Anna A Shvedova

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. doi request reprint Long-term effects of carbon containing engineered nanomaterials and asbestos in the lung: one year postexposure comparisons
    Anna A Shvedova
    NIOSH, CDC, 1095 Willowdale Rd, Morgantown, WV 26505
    Am J Physiol Lung Cell Mol Physiol 306:L170-82. 2014
  2. pmc Pulmonary exposure to single-walled carbon nanotubes does not affect the early immune response against Toxoplasma gondii
    Linda Swedin
    Institute of Environmental Medicine, Division of Molecular Toxicology, Karolinska Institutet, Stockholm, Sweden
    Part Fibre Toxicol 9:16. 2012
  3. pmc Carbon nanotubes enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells
    Anna A Shvedova
    Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Small 9:1691-5. 2013
  4. doi request reprint Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubes
    A A Shvedova
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, West Virginia University, Morgantown, WV, USA
    Toxicol Appl Pharmacol 231:235-40. 2008
  5. pmc Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis
    A A Shvedova
    Health Effects Laboratory Div, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Am J Physiol Lung Cell Mol Physiol 295:L552-65. 2008
  6. doi request reprint Mechanisms of pulmonary toxicity and medical applications of carbon nanotubes: Two faces of Janus?
    A A Shvedova
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, United States
    Pharmacol Ther 121:192-204. 2009
  7. doi request reprint Close encounters of the small kind: adverse effects of man-made materials interfacing with the nano-cosmos of biological systems
    Anna A Shvedova
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, West Virginia University, Morgantown, USA
    Annu Rev Pharmacol Toxicol 50:63-88. 2010
  8. doi request reprint The role of nanotoxicology in realizing the 'helping without harm' paradigm of nanomedicine: lessons from studies of pulmonary effects of single-walled carbon nanotubes
    A A Shvedova
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health CDC, 1095 Willowdale Road, Morgantown, WV 26505, USA
    J Intern Med 267:106-18. 2010
  9. doi request reprint Mechanisms of carbon nanotube-induced toxicity: focus on oxidative stress
    Anna A Shvedova
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, University of Rome Tor Vergata, Rome, Italy
    Toxicol Appl Pharmacol 261:121-33. 2012
  10. pmc Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity
    Anna A Shvedova
    Pathology Physiology Research Branch, HELD, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Am J Respir Cell Mol Biol 38:579-90. 2008

Collaborators

Detail Information

Publications31

  1. doi request reprint Long-term effects of carbon containing engineered nanomaterials and asbestos in the lung: one year postexposure comparisons
    Anna A Shvedova
    NIOSH, CDC, 1095 Willowdale Rd, Morgantown, WV 26505
    Am J Physiol Lung Cell Mol Physiol 306:L170-82. 2014
    ..Overall, our data suggest that long-term pulmonary toxicity of SWCNT, CNF, and asbestos is defined, not only by their chemical composition, but also by the specific surface area and type of exposure. ..
  2. pmc Pulmonary exposure to single-walled carbon nanotubes does not affect the early immune response against Toxoplasma gondii
    Linda Swedin
    Institute of Environmental Medicine, Division of Molecular Toxicology, Karolinska Institutet, Stockholm, Sweden
    Part Fibre Toxicol 9:16. 2012
    ..Here, we studied whether the sequential exposure to SWCNT via pharyngeal aspiration and infection of mice with the ubiquitous intracellular parasite Toxoplasma gondii would impact on the immune response of the host against the parasite...
  3. pmc Carbon nanotubes enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells
    Anna A Shvedova
    Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Small 9:1691-5. 2013
    ..These data are important for the design of novel theranostics platforms with modules capable of depleting or functionally suppressing MDSC to ensure effective immunosurveillance in the tumor microenvironment...
  4. doi request reprint Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubes
    A A Shvedova
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, West Virginia University, Morgantown, WV, USA
    Toxicol Appl Pharmacol 231:235-40. 2008
    ..These results demonstrate a role for NADPH oxidase-derived reactive oxygen species in determining course of pulmonary response to SWCNT...
  5. pmc Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis
    A A Shvedova
    Health Effects Laboratory Div, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Am J Physiol Lung Cell Mol Physiol 295:L552-65. 2008
    ..SWCNT inhalation was more effective than aspiration in causing inflammatory response, oxidative stress, collagen deposition, and fibrosis as well as mutations of K-ras gene locus in the lung of C57BL/6 mice...
  6. doi request reprint Mechanisms of pulmonary toxicity and medical applications of carbon nanotubes: Two faces of Janus?
    A A Shvedova
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, United States
    Pharmacol Ther 121:192-204. 2009
    ....
  7. doi request reprint Close encounters of the small kind: adverse effects of man-made materials interfacing with the nano-cosmos of biological systems
    Anna A Shvedova
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, West Virginia University, Morgantown, USA
    Annu Rev Pharmacol Toxicol 50:63-88. 2010
    ..Finally, we highlight in vivo studies of the toxicological outcomes of engineered nanomaterials, including carbon nanotubes, with an emphasis on inflammation and genotoxic responses...
  8. doi request reprint The role of nanotoxicology in realizing the 'helping without harm' paradigm of nanomedicine: lessons from studies of pulmonary effects of single-walled carbon nanotubes
    A A Shvedova
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health CDC, 1095 Willowdale Road, Morgantown, WV 26505, USA
    J Intern Med 267:106-18. 2010
    ..Finally, data on biodegradation of SWCNT by oxidative enzymes of inflammatory cells are presented in lieu of their persistence and distribution in the body...
  9. doi request reprint Mechanisms of carbon nanotube-induced toxicity: focus on oxidative stress
    Anna A Shvedova
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, University of Rome Tor Vergata, Rome, Italy
    Toxicol Appl Pharmacol 261:121-33. 2012
    ..We also discuss instances of non-oxidative stress-mediated cellular damage resulting from direct physical interference of nanomaterials with cellular structures...
  10. pmc Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity
    Anna A Shvedova
    Pathology Physiology Research Branch, HELD, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Am J Respir Cell Mol Biol 38:579-90. 2008
    ..In conclusion, enhanced acute inflammation and pulmonary injury with delayed bacterial clearance after SWCNT exposure may lead to increased susceptibility to lung infection in exposed populations...
  11. pmc Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single-walled carbon nanotubes in C57BL/6 mice
    Anna A Shvedova
    Pathology Physiology Research Branch, HELD, NIOSH, Morgantown, WV, USA
    Toxicol Appl Pharmacol 221:339-48. 2007
    ..Given that pulmonary levels of vitamin E can be manipulated through diet, its effects on SWCNT-induced inflammation may be of practical importance in optimizing protective strategies...
  12. ncbi request reprint Elevated oxidative stress in skin of B6C3F1 mice affects dermal exposure to metal working fluid
    A A Shvedova
    Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    Toxicol Ind Health 16:267-76. 2000
    ..Such changes were not observed with MWF treatment alone. These data indicate that oxidative stress can enhance dermal inflammation caused by occupational exposure to MWF...
  13. ncbi request reprint Selective peroxidation and externalization of phosphatidylserine in normal human epidermal keratinocytes during oxidative stress induced by cumene hydroperoxide
    Anna A Shvedova
    Health Effects Laboratory Division, Pathology and Physiology Research Branch, NIOSH, Morgantown, West Virginia 26505, USA
    J Invest Dermatol 118:1008-18. 2002
    ..This would make them targets for macrophage recognition and phagocytosis, and thus limit their potential to invoke inflammation or give rise to neoplastic transformations...
  14. ncbi request reprint Pro/antioxidant status in murine skin following topical exposure to cumene hydroperoxide throughout the ontogeny of skin cancer
    A A Shvedova
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Biochemistry (Mosc) 69:23-31. 2004
    ..These results suggest that COX-2-dependent oxidative metabolism is at least partially involved in Cum-OOH-induced inflammatory responses and thus tumor promotion...
  15. ncbi request reprint Metal working fluids: sub-chronic effects on pulmonary functions in B6C3F1 mice given vitamin E deficient and sufficient diets
    Anna A Shvedova
    Pathology and Physiology Research Branch, Engineering Control and Technology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Toxicology 177:285-97. 2002
    ..This is the first report that describes the increase of oxidative stress in the lungs after MWF exposure...
  16. ncbi request reprint Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells
    Anna A Shvedova
    Pathology and Physiology Research Branch, National Institute of Occupational Safety and Health, and Physiology and Pharmacology Department, West Virginia University, Morgantown 26505, USA
    J Toxicol Environ Health A 66:1909-26. 2003
    ..These data indicate that dermal exposure to unrefined SWCNT may lead to dermal toxicity due to accelerated oxidative stress in the skin of exposed workers...
  17. ncbi request reprint Antioxidant balance and free radical generation in vitamin e-deficient mice after dermal exposure to cumene hydroperoxide
    A A Shvedova
    National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Chem Res Toxicol 15:1451-9. 2002
    ..PBN adducts detected by ESR in vitamin E-deficient mice provide direct evidence for in vivo free radical generation in the skin after exposure to cumene hydroperoxide...
  18. pmc Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestos
    Ashley R Murray
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Part Fibre Toxicol 9:10. 2012
    ..While the toxicity and hazardous outcomes elicited by airborne exposure to single-walled CNT or asbestos have been widely reported, very limited data are currently available describing adverse effects of respirable CNF...
  19. doi request reprint Oxidative stress, inflammatory biomarkers, and toxicity in mouse lung and liver after inhalation exposure to 100% biodiesel or petroleum diesel emissions
    Anna A Shvedova
    a Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute of Occupational and Safety Health, Morgantown, West Virginia, USA
    J Toxicol Environ Health A 76:907-21. 2013
    ..Further studies are required to understand what combustion products in BD CE accelerate oxidative and inflammatory responses...
  20. ncbi request reprint Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice
    Anna A Shvedova
    Health Effects Laboratory Div, NIOSH, Morgantown, WV, USA
    Am J Physiol Lung Cell Mol Physiol 289:L698-708. 2005
    ..Equal doses of ultrafine carbon black particles or fine crystalline silica (SiO2) did not induce granulomas or alveolar wall thickening and caused a significantly weaker pulmonary inflammation and damage...
  21. ncbi request reprint Enhanced oxidative stress in the skin of vitamin E deficient mice exposed to semisynthetic metal working fluids
    Anna A Shvedova
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Mail Stop 2015, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Toxicology 176:135-43. 2002
    ..This study clearly delineates the role of oxidative stress in enhancing mast cell accumulation caused by topical exposure to MWFs...
  22. pmc Direct effects of carbon nanotubes on dendritic cells induce immune suppression upon pulmonary exposure
    Alexey V Tkach
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    ACS Nano 5:5755-62. 2011
    ..Preincubation of naïve T cells in vitro with SWCNT-treated dendritic cells reduced proliferation of T cells. Our data suggest that in vivo exposure to SWCNT modifies systemic immunity by modulating dendritic cell function...
  23. doi request reprint Biodiesel versus diesel exposure: enhanced pulmonary inflammation, oxidative stress, and differential morphological changes in the mouse lung
    Naveena Yanamala
    Pathology and Physiology Research Branch NIOSH CDC, Morgantown, WV 26505, USA Electronic address
    Toxicol Appl Pharmacol 272:373-83. 2013
    ..Taken together, these results clearly indicate that BD exhaust particles could exert more toxic effects compared to D. ..
  24. ncbi request reprint Single-walled carbon nanotubes: geno- and cytotoxic effects in lung fibroblast V79 cells
    Elena R Kisin
    Pathology Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 70:2071-9. 2007
    ..With two different strains of Salmonella typhimurium, no mutations were found following SWCNT exposure...
  25. ncbi request reprint Aerosolization of single-walled carbon nanotubes for an inhalation study
    Paul A Baron
    National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA
    Inhal Toxicol 20:751-60. 2008
    ..The mass output efficiency of the entire system for producing a respirable aerosol from bulk material was estimated to be about 10%...
  26. doi request reprint Graphene oxide, but not fullerenes, targets immunoproteasomes and suppresses antigen presentation by dendritic cells
    Alexey V Tkach
    Health Effects Laboratory Division, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Small 9:1686-90. 2013
    ..In contrast to C60 -fullerenes, GO decreases the intracellular levels of LMP7 immunoproteasome subunits required for processing of protein antigens. This is important for the development of DC-based vaccines...
  27. pmc Impaired clearance and enhanced pulmonary inflammatory/fibrotic response to carbon nanotubes in myeloperoxidase-deficient mice
    Anna A Shvedova
    Pathology and Physiology Research Branch, Health Effects Lab Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America
    PLoS ONE 7:e30923. 2012
    ....
  28. ncbi request reprint Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material
    Andrew D Maynard
    National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
    J Toxicol Environ Health A 67:87-107. 2004
    ..Glove deposits of SWCNT during handling were estimated at between 0.2 mg and 6 mg per hand...
  29. ncbi request reprint d-MDMA during vitamin E deficiency: effects on dopaminergic neurotoxicity and hepatotoxicity
    Elizabeth Anne Johnson
    Chronic Stress Laboratory, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health Centers for Disease Control, Mailstop 3014, 1095 Willowdale Road, 26505, Morgantown, WV, USA
    Brain Res 933:150-63. 2002
    ....
  30. doi request reprint Oxidative stress and dermal toxicity of iron oxide nanoparticles in vitro
    Ashley R Murray
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health NIOSH, M L 2015, 1095 Willowdale Road, Morgantown, WV, 26505, USA
    Cell Biochem Biophys 67:461-76. 2013
    ..These results verify the need to thoroughly evaluate the adverse effects of UVB when evaluating dermal toxicity of engineered NPs on skin. ..
  31. pmc Molecular modeling in structural nano-toxicology: interactions of nano-particles with nano-machinery of cells
    Naveena Yanamala
    Pathology and Physiology Research Branch NIOSH CDC, Morgantown, WV, USA
    Adv Drug Deliv Rev 65:2070-7. 2013
    ..A rationale on how nanoparticles of different sizes, shape, structure and chemical properties can affect the organization and functions of nano-machinery of cells is also presented. ..