Terrence M Tumpey

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. doi request reprint Local innate immune responses and influenza virus transmission and virulence in ferrets
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 205:474-85. 2012
  2. pmc Pathogenesis of pandemic influenza A (H1N1) and triple-reassortant swine influenza A (H1) viruses in mice
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 84:4194-203. 2010
  3. ncbi request reprint A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission
    Terrence M Tumpey
    Influenza Branch, Mailstop G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    Science 315:655-9. 2007
  4. doi request reprint Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Nature 501:556-9. 2013
  5. doi request reprint Genetic analysis of avian influenza A viruses isolated from domestic waterfowl in live-bird markets of Hanoi, Vietnam, preceding fatal H5N1 human infections in 2004
    Samadhan J Jadhao
    Influenza Division, MS G16, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
    Arch Virol 154:1249-61. 2009
  6. pmc Early control of H5N1 influenza virus replication by the type I interferon response in mice
    Kristy J Szretter
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 303331, USA
    J Virol 83:5825-34. 2009
  7. pmc Seasonal trivalent inactivated influenza vaccine protects against 1918 Spanish influenza virus infection in ferrets
    Melissa B Pearce
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 86:7118-25. 2012
  8. pmc Pathogenesis and transmission of swine origin A(H3N2)v influenza viruses in ferrets
    Melissa B Pearce
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 109:3944-9. 2012
  9. pmc Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus
    Claudia Pappas
    Influenza Division, Mailstop G 16, National Center for Immunization and Respiratory Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road Northeast, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 105:3064-9. 2008
  10. pmc Tropism and infectivity of influenza virus, including highly pathogenic avian H5N1 virus, in ferret tracheal differentiated primary epithelial cell cultures
    Hui Zeng
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 87:2597-607. 2013

Collaborators

Detail Information

Publications61

  1. doi request reprint Local innate immune responses and influenza virus transmission and virulence in ferrets
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 205:474-85. 2012
    ..Our findings point to a link between localized innate immunity and influenza virus transmission and disease progression...
  2. pmc Pathogenesis of pandemic influenza A (H1N1) and triple-reassortant swine influenza A (H1) viruses in mice
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 84:4194-203. 2010
    ..Taken together, these studies demonstrate that the 2009 H1N1 viruses exhibited mild to moderate virulence in mice compared with highly pathogenic viruses...
  3. ncbi request reprint A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission
    Terrence M Tumpey
    Influenza Branch, Mailstop G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    Science 315:655-9. 2007
    ..These findings confirm an essential role of hemagglutinin receptor specificity for the transmission of influenza viruses among mammals...
  4. doi request reprint Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Nature 501:556-9. 2013
    ..Our results indicate that H7N9 viruses have the capacity for efficient replication in mammals and human airway cells and highlight the need for continued public health surveillance of this emerging virus. ..
  5. doi request reprint Genetic analysis of avian influenza A viruses isolated from domestic waterfowl in live-bird markets of Hanoi, Vietnam, preceding fatal H5N1 human infections in 2004
    Samadhan J Jadhao
    Influenza Division, MS G16, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
    Arch Virol 154:1249-61. 2009
    ..The clade-1 HPAI H5N1 viruses were independently introduced into Vietnam...
  6. pmc Early control of H5N1 influenza virus replication by the type I interferon response in mice
    Kristy J Szretter
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 303331, USA
    J Virol 83:5825-34. 2009
    ..These results suggest a role for the IFN-alpha/beta response in the control of H5N1 virus replication both in vivo and in vitro, and as such it may provide some degree of protection to the host in the early stages of infection...
  7. pmc Seasonal trivalent inactivated influenza vaccine protects against 1918 Spanish influenza virus infection in ferrets
    Melissa B Pearce
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 86:7118-25. 2012
    ..These findings suggest that exposure to A(H1N1)pdm09 through immunization may provide protection against the reconstructed 1918 virus which, as a select agent, is considered to pose both biosafety and biosecurity threats...
  8. pmc Pathogenesis and transmission of swine origin A(H3N2)v influenza viruses in ferrets
    Melissa B Pearce
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 109:3944-9. 2012
    ..These findings suggest that A(H3N2)v viruses have the capacity for efficient replication and transmission in mammals and underscore the need for continued public health surveillance...
  9. pmc Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus
    Claudia Pappas
    Influenza Division, Mailstop G 16, National Center for Immunization and Respiratory Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road Northeast, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 105:3064-9. 2008
    ..These results highlight the importance of the 1918 HA, NA, and PB1 genes for optimal virus replication and virulence of this pandemic strain...
  10. pmc Tropism and infectivity of influenza virus, including highly pathogenic avian H5N1 virus, in ferret tracheal differentiated primary epithelial cell cultures
    Hui Zeng
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 87:2597-607. 2013
    ..This ferret tracheal differentiated primary epithelial cell culture system provides a valuable in vitro model for studying cellular tropism, infectivity, and the pathogenesis of influenza viruses...
  11. pmc Pathogenesis and transmission of triple-reassortant swine H1N1 influenza viruses isolated before the 2009 H1N1 pandemic
    Jessica A Belser
    Influenza Division, Infectious Disease Pathology Branch, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 85:1563-72. 2011
    ....
  12. doi request reprint Kinetics of viral replication and induction of host responses in ferrets differs between ocular and intranasal routes of inoculation
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 438:56-60. 2013
    ..These findings provide a greater understanding of the modulation of host responses following different inoculation routes and underscore the risk associated with ocular exposure to influenza viruses...
  13. pmc Pathogenesis of 1918 pandemic and H5N1 influenza virus infections in a guinea pig model: antiviral potential of exogenous alpha interferon to reduce virus shedding
    Neal Van Hoeven
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 83:2851-61. 2009
    ....
  14. pmc Mice lacking both TNF and IL-1 receptors exhibit reduced lung inflammation and delay in onset of death following infection with a highly virulent H5N1 virus
    Lucy A Perrone
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 202:1161-70. 2010
    ..In particular, H5N1 virus infections are associated with a high expression of the proinflammatory cytokines, including interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-α)...
  15. pmc Receptor specificity and transmission of H2N2 subtype viruses isolated from the pandemic of 1957
    Claudia Pappas
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    PLoS ONE 5:e11158. 2010
    ..Our studies provide a correlation between binding affinity to glycan receptors with terminal alpha 2,6-linked sialic acid and the efficiency of respiratory droplet transmission for pandemic H2N2 influenza viruses...
  16. pmc Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Science 325:484-7. 2009
    ....
  17. pmc N-linked glycosylation of the hemagglutinin protein influences virulence and antigenicity of the 1918 pandemic and seasonal H1N1 influenza A viruses
    Xiangjie Sun
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunology and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 87:8756-66. 2013
    ..These results demonstrate that glycosylation patterns of the 1918 and seasonal H1N1 viruses directly contribute to differences in virulence and are partially responsible for their distinct antigenicity. ..
  18. pmc Comparison of the levels of infectious virus in respirable aerosols exhaled by ferrets infected with influenza viruses exhibiting diverse transmissibility phenotypes
    Kortney M Gustin
    Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 87:7864-73. 2013
    ..Our findings improve our understanding of the ferret transmission model and provide support for the potential for influenza virus aerosol transmission. ..
  19. pmc Influenza virus respiratory infection and transmission following ocular inoculation in ferrets
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Pathog 8:e1002569. 2012
    ....
  20. pmc Human pulmonary microvascular endothelial cells support productive replication of highly pathogenic avian influenza viruses: possible involvement in the pathogenesis of human H5N1 virus infection
    Hui Zeng
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 86:667-78. 2012
    ..Our results highlight remarkable tropism and infectivity of the H5N1 viruses for human pulmonary endothelial cells, resulting in the potent induction of host inflammatory responses...
  21. doi request reprint Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G16, Atlanta, GA 30333, USA
    Virology 413:139-47. 2011
    ....
  22. doi request reprint Multiple genes contribute to the virulent phenotype observed in ferrets of an H5N1 influenza virus isolated from Thailand in 2004
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 413:226-30. 2011
    ..Our results demonstrate that H5N1 virus virulence determinants are polygenic and that there is an important correlation between polymerase adaptation, efficient replication in the host, and virulence...
  23. pmc Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air
    Neal Van Hoeven
    Influenza Division, Mailstop G 16, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road Northeast, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 106:3366-71. 2009
    ..These findings demonstrate that the adaptation of the HA and PB2 proteins are critical for the development of pandemic influenza strains from avian influenza viruses...
  24. pmc Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice
    Terrence M Tumpey
    Influenza Branch, Mail Stop G 16, DVRD, NCID, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
    J Virol 79:14933-44. 2005
    ....
  25. doi request reprint Inducible nitric oxide contributes to viral pathogenesis following highly pathogenic influenza virus infection in mice
    Lucy A Perrone
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 207:1576-84. 2013
    ..This study demonstrates that NO contributes to the pathogenic outcome of H5N1 and 1918 viral infections in the mouse model...
  26. pmc Infection with highly pathogenic H7 influenza viruses results in an attenuated proinflammatory cytokine and chemokine response early after infection
    Jessica A Belser
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30033, USA
    J Infect Dis 203:40-8. 2011
    ..These studies revealed that H7 viruses vary greatly in their ability to activate host innate responses and may contribute to the virulence of these viruses observed in humans...
  27. doi request reprint Use of animal models to understand the pandemic potential of highly pathogenic avian influenza viruses
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Adv Virus Res 73:55-97. 2009
    ..As avian influenza viruses continue to cause human disease and death, animal pathogenesis studies identify avenues of investigation for novel preventative and therapeutic agents that could be effective in the event of a future pandemic...
  28. pmc The 2009 pandemic H1N1 and triple-reassortant swine H1N1 influenza viruses replicate efficiently but elicit an attenuated inflammatory response in polarized human bronchial epithelial cells
    Hui Zeng
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 85:686-96. 2011
    ..In addition, their less efficient replication at human upper airway temperatures has implications for the understanding of pandemic H1N1 virus adaptation to humans...
  29. ncbi request reprint Characterization of the reconstructed 1918 Spanish influenza pandemic virus
    Terrence M Tumpey
    Influenza Branch, Mailstop G 16, Division of Viral and Rickettsial Diseases DVRD, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
    Science 310:77-80. 2005
    ..Moreover, the coordinated expression of the 1918 virus genes most certainly confers the unique high-virulence phenotype observed with this pandemic virus...
  30. doi request reprint Simvastatin and oseltamivir combination therapy does not improve the effectiveness of oseltamivir alone following highly pathogenic avian H5N1 influenza virus infection in mice
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States
    Virology 439:42-6. 2013
    ..Modest reductions in lung cytokine production in H5N1 but not H1N1 virus-infected simvastatin-treated mice indicate a potential benefit for statin use in mitigating disease following severe virus infection...
  31. pmc Seasonal trivalent inactivated influenza vaccine does not protect against newly emerging variants of influenza A (H3N2v) virus in ferrets
    Katherine V Houser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    J Virol 87:1261-3. 2013
    ..The complete absence of specific hemagglutination inhibition antibody response to A(H3N2)v is consistent with the poor cross-protection observed among TIV-immune animals...
  32. pmc Pathogenesis, transmissibility, and ocular tropism of a highly pathogenic avian influenza A (H7N3) virus associated with human conjunctivitis
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 87:5746-54. 2013
    ....
  33. pmc Oseltamivir inhibits H7 influenza virus replication in mice inoculated by the ocular route
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Antimicrob Agents Chemother 56:1616-8. 2012
    ..We demonstrate that H7 viruses possess sensitivity to neuraminidase inhibitors and that administration of oseltamivir before ocular virus challenge in mice inhibits H7N7 and H7N3 virus replication in ocular and respiratory tissues...
  34. doi request reprint Efficacy of seasonal live attenuated influenza vaccine against virus replication and transmission of a pandemic 2009 H1N1 virus in ferrets
    Melissa B Pearce
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States
    Vaccine 29:2887-94. 2011
    ..The results demonstrate that prior immunization with seasonal LAIV or H1N1 virus infection provides some cross-protection against the 2009 H1N1 virus, but had no significant effect on the transmission efficiency of the 2009 H1N1 virus...
  35. doi request reprint Pathogenesis of emerging avian influenza viruses in mammals and the host innate immune response
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Immunol Rev 225:68-84. 2008
    ..This review focuses on avian influenza viruses as a pandemic threat, their induction of host innate immune responses in mammalian species, and the contribution of these responses to the disease process...
  36. pmc Ocular infection of mice with influenza A (H7) viruses: a site of primary replication and spread to the respiratory tract
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 83:7075-84. 2009
    ..These findings demonstrate that avian influenza viruses within H7 and H5 subtypes are capable of using the eye as a portal of entry...
  37. pmc Contemporary North American influenza H7 viruses possess human receptor specificity: Implications for virus transmissibility
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 105:7558-63. 2008
    ..These results indicate that H7 influenza viruses from the North American lineage have acquired sialic acid-binding properties that more closely resemble those of human influenza viruses and have the potential to spread to naïve animals...
  38. pmc Effect of D222G mutation in the hemagglutinin protein on receptor binding, pathogenesis and transmissibility of the 2009 pandemic H1N1 influenza virus
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 6:e25091. 2011
    ..These findings suggest that although the D222G mutation does not influence virus transmission, it may be considered a molecular marker for enhanced replication in certain cell types...
  39. doi request reprint Comparative immunogenicity and cross-clade protective efficacy of mammalian cell-grown inactivated and live attenuated H5N1 reassortant vaccines in ferrets
    Kortney M Gustin
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 204:1491-9. 2011
    ..Thus, enhanced respiratory tract antibody responses elicited by LAIV were associated with improved cross-clade protection...
  40. pmc Influenza virus aerosol exposure and analytical system for ferrets
    Kortney M Gustin
    Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 108:8432-7. 2011
    ..These methods will provide improved risk assessment of emerging influenza viruses that pose a threat to public health...
  41. pmc Impact of prior seasonal H3N2 influenza vaccination or infection on protection and transmission of emerging variants of influenza A(H3N2)v virus in ferrets
    Katherine V Houser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 87:13480-9. 2013
    ..The data demonstrate in ferrets that the efficiency of A(H3N2)v transmission is disrupted by preexisting immunity induced by seasonal H3N2 virus infection. ..
  42. pmc Pathogenesis of avian influenza (H7) virus infection in mice and ferrets: enhanced virulence of Eurasian H7N7 viruses isolated from humans
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, MS G 16, 1600 Clifton Rd NE, Atlanta, GA 30333, USA
    J Virol 81:11139-47. 2007
    ..Therefore, in general, the relative virulence and cell tropism of the H7 viruses in these animal models correlated with the observed virulence in humans...
  43. pmc Ocular tropism of influenza A viruses: identification of H7 subtype-specific host responses in human respiratory and ocular cells
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    J Virol 85:10117-25. 2011
    ....
  44. doi request reprint Infection of lung epithelial cells with pandemic 2009 A(H1N1) influenza viruses reveals isolate-specific differences in infectivity and host cellular responses
    Jenish R Patel
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Viral Immunol 24:89-99. 2011
    ....
  45. pmc Lack of transmission of H5N1 avian-human reassortant influenza viruses in a ferret model
    Taronna R Maines
    Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 103:12121-6. 2006
    ..These results highlight the complexity of the genetic basis of influenza virus transmissibility and suggest that H5N1 viruses may require further adaptation to acquire this essential pandemic trait...
  46. pmc The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses
    Terrence M Tumpey
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Virol 81:10818-21. 2007
    ..Thus, the interferon-induced resistance factor Mx1 represents a key component of the murine innate immune system that mediates protection against epidemic and pandemic influenza viruses...
  47. pmc H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice
    Lucy A Perrone
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Collaborating Centers for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Pathog 4:e1000115. 2008
    ....
  48. pmc Highly pathogenic avian influenza H5N1 viruses elicit an attenuated type i interferon response in polarized human bronchial epithelial cells
    Hui Zeng
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Virol 81:12439-49. 2007
    ..The attenuation of this critical host innate immune defense may contribute to the virulence of H5N1 viruses observed in humans...
  49. doi request reprint Considerations regarding appropriate sample size for conducting ferret transmission experiments
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Future Microbiol 8:961-5. 2013
    ..A closer examination of previously published studies utilizing this model as it is currently employed reveals that the 'sample size' of these studies is not always as small as it may appear. ..
  50. pmc Ocular tropism of respiratory viruses
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Microbiol Mol Biol Rev 77:144-56. 2013
    ..Identification of shared receptor-binding preferences, host responses, and laboratory modeling protocols among these viruses provides a needed bridge between clinical and laboratory studies of virus tropism...
  51. pmc Avian influenza (H5N1) viruses isolated from humans in Asia in 2004 exhibit increased virulence in mammals
    Taronna R Maines
    Influenza Branch, Mail Stop G 16, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
    J Virol 79:11788-800. 2005
    ..However, the apparent enhancement of virulence of these viruses in humans in 2004 was better reflected in the ferret...
  52. doi request reprint Innovations in modeling influenza virus infections in the laboratory
    Kortney M Gustin
    Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Trends Microbiol 20:275-81. 2012
    ..Here, we briefly review the model systems used to study influenza virus infections, and focus particularly on recent advances that have increased our knowledge of these formidable respiratory pathogens...
  53. pmc The ferret as a model organism to study influenza A virus infection
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Dis Model Mech 4:575-9. 2011
    ..We highlight the recent and emerging uses of this species in influenza virus research that are advancing our understanding of virus-host interactions...
  54. doi request reprint Influenza A virus transmission: contributing factors and clinical implications
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Expert Rev Mol Med 12:e39. 2010
    ..A better understanding of the viral determinants necessary for efficient transmission will allow us to identify avian influenza viruses with pandemic potential...
  55. pmc 5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication
    Priya Ranjan
    Influenza Division, NCIRD, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virol J 7:102. 2010
    ..Activation of innate immune pathogen sensor Retinoic Acid Inducible Gene-I (RIG-I) has recently been shown to induce antiviral state...
  56. pmc Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice
    Kristy J Szretter
    Influenza Branch MS G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    J Virol 81:2736-44. 2007
    ..These results suggest that TNF-alpha may contribute to morbidity during H5N1 influenza virus infection, while IL-1 may be important for effective virus clearance in nonlethal H5N1 disease...
  57. ncbi request reprint Reconstruction of the 1918 pandemic influenza virus: how revealing the molecular secrets of the virus responsible for the worst pandemic in recorded history can guide our response to future influenza pandemics
    Lucy A Perrone
    Influenza Division, Mailstop G 16, National Center for Immunization and Respiratory Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
    Infect Disord Drug Targets 7:294-303. 2007
    ..Such research is being done with the hope that the knowledge gained will allow the world to better prepare for and respond to future influenza pandemics...
  58. doi request reprint Resurrected pandemic influenza viruses
    Terrence M Tumpey
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Annu Rev Microbiol 63:79-98. 2009
    ....
  59. doi request reprint Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus
    Kathy Hancock
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 361:1945-52. 2009
    ....
  60. pmc Isolation and characterization of avian influenza viruses, including highly pathogenic H5N1, from poultry in live bird markets in Hanoi, Vietnam, in 2001
    Doan C Nguyen
    Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Virol 79:4201-12. 2005
    ....
  61. doi request reprint H5N1 pathogenesis studies in mammalian models
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States
    Virus Res 178:168-85. 2013
    ..This research contributes not only to our understanding of influenza virus pathogenesis, but also identifies novel preventative and therapeutic targets to mitigate the disease burden caused by avian influenza viruses. ..