Research Topics
| Anna A ShvedovaSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
| Collaborators
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Detail Information
Publications
Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in miceAnna A Shvedova
Health Effects Laboratory Div, NIOSH, Morgantown, WV, USA
Am J Physiol Lung Cell Mol Physiol 289:L698-708. 2005..Equal doses of ultrafine carbon black particles or fine crystalline silica (SiO2) did not induce granulomas or alveolar wall thickening and caused a significantly weaker pulmonary inflammation and damage...
Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestosAshley R Murray
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
Part Fibre Toxicol 9:10. 2012..While the toxicity and hazardous outcomes elicited by airborne exposure to single-walled CNT or asbestos have been widely reported, very limited data are currently available describing adverse effects of respirable CNF...- Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single-walled carbon nanotubes in C57BL/6 miceAnna A Shvedova
Pathology Physiology Research Branch, HELD, NIOSH, Morgantown, WV, USA
Toxicol Appl Pharmacol 221:339-48. 2007..Given that pulmonary levels of vitamin E can be manipulated through diet, its effects on SWCNT-induced inflammation may be of practical importance in optimizing protective strategies... - Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivityAnna A Shvedova
Pathology Physiology Research Branch, HELD, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
Am J Respir Cell Mol Biol 38:579-90. 2008..In conclusion, enhanced acute inflammation and pulmonary injury with delayed bacterial clearance after SWCNT exposure may lead to increased susceptibility to lung infection in exposed populations... - Direct effects of carbon nanotubes on dendritic cells induce immune suppression upon pulmonary exposureAlexey V Tkach
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
ACS Nano 5:5755-62. 2011..Preincubation of naìˆve T cells in vitro with SWCNT-treated dendritic cells reduced proliferation of T cells. Our data suggest that in vivo exposure to SWCNT modifies systemic immunity by modulating dendritic cell function... - Single-walled carbon nanotubes: geno- and cytotoxic effects in lung fibroblast V79 cellsElena R Kisin
Pathology Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
J Toxicol Environ Health A 70:2071-9. 2007..With two different strains of Salmonella typhimurium, no mutations were found following SWCNT exposure... - Enhanced oxidative stress in the skin of vitamin E deficient mice exposed to semisynthetic metal working fluidsAnna A Shvedova
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Mail Stop 2015, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA
Toxicology 176:135-43. 2002..This study clearly delineates the role of oxidative stress in enhancing mast cell accumulation caused by topical exposure to MWFs... - Aerosolization of single-walled carbon nanotubes for an inhalation studyPaul A Baron
National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA
Inhal Toxicol 20:751-60. 2008..The mass output efficiency of the entire system for producing a respirable aerosol from bulk material was estimated to be about 10%... - d-MDMA during vitamin E deficiency: effects on dopaminergic neurotoxicity and hepatotoxicityElizabeth Anne Johnson
Chronic Stress Laboratory, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health Centers for Disease Control, Mailstop 3014, 1095 Willowdale Road, 26505, Morgantown, WV, USA
Brain Res 933:150-63. 2002.... - Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube materialAndrew D Maynard
National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
J Toxicol Environ Health A 67:87-107. 2004..Glove deposits of SWCNT during handling were estimated at between 0.2 mg and 6 mg per hand... - Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cellsAnna A Shvedova
Pathology and Physiology Research Branch, National Institute of Occupational Safety and Health, and Physiology and Pharmacology Department, West Virginia University, Morgantown 26505, USA
J Toxicol Environ Health A 66:1909-26. 2003..These data indicate that dermal exposure to unrefined SWCNT may lead to dermal toxicity due to accelerated oxidative stress in the skin of exposed workers... - Selective peroxidation and externalization of phosphatidylserine in normal human epidermal keratinocytes during oxidative stress induced by cumene hydroperoxideAnna A Shvedova
Health Effects Laboratory Division, Pathology and Physiology Research Branch, NIOSH, Morgantown, West Virginia 26505, USA
J Invest Dermatol 118:1008-18. 2002..This would make them targets for macrophage recognition and phagocytosis, and thus limit their potential to invoke inflammation or give rise to neoplastic transformations... 
Close encounters of the small kind: adverse effects of man-made materials interfacing with the nano-cosmos of biological systemsAnna A Shvedova
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, West Virginia University, Morgantown, USA
Annu Rev Pharmacol Toxicol 50:63-88. 2010..Finally, we highlight in vivo studies of the toxicological outcomes of engineered nanomaterials, including carbon nanotubes, with an emphasis on inflammation and genotoxic responses...- Metal working fluids: sub-chronic effects on pulmonary functions in B6C3F1 mice given vitamin E deficient and sufficient dietsAnna A Shvedova
Pathology and Physiology Research Branch, Engineering Control and Technology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Toxicology 177:285-97. 2002..This is the first report that describes the increase of oxidative stress in the lungs after MWF exposure... - Arachidonic acid-induced carbon-centered radicals and phospholipid peroxidation in cyclo-oxygenase-2-transfected PC12 cellsJianfei Jiang
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurochem 90:1036-49. 2004..Thus, COX-2 generated carbon-centered radicals but not oxygen radicals or thiyl radicals are responsible for oxidative stress in AA-challenged PC12 cells overexpressing COX-2... - Toward mechanism-based antioxidant interventions: lessons from natural antioxidantsValerian E Kagan
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
Ann N Y Acad Sci 959:188-98. 2002..Experiments are now underway to determine whether inhibition of PS oxidation by antioxidants may interfere with important signaling functions of oxidative stress in eliminating apoptotic cells... - Peroxidation of phosphatidylserine in mechanisms of apoptotic signalingYulia Y Tyurina
Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
Methods Enzymol 352:159-74. 2002 - Anti-/pro-oxidant effects of phenolic compounds in cells: are colchicine metabolites chain-breaking antioxidants?Martin Modriansky
Department of Environmental and Occupational Health, University of Pittsburgh, FORBL Room 234, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA
Toxicology 177:105-17. 2002..However, the latter retain high reactivity towards critical biomolecules in cells such as lipids, thiols, ascorbate, thereby, rendering colchicine metabolites effective radical scavengers but not effective chain-breaking antioxidants... - Nanomedicine and nanotoxicology: two sides of the same coinValerian E Kagan
Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
Nanomedicine 1:313-6. 2005.... - Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment: implications for the resolution of inflammationYulia Y Tyurina
Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, and Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
J Biol Chem 282:8498-509. 2007..scavenger, DAF-2. Thus, macrophage-induced nitrosylation/oxidation plays an important role in cell clearance, and hence in the resolution of inflammation... - An epigrammatic (abridged) recounting of the myriad tales of astonishing deeds and dire consequences pertaining to nitric oxide and reactive oxygen species in mitochondria with an ancillary missive concerning the origins of apoptosisDiane E Heck
Departments of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
Toxicology 208:259-71. 2005....