Aleksandr B Stefaniak

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. pmc Dissolution of the metal sensitizers Ni, Be, Cr in artificial sweat to improve estimates of dermal bioaccessibility
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Environ Sci Process Impacts 16:341-51. 2014
  2. doi Release of beryllium into artificial airway epithelial lining fluid
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    Arch Environ Occup Health 67:219-28. 2012
  3. pmc International guidelines for the in vivo assessment of skin properties in non-clinical settings: part 1. pH
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Skin Res Technol 19:59-68. 2013
  4. ncbi A theoretical framework for evaluating analytical digestion methods for poorly soluble particulate beryllium
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Anal Bioanal Chem 387:2411-7. 2007
  5. doi Dissolution of beryllium in artificial lung alveolar macrophage phagolysosomal fluid
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Mail Stop H 2703, Morgantown, WV 26505, USA
    Chemosphere 83:1181-7. 2011
  6. doi Size-selective poorly soluble particulate reference materials for evaluation of quantitative analytical methods
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdate Road, Morgantown, WV 26505, USA
    Anal Bioanal Chem 391:2071-7. 2008
  7. doi Release of beryllium from beryllium-containing materials in artificial skin surface film liquids
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Ann Occup Hyg 55:57-69. 2011
  8. doi Physicochemical characteristics of aerosol particles generated during the milling of beryllium silicate ores: implications for risk assessment
    Aleksandr B Stefaniak
    Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 71:1468-81. 2008
  9. doi Dissolution of cemented carbide powders in artificial sweat: implications for cobalt sensitization and contact dermatitis
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mailstop H 2800, Morgantown, WV 26505, USA
    J Environ Monit 12:1815-22. 2010
  10. ncbi Differences in dissolution behavior in a phagolysosomal simulant fluid for single-constituent and multi-constituent materials associated with beryllium sensitization and chronic beryllium disease
    Aleksandr B Stefaniak
    Industrial Hygiene and Safety Group, MS K553, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Toxicol In Vitro 20:82-95. 2006

Collaborators

Detail Information

Publications46

  1. pmc Dissolution of the metal sensitizers Ni, Be, Cr in artificial sweat to improve estimates of dermal bioaccessibility
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Environ Sci Process Impacts 16:341-51. 2014
    ....
  2. doi Release of beryllium into artificial airway epithelial lining fluid
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    Arch Environ Occup Health 67:219-28. 2012
    ....
  3. pmc International guidelines for the in vivo assessment of skin properties in non-clinical settings: part 1. pH
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Skin Res Technol 19:59-68. 2013
    ..Hence, guidelines are needed for consistent measurement of skin surface pH in environments that are difficult to control...
  4. ncbi A theoretical framework for evaluating analytical digestion methods for poorly soluble particulate beryllium
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Anal Bioanal Chem 387:2411-7. 2007
    ..Figure Generation of aerosol particles during machining of beryllium oxide...
  5. doi Dissolution of beryllium in artificial lung alveolar macrophage phagolysosomal fluid
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Mail Stop H 2703, Morgantown, WV 26505, USA
    Chemosphere 83:1181-7. 2011
    ..Materials associated with elevated prevalence of CBD had faster beryllium dissolution rates [10(-7)-10(-8)gcm(-2)d(-1)] than materials not associated with elevated prevalence (p<0.05)...
  6. doi Size-selective poorly soluble particulate reference materials for evaluation of quantitative analytical methods
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdate Road, Morgantown, WV 26505, USA
    Anal Bioanal Chem 391:2071-7. 2008
    ..01 g/cm(3)). The data support more detailed characterization of the sludge materials for use as size-selective RMs. This work illustrates an approach that can be used to develop RMs that are difficult to digest...
  7. doi Release of beryllium from beryllium-containing materials in artificial skin surface film liquids
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Ann Occup Hyg 55:57-69. 2011
    ..The purpose of this study was to investigate the hypothesis that particulate beryllium compounds in contact with skin surface release ions via dissolution in sweat...
  8. doi Physicochemical characteristics of aerosol particles generated during the milling of beryllium silicate ores: implications for risk assessment
    Aleksandr B Stefaniak
    Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 71:1468-81. 2008
    ..While finished product beryllium hydroxide particles may confer bioavailability similar to that of high-CBD risk aerosols, physical exposure factors (i.e., large particle sizes) may limit development of alveolar lung burdens...
  9. doi Dissolution of cemented carbide powders in artificial sweat: implications for cobalt sensitization and contact dermatitis
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mailstop H 2800, Morgantown, WV 26505, USA
    J Environ Monit 12:1815-22. 2010
    ..Observed dissolution rates for cobalt in artificial sweat indicate that dermal uptake may be sufficient to induce cobalt sensitization and allergic dermatitis...
  10. ncbi Differences in dissolution behavior in a phagolysosomal simulant fluid for single-constituent and multi-constituent materials associated with beryllium sensitization and chronic beryllium disease
    Aleksandr B Stefaniak
    Industrial Hygiene and Safety Group, MS K553, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Toxicol In Vitro 20:82-95. 2006
    ..Additional studies of the dissolution behavior of beryllium materials in a variety of mixture configurations will aid in developing exposure-response models to improve understanding of the risk of beryllium sensitization and CBD...
  11. pmc Persistence of tungsten oxide particle/fiber mixtures in artificial human lung fluids
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Part Fibre Toxicol 7:38. 2010
    ..The aim of this research was to investigate whether fiber-containing TBOs had prolonged biodurability in artificial lung fluids compared to tungsten metal or WO3 and therefore potentially could pose a greater inhalation hazard...
  12. ncbi Characterization of phagolysosomal simulant fluid for study of beryllium aerosol particle dissolution
    A B Stefaniak
    Health Safety and Radiation Protection Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Toxicol In Vitro 19:123-34. 2005
    ..In addition, the critical approach used to evaluate and adjust the composition of PSF may serve as a framework for characterizing PSF to study dissolution of other metal and oxide particles...
  13. doi Influence of artificial gastric juice composition on bioaccessibility of cobalt- and tungsten-containing powders
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Int J Hyg Environ Health 213:107-15. 2010
    ..Nonetheless, ingestion exposure may not contribute appreciably to total body burden given the short residence time of material in the stomach and relatively long dissolution half-times of these materials (t(1/2) = 60 to 380 days)...
  14. doi Characterization of exposures among cemented tungsten carbide workers. Part I: Size-fractionated exposures to airborne cobalt and tungsten particles
    Aleksandr B Stefaniak
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Expo Sci Environ Epidemiol 19:475-91. 2009
    ..By characterizing size-selective and co-exposures as well as multiple exposure pathways, this series of papers offer an approach for developing biologically meaningful exposure metrics for use in epidemiology...
  15. doi Sensitization and chronic beryllium disease at a primary manufacturing facility, part 3: exposure-response among short-term workers
    Christine R Schuler
    Division of Respiratory Disease Studies, Field Studies Branch, NIOSH, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Scand J Work Environ Health 38:270-81. 2012
    ..We examined exposure-response relations using personal exposure estimates in a beryllium worker cohort with limited work tenure to minimize exposure misclassification...
  16. ncbi Surface area of respirable beryllium metal, oxide, and copper alloy aerosols and implications for assessment of exposure risk of chronic beryllium disease
    Aleksandr B Stefaniak
    Industrial Hygiene and Safety Group HSR 5, MS K553, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    AIHA J (Fairfax, Va) 64:297-305. 2003
    ..To avoid errors in predicting bioavailability of beryllium and the associated risks for CBD, the mechanisms of particle formation should be understood and the SSA of beryllium particles should be measured directly...
  17. doi Sensitization and chronic beryllium disease at a primary manufacturing facility, part 1: historical exposure reconstruction
    M Abbas Virji
    National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Scand J Work Environ Health 38:247-58. 2012
    ..The objective of this study was to develop historical estimates of size-selective personal exposure to beryllium for an epidemiologic study...
  18. ncbi Exposure pathway assessment at a copper-beryllium alloy facility
    Gregory A Day
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, WV 26505, USA
    Ann Occup Hyg 51:67-80. 2007
    ..Based on our current understanding of the multiple exposure pathways that may lead to sensitization, we support prudent control practices such as use of protective gloves to minimize skin exposure to beryllium salts and fine particles...
  19. doi Sensitization and chronic beryllium disease at a primary manufacturing facility, part 2: validation of historical exposures
    Ji Young Park
    National Institute for Occupational Safety and Health NIOSH, Division of Respiratory Disease Studies, Morgantown, WV, USA
    Scand J Work Environ Health 38:259-69. 2012
    ..The JEM was generated for an epidemiologic study to examine quantitative exposure-response relationships with sensitization and chronic beryllium disease...
  20. ncbi Characterization of physicochemical properties of beryllium aerosols associated with prevalence of chronic beryllium disease
    Aleksandr B Stefaniak
    Industrial Hygiene and Safety Group HSR 5, MS K553, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    J Environ Monit 6:523-32. 2004
    ..However, a scientific basis does not yet exist to replace mass as the current metric of exposure...
  21. ncbi Characteristics of dusts encountered during the production of cemented tungsten carbides
    Aleksandr B Stefaniak
    Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Ind Health 45:793-803. 2007
    ..Variability in aerosol respirability and chemical heterogeneity could translate into differences in toxicity and support detailed characterization of physicochemical properties during exposure assessments...
  22. doi Release of beryllium from mineral ores in artificial lung and skin surface fluids
    Matthew G Duling
    Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Environ Geochem Health 34:313-22. 2012
    ..These data indicate that it is prudent to control skin and inhalation exposures to bertrandite dusts...
  23. ncbi Bioavailability of beryllium oxide particles: an in vitro study in the murine J774A.1 macrophage cell line model
    Gregory A Day
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, West Virginia, USA
    Exp Lung Res 31:341-60. 2005
    ....
  24. doi Characteristics of beryllium exposure to small particles at a beryllium production facility
    M Abbas Virji
    National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Ann Occup Hyg 55:70-85. 2011
    ..Consideration of biologically relevant aspects of exposure such as beryllium particle size distribution, chemical form, and solubility will likely improve exposure assessment...
  25. doi Comparison of free radical generation by pre- and post-sintered cemented carbide particles
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    J Occup Environ Hyg 7:23-34. 2010
    ..Improved understanding of particle surface chemistry elucidated the importance of biologically active surface area in generation of ROS by particle mixtures...
  26. doi Migration of Beryllium via Multiple Exposure Pathways among Work Processes in Four Different Facilities
    Jenna L Armstrong
    a Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia
    J Occup Environ Hyg 11:781-92. 2014
    ....
  27. doi Measurement of airborne nanoparticle surface area using a filter-based gas adsorption method for inhalation toxicology experiments
    Ryan F LeBuf
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    Nanotoxicology 5:687-99. 2011
    ....
  28. pmc A reconsideration of acute Beryllium disease
    Kristin J Cummings
    Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    Environ Health Perspect 117:1250-6. 2009
    ....
  29. doi Formulation and stability of a novel artificial human sweat under conditions of storage and use
    Christopher J Harvey
    National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicol In Vitro 24:1790-6. 2010
    ..This sweat model may aid researchers in understanding potential release and percutaneous absorption of chemicals in contact with human skin surface liquids...
  30. doi Characterization of cleaning and disinfecting tasks and product use among hospital occupations
    Rena Saito
    Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia
    Am J Ind Med 58:101-11. 2015
    ..The objective of this study was to identify and characterize cleaning/disinfecting tasks and products used among hospital occupations...
  31. doi Nanoscale reference materials for environmental, health and safety measurements: needs, gaps and opportunities
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Nanotoxicology 7:1325-37. 2013
    ....
  32. pmc Comparison of field portable measurements of ultrafine TiO2: X-ray fluorescence, laser-induced breakdown spectroscopy, and Fourier-transform infrared spectroscopy
    Ryan F LeBouf
    Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV, 26505 USA
    Environ Sci Process Impacts 15:1191-8. 2013
    ..995 and 0.998. FTIR measurements were less dependable due to interference from the PCTE filter media and overestimated mass by 2% with an R(2) of 0.831...
  33. ncbi Dissolution of materials in artificial skin surface film liquids
    Aleksandr B Stefaniak
    Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Toxicol In Vitro 20:1265-83. 2006
    ....
  34. doi Validation of evacuated canisters for sampling volatile organic compounds in healthcare settings
    Ryan F LeBouf
    National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    J Environ Monit 14:977-83. 2012
    ..This sampling and analysis approach is a viable (i.e., accurate and stable) methodology that will enable development of VOC profiles for mixed exposures experienced by healthcare workers...
  35. doi Characterization of exposures among cemented tungsten carbide workers. Part II: Assessment of surface contamination and skin exposures to cobalt, chromium and nickel
    Gregory A Day
    Division of Respiratory Disease Studies, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 2888, USA
    J Expo Sci Environ Epidemiol 19:423-34. 2009
    ..Epidemiologic studies of associated adverse health effects will likely require more biologically relevant exposure metrics to improve the ability to detect exposure-response relationships...
  36. ncbi Beryllium exposure: dermal and immunological considerations
    Gregory A Day
    Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS 2703, Morgantown, WV 26505 2888, USA
    Int Arch Occup Environ Health 79:161-4. 2006
    ....
  37. pmc Cytotoxicity and characterization of particles collected from an indium-tin oxide production facility
    Melissa A Badding
    a Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    J Toxicol Environ Health A 77:1193-209. 2014
    ..However, the effects on cell viability reveal that several of the compounds are cytotoxic, and therefore, exposures need to be carefully monitored in the industrial setting. ..
  38. pmc Lung biodurability and free radical production of cellulose nanomaterials
    Aleksandr B Stefaniak
    Division of Respiratory Diseases Studies, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Inhal Toxicol 26:733-49. 2014
    ..The production of ·OH radicals indicates the need for additional studies to characterize the potential inhalation hazards of cellulose...
  39. pmc Exposure to volatile organic compounds in healthcare settings
    Ryan F LeBouf
    National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Occup Environ Med 71:642-50. 2014
    ..To identify and summarise volatile organic compound (VOC) exposure profiles of healthcare occupations...
  40. doi Toxicological evaluation of lung responses after intratracheal exposure to non-dispersed titanium dioxide nanorods
    Jenny R Roberts
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 74:790-810. 2011
    ..To summarize, non-dispersed TiO₂ nanorods were found to induce radical formation and cellular oxidant production, and to generate transient and reversible pneumotoxic effects, and to not markedly alter pulmonary immune function...
  41. doi The Effect of Cerium Oxide Nanoparticle Valence State on Reactive Oxygen Species and Toxicity
    Katherine M Dunnick
    National Institute for Occupational Safety and Health, HELD, 1095 Willowdale Rd, Morgantown, WV, 26505, USA
    Biol Trace Elem Res 166:96-107. 2015
    ....
  42. pmc Effects of nitrogen-doped multi-walled carbon nanotubes compared to pristine multi-walled carbon nanotubes on human small airway epithelial cells
    Amy L Mihalchik
    Pharmaceutical and Pharmacological Sciences, West Virginia University School of Pharmacy, Morgantown, WV 26505, United States Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States
    Toxicology 333:25-36. 2015
    ..Our results indicate that ND-MWCNT induce effects in SAEC over a time and dose-related manner which differ from MWCNT-7. Therefore, the physicochemical characteristics of the materials appear to alter their biological effects. ..
  43. doi Formulation and stability of a novel artificial sebum under conditions of storage and use
    Aleksandr B Stefaniak
    National Institute for Occupational Safety and Health, MS H2702, 1095 Willowdale Road, Morgantown, WV 26505
    Int J Cosmet Sci 32:347-55. 2010
    ..A model artificial sebum was formulated and characterized to aid researchers in understanding potential release of chemicals from materials in contact with skin and subsequent partitioning and absorption. ..
  44. ncbi Summary of historical beryllium uses and airborne concentration levels at Los Alamos National Laboratory
    Aleksandr B Stefaniak
    Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
    Appl Occup Environ Hyg 18:708-15. 2003
    ....
  45. ncbi Trace-level beryllium analysis in the laboratory and in the field: state of the art, challenges and opportunities
    Michael J Brisson
    Washington Savannah River Company, Savannah River Site, Aiken, SC 29808, USA
    J Environ Monit 8:605-11. 2006
    ..Recognizing and addressing these challenges will present opportunities for laboratories, research and development organizations, instrument manufacturers and others...