Research Topics
Genomes and Genes | Terrence M TumpeySummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
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Publications
Local innate immune responses and influenza virus transmission and virulence in ferretsTaronna R Maines
Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Infect Dis 205:474-85. 2012..Our findings point to a link between localized innate immunity and influenza virus transmission and disease progression...
Pathogenesis of pandemic influenza A (H1N1) and triple-reassortant swine influenza A (H1) viruses in miceJessica A Belser
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 84:4194-203. 2010..Taken together, these studies demonstrate that the 2009 H1N1 viruses exhibited mild to moderate virulence in mice compared with highly pathogenic viruses...
A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmissionTerrence M Tumpey
Influenza Branch, Mailstop G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
Science 315:655-9. 2007..These findings confirm an essential role of hemagglutinin receptor specificity for the transmission of influenza viruses among mammals...- Seasonal trivalent inactivated influenza vaccine protects against 1918 Spanish influenza virus infection in ferretsMelissa B Pearce
Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
J Virol 86:7118-25. 2012..These findings suggest that exposure to A(H1N1)pdm09 through immunization may provide protection against the reconstructed 1918 virus which, as a select agent, is considered to pose both biosafety and biosecurity threats... - Pathogenesis and transmission of swine origin A(H3N2)v influenza viruses in ferretsMelissa B Pearce
Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Proc Natl Acad Sci U S A 109:3944-9. 2012..These findings suggest that A(H3N2)v viruses have the capacity for efficient replication and transmission in mammals and underscore the need for continued public health surveillance... - Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virusClaudia Pappas
Influenza Division, Mailstop G 16, National Center for Immunization and Respiratory Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road Northeast, Atlanta, GA 30333, USA
Proc Natl Acad Sci U S A 105:3064-9. 2008..These results highlight the importance of the 1918 HA, NA, and PB1 genes for optimal virus replication and virulence of this pandemic strain... - Early control of H5N1 influenza virus replication by the type I interferon response in miceKristy J Szretter
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 303331, USA
J Virol 83:5825-34. 2009..These results suggest a role for the IFN-alpha/beta response in the control of H5N1 virus replication both in vivo and in vitro, and as such it may provide some degree of protection to the host in the early stages of infection... - Genetic analysis of avian influenza A viruses isolated from domestic waterfowl in live-bird markets of Hanoi, Vietnam, preceding fatal H5N1 human infections in 2004Samadhan J Jadhao
Influenza Division, MS G16, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
Arch Virol 154:1249-61. 2009..The clade-1 HPAI H5N1 viruses were independently introduced into Vietnam... - Pathogenesis and transmission of triple-reassortant swine H1N1 influenza viruses isolated before the 2009 H1N1 pandemicJessica A Belser
Influenza Division, Infectious Disease Pathology Branch, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 85:1563-72. 2011.... - Pathogenesis of 1918 pandemic and H5N1 influenza virus infections in a guinea pig model: antiviral potential of exogenous alpha interferon to reduce virus sheddingNeal Van Hoeven
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 83:2851-61. 2009.... - Characterization of the reconstructed 1918 Spanish influenza pandemic virusTerrence M Tumpey
Influenza Branch, Mailstop G 16, Division of Viral and Rickettsial Diseases DVRD, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
Science 310:77-80. 2005..Moreover, the coordinated expression of the 1918 virus genes most certainly confers the unique high-virulence phenotype observed with this pandemic virus... - Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and miceTaronna R Maines
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Science 325:484-7. 2009.... - Receptor specificity and transmission of H2N2 subtype viruses isolated from the pandemic of 1957Claudia Pappas
Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
PLoS ONE 5:e11158. 2010..Our studies provide a correlation between binding affinity to glycan receptors with terminal alpha 2,6-linked sialic acid and the efficiency of respiratory droplet transmission for pandemic H2N2 influenza viruses... - Mice lacking both TNF and IL-1 receptors exhibit reduced lung inflammation and delay in onset of death following infection with a highly virulent H5N1 virusLucy A Perrone
Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
J Infect Dis 202:1161-70. 2010..In particular, H5N1 virus infections are associated with a high expression of the proinflammatory cytokines, including interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-α)... - Influenza virus respiratory infection and transmission following ocular inoculation in ferretsJessica A Belser
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
PLoS Pathog 8:e1002569. 2012.... - Human pulmonary microvascular endothelial cells support productive replication of highly pathogenic avian influenza viruses: possible involvement in the pathogenesis of human H5N1 virus infectionHui Zeng
Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
J Virol 86:667-78. 2012..Our results highlight remarkable tropism and infectivity of the H5N1 viruses for human pulmonary endothelial cells, resulting in the potent induction of host inflammatory responses... - Multiple genes contribute to the virulent phenotype observed in ferrets of an H5N1 influenza virus isolated from Thailand in 2004Taronna R Maines
Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Virology 413:226-30. 2011..Our results demonstrate that H5N1 virus virulence determinants are polygenic and that there is an important correlation between polymerase adaptation, efficient replication in the host, and virulence... - Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 virusesTaronna R Maines
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G16, Atlanta, GA 30333, USA
Virology 413:139-47. 2011.... - Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the airNeal Van Hoeven
Influenza Division, Mailstop G 16, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road Northeast, Atlanta, GA 30333, USA
Proc Natl Acad Sci U S A 106:3366-71. 2009..These findings demonstrate that the adaptation of the HA and PB2 proteins are critical for the development of pandemic influenza strains from avian influenza viruses... - Infection with highly pathogenic H7 influenza viruses results in an attenuated proinflammatory cytokine and chemokine response early after infectionJessica A Belser
Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30033, USA
J Infect Dis 203:40-8. 2011..These studies revealed that H7 viruses vary greatly in their ability to activate host innate responses and may contribute to the virulence of these viruses observed in humans... - Use of animal models to understand the pandemic potential of highly pathogenic avian influenza virusesJessica A Belser
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Adv Virus Res 73:55-97. 2009..As avian influenza viruses continue to cause human disease and death, animal pathogenesis studies identify avenues of investigation for novel preventative and therapeutic agents that could be effective in the event of a future pandemic... - The 2009 pandemic H1N1 and triple-reassortant swine H1N1 influenza viruses replicate efficiently but elicit an attenuated inflammatory response in polarized human bronchial epithelial cellsHui Zeng
Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 85:686-96. 2011..In addition, their less efficient replication at human upper airway temperatures has implications for the understanding of pandemic H1N1 virus adaptation to humans... - Oseltamivir inhibits H7 influenza virus replication in mice inoculated by the ocular routeJessica A Belser
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Antimicrob Agents Chemother 56:1616-8. 2012..We demonstrate that H7 viruses possess sensitivity to neuraminidase inhibitors and that administration of oseltamivir before ocular virus challenge in mice inhibits H7N7 and H7N3 virus replication in ocular and respiratory tissues... - Pathogenesis of emerging avian influenza viruses in mammals and the host innate immune responseTaronna R Maines
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Immunol Rev 225:68-84. 2008..This review focuses on avian influenza viruses as a pandemic threat, their induction of host innate immune responses in mammalian species, and the contribution of these responses to the disease process... - Pathogenesis of avian influenza (H7) virus infection in mice and ferrets: enhanced virulence of Eurasian H7N7 viruses isolated from humansJessica A Belser
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, MS G 16, 1600 Clifton Rd NE, Atlanta, GA 30333, USA
J Virol 81:11139-47. 2007..Therefore, in general, the relative virulence and cell tropism of the H7 viruses in these animal models correlated with the observed virulence in humans... - Efficacy of seasonal live attenuated influenza vaccine against virus replication and transmission of a pandemic 2009 H1N1 virus in ferretsMelissa B Pearce
Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States
Vaccine 29:2887-94. 2011..The results demonstrate that prior immunization with seasonal LAIV or H1N1 virus infection provides some cross-protection against the 2009 H1N1 virus, but had no significant effect on the transmission efficiency of the 2009 H1N1 virus... - Comparative immunogenicity and cross-clade protective efficacy of mammalian cell-grown inactivated and live attenuated H5N1 reassortant vaccines in ferretsKortney M Gustin
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
J Infect Dis 204:1491-9. 2011..Thus, enhanced respiratory tract antibody responses elicited by LAIV were associated with improved cross-clade protection... - Effect of D222G mutation in the hemagglutinin protein on receptor binding, pathogenesis and transmissibility of the 2009 pandemic H1N1 influenza virusJessica A Belser
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
PLoS ONE 6:e25091. 2011..These findings suggest that although the D222G mutation does not influence virus transmission, it may be considered a molecular marker for enhanced replication in certain cell types... - Contemporary North American influenza H7 viruses possess human receptor specificity: Implications for virus transmissibilityJessica A Belser
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Proc Natl Acad Sci U S A 105:7558-63. 2008..These results indicate that H7 influenza viruses from the North American lineage have acquired sialic acid-binding properties that more closely resemble those of human influenza viruses and have the potential to spread to naïve animals... - Influenza virus aerosol exposure and analytical system for ferretsKortney M Gustin
Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Proc Natl Acad Sci U S A 108:8432-7. 2011..These methods will provide improved risk assessment of emerging influenza viruses that pose a threat to public health... - Ocular infection of mice with influenza A (H7) viruses: a site of primary replication and spread to the respiratory tractJessica A Belser
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 83:7075-84. 2009..These findings demonstrate that avian influenza viruses within H7 and H5 subtypes are capable of using the eye as a portal of entry... - Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in miceTerrence M Tumpey
Influenza Branch, Mail Stop G 16, DVRD, NCID, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
J Virol 79:14933-44. 2005.... - Avian influenza (H5N1) viruses isolated from humans in Asia in 2004 exhibit increased virulence in mammalsTaronna R Maines
Influenza Branch, Mail Stop G-16, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, N.E, Atlanta, GA 30333, USA
J Virol 79:11788-800. 2005..However, the apparent enhancement of virulence of these viruses in humans in 2004 was better reflected in the ferret... - The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza virusesTerrence M Tumpey
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Virol 81:10818-21. 2007..Thus, the interferon-induced resistance factor Mx1 represents a key component of the murine innate immune system that mediates protection against epidemic and pandemic influenza viruses... - Ocular tropism of influenza A viruses: identification of H7 subtype-specific host responses in human respiratory and ocular cellsJessica A Belser
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
J Virol 85:10117-25. 2011.... - Lack of transmission of H5N1 avian-human reassortant influenza viruses in a ferret modelTaronna R Maines
Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Proc Natl Acad Sci U S A 103:12121-6. 2006..These results highlight the complexity of the genetic basis of influenza virus transmissibility and suggest that H5N1 viruses may require further adaptation to acquire this essential pandemic trait... - Infection of lung epithelial cells with pandemic 2009 A(H1N1) influenza viruses reveals isolate-specific differences in infectivity and host cellular responsesJenish R Patel
Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Viral Immunol 24:89-99. 2011.... - H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of miceLucy A Perrone
Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Collaborating Centers for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
PLoS Pathog 4:e1000115. 2008.... - Highly pathogenic avian influenza H5N1 viruses elicit an attenuated type i interferon response in polarized human bronchial epithelial cellsHui Zeng
Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Virol 81:12439-49. 2007..The attenuation of this critical host innate immune defense may contribute to the virulence of H5N1 viruses observed in humans... - Innovations in modeling influenza virus infections in the laboratoryKortney M Gustin
Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Trends Microbiol 20:275-81. 2012..Here, we briefly review the model systems used to study influenza virus infections, and focus particularly on recent advances that have increased our knowledge of these formidable respiratory pathogens... - Influenza A virus transmission: contributing factors and clinical implicationsJessica A Belser
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Expert Rev Mol Med 12:e39. 2010..A better understanding of the viral determinants necessary for efficient transmission will allow us to identify avian influenza viruses with pandemic potential... - 5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replicationPriya Ranjan
Influenza Division, NCIRD, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Virol J 7:102. 2010..Activation of innate immune pathogen sensor Retinoic Acid Inducible Gene-I (RIG-I) has recently been shown to induce antiviral state... - The ferret as a model organism to study influenza A virus infectionJessica A Belser
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Dis Model Mech 4:575-9. 2011..We highlight the recent and emerging uses of this species in influenza virus research that are advancing our understanding of virus-host interactions... - Reconstruction of the 1918 pandemic influenza virus: how revealing the molecular secrets of the virus responsible for the worst pandemic in recorded history can guide our response to future influenza pandemicsLucy A Perrone
Influenza Division, Mailstop G 16, National Center for Immunization and Respiratory Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
Infect Disord Drug Targets 7:294-303. 2007..Such research is being done with the hope that the knowledge gained will allow the world to better prepare for and respond to future influenza pandemics... - Resurrected pandemic influenza virusesTerrence M Tumpey
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Annu Rev Microbiol 63:79-98. 2009.... - Isolation and characterization of avian influenza viruses, including highly pathogenic H5N1, from poultry in live bird markets in Hanoi, Vietnam, in 2001Doan C Nguyen
Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Virol 79:4201-12. 2005.... - Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virusKathy Hancock
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
N Engl J Med 361:1945-52. 2009.... - Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in miceKristy J Szretter
Influenza Branch MS G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
J Virol 81:2736-44. 2007..These results suggest that TNF-alpha may contribute to morbidity during H5N1 influenza virus infection, while IL-1 may be important for effective virus clearance in nonlethal H5N1 disease... - Seasonal trivalent inactivated influenza vaccine does not protect against newly emerging variants of influenza A (H3N2v) virus in ferretsKatherine V Houser
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
J Virol 87:1261-3. 2013..The complete absence of specific hemagglutination inhibition antibody response to A(H3N2)v is consistent with the poor cross-protection observed among TIV-immune animals...