Research Topics
Species | Wun Ju ShiehSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
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Detail Information
Publications
Pathologic studies on suspect animal and human cases of Rift Valley fever from an outbreak in Eastern Africa, 2006-2007Wun Ju Shieh
Infectious Disease Pathology Branch, Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Am J Trop Med Hyg 83:38-42. 2010..Pathologic studies on postmortem tissue samples can help establish the diagnosis of RVF, differentiating from endemic diseases with clinical manifestations similar to RVF, such as malaria, leptospirosis, or yellow fever...- Pathologic studies of fatal cases in outbreak of hand, foot, and mouth disease, TaiwanW J Shieh
Centers for Disease Control and Prevention, 1600 Clifton Road, Mail Stop G32, Atlanta, GA 30333, USA
Emerg Infect Dis 7:146-8. 2001..Pathologic studies of two fatal cases with similar clinical features revealed two different causative agents, emphasizing the need for postmortem examinations and modern pathologic techniques in an outbreak investigation... - Diagnosis of influenza from respiratory autopsy tissues: detection of virus by real-time reverse transcription-PCR in 222 casesAmy M Denison
Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
J Mol Diagn 13:123-8. 2011..We also determined that testing of all available respiratory tissues is critical for optimal detection of influenza virus in postmortem tissues... 
Persistent Yersinia pestis antigens in ischemic tissues of a patient with septicemic plagueJeannette Guarner
Infectious Diseases Pathology Activity, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Hum Pathol 36:850-3. 2005....- Variant Creutzfeldt-Jakob disease death, United StatesErmias D Belay
Division of Viral and Rickettsial Disease, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 11:1351-4. 2005..The reports of bloodborne transmission of vCJD in 2 patients, 1 of whom was heterozygous for methionine and valine at polymorphic codon 129, add to the uncertainty about the future of the vCJD outbreak... - Fatal toxic shock syndrome associated with Clostridium sordellii after medical abortionMarc Fischer
Centers for Disease Control and Prevention, Atlanta, USA
N Engl J Med 353:2352-60. 2005..These cases indicate the need for physician awareness of this syndrome and for further study of its association with medical abortion... - Influenza-associated deaths among children in the United States, 2003-2004Niranjan Bhat
Epidemic Intelligence Service, Career Development Division, Office of Workforce and Career Development National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
N Engl J Med 353:2559-67. 2005..Although influenza is common among children, pediatric mortality related to laboratory-confirmed influenza has not been assessed nationally... - Histopathologic and immunohistochemical features of fatal influenza virus infection in children during the 2003-2004 seasonJeannette Guarner
Infectious Disease Pathology Activity, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Clin Infect Dis 43:132-40. 2006..The Centers for Disease Control and Prevention enhanced national surveillance for influenza-associated deaths among children because of early reports of pediatric deaths during the 2003-2004 influenza season... - Molecular diagnosis of Nocardia farcinica from a cerebral abscessKathleen M Tatti
Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, National Center for Infectious Diseases, Atlanta, Georgia 30333, USA
Hum Pathol 37:1117-21. 2006..A species-specific polymerase chain reaction assay confirmed N farcinica as the etiologic agent... - Detection of West Nile virus in formalin-fixed, paraffin-embedded human tissues by RT-PCR: a useful adjunct to conventional tissue-based diagnostic methodsJulu Bhatnagar
Infectious Disease Pathology Activity, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Mailstop G32, Atlanta, GA 30333, United States
J Clin Virol 38:106-11. 2007.... - Toxic shock associated with Clostridium sordellii and Clostridium perfringens after medical and spontaneous abortionAdam L Cohen
Prevention and Response Branch, Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Obstet Gynecol 110:1027-33. 2007..To better understand the risk of fatal toxic shock caused by Clostridium sordellii in women who had a recent medical abortion with mifepristone and misoprostol... 
Pathology and pathogenesis of fatal Bordetella pertussis infection in infantsChristopher D Paddock
Infectious Disease Pathology Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Clin Infect Dis 47:328-38. 2008....- 2009 pandemic influenza A (H1N1): pathology and pathogenesis of 100 fatal cases in the United StatesWun Ju Shieh
Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 32, Atlanta, GA 30333, USA
Am J Pathol 177:166-75. 2010..Underlying medical conditions and bacterial co-infections contributed to the fatal outcome of this infection. More studies are needed to understand the multifactorial pathogenesis of this infection... - CD8-mediated protection against Ebola virus infection is perforin dependentManisha Gupta
Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Immunol 174:4198-202. 2005..These findings suggest that the clearance of Ebola virus is perforin-dependent and provide an additional example showing that this basic immunologic mechanism is not limited to the clearance of noncytopathic viruses... - Human monkeypox infection: a family cluster in the midwestern United StatesJames J Sejvar
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30033, USA
J Infect Dis 190:1833-40. 2004..We describe a cluster of monkeypox in a family with a spectrum of clinical illness, including encephalitis, and outline the laboratory confirmation of monkeypox... - Monkeypox transmission and pathogenesis in prairie dogsJeannette Guarner
Infectious Disease Pathology Activity, Centers for Disease Control and Prevention, Mailstop G32, 1600 Clifton Road NE, Atlanta, GA 30333, USA
Emerg Infect Dis 10:426-31. 2004..Prairie dogs offer insights into transmission, pathogenesis, and new vaccine and treatment trials because they are susceptible to severe monkeypox infection... - Persistent infection with ebola virus under conditions of partial immunityManisha Gupta
Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 78:958-67. 2004.... - Elucidation of Nipah virus morphogenesis and replication using ultrastructural and molecular approachesCynthia S Goldsmith
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Mailstop G30, 1600 Clifton Road NE, Atlanta, GA 30333, USA
Virus Res 92:89-98. 2003..Ultrastructural ISH studies suggest these inclusions play an important role in the transcription process... - Investigation of bioterrorism-related anthrax, United States, 2001: epidemiologic findingsDaniel B Jernigan
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Emerg Infect Dis 8:1019-28. 2002..Continued vigilance for cases is needed among health-care providers and members of the public health and law enforcement communities... - Molecular and immunological methods to detect rotavirus in formalin-fixed tissueKathleen M Tatti
Division of Viral and Rickettsial Disease, Centers for Disease Control and Prevention, National Center for Infectious Diseases, Infectious Disease Pathology Activity, 1600 Clifton Road, NE, Mailstop G30, Atlanta, GA 30333, USA
J Virol Methods 105:305-19. 2002..These techniques should prove valuable to detect rotavirus antigens and nucleic acids in tissues from patients infected naturally with rotavirus or with intussususception associated with rotavirus vaccine... - Surveillance for unexplained deaths and critical illnesses due to possibly infectious causes, United States, 1995-1998Rana A Hajjeh
Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 8:145-53. 2002..The UNEX network model would improve U.S. diagnostic capacities and preparedness for emerging infections... - Long-term disease surveillance in Bandundu region, Democratic Republic of the Congo: a model for early detection and prevention of Ebola hemorrhagic feverE S Lloyd
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Infect Dis 179:S274-80. 1999.... - Transmission of Black Creek Canal virus between cotton ratsK L Hutchinson
Special Pathogens Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Med Virol 60:70-6. 2000..J. Med. Virol. 60:70-76, 2000. Published 2000 Wiley-Liss, Inc... - Histopathologic and immunohistochemical characterization of Nipah virus infection in the guinea pigF J Torres-Velez
College of Veterinary Medicine, Department of Veterinary Pathology, 501 DW Brooks Drive, Athens, GA 30602 7388 USA
Vet Pathol 45:576-85. 2008.... - A novel immunohistochemical assay for the detection of Ebola virus in skin: implications for diagnosis, spread, and surveillance of Ebola hemorrhagic fever. Commission de Lutte contre les Epidémies à KikwitS R Zaki
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Infect Dis 179:S36-47. 1999..IHC testing of formalin-fixed skin specimens is a safe, sensitive, and specific method for laboratory diagnosis of EHF and should be useful for EHF surveillance and prevention... - Bioterrorism-related inhalational anthrax: the first 10 cases reported in the United StatesJ A Jernigan
NCID, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 7:933-44. 2001..With multidrug antibiotic regimens and supportive care, survival of patients (60%) was markedly higher (<15%) than previously reported... - Usefulness of immunohistochemical diagnosis of streptococcus pneumoniae in formalin-fixed, paraffin-embedded specimens compared with culture and gram stain techniquesJeannette Guarner
Infectious Diseases Pathology Activity, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Am J Clin Pathol 127:612-8. 2007..Compared with culture, the immunohistochemical assay showed 100% sensitivity and 71% specificity. Immunohistochemical analysis has the diagnostic advantage of correlating host inflammatory reaction with presence of pneumococci... - Histopathologic, immunohistochemical, and polymerase chain reaction assays in the study of cases with fatal sporadic myocarditisJeannette Guarner
Infectious Disease Pathology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Hum Pathol 38:1412-9. 2007..Accurately identifying an infectious agent is the foundation for clinical and public health interventions. Despite using multiple diagnostic methods, an organism could only be detected in a small proportion of sporadic myocarditis cases... - The pathology of rotavirus-associated deaths, using new molecular diagnosticsMaureen Lynch
Viral Gastroenteritis Section, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Clin Infect Dis 37:1327-33. 2003..The part played by rotavirus in fatal cases is unclear and requires additional investigation of diarrhea-associated deaths, because a better understanding might alter the approach to treatment and the need for antiviral therapy... - Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in miceKristy J Szretter
Influenza Branch MS G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
J Virol 81:2736-44. 2007..These results suggest that TNF-alpha may contribute to morbidity during H5N1 influenza virus infection, while IL-1 may be important for effective virus clearance in nonlethal H5N1 disease... - The role of pathology in an investigation of an outbreak of West Nile encephalitis in New York, 1999W J Shieh
Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Emerg Infect Dis 6:370-2. 2000..Histopathologic and immunopathologic examinations performed on human autopsy materials helped guide subsequent laboratory and epidemiologic investigations that led to identification of the etiologic agent... - Fatal malaria infection in travelers: novel immunohistochemical assays for the detection of Plasmodium falciparum in tissues and implications for pathogenesisGillian L Genrich
Infectious Disease Pathology and Malaria Branches, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Am J Trop Med Hyg 76:251-9. 2007..vivax. Immunostaining patterns were predominately cytoplasmic and membranous. P. falciparum antigens were detected in a variety of organs but were most abundant in the blood vessels of brain, heart, and lung tissues... - Leptospirosis mimicking acute cholecystitis among athletes participating in a triathlonJ Guarner
Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, and Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Hum Pathol 32:750-2. 2001..If a cholecystectomy is performed in febrile patients with suspicious environmental or animal exposure, pathologic studies for leptospirosis on formalin-fixed, paraffin-embedded tissues may be of great value...