Christina F Spiropoulou

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. pmc Host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic new world clade B arenaviruses
    Jonathan Abraham
    Department of Medicine, Children s Hospital, Harvard Medical School, Boston, MA, USA
    PLoS Pathog 5:e1000358. 2009
  2. doi request reprint The role of endothelial activation in dengue hemorrhagic fever and hantavirus pulmonary syndrome
    Christina F Spiropoulou
    Centers for Disease Control and Prevention, Atlanta, GA, USA
    Virulence 4:525-36. 2013
  3. pmc New World arenavirus clade C, but not clade A and B viruses, utilizes alpha-dystroglycan as its major receptor
    Christina F Spiropoulou
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 76:5140-6. 2002
  4. ncbi request reprint Sin Nombre virus glycoprotein trafficking
    C F Spiropoulou
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 308:48-63. 2003
  5. pmc Andes and Prospect Hill hantaviruses differ in early induction of interferon although both can downregulate interferon signaling
    Christina F Spiropoulou
    Special Pathogens Branch, G 14, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    J Virol 81:2769-76. 2007
  6. ncbi request reprint RIG-I activation inhibits ebolavirus replication
    Christina F Spiropoulou
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Virology 392:11-5. 2009
  7. pmc Distinct and overlapping roles of Nipah virus P gene products in modulating the human endothelial cell antiviral response
    Michael K Lo
    Centers for Disease Control and Prevention, Viral Special Pathogens Branch, Atlanta, Georgia, United States of America
    PLoS ONE 7:e47790. 2012
  8. pmc Single-dose replication-defective VSV-based Nipah virus vaccines provide protection from lethal challenge in Syrian hamsters
    Michael K Lo
    Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States Electronic address
    Antiviral Res 101:26-9. 2014
  9. pmc Reverse genetics recovery of Lujo virus and role of virus RNA secondary structures in efficient virus growth
    Eric Bergeron
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 86:10759-65. 2012
  10. doi request reprint Activation and cell death in human dendritic cells infected with Nipah virus
    Manisha Gupta
    Viral Special Pathogens Branch, NCEZID, DHCPP, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 441:49-56. 2013

Collaborators

Detail Information

Publications25

  1. pmc Host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic new world clade B arenaviruses
    Jonathan Abraham
    Department of Medicine, Children s Hospital, Harvard Medical School, Boston, MA, USA
    PLoS Pathog 5:e1000358. 2009
    ....
  2. doi request reprint The role of endothelial activation in dengue hemorrhagic fever and hantavirus pulmonary syndrome
    Christina F Spiropoulou
    Centers for Disease Control and Prevention, Atlanta, GA, USA
    Virulence 4:525-36. 2013
    ..Understanding the dynamics between viral infection and the dysregulation of the endothelial cell barrier will help us to define potential therapeutic targets for reducing disease severity. ..
  3. pmc New World arenavirus clade C, but not clade A and B viruses, utilizes alpha-dystroglycan as its major receptor
    Christina F Spiropoulou
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 76:5140-6. 2002
    ..In addition, GP1 amino acid position 259 also appears to be important, since all arenaviruses showing high-affinity alpha-DG binding possess a bulky aromatic amino acid (tyrosine or phenylalanine) at this position...
  4. ncbi request reprint Sin Nombre virus glycoprotein trafficking
    C F Spiropoulou
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 308:48-63. 2003
    ..This pool of G1 is predominantly localized in late endosomes-lysosomes...
  5. pmc Andes and Prospect Hill hantaviruses differ in early induction of interferon although both can downregulate interferon signaling
    Christina F Spiropoulou
    Special Pathogens Branch, G 14, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    J Virol 81:2769-76. 2007
    ....
  6. ncbi request reprint RIG-I activation inhibits ebolavirus replication
    Christina F Spiropoulou
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Virology 392:11-5. 2009
    ..These findings indicate that RIG-I-based therapies may provide an attractive approach for antivirals against Ebola hemorrhagic fever, and possibly other HF viruses...
  7. pmc Distinct and overlapping roles of Nipah virus P gene products in modulating the human endothelial cell antiviral response
    Michael K Lo
    Centers for Disease Control and Prevention, Viral Special Pathogens Branch, Atlanta, Georgia, United States of America
    PLoS ONE 7:e47790. 2012
    ..The results of this study also provide an opportunity to verify the results of earlier artificial plasmid expression studies in the context of authentic viral infection...
  8. pmc Single-dose replication-defective VSV-based Nipah virus vaccines provide protection from lethal challenge in Syrian hamsters
    Michael K Lo
    Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States Electronic address
    Antiviral Res 101:26-9. 2014
    ..This highly effective single-dose protection coupled with an enhanced safety profile makes these candidates ideal for potential use in livestock and humans. ..
  9. pmc Reverse genetics recovery of Lujo virus and role of virus RNA secondary structures in efficient virus growth
    Eric Bergeron
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 86:10759-65. 2012
    ..The technology for producing recombinant Lujo virus now provides a method to precisely investigate the molecular determinants of virulence of this newly identified pathogen...
  10. doi request reprint Activation and cell death in human dendritic cells infected with Nipah virus
    Manisha Gupta
    Viral Special Pathogens Branch, NCEZID, DHCPP, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 441:49-56. 2013
    ..Interestingly, DCs treated with inactivated NiV also show signs of apoptosis. These findings indicate that NiV infected DCs could play an important role in NiV pathogenesis...
  11. ncbi request reprint Inhibitors of the tick-borne, hemorrhagic Fever-associated flaviviruses
    Mike Flint
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Antimicrob Agents Chemother 58:3206-16. 2014
    ..The S603 and C666 residues were predicted to lie in the active site of the AHFV NS5 polymerase, implicating the catalytic center of the enzyme as the binding site for 2'-CMC. ..
  12. pmc Andes virus disrupts the endothelial cell barrier by induction of vascular endothelial growth factor and downregulation of VE-cadherin
    Punya Shrivastava-Ranjan
    Special Pathogens Branch, G 14, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
    J Virol 84:11227-34. 2010
    ..These data implicate virus induction of VEGF and reduction in VE-cadherin in the endothelial cell permeability seen in HPS and suggest potential immunotherapeutic targets for the treatment of the disease...
  13. pmc Rift Valley fever virus clearance and protection from neurologic disease are dependent on CD4+ T cell and virus-specific antibody responses
    Kimberly A Dodd
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 87:6161-71. 2013
    ..Together, these results indicate CD4(+) T cells are critical determinants of RVFV pathogenesis and play an important role in preventing onset of neurologic disease...
  14. doi request reprint Hantavirus pulmonary syndrome
    Adam MacNeil
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
    Virus Res 162:138-47. 2011
    ..However, virus infection results in microvascular leakage, which is the hallmark of HPS. This article briefly reviews the knowledge on HPS-associated hantaviruses accumulated since their discovery, less than 20 years ago...
  15. doi request reprint Serology and cytokine profiles in patients infected with the newly discovered Bundibugyo ebolavirus
    Manisha Gupta
    Viral Special Pathogens Branch, NCEZID, DHCPP, Centers for Disease Control and Prevention, Atlanta, GA 30033, USA
    Virology 423:119-24. 2012
    ..Thus, our results imply that disease severity in these patients is not due to the multi-organ failure and septic shock caused by a flood of inflammatory cytokines, as seen in infections with other Ebolavirus species...
  16. ncbi request reprint Reduced virus replication, proinflammatory cytokine production, and delayed macrophage cell death in human PBMCs infected with the newly discovered Bundibugyo ebolavirus relative to Zaire ebolavirus
    Manisha Gupta
    Special Pathogens Branch, DVRD, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Virology 402:203-8. 2010
    ..The findings of slower Bundibugyo ebolavirus replication, lower production of proinflammatory cytokines and delay in macrophage cell death provide insight into the basis of the lower case fatality observed with Bundibugyo ebolavirus...
  17. pmc Kyasanur Forest disease virus infection in mice is associated with higher morbidity and mortality than infection with the closely related Alkhurma hemorrhagic fever virus
    Kimberly A Dodd
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America University of California, Davis, School of Veterinary Medicine, Davis, California, United States of America
    PLoS ONE 9:e100301. 2014
    ..Case reports suggest KFDV is more commonly associated with hepatic and gastrointestinal manifestations whereas AHFV is more commonly associated with neurologic disease...
  18. pmc Host mTORC1 signaling regulates andes virus replication
    Shannon McNulty
    Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA
    J Virol 87:912-22. 2013
    ....
  19. pmc Severe hemorrhagic fever in strain 13/N guinea pigs infected with Lujo virus
    Brian H Bird
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Negl Trop Dis 6:e1801. 2012
    ..Establishing an animal LUJV model is an important first step towards understanding the high pathogenicity of LUJV and developing vaccines and antiviral therapeutic drugs for this highly transmissible and lethal emerging pathogen...
  20. pmc Small interfering RNA inhibition of Andes virus replication
    Cheng Feng Chiang
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 9:e99764. 2014
    ..Taken together, our findings indicate that siRNAs targeting the ANDV genome efficiently inhibit ANDV replication, and show promise as a strategy for developing therapeutics against ANDV infection. ..
  21. pmc Rift valley Fever virus encephalitis is associated with an ineffective systemic immune response and activated T cell infiltration into the CNS in an immunocompetent mouse model
    Kimberly A Dodd
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America University of California, Davis, School of Veterinary Medicine, Davis, California, United States of America
    PLoS Negl Trop Dis 8:e2874. 2014
    ..In order to design targeted interventions, the basic pathogenesis of RVFV encephalitis must be better understood...
  22. pmc Use of monoclonal antibodies against Hendra and Nipah viruses in an antigen capture ELISA
    Cheng Feng Chiang
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Virol J 7:115. 2010
    ..Outbreaks of Hendra (HeV) and Nipah (NiV) viruses have been reported starting in 1994 and 1998, respectively. Both viruses are capable of causing fatal disease in humans and effecting great economical loss in the livestock industry...
  23. ncbi request reprint Evaluation of luciferase and GFP-expressing Nipah viruses for rapid quantitative antiviral screening
    Michael K Lo
    Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States Electronic address
    Antiviral Res 106:53-60. 2014
    ..These reporter NiVs will not only facilitate antiviral screening, but also the study of host cell components that influence the virus life cycle. ..
  24. pmc Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome
    Jonathan S Towner
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 78:4330-41. 2004
    ..Furthermore, both sequence and epidemiologic data are consistent with the outbreak having originated from a single introduction into the human population...
  25. pmc Rift Valley fever virus vaccine lacking the NSs and NSm genes is safe, nonteratogenic, and confers protection from viremia, pyrexia, and abortion following challenge in adult and pregnant sheep
    Brian H Bird
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 14, Atlanta, GA 30329, USA
    J Virol 85:12901-9. 2011
    ..As expected, all 3 sham-vaccinated controls experienced viremia, fetal death, and abortion postchallenge. These results demonstrate that the ΔNSs-ΔNSm rRVFV vaccine is safe and nonteratogenic and confers high-level protection in sheep...