Research Topics
Genomes and Genes | Krishnan SriramSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
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Publications
Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's diseaseKrishnan Sriram
Centers for Disease Control and Prevention NIOSH, Morgantown, West Virginia 26505, USA
FASEB J 16:1474-6. 2002..Moreover, because TNF-alpha is synthesized predominantly by microglia and astrocytes, our findings implicate the participation of glial cells in MPTP-induced neurotoxicity. Similar mechanisms may underlie the etiopathogenesis of PD...- Induction of gp130-related cytokines and activation of JAK2/STAT3 pathway in astrocytes precedes up-regulation of glial fibrillary acidic protein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of neurodegeneration: key signaling pathway for astKrishnan Sriram
HELD TMBB, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
J Biol Chem 279:19936-47. 2004..Taken together, our results suggest that the gp130-mediated activation of JAK2/STAT3 signaling pathway may play a key role in the induction of astrogliosis... - Focused microwave irradiation of the brain preserves in vivo protein phosphorylation: comparison with other methods of sacrifice and analysis of multiple phosphoproteinsJames P O'Callaghan
HELD TMBB, Centers for Disease Control and Prevention NIOSH, Mailstop L 3014, 1095 Willowdale Road, Morgantown, WV 26505, USA
J Neurosci Methods 135:159-68. 2004..Our results indicate that focused microwave irradiation sacrifice may be required to achieve biologically relevant data for the in vivo protein phosphorylation state of many phosphoproteins... - Glial fibrillary acidic protein and related glial proteins as biomarkers of neurotoxicityJames P O'Callaghan
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Expert Opin Drug Saf 4:433-42. 2005..The implementation of GFAP and related glial biomarkers in neurotoxicity screens may serve as the basis for further development of molecular signatures predictive of adverse effects on the nervous system... - Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor-alphaKrishnan Sriram
Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
J Neurochem 96:706-18. 2006..These findings support the hypothesis that TNF-alpha may play a role in the selective vulnerability of the nigrostriatal pathway associated with dopaminergic neurotoxicity and perhaps Parkinson's disease... 
Trimethyltin-induced neurotoxicity: gene expression pathway analysis, q-RT-PCR and immunoblotting reveal early effects associated with hippocampal damage and gliosisA R Little
Molecular Neurotoxicology Laboratory, Health Effects Research Laboratory, Centers for Disease Control and Prevention NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
Neurotoxicol Teratol 34:72-82. 2012..These observations provide new insight into early events associated with neuronal degeneration and associated glial activation that may serve as the basis for discovery and development of biomarkers of neurotoxicity...- Defining "neuroinflammation"James P O'Callaghan
Centers for Disease Control and Prevention NIOSH Morgantown, West Virginia, USA
Ann N Y Acad Sci 1139:318-30. 2008.... - Spinal glia and chronic painJames P O'Callaghan
Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Metabolism 59:S21-6. 2010.... - Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF-alphaKrishnan Sriram
Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
FASEB J 20:670-82. 2006..Taken together, our results are indicative of a region-specific and dual role for TNF-alpha in the brain: a promoter of neurodegeneration in striatum and a protector against neurodegeneration in hippocampus... - Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumesKrishnan Sriram
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Arch Toxicol 84:521-40. 2010..Whether such perturbations will lead to PD-like neuropathological manifestations remains to be elucidated... - Manganese accumulation in nail clippings as a biomarker of welding fume exposure and neurotoxicityKrishnan Sriram
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
Toxicology 291:73-82. 2012..The non-invasive means by which nail clippings can be collected, stored, and transported with relative ease, make it an attractive surrogate for biomonitoring WF exposures in occupational settings... - Alterations in welding process voltage affect the generation of ultrafine particles, fume composition, and pulmonary toxicityJames M Antonini
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Nanotoxicology 5:700-10. 2011..In summary, a modest raise in welding voltage affected fume size and elemental composition and altered the temporal lung toxicity profile... - Pulmonary toxicity and extrapulmonary tissue distribution of metals after repeated exposure to different welding fumesJames M Antonini
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virgina 26505, USA
Inhal Toxicol 22:805-16. 2010..Importantly, increased deposition of Mn, but not other metals, was observed in discrete brain regions, including dopamine-rich areas (e.g., striatum and midbrain)... - Nanotechnology: toxicologic pathologyAnn F Hubbs
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Toxicol Pathol 41:395-409. 2013..Thus, the pathology assessment is facilitated by understanding the unique features at the nanoscale and the tools that can assist in evaluating nanotoxicology studies... - Mild steel welding fume causes manganese accumulation and subtle neuroinflammatory changes but not overt neuronal damage in discrete brain regions of rats after short-term inhalation exposureJames M Antonini
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Neurotoxicology 30:915-25. 2009..The neurofunctional significance of these findings currently is being investigated in longer, more chronic welding fume exposure studies... - Respiratory and olfactory cytotoxicity of inhaled 2,3-pentanedione in Sprague-Dawley ratsAnn F Hubbs
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Am J Pathol 181:829-44. 2012..Claudin-1 expression increased in the OB and striatum. We conclude that 2,3-pentanedione is a respiratory hazard that can also alter gene expression in the brain... - Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumesKrishnan Sriram
Toxicology and Molecular Biology Branch, Mailstop L 3014, CDC NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA
FASEB J 24:4989-5002. 2010..Whether these molecular alterations culminate in neurobehavioral and neuropathological deficits reminiscent of PD remains to be ascertained... - Protracted exposure to supraphysiological levels of corticosterone does not cause neuronal loss or damage and protects against kainic acid-induced neurotoxicity in the hippocampus of C57BL/6J miceStanley A Benkovic
Toxicology and Molecular Biology Branch, Centers for Disease Control and Prevention National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Neurotoxicology 30:965-76. 2009..Our data indicate supraphysiological levels of CORT do not cause neuronal death or injury in hippocampus of C57BL/6J mice and provide neuroprotection against KA-induced neural damage... 
Differential mouse pulmonary dose and time course responses to titanium dioxide nanospheres and nanobeltsDale W Porter
National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Toxicol Sci 131:179-93. 2013..In summary, our data indicate that TiO(2) NP shape alters pulmonary responses, with severity of responses being ranked as NS < NB1 < NB2...- Corticosterone regulates expression of CCL2 in the intact and chemically injured hippocampusAlvin R Little
Molecular Neurotoxicology Laboratory, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, CDC-NIOSH, TMBB-HELD, MS 3014, 1095 Willowdale Road, Morgantown, WV 26505, USA
Neurosci Lett 399:162-6. 2006..In summary, our data indicate that in the CNS, CCL2 gene expression is under negative regulation by glucocorticoids... - Neurotoxicity following acute inhalation exposure to the oil dispersant COREXIT EC9500AKrishnan Sriram
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Toxicology and Molecular Biology Branch, Morgantown, West Virginia 26505, USA
J Toxicol Environ Health A 74:1405-18. 2011..Whether such acute molecular aberrations might persist and produce chronic neurological deficits remains to be ascertained... - Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubesDale W Porter
National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Toxicology 269:136-47. 2010..Furthermore, the observation that MWCNT reach the pleura after aspiration exposure indicates that more extensive investigations are needed to fully assess if pleural penetration results in any adverse health outcomes... - Nanotoxicology--a pathologist's perspectiveAnn F Hubbs
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
Toxicol Pathol 39:301-24. 2011..This review provides an introduction to the pathology and toxicology of nanoparticulates... - Do early-life insults contribute to the late-life development of Parkinson and Alzheimer diseases?Diane B Miller
Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Metabolism 57:S44-9. 2008..More definitive knowledge of the key risk factors involved will be needed to implement intervention and preventative strategies early in life to dampen or prevent any adverse late-life outcomes... - d-MDMA during vitamin E deficiency: effects on dopaminergic neurotoxicity and hepatotoxicityElizabeth Anne Johnson
Chronic Stress Laboratory, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health Centers for Disease Control, Mailstop 3014, 1095 Willowdale Road, 26505, Morgantown, WV, USA
Brain Res 933:150-63. 2002.... - Elevated environmental temperature and methamphetamine neurotoxicityDiane B Miller
Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, Centers for Disease Control, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
Environ Res 92:48-53. 2003..Single-dose regimens may aid in uncovering the as yet unknown mechanism(s) of substituted amphetamine neurotoxicity because they reduce the inherent complexity present in repeated dosage regimens... - Brain concentrations of d-MDMA are increased after stressElizabeth Anne Johnson
Chronic Stress Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health Centers for Disease Control, 1095 Willowdale Road, Morgantown, VA 26505, USA
Psychopharmacology (Berl) 173:278-86. 2004..Various stressors and hypothermia protect against d-MDMA-induced neurotoxicity through unknown mechanisms, one of which could be a reduction in the distribution of d-MDMA to the brain... - Associations of cortical astrogliosis with cognitive performance and dementia statusMichael L Kashon
Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505, USA
J Alzheimers Dis 6:595-604; discussion 673-81. 2004..Our findings underscore the need to look beyond standard neuropathological measures putatively linked to specific neuropathological conditions in efforts to identify common cellular and molecular processes that contribute to dementia... - Depression, cytokines, and glial functionDiane B Miller
Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Metabolism 54:33-8. 2005..We suggest that glial cells, both as a source and target of cytokines, represent the overlooked targets involved in the etiology of depression... - Development of an animal model to study the potential neurotoxic effects associated with welding fume inhalationJames M Antonini
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
Neurotoxicology 27:745-51. 2006..With the development of this novel system, an animal model has been established using controlled welding exposures to investigate the possible mechanisms by which welding fume may affect the central nervous system... - The pharmacology of wakefulnessDiane B Miller
Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Metabolism 55:S13-9. 2006.... - Work, obesity, and occupational safety and healthPaul A Schulte
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA
Am J Public Health 97:428-36. 2007.... - Area under the curve and other summary indicators of repeated waking cortisol measurementsDesta B Fekedulegn
Biostatistics and Epidemiology Branch, National Institute for Occupational Safety and Health, HELD BEB, MS 4050, 1095 Willowdale Rd, Morgantown, WV 26505, USA
Psychosom Med 69:651-9. 2007..The latter parameters, AUC(I), however, is seldom used by research scientists... - Chronic treatment with supraphysiological levels of corticosterone enhances D-MDMA-induced dopaminergic neurotoxicity in the C57BL/6J female mouseElizabeth Anne Johnson
Chronic Stress and Molecular Neurotoxicology Laboratories, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health Centers for Disease Control, 1095 Willowdale Road, Morgantown, WV 26505, USA
Brain Res 933:130-8. 2002..An examination of other mouse strains and models of neurotoxic injury would be useful in determining the general validity of the glucocorticoid neuroendangerment hypothesis... - Divergent roles for tumor necrosis factor-alpha in the brainKrishnan Sriram
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, CDC NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
J Neuroimmune Pharmacol 2:140-53. 2007..Here, we review the differential role of TNF-alpha in response to brain injury, with emphasis on neurodegeneration, and discuss the possible mechanisms for such diverse and region-specific effects... - Neuroendocrine aspects of the response to stressDiane B Miller
Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Metabolism 51:5-10. 2002..Advances in molecular biology provide the tools and new opportunities for identifying these therapeutic targets... - Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2Ann F Hubbs
Experimental Pathology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health CDC, 1095 Willowdale Road, Morgantown, WV 26505, USA
Am J Pathol 170:2068-76. 2007..If this role is confirmed, it may suggest new approaches to treating genetically and chemically induced myelin degenerative diseases...