Research Topics
| Ralph A TrippSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
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Detail Information
Publications
Respiratory syncytial virus G and/or SH protein alters Th1 cytokines, natural killer cells, and neutrophils responding to pulmonary infection in BALB/c miceR A Tripp
Division of Viral and Rickettsial Diseases, National Center of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 73:7099-107. 1999..These data show that G and/or SH protein has a marked impact on the inflammatory and innate immune response to RSV infection...
Substance P receptor expression on lymphocytes is associated with the immune response to respiratory syncytial virus infectionRalph A Tripp
Division of Viral and Rickettsial Diseases, National Center of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Neuroimmunol 129:141-53. 2002..These results suggest that SP receptor expression may be important in the development of primary and secondary immune responses to respiratory virus infections...- Peripheral blood mononuclear cells from infants hospitalized because of respiratory syncytial virus infection express T helper-1 and T helper-2 cytokines and CC chemokine messenger RNARalph A Tripp
National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, Respiratory and Enteric Virus Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Infect Dis 185:1388-94. 2002..The results suggest that RSV infection induces both Th1 and Th2 cytokine expression and CC chemokine expression... - CX3C chemokine mimicry by respiratory syncytial virus G glycoproteinR A Tripp
National Centers for Infectious Diseases, Division of Viral and Rickettsial Diseases, Respiratory and Enteric Virus Branch, Mailstop G 09, 1600 Clifton Rd, Atlanta, GA, USA
Nat Immunol 2:732-8. 2001..We also show that CX3CR1 facilitates RSV infection of cells. Thus, G glycoprotein interaction with CX3CR1 probably plays a key role in the biology of RSV infection... - CD4(+) T cell frequencies and Th1/Th2 cytokine patterns expressed in the acute and memory response to respiratory syncytial virus I-E(d)-restricted peptidesR A Tripp
Division of Viral and Rickettsial Diseases, National Center of Infectious Diseases, Atlanta, Georgia 30333, USA
Cell Immunol 207:59-71. 2001..The frequency and breadth of cytokine expression by I-E(d)-restricted CD4(+) T cells to peptide stimulation was diminished in the memory response... - Respiratory syncytial virus G and/or SH glycoproteins modify CC and CXC chemokine mRNA expression in the BALB/c mouseR A Tripp
Division of Viral and Rickettsial Diseases, National Center of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 74:6227-9. 2000..The results suggest that RSV G and/or SH proteins inhibit early MIP-1alpha, MIP-1beta, MIP-2, MCP-1, and IP-10 mRNA expression. TCA-3 mRNA expression was found to be increased during PIV-3 infection... - TH(1)- and TH(2)-TYPE cytokine expression by activated t lymphocytes from the lung and spleen during the inflammatory response to respiratory syncytial virusR A Tripp
Division of Viral and Rickettsial Diseases, National Center of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA
Cytokine 12:801-7. 2000..These data demonstrate that RSV-induced pulmonary inflammation involves extensive cellular activation and cytokine expression, particularly by CD54(+)and CD102(+)lymphocytes in the lung... - CD40 ligand (CD154) enhances the Th1 and antibody responses to respiratory syncytial virus in the BALB/c mouseR A Tripp
Division of Viral and Rickettsial Diseases, National Center of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Immunol 164:5913-21. 2000..These data suggest that CD40L may have the adjuvant properties needed to optimize the safety and efficacy of RSV vaccines... - Respiratory syncytial virus infection and G and/or SH protein expression contribute to substance P, which mediates inflammation and enhanced pulmonary disease in BALB/c miceR A Tripp
Division of Viral and Rickettsial Diseases, National Center of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 74:1614-22. 2000..These data suggest that SP may be an important contributor to the inflammatory response to RSV infection and that anti-SP F(ab)(2) antibodies might be used to ameliorate RSV-associated disease... - Role of cytokines in the development and maintenance of memory T cells during respiratory viral infectionRalph A Tripp
Centers for Disease Control and Prevention, National Center for Infectious Diseases, Respiratory and Enteric Viruses Branch, 1600 Clifton Rd, Mailstop G 09, Atlanta, GA 30333, USA
Curr Pharm Des 9:51-9. 2003..This review addresses aspects of T cell biology that constitute the response to respiratory viral infections... - Respiratory syncytial virus G protein and G protein CX3C motif adversely affect CX3CR1+ T cell responsesJennifer Harcourt
Division of Viral and Rickettsial Diseases, Viral and Enteric Virus Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Immunol 176:1600-8. 2006..In addition, we show that CX3CR1+ cells constitute a major component of the cytotoxic response to RSV infection. These results suggest that G protein and the G protein CX3C motif reduce the antiviral T cell response to RSV infection... - Pulmonary delivery of respiratory syncytial virus DNA vaccines using macroaggregated albumin particlesJennifer L Harcourt
Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, National Center for Infectious Diseases, 1600 Clifton Road NE, Mailstop G-09, Atlanta, GA 30333, USA
Vaccine 22:2248-60. 2004..This study shows that MAA may be a useful carrier for RSV DNA vaccines... - Prophylactic treatment with a G glycoprotein monoclonal antibody reduces pulmonary inflammation in respiratory syncytial virus (RSV)-challenged naive and formalin-inactivated RSV-immunized BALB/c miceGertrud U Radu
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop G 18, Atlanta, GA 30333, USA
J Virol 84:9632-6. 2010..It is possible that antibodies with similar reactivities might prevent enhanced disease and improve the safety of nonlive virus vaccines... - Treatment with respiratory syncytial virus G glycoprotein monoclonal antibody or F(ab')2 components mediates reduced pulmonary inflammation in miceCongrong Miao
National Centers for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Gen Virol 90:1119-23. 2009..Thus, this mAb has two independent actions that could facilitate treatment and/or prevention of RSV infection by reducing both virus replication and virus-induced pulmonary inflammation... - Enhanced disease and pulmonary eosinophilia associated with formalin-inactivated respiratory syncytial virus vaccination are linked to G glycoprotein CX3C-CX3CR1 interaction and expression of substance PLia M Haynes
Division of Viral and Rickettsial Diseases, National Center of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Virol 77:9831-44. 2003..These data suggest that the G glycoprotein, and in particular the G glycoprotein CX3C motif, is key in the enhanced inflammatory response to FI-RSV vaccination, possibly through the induction of substance P... - Anti-G protein antibody responses to respiratory syncytial virus infection or vaccination are associated with inhibition of G protein CX3C-CX3CR1 binding and leukocyte chemotaxisJennifer L Harcourt
National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, Respiratory and Enteric Virus Branch, Atlanta, GA, USA
J Infect Dis 190:1936-40. 2004..In the present study, we show that anti-RSV G protein antibody responses after recent RSV infection or vaccination are associated with inhibition of RSV G protein CX3C-CX3CR1 interaction and RSV G protein-mediated leukocyte chemotaxis... - CD40 ligand (CD154) improves the durability of respiratory syncytial virus DNA vaccination in BALB/c miceJennifer L Harcourt
National Centers for Infectious Diseases, Division of Viral and Rickettsial Diseases, Respiratory and Enteric Virus Branch, 1600 Clifton Road NE, Mailstop G-09, Atlanta, GA 30333, USA
Vaccine 21:2964-79. 2003..The addition of CD40L to DNA vaccines encoding the F glycoprotein enhanced virus clearance and some aspects of the immune response to RSV challenge, suggesting that CD40L may enhance the durability of RSV DNA vaccines... - Human metapneumovirus persists in BALB/c mice despite the presence of neutralizing antibodiesRene Alvarez
Division of Respiratory and Enteric Viruses, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
J Virol 78:14003-11. 2004..This study shows that BALB/c mice are amenable for HMPV studies and indicates that HMPV persists as infectious virus in the lungs of normal mice for several weeks postinfection... - Monoclonal antibodies to SARS-associated coronavirus (SARS-CoV): identification of neutralizing and antibodies reactive to S, N, M and E viral proteinsRalph A Tripp
National Centers for Infectious Diseases, Division of Viral and Rickettsial Diseases, Respiratory and Enteric Virus Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, Mailstop G-09, Atlanta, GA 30333, USA
J Virol Methods 128:21-8. 2005..The mAbs characterized should prove useful for developing SARS-CoV diagnostic assays and for studying the biology of infection and pathogenesis of disease... 
Therapeutic monoclonal antibody treatment targeting respiratory syncytial virus (RSV) G protein mediates viral clearance and reduces the pathogenesis of RSV infection in BALB/c miceLia M Haynes
National Centers for Immunization and Respiratory Diseases, Div of Viral Diseases, Respiratory and Gastroenteritis Viruses Branch, 1600 Clifton Rd NE, Mailstop G 18, Atlanta, GA 30333, USA
J Infect Dis 200:439-47. 2009....- Serological cross-reactivity of members of the Metapneumovirus genusRene Alvarez
Division of Respiratory and Enteric Viruses, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Virus Res 105:67-73. 2004..These reagents provide new tools and methods for investigating HMPV infection, for differentiating HMPV from RSV infection, and may be useful for characterizing potential links between HMPV with other respiratory complications... - Neutralizing anti-F glycoprotein and anti-substance P antibody treatment effectively reduces infection and inflammation associated with respiratory syncytial virus infectionLia M Haynes
Respiratory and Enteric Virus Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 76:6873-81. 2002..The results suggest that combined anti-viral and anti-SP antibody treatment may be effective in treating RSV disease... - The G glycoprotein of respiratory syncytial virus depresses respiratory rates through the CX3C motif and substance PRalph A Tripp
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 77:6580-4. 2003..These data suggest new approaches for treating some aspects of RSV disease... - Combination therapy using monoclonal antibodies against respiratory syncytial virus (RSV) G glycoprotein protects from RSV disease in BALB/c miceHayat Caidi
National Center for Immunization and Respiratory Diseases, Division of Viral Diseases, Gastroenteritis and Respiratory Viruses Laboratory Branch, Centers for Disease Control and Prevention CDC, Atlanta, GA, USA
PLoS ONE 7:e51485. 2012..The results suggest that anti-RSV G protein mAbs that react at or near the CCR and can block RSV G protein-mediated activities are effective at preventing RSV disease and may be an effective strategy for RSV therapeutic treatment... - Therapeutic applications of RNAi for silencing virus replicationRalph A Tripp
Department of Infectious Diseases, College of Veterinary Medicine, Center for Disease Intervention, University of Georgia, Athens, GA, USA
Methods Mol Biol 555:43-61. 2009..The methods and caveats to achieve these goals are discussed... - Real-time detection of virus particles and viral protein expression with two-color nanoparticle probesAmit Agrawal
Department of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322, USA
J Virol 79:8625-8. 2005..A major development is use of dual-color quantum dots or fluorescence energy transfer nanobeads that can be simultaneously excited with a single light source... - An in vitro model of the leukocyte interactions associated with granuloma formation in Mycobacterium tuberculosis infectionKristin A Birkness
Mycobacteriology Laboratory Branch, Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, GA, USA
Immunol Cell Biol 85:160-8. 2007..001). This model may provide insight into the earliest stages of granuloma formation in those newly infected... - Surveillance of feral cats for influenza A virus in north central FloridaJames T Gordy
Department of Infectious Diseases, University of Georgia, Athens, GA, USA
Influenza Other Respi Viruses 6:341-7. 2012..Experimental infections have demonstrated transmission of influenza viruses in cats... - Pathogenesis of respiratory syncytial virus infectionRalph A Tripp
Division of Viral and Rickettsial Diseases, Viral and Enteric Virus Branch, Centers for Disease Control and Prevention, Atlanta, Georgia
Viral Immunol 17:165-81. 2004..This review summarizes important aspects of these findings, and provides current perspective on processes that may contribute to RSV disease pathogenesis... - Comparison of the receptor binding properties of contemporary swine isolates and early human pandemic H1N1 isolates (Novel 2009 H1N1)Konrad C Bradley
Department of Microbiology and Immunology, Emory University School of Medicine, 1510 Clifton Rd, Atlanta, GA 30322, USA
Virology 413:169-82. 2011.... - Counting single native biomolecules and intact viruses with color-coded nanoparticlesAmit Agrawal
Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, 101 Woodruff Circle Suite 2001, Atlanta, GA 30322, USA
Anal Chem 78:1061-70. 2006.... - Adenovirus 36, adiposity, and bone strength in late-adolescent femalesEmma M Laing
Department of Foods and Nutrition, The University of Georgia, Athens, GA, USA
J Bone Miner Res 28:489-96. 2013..These data support an association of adiposity and cortical bone strength at the radius with the presence of neutralizing antibodies to Ad36 in late-adolescent females. © 2013 American Society for Bone and Mineral Research... - The brume surrounding respiratory syncytial virus persistenceRalph A Tripp
Am J Respir Crit Care Med 169:778-9. 2004 - The immune response to human metapneumovirus is associated with aberrant immunity and impaired virus clearance in BALB/c miceRene Alvarez
College of Veterinary Medicine, Department of Infectious University of Georgia, Athens, GA 30602, USA
J Virol 79:5971-8. 2005..These features are consistent with virus persistence and indicate that the immune response to HMPV is unique compared to the immune response to RSV... - Serum mannose-binding lectin levels are linked with respiratory syncytial virus (RSV) diseaseLucas Zimon Giacomini Ribeiro
Laboratorio de Virologia, Instituto de Ciencias Biomedicas, Universidade Federal de Uberlândia UFU, Av Pará, 1720, Bloco 4C, andar superior, Campus Umuarama, 38400 902, Uberlandia, Minas Gerais, Brazil
J Clin Immunol 28:166-73. 2008..These results suggest that low serum MBL levels may be a marker of RSV disease severity in children and that MBL may be important in limiting RSV disease pathogenesis... - Bioconjugated nanoparticle detection of respiratory syncytial virus infectionRalph A Tripp
College of Veterinary Medicine, Department of Infectious Diseases, Center for Disease Intervention, University of Georgia, Athens, GA 30602, USA
Int J Nanomedicine 2:117-24. 2007.... - Respiratory syncytial virus (RSV) infects neuronal cells and processes that innervate the lung by a process involving RSV G proteinXia-Qing Li
Department of Infectious Diseases, University of Georgia, College of Veterinary Medicine, Athens, GA 30602, USA
J Virol 80:537-40. 2006..These findings suggest a mechanism for disease chronicity and have important implications for RSV disease intervention strategies... - Rapid and sensitive detection of respiratory virus molecular signatures using a silver nanorod array SERS substrateSaratchandra Shanmukh
Department of Chemistry, Physics and Astronomy and Center for Disease Intervention, Department of Infectious Diseases, University of Georgia, Athens, Georgia 30602, USA
Nano Lett 6:2630-6. 2006..The method provides rapid diagnostics for detection and characterization of viruses generating reproducible spectra without viral manipulation... - Perspective on the host response to human metapneumovirus infection: what can we learn from respiratory syncytial virus infections?Surendran Mahalingam
Viral Arthritis Asthma Research Group, School of Health Sciences, University of Canberra, Canberra, ACT 2601, Australia
Microbes Infect 8:285-93. 2006..This review provides a current perspective on the processes associated with HMPV infection, immunity, and disease pathogenesis... - Cytokines and respiratory syncytial virus infectionRalph A Tripp
College of Veterinary Medicine, Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA
Proc Am Thorac Soc 2:147-9. 2005..In this report, we discuss the role of cytokines and chemokines in the response to RSV infection, and the potential role for suppressor of cytokine signaling (SOCS) proteins in regulating these responses...