmodium falciparum vaccine in Aotus nancymai monkeysWilliam E Collins
Division of Parasitic Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Atlanta, Georgia 30341, USA
Am J Trop Med Hyg 73:686-93. 2005..None of the other 5 antigen-adjuvant combinations were able to provide discernable levels of protection based on log(parasitemia) and log(cumulative parasitemia) to Day 11... - Potential serological biomarkers of cerebral malariaNaomi W Lucchi
Atlanta Research and Education Foundation, Decatur, GA, USA
Dis Markers 31:327-35. 2011..We propose three main areas in which researchers can attempt to identify CM biomarkers: 1) early biomarkers, 2) diagnostic biomarkers and 3) prognostic biomarkers... - Polymorphisms in genes of interleukin 12 and its receptors and their association with protection against severe malarial anaemia in children in western KenyaLyna Zhang
Malaria Branch, Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Malar J 9:87. 2010..Based on the biological relevance of IL12 in malaria anaemia, the relationship between genetic polymorphisms of IL12 and its receptors and SMA was examined... - Modulation of immune responses during HIV-malaria co-infection in pregnancyRenee M Ned
Malaria Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, Chamblee, GA 30341, USA
Trends Parasitol 21:284-91. 2005..In this article, we review current data about humoral and cellular responses to HIV-placental-malaria co-infection and present an immunological hypothesis to explain the epidemiological findings... - Multiple genetic backgrounds of the amplified Plasmodium falciparum multidrug resistance (pfmdr1) gene and selective sweep of 184F mutation in CambodiaSumiti Vinayak
Atlanta Research and Education Foundation, Atlanta, Georgia, USA
J Infect Dis 201:1551-60. 2010..In the present study, we investigated evidence for a selective sweep around pfmdr1 because of the spread of adaptive mutation and/or multiple copies of this gene in the P. falciparum population in Cambodia... - Limited genetic variation in the Plasmodium falciparum heme detoxification protein (HDP)Sumiti Vinayak
Atlanta Research and Education Foundation, Atlanta, GA, USA
Infect Genet Evol 9:286-9. 2009..In conclusion, HDP is a conserved target for future antimalarial development... - Immunity to placental malaria. IV. Placental malaria is associated with up-regulation of macrophage migration inhibitory factor in intervillous bloodSujittra Chaisavaneeyakorn
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, United States Department of Health and Human Services, Atlanta, Georgia 30341, USA
J Infect Dis 186:1371-5. 2002..02). Primigravid and secundigravid women had significantly higher levels of MIF in their IVB plasma than did multigravid women (P<.05). HIV infection did not significantly alter MIF levels in any site examined... - Pyrosequencing, a high-throughput method for detecting single nucleotide polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes of Plasmodium falciparumZhiyong Zhou
Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Chamblee, Georgia 30341, USA
J Clin Microbiol 44:3900-10. 2006..Thus, pyrosequencing is a practical alternative method that can be used in a high-throughput format for molecular surveillance of antimalarial-drug resistance... - Historical Shifts in Brazilian P. falciparum Population Structure and Drug Resistance AllelesSean M Griffing
Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America Atlanta Research and Education Foundation, Decatur, Georgia, United States of America
PLoS ONE 8:e58984. 2013..The Brazilian Amazon basin may have sufficient internal migration for drug resistance reported in any particular region to rapidly spread to other parts of basin under similar drug pressure... - Macrophage migration inhibitory factor is associated with mortality in cerebral malaria patients in IndiaVidhan Jain
Malaria Branch, Division of Parasitic Diseases, National Center for Zoonotic Vector Borne and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
BMC Res Notes 2:36. 2009..004). CONCLUSION: This study suggests that elevated levels of MIF in the peripheral blood of cerebral malaria patients may be associated with fatal outcomes... - Development, characterization and immunogenicity of a multi-stage, multi-valent Plasmodium falciparum vaccine antigen (FALVAC-1A) expressed in Escherichia coliZhiyong Zhou
Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Hum Vaccin 2:14-23. 2006..falciparum parasites as demonstrated by inhibition of sporozoite invasion, antibody dependent cellular inhibition and the immunofluorescence assay... - Antibody responses to the merozoite surface protein-1 complex in cerebral malaria patients in IndiaNaomi W Lucchi
Malaria Branch, Division of Parasitic Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Malar J 7:121. 2008.... - Influence of adjuvants in inducing immune responses to different epitopes included in a multiepitope, multivalent, multistage Plasmodium falciparum candidate vaccine (FALVAC-1) in outbred miceAsimah Rafi-Janajreh
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 4770 Buford Highway, Mail Stop F-12, Atlanta, GA 30341, USA
Exp Parasitol 101:3-12. 2002..In conclusion, this study demonstrated that with suitable adjuvant such as QS-21, it is possible to elicit immune responses to most of the epitopes included in the FALVAC-1 vaccine... - Real-time loop-mediated isothermal amplification (RealAmp) for the species-specific identification of Plasmodium vivaxJaymin C Patel
Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
PLoS ONE 8:e54986. 2013..40-100%) compared to the gold standard nested-PCR method. The new primers also proved to be more sensitive than the published species-specific primers specifically developed for the LAMP method in detecting P. vivax... - CXCL4 and CXCL10 predict risk of fatal cerebral malariaNana O Wilson
Morehouse School of Medicine, Department of Microbiology, Biochemistry and Immunology, Atlanta, Georgia 30310, USA
Dis Markers 30:39-49. 2011..0001) with an area under the curve (AUC)=1. These results suggest that CXCL4 and CXCL10 play a prominent role in pathogenesis of CM associated death and may be used as functional or surrogate biomarkers for predicting CM severity... - Molecular diagnosis of malaria by photo-induced electron transfer fluorogenic primers: PET-PCRNaomi W Lucchi
Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
PLoS ONE 8:e56677. 2013..Further validation of this technique in the field will help to assess its utility for large scale screening in malaria control and elimination programs... - Variants in ABCB1, TGFB1, and XRCC1 genes and susceptibility to viral hepatitis A infection in Mexican AmericansLyna Zhang
Office of Public Health Genomics, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Diseases Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
Hepatology 55:1008-18. 2012..71-0.89; FDR-P = 0.0007). Conclusion: Genetic variants in ABCB1, TGFB1, and XRCC1 appear to be associated with susceptibility to HAV infection among Mexican Americans. Replication studies involving larger population samples are warranted... - Real-time fluorescence loop mediated isothermal amplification for the diagnosis of malariaNaomi W Lucchi
Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
PLoS ONE 5:e13733. 2010..This tool can provide an alternative to conventional PCR based diagnostic methods for field use in clinical and operational programs... - Immunity to placental malaria. III. Impairment of interleukin(IL)-12, not IL-18, and interferon-inducible protein-10 responses in the placental intervillous blood of human immunodeficiency virus/malaria-coinfected womenSujittra Chaisavaneeyakorn
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
J Infect Dis 185:127-31. 2002.... - Gonadotropin-releasing hormone alters the T helper cytokine balance in the pregnant ratVishwa Deep Dixit
Department of Physiology, Morehouse School of Medicine, Atlanta, Georgia 30310-1495, USA
Biol Reprod 68:2215-21. 2003..Our results suggest an additional function for GnRH as a Th-1 inducer and Th-2 inhibitor. GnRH can thus skew the cytokine balance to predominantly Th-1 type in pregnancy, leading to the termination of pregnancy in rats...