Petia P Simeonova

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi request reprint Arsenic and atherosclerosis
    Petia P Simeonova
    Tissue Injury Team, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute of Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 198:444-9. 2004
  2. pmc Cardiovascular effects of pulmonary exposure to single-wall carbon nanotubes
    Zheng Li
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Environ Health Perspect 115:377-82. 2007
  3. ncbi request reprint c-Src-dependent activation of the epidermal growth factor receptor and mitogen-activated protein kinase pathway by arsenic. Role in carcinogenesis
    Petia P Simeonova
    TMBB, HELD, National Institute for Occupational Safety and Health, Centers for Disease Control, Morgantown, West Virginia 26505, USA
    J Biol Chem 277:2945-50. 2002
  4. doi request reprint Engineered nanoparticle respiratory exposure and potential risks for cardiovascular toxicity: predictive tests and biomarkers
    Petia P Simeonova
    Tissue Injury Team, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Inhal Toxicol 21:68-73. 2009
  5. pmc Arsenic exposure accelerates atherogenesis in apolipoprotein E(-/-) mice
    Petia P Simeonova
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Environ Health Perspect 111:1744-8. 2003
  6. ncbi request reprint Role of CC chemokines in skeletal muscle functional restoration after injury
    Gordon L Warren
    NIOSH, 1095 Willowdale Road, Morgantown, WV 26505
    Am J Physiol Cell Physiol 286:C1031-6. 2004
  7. doi request reprint Identification of systemic markers from a pulmonary carbon nanotube exposure
    Aaron Erdely
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Occup Environ Med 53:S80-6. 2011
  8. pmc Type I interferon and pattern recognition receptor signaling following particulate matter inhalation
    Aaron Erdely
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Part Fibre Toxicol 9:25. 2012
  9. doi request reprint Relationship between pulmonary and systemic markers of exposure to multiple types of welding particulate matter
    Aaron Erdely
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, United States
    Toxicology 287:153-9. 2011
  10. doi request reprint Inhalation exposure of gas-metal arc stainless steel welding fume increased atherosclerotic lesions in apolipoprotein E knockout mice
    Aaron Erdely
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, United States
    Toxicol Lett 204:12-6. 2011

Detail Information

Publications24

  1. ncbi request reprint Arsenic and atherosclerosis
    Petia P Simeonova
    Tissue Injury Team, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute of Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 198:444-9. 2004
    ..This may provide the pathophysiological basis for atherogenic potential of arsenic. Consistent with these data, arsenic accelerates atherosclerosis in apolipoprotein E (ApoE) deficient mice, a model of human atherosclerosis...
  2. pmc Cardiovascular effects of pulmonary exposure to single-wall carbon nanotubes
    Zheng Li
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Environ Health Perspect 115:377-82. 2007
    ..Engineered nanosized materials, such as single-wall carbon nanotubes (SWCNT), are emerging as technologically important in different industries...
  3. ncbi request reprint c-Src-dependent activation of the epidermal growth factor receptor and mitogen-activated protein kinase pathway by arsenic. Role in carcinogenesis
    Petia P Simeonova
    TMBB, HELD, National Institute for Occupational Safety and Health, Centers for Disease Control, Morgantown, West Virginia 26505, USA
    J Biol Chem 277:2945-50. 2002
    ..This response is also accompanied with an increase in c-Src levels interacting with EGFR. These findings represent a potential pathway for mediating arsenic-induced phenotypic changes in the uroepithelium...
  4. doi request reprint Engineered nanoparticle respiratory exposure and potential risks for cardiovascular toxicity: predictive tests and biomarkers
    Petia P Simeonova
    Tissue Injury Team, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Inhal Toxicol 21:68-73. 2009
    ..Future studies to evaluate the systemic effects of carbon nanotube exposure under workplace or environmental exposure paradigms should be conducted...
  5. pmc Arsenic exposure accelerates atherogenesis in apolipoprotein E(-/-) mice
    Petia P Simeonova
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Environ Health Perspect 111:1744-8. 2003
    ..Induction of endothelial inflammatory activity may play a role in arsenic-related vascular effects...
  6. ncbi request reprint Role of CC chemokines in skeletal muscle functional restoration after injury
    Gordon L Warren
    NIOSH, 1095 Willowdale Road, Morgantown, WV 26505
    Am J Physiol Cell Physiol 286:C1031-6. 2004
    ..The data suggest that MCP-1/CCR2 plays a role in the regeneration and recovery of function after traumatic muscle injury...
  7. doi request reprint Identification of systemic markers from a pulmonary carbon nanotube exposure
    Aaron Erdely
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Occup Environ Med 53:S80-6. 2011
    ..Interest exists for early monitoring of worker exposure to engineered nanomaterials. Here, we highlight quantitative systemic markers of early effects after carbon nanotube (CNT) exposure...
  8. pmc Type I interferon and pattern recognition receptor signaling following particulate matter inhalation
    Aaron Erdely
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Part Fibre Toxicol 9:25. 2012
    ..Whole blood cells, aorta and lung were harvested for global gene expression analysis with subsequent Ingenuity Pathway Analysis and confirmatory qRT-PCR. Serum was collected for protein profiling...
  9. doi request reprint Relationship between pulmonary and systemic markers of exposure to multiple types of welding particulate matter
    Aaron Erdely
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, United States
    Toxicology 287:153-9. 2011
    ..In conclusion, varying types of welding fumes elicit quantitatively different systemic inflammatory and/or stress responses...
  10. doi request reprint Inhalation exposure of gas-metal arc stainless steel welding fume increased atherosclerotic lesions in apolipoprotein E knockout mice
    Aaron Erdely
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, United States
    Toxicol Lett 204:12-6. 2011
    ..These results complement epidemiological and functional human studies that suggest welding may result in adverse cardiovascular effects...
  11. ncbi request reprint Macrophages and skeletal muscle regeneration: a clodronate-containing liposome depletion study
    Mukesh Summan
    Health Effects Laboratory Div, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1488-95. 2006
    ..In conclusion, a significant reduction of the initial monocyte/macrophage influx into the injured muscle is associated with not improved, but moderately impaired, repair processes after skeletal muscle injury...
  12. doi request reprint Cross-talk between lung and systemic circulation during carbon nanotube respiratory exposure. Potential biomarkers
    Aaron Erdely
    Toxicology and Molecular Biology Branch and Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Nano Lett 9:36-43. 2009
    ..The approach described here will foster the development of biomarkers for application in human screening of nanoparticle exposure...
  13. ncbi request reprint Inflammatory mediators and skeletal muscle injury: a DNA microarray analysis
    Mukesh Summan
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, USA
    J Interferon Cytokine Res 23:237-45. 2003
    ....
  14. doi request reprint Potential in vitro effects of carbon nanotubes on human aortic endothelial cells
    Valerie G Walker
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Toxicol Appl Pharmacol 236:319-28. 2009
    ..04-0.4 microg/ml)] or in any tested concentrations at 3 h post-exposure. Overall, the results indicate that SWCNT and MWCNT exposure induce direct effects on endothelial cells in a dose-dependent manner...
  15. pmc Arginase activities and global arginine bioavailability in wild-type and ApoE-deficient mice: responses to high fat and high cholesterol diets
    Aaron Erdely
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America
    PLoS ONE 5:e15253. 2010
    ..These results raise the possibility that systemic changes in arginase activity and global arginine bioavailability may be contributing factors in the initiation and/or progression of cardiovascular disease...
  16. doi request reprint Lung tumor production and tissue metal distribution after exposure to manual metal ARC-stainless steel welding fume in A/J and C57BL/6J mice
    Patti C Zeidler-Erdely
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, 1095 Willowdale Road M S L2015, Morgantown, WV 26505, USA
    J Toxicol Environ Health A 74:728-36. 2011
    ..In addition, long-term extrapulmonary tissue alterations in metals in the susceptible A/J mouse suggest that the adverse effects of this fume might be cumulative...
  17. ncbi request reprint Arsenic carcinogenicity: relevance of c-Src activation
    Petia P Simeonova
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, USA
    Mol Cell Biochem 234:277-82. 2002
    ..Increasing evidence indicates that arsenic acts at the level of tumor promotion by modulating the signaling pathways responsible for cell growth. One of this pathways might include c-Src dependent EGFR and MAPK activation...
  18. pmc Work, obesity, and occupational safety and health
    Paul A Schulte
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA
    Am J Public Health 97:428-36. 2007
    ....
  19. ncbi request reprint Biomarkers to assess potential developmental immunotoxicity in children
    Michael I Luster
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 206:229-36. 2005
    ..Quantification of the immune response to childhood vaccine, while up to the present used sparingly, may represent an excellent indicator for developmental immunotoxicity when conducted under appropriate conditions...
  20. ncbi request reprint Arsenic and urinary bladder cell proliferation
    Michael I Luster
    Inflammatory Disease Teams, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, USA
    Toxicol Appl Pharmacol 198:419-23. 2004
    ..This may play a non-epigenetic role in carcinogenesis by increasing the proliferation of initiated cells or increasing the mutational rate...
  21. ncbi request reprint IL-1beta gene polymorphisms influence hepatitis B vaccination
    Berran Yucesoy
    National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26508, USA
    Vaccine 20:3193-6. 2002
    ....
  22. pmc Mechanisms of skeletal muscle injury and repair revealed by gene expression studies in mouse models
    Gordon L Warren
    Division of Physical Therapy, Georgia State University, Atlanta, GA 30303, USA
    J Physiol 582:825-41. 2007
    ..In conclusion, knowledge of the sets of genes associated specifically with the nature of the injury may have application for development of new strategies for acceleration of the recovery process in injured skeletal muscle...
  23. ncbi request reprint Physiological role of tumor necrosis factor alpha in traumatic muscle injury
    Gordon L Warren
    Department of Physical Therapy, Georgia State University, Atlanta, Georgia, USA
    FASEB J 16:1630-2. 2002
    ..These data indicate that TNF-alpha is involved in the recovery of muscle function after traumatic muscle injury, and this effect might be associated with modulation of muscle regulatory genes, including MyoD...
  24. ncbi request reprint Chemokine receptor CCR2 involvement in skeletal muscle regeneration
    Gordon L Warren
    Department of Physical Therapy, Georgia State University, Atlanta, Georgia, USA
    FASEB J 19:413-5. 2005
    ..In conclusion, the study delineates that signaling through CCR2 is involved in muscle precursor cell activities necessary for complete and rapid regeneration of injured skeletal muscle...