Manori J Silva
Affiliation: Centers for Disease Control and Prevention
Silva M, Samandar E, Preau J, Reidy J, Needham L, Calafat A. Quantification of 22 phthalate metabolites in human urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;860:106-12 pubmed
Silva M, Samandar E, Calafat A, Ye X. Identification of di-2-ethylhexyl terephthalate (DEHTP) metabolites using human liver microsomes for biomonitoring applications. Toxicol In Vitro. 2015;29:716-21 pubmed publisher
..Nonetheless, data on the urinary excretion fraction and temporal stability of these metabolites, among other considerations, are needed to demonstrate their utility as exposure biomarkers. ..
Silva M, Hilton D, Furr J, Gray L, Preau J, Calafat A, et al
. Quantification of tetrabromo benzoic acid and tetrabromo phthalic acid in rats exposed to the flame retardant Uniplex FPR-45. Arch Toxicol. 2016;90:551-7 pubmed publisher
..Additional research can provide useful information to better understand the composition and in vivo toxicokinetics of these commercial mixtures. ..
Silva M, Bontke T, Calafat A, Ye X. Identification of potential biomarkers of exposure to diundecyl phthalate. Environ Res. 2016;148:137-143 pubmed publisher
..Taken together, these findings suggest that with the appropriate mass spectrometry quantification techniques, MHUP and MCDP may serve as suitable biomarkers for assessing background exposure to DUP. ..
Wolff M, Pajak A, Pinney S, Windham G, Galvez M, Rybak M, et al
. Associations of urinary phthalate and phenol biomarkers with menarche in a multiethnic cohort of young girls. Reprod Toxicol. 2017;67:56-64 pubmed publisher
..These analytes were also associated with age at breast development in this cohort. Findings from this prospective study suggest that some childhood exposures are associated with pubertal timing. ..
Silva M, Wong L, Samandar E, Preau J, Calafat A, Ye X. Exposure to di-2-ethylhexyl terephthalate in a convenience sample of U.S. adults from 2000 to 2016. Arch Toxicol. 2017;91:3287-3291 pubmed publisher
..Nevertheless, general population exposure data using MEHHTP and MECPTP as exposure biomarkers would increase our understanding of exposure to DEHTP, one of the known DEHP alternatives. ..
Silva M, Jia T, Samandar E, Preau J, Calafat A. Environmental exposure to the plasticizer 1,2-cyclohexane dicarboxylic acid, diisononyl ester (DINCH) in U.S. adults (2000-2012). Environ Res. 2013;126:159-63 pubmed publisher
..The presence of oxidative metabolites of DINCH in urine suggests that these oxidative metabolites can be used as DINCH biomarkers for exposure assessment even at environmental exposure levels. ..