Krishnan Sriram

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi request reprint Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's disease
    Krishnan Sriram
    Centers for Disease Control and Prevention NIOSH, Morgantown, West Virginia 26505, USA
    FASEB J 16:1474-6. 2002
  2. ncbi request reprint Induction of gp130-related cytokines and activation of JAK2/STAT3 pathway in astrocytes precedes up-regulation of glial fibrillary acidic protein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of neurodegeneration: key signaling pathway for ast
    Krishnan Sriram
    HELD TMBB, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    J Biol Chem 279:19936-47. 2004
  3. ncbi request reprint Focused microwave irradiation of the brain preserves in vivo protein phosphorylation: comparison with other methods of sacrifice and analysis of multiple phosphoproteins
    James P O'Callaghan
    HELD TMBB, Centers for Disease Control and Prevention NIOSH, Mailstop L 3014, 1095 Willowdale Road, Morgantown, WV 26505, USA
    J Neurosci Methods 135:159-68. 2004
  4. ncbi request reprint Glial fibrillary acidic protein and related glial proteins as biomarkers of neurotoxicity
    James P O'Callaghan
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Expert Opin Drug Saf 4:433-42. 2005
  5. ncbi request reprint Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor-alpha
    Krishnan Sriram
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Neurochem 96:706-18. 2006
  6. doi request reprint Trimethyltin-induced neurotoxicity: gene expression pathway analysis, q-RT-PCR and immunoblotting reveal early effects associated with hippocampal damage and gliosis
    A R Little
    Molecular Neurotoxicology Laboratory, Health Effects Research Laboratory, Centers for Disease Control and Prevention NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Neurotoxicol Teratol 34:72-82. 2012
  7. doi request reprint Defining "neuroinflammation"
    James P O'Callaghan
    Centers for Disease Control and Prevention NIOSH Morgantown, West Virginia, USA
    Ann N Y Acad Sci 1139:318-30. 2008
  8. doi request reprint Spinal glia and chronic pain
    James P O'Callaghan
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Metabolism 59:S21-6. 2010
  9. ncbi request reprint Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF-alpha
    Krishnan Sriram
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    FASEB J 20:670-82. 2006
  10. doi request reprint Acute pulmonary dose-responses to inhaled multi-walled carbon nanotubes
    Dale W Porter
    National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Nanotoxicology 7:1179-94. 2013

Detail Information

Publications38

  1. ncbi request reprint Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's disease
    Krishnan Sriram
    Centers for Disease Control and Prevention NIOSH, Morgantown, West Virginia 26505, USA
    FASEB J 16:1474-6. 2002
    ..Moreover, because TNF-alpha is synthesized predominantly by microglia and astrocytes, our findings implicate the participation of glial cells in MPTP-induced neurotoxicity. Similar mechanisms may underlie the etiopathogenesis of PD...
  2. ncbi request reprint Induction of gp130-related cytokines and activation of JAK2/STAT3 pathway in astrocytes precedes up-regulation of glial fibrillary acidic protein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of neurodegeneration: key signaling pathway for ast
    Krishnan Sriram
    HELD TMBB, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    J Biol Chem 279:19936-47. 2004
    ..Taken together, our results suggest that the gp130-mediated activation of JAK2/STAT3 signaling pathway may play a key role in the induction of astrogliosis...
  3. ncbi request reprint Focused microwave irradiation of the brain preserves in vivo protein phosphorylation: comparison with other methods of sacrifice and analysis of multiple phosphoproteins
    James P O'Callaghan
    HELD TMBB, Centers for Disease Control and Prevention NIOSH, Mailstop L 3014, 1095 Willowdale Road, Morgantown, WV 26505, USA
    J Neurosci Methods 135:159-68. 2004
    ..Our results indicate that focused microwave irradiation sacrifice may be required to achieve biologically relevant data for the in vivo protein phosphorylation state of many phosphoproteins...
  4. ncbi request reprint Glial fibrillary acidic protein and related glial proteins as biomarkers of neurotoxicity
    James P O'Callaghan
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Expert Opin Drug Saf 4:433-42. 2005
    ..The implementation of GFAP and related glial biomarkers in neurotoxicity screens may serve as the basis for further development of molecular signatures predictive of adverse effects on the nervous system...
  5. ncbi request reprint Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor-alpha
    Krishnan Sriram
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Neurochem 96:706-18. 2006
    ..These findings support the hypothesis that TNF-alpha may play a role in the selective vulnerability of the nigrostriatal pathway associated with dopaminergic neurotoxicity and perhaps Parkinson's disease...
  6. doi request reprint Trimethyltin-induced neurotoxicity: gene expression pathway analysis, q-RT-PCR and immunoblotting reveal early effects associated with hippocampal damage and gliosis
    A R Little
    Molecular Neurotoxicology Laboratory, Health Effects Research Laboratory, Centers for Disease Control and Prevention NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Neurotoxicol Teratol 34:72-82. 2012
    ..These observations provide new insight into early events associated with neuronal degeneration and associated glial activation that may serve as the basis for discovery and development of biomarkers of neurotoxicity...
  7. doi request reprint Defining "neuroinflammation"
    James P O'Callaghan
    Centers for Disease Control and Prevention NIOSH Morgantown, West Virginia, USA
    Ann N Y Acad Sci 1139:318-30. 2008
    ....
  8. doi request reprint Spinal glia and chronic pain
    James P O'Callaghan
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Metabolism 59:S21-6. 2010
    ....
  9. ncbi request reprint Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF-alpha
    Krishnan Sriram
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    FASEB J 20:670-82. 2006
    ..Taken together, our results are indicative of a region-specific and dual role for TNF-alpha in the brain: a promoter of neurodegeneration in striatum and a protector against neurodegeneration in hippocampus...
  10. doi request reprint Acute pulmonary dose-responses to inhaled multi-walled carbon nanotubes
    Dale W Porter
    National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Nanotoxicology 7:1179-94. 2013
    ..Acute inhalation of MWCNT induced dose-dependent pulmonary inflammation and damage with rapid development of pulmonary fibrosis, and also demonstrated that MWCNT can reach the pleura after inhalation exposure...
  11. ncbi request reprint Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes
    Krishnan Sriram
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Arch Toxicol 84:521-40. 2010
    ..Whether such perturbations will lead to PD-like neuropathological manifestations remains to be elucidated...
  12. doi request reprint Manganese accumulation in nail clippings as a biomarker of welding fume exposure and neurotoxicity
    Krishnan Sriram
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Toxicology 291:73-82. 2012
    ..The non-invasive means by which nail clippings can be collected, stored, and transported with relative ease, make it an attractive surrogate for biomonitoring WF exposures in occupational settings...
  13. doi request reprint Alterations in welding process voltage affect the generation of ultrafine particles, fume composition, and pulmonary toxicity
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Nanotoxicology 5:700-10. 2011
    ..In summary, a modest raise in welding voltage affected fume size and elemental composition and altered the temporal lung toxicity profile...
  14. doi request reprint Pulmonary toxicity and extrapulmonary tissue distribution of metals after repeated exposure to different welding fumes
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virgina 26505, USA
    Inhal Toxicol 22:805-16. 2010
    ..Importantly, increased deposition of Mn, but not other metals, was observed in discrete brain regions, including dopamine-rich areas (e.g., striatum and midbrain)...
  15. doi request reprint Nanotechnology: toxicologic pathology
    Ann F Hubbs
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Toxicol Pathol 41:395-409. 2013
    ..Thus, the pathology assessment is facilitated by understanding the unique features at the nanoscale and the tools that can assist in evaluating nanotoxicology studies...
  16. doi request reprint Mild steel welding fume causes manganese accumulation and subtle neuroinflammatory changes but not overt neuronal damage in discrete brain regions of rats after short-term inhalation exposure
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Neurotoxicology 30:915-25. 2009
    ..The neurofunctional significance of these findings currently is being investigated in longer, more chronic welding fume exposure studies...
  17. pmc Differential mouse pulmonary dose and time course responses to titanium dioxide nanospheres and nanobelts
    Dale W Porter
    National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Toxicol Sci 131:179-93. 2013
    ..In summary, our data indicate that TiO(2) NP shape alters pulmonary responses, with severity of responses being ranked as NS < NB1 < NB2...
  18. ncbi request reprint Corticosterone regulates expression of CCL2 in the intact and chemically injured hippocampus
    Alvin R Little
    Molecular Neurotoxicology Laboratory, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, CDC NIOSH, TMBB HELD, MS 3014, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Neurosci Lett 399:162-6. 2006
    ..In summary, our data indicate that in the CNS, CCL2 gene expression is under negative regulation by glucocorticoids...
  19. doi request reprint Respiratory and olfactory cytotoxicity of inhaled 2,3-pentanedione in Sprague-Dawley rats
    Ann F Hubbs
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Am J Pathol 181:829-44. 2012
    ..Claudin-1 expression increased in the OB and striatum. We conclude that 2,3-pentanedione is a respiratory hazard that can also alter gene expression in the brain...
  20. doi request reprint Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes
    Krishnan Sriram
    Toxicology and Molecular Biology Branch, Mailstop L 3014, CDC NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA
    FASEB J 24:4989-5002. 2010
    ..Whether these molecular alterations culminate in neurobehavioral and neuropathological deficits reminiscent of PD remains to be ascertained...
  21. doi request reprint Protracted exposure to supraphysiological levels of corticosterone does not cause neuronal loss or damage and protects against kainic acid-induced neurotoxicity in the hippocampus of C57BL/6J mice
    Stanley A Benkovic
    Toxicology and Molecular Biology Branch, Centers for Disease Control and Prevention National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Neurotoxicology 30:965-76. 2009
    ..Our data indicate supraphysiological levels of CORT do not cause neuronal death or injury in hippocampus of C57BL/6J mice and provide neuroprotection against KA-induced neural damage...
  22. doi request reprint Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes
    Dale W Porter
    National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicology 269:136-47. 2010
    ..Furthermore, the observation that MWCNT reach the pleura after aspiration exposure indicates that more extensive investigations are needed to fully assess if pleural penetration results in any adverse health outcomes...
  23. doi request reprint Neurotoxicity following acute inhalation exposure to the oil dispersant COREXIT EC9500A
    Krishnan Sriram
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Toxicology and Molecular Biology Branch, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 74:1405-18. 2011
    ..Whether such acute molecular aberrations might persist and produce chronic neurological deficits remains to be ascertained...
  24. doi request reprint Nanotoxicology--a pathologist's perspective
    Ann F Hubbs
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Toxicol Pathol 39:301-24. 2011
    ..This review provides an introduction to the pathology and toxicology of nanoparticulates...
  25. doi request reprint Do early-life insults contribute to the late-life development of Parkinson and Alzheimer diseases?
    Diane B Miller
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Metabolism 57:S44-9. 2008
    ..More definitive knowledge of the key risk factors involved will be needed to implement intervention and preventative strategies early in life to dampen or prevent any adverse late-life outcomes...
  26. ncbi request reprint d-MDMA during vitamin E deficiency: effects on dopaminergic neurotoxicity and hepatotoxicity
    Elizabeth Anne Johnson
    Chronic Stress Laboratory, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health Centers for Disease Control, Mailstop 3014, 1095 Willowdale Road, 26505, Morgantown, WV, USA
    Brain Res 933:150-63. 2002
    ....
  27. ncbi request reprint Elevated environmental temperature and methamphetamine neurotoxicity
    Diane B Miller
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, Centers for Disease Control, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Environ Res 92:48-53. 2003
    ..Single-dose regimens may aid in uncovering the as yet unknown mechanism(s) of substituted amphetamine neurotoxicity because they reduce the inherent complexity present in repeated dosage regimens...
  28. ncbi request reprint Brain concentrations of d-MDMA are increased after stress
    Elizabeth Anne Johnson
    Chronic Stress Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health Centers for Disease Control, 1095 Willowdale Road, Morgantown, VA 26505, USA
    Psychopharmacology (Berl) 173:278-86. 2004
    ..Various stressors and hypothermia protect against d-MDMA-induced neurotoxicity through unknown mechanisms, one of which could be a reduction in the distribution of d-MDMA to the brain...
  29. ncbi request reprint Associations of cortical astrogliosis with cognitive performance and dementia status
    Michael L Kashon
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505, USA
    J Alzheimers Dis 6:595-604; discussion 673-81. 2004
    ..Our findings underscore the need to look beyond standard neuropathological measures putatively linked to specific neuropathological conditions in efforts to identify common cellular and molecular processes that contribute to dementia...
  30. ncbi request reprint Depression, cytokines, and glial function
    Diane B Miller
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Metabolism 54:33-8. 2005
    ..We suggest that glial cells, both as a source and target of cytokines, represent the overlooked targets involved in the etiology of depression...
  31. ncbi request reprint Development of an animal model to study the potential neurotoxic effects associated with welding fume inhalation
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Neurotoxicology 27:745-51. 2006
    ..With the development of this novel system, an animal model has been established using controlled welding exposures to investigate the possible mechanisms by which welding fume may affect the central nervous system...
  32. ncbi request reprint The pharmacology of wakefulness
    Diane B Miller
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Metabolism 55:S13-9. 2006
    ....
  33. pmc Work, obesity, and occupational safety and health
    Paul A Schulte
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA
    Am J Public Health 97:428-36. 2007
    ....
  34. ncbi request reprint Area under the curve and other summary indicators of repeated waking cortisol measurements
    Desta B Fekedulegn
    Biostatistics and Epidemiology Branch, National Institute for Occupational Safety and Health, HELD BEB, MS 4050, 1095 Willowdale Rd, Morgantown, WV 26505, USA
    Psychosom Med 69:651-9. 2007
    ..The latter parameters, AUC(I), however, is seldom used by research scientists...
  35. ncbi request reprint Chronic treatment with supraphysiological levels of corticosterone enhances D-MDMA-induced dopaminergic neurotoxicity in the C57BL/6J female mouse
    Elizabeth Anne Johnson
    Chronic Stress and Molecular Neurotoxicology Laboratories, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health Centers for Disease Control, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Brain Res 933:130-8. 2002
    ..An examination of other mouse strains and models of neurotoxic injury would be useful in determining the general validity of the glucocorticoid neuroendangerment hypothesis...
  36. ncbi request reprint Divergent roles for tumor necrosis factor-alpha in the brain
    Krishnan Sriram
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, CDC NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
    J Neuroimmune Pharmacol 2:140-53. 2007
    ..Here, we review the differential role of TNF-alpha in response to brain injury, with emphasis on neurodegeneration, and discuss the possible mechanisms for such diverse and region-specific effects...
  37. ncbi request reprint Neuroendocrine aspects of the response to stress
    Diane B Miller
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Metabolism 51:5-10. 2002
    ..Advances in molecular biology provide the tools and new opportunities for identifying these therapeutic targets...
  38. pmc Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2
    Ann F Hubbs
    Experimental Pathology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health CDC, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Am J Pathol 170:2068-76. 2007
    ..If this role is confirmed, it may suggest new approaches to treating genetically and chemically induced myelin degenerative diseases...