Anna A Shvedova

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi request reprint Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice
    Anna A Shvedova
    Health Effects Laboratory Div, NIOSH, Morgantown, WV, USA
    Am J Physiol Lung Cell Mol Physiol 289:L698-708. 2005
  2. pmc Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestos
    Ashley R Murray
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Part Fibre Toxicol 9:10. 2012
  3. pmc Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single-walled carbon nanotubes in C57BL/6 mice
    Anna A Shvedova
    Pathology Physiology Research Branch, HELD, NIOSH, Morgantown, WV, USA
    Toxicol Appl Pharmacol 221:339-48. 2007
  4. pmc Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity
    Anna A Shvedova
    Pathology Physiology Research Branch, HELD, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Am J Respir Cell Mol Biol 38:579-90. 2008
  5. doi request reprint Oxidative stress, inflammatory biomarkers, and toxicity in mouse lung and liver after inhalation exposure to 100% biodiesel or petroleum diesel emissions
    Anna A Shvedova
    a Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute of Occupational and Safety Health, Morgantown, West Virginia, USA
    J Toxicol Environ Health A 76:907-21. 2013
  6. ncbi request reprint Single-walled carbon nanotubes: geno- and cytotoxic effects in lung fibroblast V79 cells
    Elena R Kisin
    Pathology Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 70:2071-9. 2007
  7. pmc Carbon nanotubes enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells
    Anna A Shvedova
    Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Small 9:1691-5. 2013
  8. doi request reprint Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells
    Alexey V Tkach
    Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Small 9:1686-90. 2013
  9. pmc Direct effects of carbon nanotubes on dendritic cells induce immune suppression upon pulmonary exposure
    Alexey V Tkach
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    ACS Nano 5:5755-62. 2011
  10. doi request reprint Long-term effects of carbon containing engineered nanomaterials and asbestos in the lung: one year postexposure comparisons
    Anna A Shvedova
    NIOSH, CDC, 1095 Willowdale Rd, Morgantown, WV 26505
    Am J Physiol Lung Cell Mol Physiol 306:L170-82. 2014

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice
    Anna A Shvedova
    Health Effects Laboratory Div, NIOSH, Morgantown, WV, USA
    Am J Physiol Lung Cell Mol Physiol 289:L698-708. 2005
    ..Equal doses of ultrafine carbon black particles or fine crystalline silica (SiO2) did not induce granulomas or alveolar wall thickening and caused a significantly weaker pulmonary inflammation and damage...
  2. pmc Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestos
    Ashley R Murray
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Part Fibre Toxicol 9:10. 2012
    ..While the toxicity and hazardous outcomes elicited by airborne exposure to single-walled CNT or asbestos have been widely reported, very limited data are currently available describing adverse effects of respirable CNF...
  3. pmc Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single-walled carbon nanotubes in C57BL/6 mice
    Anna A Shvedova
    Pathology Physiology Research Branch, HELD, NIOSH, Morgantown, WV, USA
    Toxicol Appl Pharmacol 221:339-48. 2007
    ..Given that pulmonary levels of vitamin E can be manipulated through diet, its effects on SWCNT-induced inflammation may be of practical importance in optimizing protective strategies...
  4. pmc Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity
    Anna A Shvedova
    Pathology Physiology Research Branch, HELD, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Am J Respir Cell Mol Biol 38:579-90. 2008
    ..In conclusion, enhanced acute inflammation and pulmonary injury with delayed bacterial clearance after SWCNT exposure may lead to increased susceptibility to lung infection in exposed populations...
  5. doi request reprint Oxidative stress, inflammatory biomarkers, and toxicity in mouse lung and liver after inhalation exposure to 100% biodiesel or petroleum diesel emissions
    Anna A Shvedova
    a Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute of Occupational and Safety Health, Morgantown, West Virginia, USA
    J Toxicol Environ Health A 76:907-21. 2013
    ..Further studies are required to understand what combustion products in BD CE accelerate oxidative and inflammatory responses...
  6. ncbi request reprint Single-walled carbon nanotubes: geno- and cytotoxic effects in lung fibroblast V79 cells
    Elena R Kisin
    Pathology Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 70:2071-9. 2007
    ..With two different strains of Salmonella typhimurium, no mutations were found following SWCNT exposure...
  7. pmc Carbon nanotubes enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells
    Anna A Shvedova
    Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Small 9:1691-5. 2013
    ..These data are important for the design of novel theranostics platforms with modules capable of depleting or functionally suppressing MDSC to ensure effective immunosurveillance in the tumor microenvironment...
  8. doi request reprint Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells
    Alexey V Tkach
    Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Small 9:1686-90. 2013
    ..In contrast to C60 -fullerenes, GO decreases the intracellular levels of LMP7 immunoproteasome subunits required for processing of protein antigens. This is important for the development of DC-based vaccines...
  9. pmc Direct effects of carbon nanotubes on dendritic cells induce immune suppression upon pulmonary exposure
    Alexey V Tkach
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    ACS Nano 5:5755-62. 2011
    ..Preincubation of naìˆve T cells in vitro with SWCNT-treated dendritic cells reduced proliferation of T cells. Our data suggest that in vivo exposure to SWCNT modifies systemic immunity by modulating dendritic cell function...
  10. doi request reprint Long-term effects of carbon containing engineered nanomaterials and asbestos in the lung: one year postexposure comparisons
    Anna A Shvedova
    NIOSH, CDC, 1095 Willowdale Rd, Morgantown, WV 26505
    Am J Physiol Lung Cell Mol Physiol 306:L170-82. 2014
    ..Overall, our data suggest that long-term pulmonary toxicity of SWCNT, CNF, and asbestos is defined, not only by their chemical composition, but also by the specific surface area and type of exposure. ..
  11. ncbi request reprint Enhanced oxidative stress in the skin of vitamin E deficient mice exposed to semisynthetic metal working fluids
    Anna A Shvedova
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Mail Stop 2015, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Toxicology 176:135-43. 2002
    ..This study clearly delineates the role of oxidative stress in enhancing mast cell accumulation caused by topical exposure to MWFs...
  12. ncbi request reprint Aerosolization of single-walled carbon nanotubes for an inhalation study
    Paul A Baron
    National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA
    Inhal Toxicol 20:751-60. 2008
    ..The mass output efficiency of the entire system for producing a respirable aerosol from bulk material was estimated to be about 10%...
  13. ncbi request reprint d-MDMA during vitamin E deficiency: effects on dopaminergic neurotoxicity and hepatotoxicity
    Elizabeth Anne Johnson
    Chronic Stress Laboratory, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health Centers for Disease Control, Mailstop 3014, 1095 Willowdale Road, 26505, Morgantown, WV, USA
    Brain Res 933:150-63. 2002
    ....
  14. ncbi request reprint Selective peroxidation and externalization of phosphatidylserine in normal human epidermal keratinocytes during oxidative stress induced by cumene hydroperoxide
    Anna A Shvedova
    Health Effects Laboratory Division, Pathology and Physiology Research Branch, NIOSH, Morgantown, West Virginia 26505, USA
    J Invest Dermatol 118:1008-18. 2002
    ..This would make them targets for macrophage recognition and phagocytosis, and thus limit their potential to invoke inflammation or give rise to neoplastic transformations...
  15. ncbi request reprint Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
    Andrew D Maynard
    National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
    J Toxicol Environ Health A 67:87-107. 2004
    ..Glove deposits of SWCNT during handling were estimated at between 0.2 mg and 6 mg per hand...
  16. ncbi request reprint Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells
    Anna A Shvedova
    Pathology and Physiology Research Branch, National Institute of Occupational Safety and Health, and Physiology and Pharmacology Department, West Virginia University, Morgantown 26505, USA
    J Toxicol Environ Health A 66:1909-26. 2003
    ..These data indicate that dermal exposure to unrefined SWCNT may lead to dermal toxicity due to accelerated oxidative stress in the skin of exposed workers...
  17. doi request reprint Oxidative stress and dermal toxicity of iron oxide nanoparticles in vitro
    Ashley R Murray
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health NIOSH, M L 2015, 1095 Willowdale Road, Morgantown, WV, 26505, USA
    Cell Biochem Biophys 67:461-76. 2013
    ..These results verify the need to thoroughly evaluate the adverse effects of UVB when evaluating dermal toxicity of engineered NPs on skin. ..
  18. doi request reprint Close encounters of the small kind: adverse effects of man-made materials interfacing with the nano-cosmos of biological systems
    Anna A Shvedova
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, West Virginia University, Morgantown, USA
    Annu Rev Pharmacol Toxicol 50:63-88. 2010
    ..Finally, we highlight in vivo studies of the toxicological outcomes of engineered nanomaterials, including carbon nanotubes, with an emphasis on inflammation and genotoxic responses...
  19. pmc Molecular modeling in structural nano-toxicology: Interactions of nano-particles with nano-machinery of cells
    Naveena Yanamala
    Pathology and Physiology Research Branch NIOSH CDC, Morgantown, WV, USA
    Adv Drug Deliv Rev 65:2070-7. 2013
    ..A rationale on how nanoparticles of different sizes, shape, structure and chemical properties can affect the organization and functions of nano-machinery of cells is also presented. ..
  20. ncbi request reprint Metal working fluids: sub-chronic effects on pulmonary functions in B6C3F1 mice given vitamin E deficient and sufficient diets
    Anna A Shvedova
    Pathology and Physiology Research Branch, Engineering Control and Technology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Toxicology 177:285-97. 2002
    ..This is the first report that describes the increase of oxidative stress in the lungs after MWF exposure...
  21. ncbi request reprint Arachidonic acid-induced carbon-centered radicals and phospholipid peroxidation in cyclo-oxygenase-2-transfected PC12 cells
    Jianfei Jiang
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurochem 90:1036-49. 2004
    ..Thus, COX-2 generated carbon-centered radicals but not oxygen radicals or thiyl radicals are responsible for oxidative stress in AA-challenged PC12 cells overexpressing COX-2...
  22. ncbi request reprint Toward mechanism-based antioxidant interventions: lessons from natural antioxidants
    Valerian E Kagan
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Ann N Y Acad Sci 959:188-98. 2002
    ..Experiments are now underway to determine whether inhibition of PS oxidation by antioxidants may interfere with important signaling functions of oxidative stress in eliminating apoptotic cells...
  23. ncbi request reprint Peroxidation of phosphatidylserine in mechanisms of apoptotic signaling
    Yulia Y Tyurina
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Methods Enzymol 352:159-74. 2002
  24. ncbi request reprint Anti-/pro-oxidant effects of phenolic compounds in cells: are colchicine metabolites chain-breaking antioxidants?
    Martin Modriansky
    Department of Environmental and Occupational Health, University of Pittsburgh, FORBL Room 234, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA
    Toxicology 177:105-17. 2002
    ..However, the latter retain high reactivity towards critical biomolecules in cells such as lipids, thiols, ascorbate, thereby, rendering colchicine metabolites effective radical scavengers but not effective chain-breaking antioxidants...
  25. ncbi request reprint Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphatidylserine externalization and macrophage engulfment: implications for the resolution of inflammation
    Yulia Y Tyurina
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, and Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Biol Chem 282:8498-509. 2007
    ..scavenger, DAF-2. Thus, macrophage-induced nitrosylation/oxidation plays an important role in cell clearance, and hence in the resolution of inflammation...
  26. ncbi request reprint An epigrammatic (abridged) recounting of the myriad tales of astonishing deeds and dire consequences pertaining to nitric oxide and reactive oxygen species in mitochondria with an ancillary missive concerning the origins of apoptosis
    Diane E Heck
    Departments of Pharmacology and Toxicology, Rutgers University, Piscataway, NJ 08854, USA
    Toxicology 208:259-71. 2005
    ....
  27. ncbi request reprint Nanomedicine and nanotoxicology: two sides of the same coin
    Valerian E Kagan
    Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Nanomedicine 1:313-6. 2005
    ....