Research Topics
Genomes and Genes | Petia P SimeonovaSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
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Publications
Arsenic and atherosclerosisPetia P Simeonova
Tissue Injury Team, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute of Occupational Safety and Health, Morgantown, WV 26505, USA
Toxicol Appl Pharmacol 198:444-9. 2004..This may provide the pathophysiological basis for atherogenic potential of arsenic. Consistent with these data, arsenic accelerates atherosclerosis in apolipoprotein E (ApoE) deficient mice, a model of human atherosclerosis...- c-Src-dependent activation of the epidermal growth factor receptor and mitogen-activated protein kinase pathway by arsenic. Role in carcinogenesisPetia P Simeonova
TMBB, HELD, National Institute for Occupational Safety and Health, Centers for Disease Control, Morgantown, West Virginia 26505, USA
J Biol Chem 277:2945-50. 2002..This response is also accompanied with an increase in c-Src levels interacting with EGFR. These findings represent a potential pathway for mediating arsenic-induced phenotypic changes in the uroepithelium... - Role of CC chemokines in skeletal muscle functional restoration after injuryGordon L Warren
NIOSH, 1095 Willowdale Road, Morgantown, WV 26505
Am J Physiol Cell Physiol 286:C1031-6. 2004..The data suggest that MCP-1/CCR2 plays a role in the regeneration and recovery of function after traumatic muscle injury... 
Arsenic exposure accelerates atherogenesis in apolipoprotein E(-/-) micePetia P Simeonova
Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Environ Health Perspect 111:1744-8. 2003..Induction of endothelial inflammatory activity may play a role in arsenic-related vascular effects...
Engineered nanoparticle respiratory exposure and potential risks for cardiovascular toxicity: predictive tests and biomarkersPetia P Simeonova
Tissue Injury Team, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Inhal Toxicol 21:68-73. 2009..Future studies to evaluate the systemic effects of carbon nanotube exposure under workplace or environmental exposure paradigms should be conducted...- Identification of systemic markers from a pulmonary carbon nanotube exposureAaron Erdely
Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
J Occup Environ Med 53:S80-6. 2011..Interest exists for early monitoring of worker exposure to engineered nanomaterials. Here, we highlight quantitative systemic markers of early effects after carbon nanotube (CNT) exposure... - Relationship between pulmonary and systemic markers of exposure to multiple types of welding particulate matterAaron Erdely
Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, United States
Toxicology 287:153-9. 2011..In conclusion, varying types of welding fumes elicit quantitatively different systemic inflammatory and/or stress responses... - Inhalation exposure of gas-metal arc stainless steel welding fume increased atherosclerotic lesions in apolipoprotein E knockout miceAaron Erdely
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, United States
Toxicol Lett 204:12-6. 2011..These results complement epidemiological and functional human studies that suggest welding may result in adverse cardiovascular effects... - Cardiovascular effects of pulmonary exposure to single-wall carbon nanotubesZheng Li
Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Environ Health Perspect 115:377-82. 2007..Engineered nanosized materials, such as single-wall carbon nanotubes (SWCNT), are emerging as technologically important in different industries... - Cross-talk between lung and systemic circulation during carbon nanotube respiratory exposure. Potential biomarkersAaron Erdely
Toxicology and Molecular Biology Branch and Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Nano Lett 9:36-43. 2009..The approach described here will foster the development of biomarkers for application in human screening of nanoparticle exposure... - Type I interferon and pattern recognition receptor signaling following particulate matter inhalationAaron Erdely
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
Part Fibre Toxicol 9:25. 2012..Whole blood cells, aorta and lung were harvested for global gene expression analysis with subsequent Ingenuity Pathway Analysis and confirmatory qRT-PCR. Serum was collected for protein profiling... - Macrophages and skeletal muscle regeneration: a clodronate-containing liposome depletion studyMukesh Summan
Health Effects Laboratory Div, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Am J Physiol Regul Integr Comp Physiol 290:R1488-95. 2006..In conclusion, a significant reduction of the initial monocyte/macrophage influx into the injured muscle is associated with not improved, but moderately impaired, repair processes after skeletal muscle injury... - Inflammatory mediators and skeletal muscle injury: a DNA microarray analysisMukesh Summan
Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, USA
J Interferon Cytokine Res 23:237-45. 2003.... - Arginase activities and global arginine bioavailability in wild-type and ApoE-deficient mice: responses to high fat and high cholesterol dietsAaron Erdely
Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America
PLoS ONE 5:e15253. 2010..These results raise the possibility that systemic changes in arginase activity and global arginine bioavailability may be contributing factors in the initiation and/or progression of cardiovascular disease... - Potential in vitro effects of carbon nanotubes on human aortic endothelial cellsValerie G Walker
Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
Toxicol Appl Pharmacol 236:319-28. 2009..04-0.4 microg/ml)] or in any tested concentrations at 3 h post-exposure. Overall, the results indicate that SWCNT and MWCNT exposure induce direct effects on endothelial cells in a dose-dependent manner... - Lung tumor production and tissue metal distribution after exposure to manual metal ARC-stainless steel welding fume in A/J and C57BL/6J micePatti C Zeidler-Erdely
Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, 1095 Willowdale Road M S L2015, Morgantown, WV 26505, USA
J Toxicol Environ Health A 74:728-36. 2011..In addition, long-term extrapulmonary tissue alterations in metals in the susceptible A/J mouse suggest that the adverse effects of this fume might be cumulative... - Arsenic carcinogenicity: relevance of c-Src activationPetia P Simeonova
Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, USA
Mol Cell Biochem 234:277-82. 2002..Increasing evidence indicates that arsenic acts at the level of tumor promotion by modulating the signaling pathways responsible for cell growth. One of this pathways might include c-Src dependent EGFR and MAPK activation... - Work, obesity, and occupational safety and healthPaul A Schulte
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA
Am J Public Health 97:428-36. 2007.... - Biomarkers to assess potential developmental immunotoxicity in childrenMichael I Luster
Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA
Toxicol Appl Pharmacol 206:229-36. 2005..Quantification of the immune response to childhood vaccine, while up to the present used sparingly, may represent an excellent indicator for developmental immunotoxicity when conducted under appropriate conditions... - Arsenic and urinary bladder cell proliferationMichael I Luster
Inflammatory Disease Teams, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, USA
Toxicol Appl Pharmacol 198:419-23. 2004..This may play a non-epigenetic role in carcinogenesis by increasing the proliferation of initiated cells or increasing the mutational rate... - IL-1beta gene polymorphisms influence hepatitis B vaccinationBerran Yucesoy
National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26508, USA
Vaccine 20:3193-6. 2002.... - Physiological role of tumor necrosis factor alpha in traumatic muscle injuryGordon L Warren
Department of Physical Therapy, Georgia State University, Atlanta, Georgia, USA
FASEB J 16:1630-2. 2002..These data indicate that TNF-alpha is involved in the recovery of muscle function after traumatic muscle injury, and this effect might be associated with modulation of muscle regulatory genes, including MyoD... - Mechanisms of skeletal muscle injury and repair revealed by gene expression studies in mouse modelsGordon L Warren
Division of Physical Therapy, Georgia State University, Atlanta, GA 30303, USA
J Physiol 582:825-41. 2007..In conclusion, knowledge of the sets of genes associated specifically with the nature of the injury may have application for development of new strategies for acceleration of the recovery process in injured skeletal muscle... - Chemokine receptor CCR2 involvement in skeletal muscle regenerationGordon L Warren
Department of Physical Therapy, Georgia State University, Atlanta, Georgia, USA
FASEB J 19:413-5. 2005..In conclusion, the study delineates that signaling through CCR2 is involved in muscle precursor cell activities necessary for complete and rapid regeneration of injured skeletal muscle...