Manori J Silva

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. doi request reprint Environmental exposure to the plasticizer 1,2-cyclohexane dicarboxylic acid, diisononyl ester (DINCH) in U.S. adults (2000-2012)
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA Electronic address
    Environ Res 126:159-63. 2013
  2. ncbi request reprint Improved quantitative detection of 11 urinary phthalate metabolites in humans using liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy NE, Mailstop F17, Atlanta, GA 30341 3724, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 789:393-404. 2003
  3. ncbi request reprint Automated solid-phase extraction and quantitative analysis of 14 phthalate metabolites in human serum using isotope dilution-high-performance liquid chromatography-tandem mass spectrometry
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Anal Toxicol 29:819-24. 2005
  4. ncbi request reprint Measurement of eight urinary metabolites of di(2-ethylhexyl) phthalate as biomarkers for human exposure assessment
    M J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Biomarkers 11:1-13. 2006
  5. ncbi request reprint Urinary biomarkers of di-isononyl phthalate in rats
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Toxicology 223:101-12. 2006
  6. pmc Oxidative metabolites of diisononyl phthalate as biomarkers for human exposure assessment
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 114:1158-61. 2006
  7. ncbi request reprint Assessment of human exposure to di-isodecyl phthalate using oxidative metabolites as biomarkers
    M J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Biomarkers 12:133-44. 2007
  8. ncbi request reprint Quantification of 22 phthalate metabolites in human urine
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States
    J Chromatogr B Analyt Technol Biomed Life Sci 860:106-12. 2007
  9. ncbi request reprint Metabolite profiles of di-n-butyl phthalate in humans and rats
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Sci Technol 41:7576-80. 2007
  10. doi request reprint Cross validation and ruggedness testing of analytical methods used for the quantification of urinary phthalate metabolites
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States
    J Chromatogr B Analyt Technol Biomed Life Sci 873:180-6. 2008

Collaborators

Detail Information

Publications39

  1. doi request reprint Environmental exposure to the plasticizer 1,2-cyclohexane dicarboxylic acid, diisononyl ester (DINCH) in U.S. adults (2000-2012)
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA Electronic address
    Environ Res 126:159-63. 2013
    ..The presence of oxidative metabolites of DINCH in urine suggests that these oxidative metabolites can be used as DINCH biomarkers for exposure assessment even at environmental exposure levels...
  2. ncbi request reprint Improved quantitative detection of 11 urinary phthalate metabolites in humans using liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy NE, Mailstop F17, Atlanta, GA 30341 3724, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 789:393-404. 2003
    ....
  3. ncbi request reprint Automated solid-phase extraction and quantitative analysis of 14 phthalate metabolites in human serum using isotope dilution-high-performance liquid chromatography-tandem mass spectrometry
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Anal Toxicol 29:819-24. 2005
    ..The method is accurate, precise, and sensitive, with limits of detection in the low nanogram-per-milliliter range...
  4. ncbi request reprint Measurement of eight urinary metabolites of di(2-ethylhexyl) phthalate as biomarkers for human exposure assessment
    M J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Biomarkers 11:1-13. 2006
    ..6% (MEHP) and 31.8% (MECPP) in the adults. Whether the observed differences reflect differences in route/duration of the exposure, age and/or health status of the individuals is presently unknown...
  5. ncbi request reprint Urinary biomarkers of di-isononyl phthalate in rats
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Toxicology 223:101-12. 2006
    ....
  6. pmc Oxidative metabolites of diisononyl phthalate as biomarkers for human exposure assessment
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 114:1158-61. 2006
    ..Therefore, we concluded that the prevalence of human exposure to DINP is underestimated by using MINP as the sole DINP urinary biomarker...
  7. ncbi request reprint Assessment of human exposure to di-isodecyl phthalate using oxidative metabolites as biomarkers
    M J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Biomarkers 12:133-44. 2007
    ..These data also suggest that unless oxidative metabolites are measured, the prevalence of exposure to DiDP will probably be underestimated...
  8. ncbi request reprint Quantification of 22 phthalate metabolites in human urine
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States
    J Chromatogr B Analyt Technol Biomed Life Sci 860:106-12. 2007
    ....
  9. ncbi request reprint Metabolite profiles of di-n-butyl phthalate in humans and rats
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Sci Technol 41:7576-80. 2007
    ..In addition to MBP, MCPP and MHBP may be adequate biomarkers of exposure to DBP in occupational settings orin potential high-exposure scenarios...
  10. doi request reprint Cross validation and ruggedness testing of analytical methods used for the quantification of urinary phthalate metabolites
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States
    J Chromatogr B Analyt Technol Biomed Life Sci 873:180-6. 2008
    ....
  11. doi request reprint Urinary and serum metabolites of di-n-pentyl phthalate in rats
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States
    Chemosphere 82:431-6. 2011
    ..Nonetheless, based on the urinary levels of MHPP, our preliminary data suggest that human exposure to DPP in the United States is rather limited...
  12. ncbi request reprint Urinary oxidative metabolites of di(2-ethylhexyl) phthalate in humans
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Mailstop F17, 4770 Buford Hwy NE, Atlanta, GA 30341, USA
    Toxicology 219:22-32. 2006
    ..Although quantitative information is not available, our findings suggest that, despite potential differences among species, the oxidative metabolism of DEHP in humans and rodents results in similar urinary metabolic products...
  13. ncbi request reprint Detection of phthalate metabolites in human saliva
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mail Stop F 17, Atlanta, GA 30341, USA
    Arch Toxicol 79:647-52. 2005
    ....
  14. ncbi request reprint Glucuronidation patterns of common urinary and serum monoester phthalate metabolites
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy NE, Mailstop F17, Atlanta, GA 30341, USA
    Arch Toxicol 77:561-7. 2003
    ..Serum mBzP was largely below the method limit of detection. Interestingly, the serum mEP and mBP levels were less than 3% and 47%, respectively, of their urinary levels, whereas the level of mEHP was similar both in urine and serum...
  15. ncbi request reprint Urinary metabolites of di-n-octyl phthalate in rats
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Mailstop F17, 4770 Buford Hwy NE, Atlanta, GA 30341, USA
    Toxicology 210:123-33. 2005
    ..We also studied the in vitro metabolism of DnOP and MnOP by rat liver microsomes. DnOP produced MnOP, MHOP, and PA in vitro whereas, MnOP produced MHOP and PA in vitro at detectable levels...
  16. pmc Correcting for the influence of sampling conditions on biomarkers of exposure to phenols and phthalates: a 2-step standardization method based on regression residuals
    Marion Mortamais
    Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, INSERM, Institut Albert Bonniot U823, Grenoble, France
    Environ Health 11:29. 2012
    ....
  17. pmc Mono(2-ethyl-5-hydroxyhexyl) phthalate and mono-(2-ethyl-5-oxohexyl) phthalate as biomarkers for human exposure assessment to di-(2-ethylhexyl) phthalate
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341, USA
    Environ Health Perspect 112:327-30. 2004
    ....
  18. pmc Assessing human exposure to phthalates using monoesters and their oxidized metabolites as biomarkers
    Dana B Barr
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 111:1148-51. 2003
    ....
  19. ncbi request reprint Urinary and amniotic fluid levels of phthalate monoesters in rats after the oral administration of di(2-ethylhexyl) phthalate and di-n-butyl phthalate
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Mailstop F17, Atlanta, GA 30341, USA
    Toxicology 217:22-30. 2006
    ..Although no firm conclusions could be drawn from the urinary MBP data, the MEHP results suggest that maternal urinary MEHP levels may be useful surrogate markers for fetal exposure to DEHP...
  20. ncbi request reprint Mono-(3-carboxypropyl) phthalate, a metabolite of di-n-octyl phthalate
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Toxicol Environ Health A 69:215-27. 2006
    ....
  21. pmc Selecting adequate exposure biomarkers of diisononyl and diisodecyl phthalates: data from the 2005-2006 National Health and Nutrition Examination Survey
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 119:50-5. 2011
    ..Objectives: We assessed exposure to DINP and DIDP in a representative sample of persons ≥ 6 years of age in the U.S. general population from the 2005-2006 National Health and Nutrition Examination Survey (NHANES)...
  22. doi request reprint Estimated daily intake of phthalates in occupationally exposed groups
    Cynthia J Hines
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45230, USA
    J Expo Sci Environ Epidemiol 21:133-41. 2011
    ..These intake estimates are subject to several uncertainties; however, an occupational contribution to phthalate daily intake is clearly indicated in some industries...
  23. doi request reprint Occupational exposure to diisononyl phthalate (DiNP) in polyvinyl chloride processing operations
    Cynthia J Hines
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA
    Int Arch Occup Environ Health 85:317-25. 2012
    ..We present DiNP metabolite urinary concentrations in PVC processing workers, estimate DiNP daily intake for these workers, and compare worker estimates to other populations...
  24. ncbi request reprint Quantitative detection of nine phthalate metabolites in human serum using reversed-phase high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Anal Toxicol 27:284-9. 2003
    ..In addition, it allows the direct measurement of the active phthalate monoester metabolites reportedly responsible for the reproductive and developmental toxicity of certain phthalates...
  25. pmc Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341, USA
    Environ Health Perspect 112:331-8. 2004
    ....
  26. ncbi request reprint In vitro metabolites of di-2-ethylhexyl adipate (DEHA) as biomarkers of exposure in human biomonitoring applications
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, United States
    Chem Res Toxicol 26:1498-502. 2013
    ..Therefore, the use of these specific metabolites for assessing the exposure of DEHA may be limited to highly exposed populations. ..
  27. ncbi request reprint Analysis of human urine for fifteen phthalate metabolites using automated solid-phase extraction
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Mailstop F17, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 805:161-7. 2004
    ..The method was validated on spiked pooled urine samples and on pooled urine samples from persons with no known exposure to phthalates...
  28. pmc Variability over 1 week in the urinary concentrations of metabolites of diethyl phthalate and di(2-ethylhexyl) phthalate among eight adults: an observational study
    James L Preau
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 118:1748-54. 2010
    ..Several reports suggest that concentrations of phthalate metabolites in a spot urine sample can provide a reliable estimation of exposure to phthalates for up to several months...
  29. doi request reprint Identification of potential biomarkers of exposure to di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH), an alternative for phthalate plasticizers
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Expo Sci Environ Epidemiol 22:204-11. 2012
    ..Our results suggest that several urinary oxidative metabolites, specifically CHDA, mono oxoisononyl ester and MHNCH may be used as specific biomarkers of DINCH exposure in humans...
  30. ncbi request reprint Human exposure assessment to environmental chemicals using biomonitoring
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Int J Androl 29:166-71; discussion 181-5. 2006
    ..The use of biomonitoring in human risk assessment is not discussed...
  31. doi request reprint Temporal stability of eight phthalate metabolites and their glucuronide conjugates in human urine
    Ella Samandar
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Mailstop F 53, Atlanta, GA 30341, USA
    Environ Res 109:641-6. 2009
    ..Based on these findings, we recommend transferring urine specimens to a cooler or a refrigerator immediately after collection followed by permanent storage at subfreezing temperatures within hours of sample collection...
  32. ncbi request reprint Urinary metabolites of diisodecyl phthalate in rats
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Toxicology 236:114-22. 2007
    ..Additional research on the toxicokinetics of these metabolites is needed to understand the extent of human exposure to DiDP from the urinary concentrations of MCiNP and other DiDP secondary metabolites...
  33. doi request reprint Urinary phthalate metabolite concentrations among workers in selected industries: a pilot biomonitoring study
    Cynthia J Hines
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH, USA
    Ann Occup Hyg 53:1-17. 2009
    ..In summary, using urinary metabolites, we successfully identified workplaces with likely occupational phthalate exposure. Additional work is needed to distinguish occupational from non-occupational sources in low-exposure workplaces...
  34. doi request reprint An estimate of phthalate exposure among pregnant women living in Trujillo, Peru
    Elizabeth Ann Irvin
    Department of Environmental Health Science, The University of Georgia, College of Public Health, Athens, GA, USA
    Chemosphere 80:1301-7. 2010
    ..Five of nine unadjusted urinary metabolites and four of nine creatinine-adjusted urinary metabolites were significantly lower in this group of pregnant women living in Peru compared to pregnant women in the US general population...
  35. ncbi request reprint Determination of 16 phthalate metabolites in urine using automated sample preparation and on-line preconcentration/high-performance liquid chromatography/tandem mass spectrometry
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Mailstop F17, Atlanta, Georgia 30341, USA
    Anal Chem 77:2985-91. 2005
    ....
  36. ncbi request reprint Quantifying phthalate metabolites in human meconium and semen using automated off-line solid-phase extraction coupled with on-line SPE and isotope-dilution high-performance liquid chromatography--tandem mass spectrometry
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Anal Chem 78:6651-5. 2006
    ....
  37. ncbi request reprint Automated solid phase extraction and quantitative analysis of human milk for 13 phthalate metabolites
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 805:49-56. 2004
    ..We detected several phthalate metabolites in pooled human breast milk samples, suggesting that phthalates can be incorporated into breast milk and transferred to the nursing child...
  38. ncbi request reprint Determination of total phthalates in urine by isotope-dilution liquid chromatography-tandem mass spectrometry
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 814:355-60. 2005
    ..The present method accurately assesses total exposure to phthalates without noticeable contamination from the ubiquitous phthalates in the environment, but it gives no information about the parent phthalate...
  39. ncbi request reprint Exposure to di-(2-ethylhexyl) phthalate among premature neonates in a neonatal intensive care unit
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Pediatrics 113:e429-34. 2004
    ..Because of their smaller size, children and especially premature and small infants may receive a larger dose of DEHP on a milligram per kilogram basis than adults when the same-size medical device is used for all ages...