Research Topics
Genomes and Genes | Suryaprakash SambharaSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
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Publications
Avian influenza vaccines: what's all the flap?Suryaprakash Sambhara
Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Lancet 367:1636-8. 2006- NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-IZhu Guo
Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Am J Respir Cell Mol Biol 36:263-9. 2007..These results provide further information on the mechanism by which IAV NS1 antagonizes the host antiviral response... - Breaking the immunogenicity barrier of bird flu vaccinesSuryaprakash Sambhara
Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Lancet 370:544-5. 2007 
H5N1 Avian influenza: preventive and therapeutic strategies against a pandemicSuryaprakash Sambhara
Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Annu Rev Med 61:187-98. 2010....- Immunosenescence and influenza vaccine efficacySuryaprakash Sambhara
Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
Curr Top Microbiol Immunol 333:413-29. 2009.... 
Needle-free skin patch delivery of a vaccine for a potentially pandemic influenza virus provides protection against lethal challenge in miceSanjay Garg
Influenza Division, Mail Stop G 16, CCID, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
Clin Vaccine Immunol 14:926-8. 2007....- TLR7 recognition is dispensable for influenza virus A infection but important for the induction of hemagglutinin-specific antibodies in response to the 2009 pandemic split vaccine in miceVictoria Jeisy-Scott
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
J Virol 86:10988-98. 2012..Taken together, our data demonstrate that TLR7 plays an important role in vaccine-induced humoral immune responses to influenza virus through the interaction with viral RNA present in the split vaccine... - The 3' untranslated regions of influenza genomic sequences are 5'PPP-independent ligands for RIG-IWilliam G Davis
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
PLoS ONE 7:e32661. 2012..Our findings demonstrated that RNA sequence, length, and secondary structure all contributed to whether or not the 5'PPP moiety is needed for interferon induction by RIG-I... - 5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replicationPriya Ranjan
Influenza Division, NCIRD, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Virol J 7:102. 2010..Activation of innate immune pathogen sensor Retinoic Acid Inducible Gene-I (RIG-I) has recently been shown to induce antiviral state... - Increased MDSC accumulation and Th2 biased response to influenza A virus infection in the absence of TLR7 in miceVictoria Jeisy-Scott
Influenza Division, National Center for Immunization and Respiratory, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
PLoS ONE 6:e25242. 2011..Our findings indicate that TLR7 modulates the accumulation of MDSCs during an IAV infection in mice, and that lack of TLR7 signaling leads to a Th2-biased response... - A broadly protective vaccine against globally dispersed clade 1 and clade 2 H5N1 influenza virusesMary A Hoelscher
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Infect Dis 197:1185-8. 2008..We developed an adenoviral vector-based vaccine that contains hemagglutinin protein from clade 1 and clade 2 viruses, as well as conserved nucleoprotein, to broaden the vaccine coverage against H5N1 viruses... - Early control of H5N1 influenza virus replication by the type I interferon response in miceKristy J Szretter
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 303331, USA
J Virol 83:5825-34. 2009..These results suggest a role for the IFN-alpha/beta response in the control of H5N1 virus replication both in vivo and in vitro, and as such it may provide some degree of protection to the host in the early stages of infection... - Protein energy malnutrition decreases immunity and increases susceptibility to influenza infection in miceAndrew K Taylor
Influenza Division, National Center for Immunization and Respiratory Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Infect Dis 207:501-10. 2013..Protein energy malnutrition (PEM), a common cause of secondary immune deficiency in children, is associated with an increased risk of infections. Very few studies have addressed the relevance of PEM as a risk factor for influenza... - Rapid differentiation of monocytes into type I IFN-producing myeloid dendritic cells as an antiviral strategy against influenza virus infectionWeiping Cao
Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Immunol 189:2257-65. 2012..Taken together, our results demonstrate that the host responds to influenza virus infection by initiating rapid differentiation of circulating monocytes into IFN-producing mDCs, which contribute to innate antiviral immune responses... - Significant impact of sequence variations in the nucleoprotein on CD8 T cell-mediated cross-protection against influenza A virus infectionsWeimin Zhong
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
PLoS ONE 5:e10583. 2010..However, it is not clear to what extent such pre-existing cellular immunity can provide cross-subtype protection against novel emerging influenza A viruses... - Strategies to alleviate original antigenic sin responses to influenza virusesJin Hyang Kim
Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Center, Emory University, Atlanta, GA 30329, USA
Proc Natl Acad Sci U S A 109:13751-6. 2012..Taken together, our studies provide at least three ways of overcoming original antigenic sin... - Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in miceKristy J Szretter
Influenza Branch MS G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
J Virol 81:2736-44. 2007..These results suggest that TNF-alpha may contribute to morbidity during H5N1 influenza virus infection, while IL-1 may be important for effective virus clearance in nonlethal H5N1 disease... - Vaccines against epidemic and pandemic influenzaMary Hoelscher
National Center for Immunization and Respiratory Diseases, Influenza Division, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Mail Stop G47, 1600 Clifton Road, Atlanta, GA 30333, USA
Expert Opin Drug Deliv 5:1139-57. 2008..2% only [1] . In addition, H5N1 avian influenza viruses have the potential to cause a pandemic. However, H5N1 vaccines currently licensed in the US are poorly immunogenic in high doses in the absence of an adjuvant even in healthy adults... - Antiviral defense: RIG-Ing the immune system to STINGJ Bradford Bowzard
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Cytokine Growth Factor Rev 20:1-5. 2009..Here we discuss results of recent investigations into the initiation and transmission of signals through the RIG-I pathway... - Immunosenescence and Challenges of Vaccination against Influenza in the Aging PopulationAdrian J Reber
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA
Aging Dis 3:68-90. 2012..This review focuses on the status of immunity, responses to influenza vaccination, and strategies that are currently being explored to elicit enhanced immune responses in this high risk population... - Impaired antigen-induced CD8+ T cell clonal expansion in aging is due to defects in antigen presenting cell functionJulie Plowden
Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Cell Immunol 229:86-92. 2004..The aged APCs were defective in costimulatory molecule expression and cytokine and chemokine secretion. These data indicate that defects in APC function lead to poor T cell clonal expansion and function in aging... - PAMPer and tRIGer: ligand-induced activation of RIG-IJ Bradford Bowzard
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta GA, 30333, United States
Trends Biochem Sci 36:314-9. 2011..Recent work has begun to clarify the required characteristics of RIG-I activators and is setting the stage for the identification of authentic ligands used during viral infection... - Innate immunity in aging: impact on macrophage functionJulie Plowden
Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Aging Cell 3:161-7. 2004..In this paper, we review the literature addressing the impact of aging on the macrophage population... - Infection of lung epithelial cells with pandemic 2009 A(H1N1) influenza viruses reveals isolate-specific differences in infectivity and host cellular responsesJenish R Patel
Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Viral Immunol 24:89-99. 2011.... - RIG-I activation inhibits ebolavirus replicationChristina F Spiropoulou
Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Virology 392:11-5. 2009..These findings indicate that RIG-I-based therapies may provide an attractive approach for antivirals against Ebola hemorrhagic fever, and possibly other HF viruses... - Development of adenoviral-vector-based pandemic influenza vaccine against antigenically distinct human H5N1 strains in miceMary A Hoelscher
Influenza Branch, Division of Rickettsial and Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Lancet 367:475-81. 2006..01). INTERPRETATION: Our findings highlight the potential of an Ad-vector-based delivery system, which is both egg-independent and adjuvant-independent and offers stockpiling options for the development of a pandemic influenza vaccine... - Cytoplasmic nucleic acid sensors in antiviral immunityPriya Ranjan
Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Trends Mol Med 15:359-68. 2009..An increased understanding of these molecular aspects of innate immunity will guide the development of novel antiviral therapeutics... - Immunity to influenza: the challenges of protecting an aging populationJacqueline M Katz
Influenza Branch, Mailstop G 16, Division of Viral and Rickettsial Diseases Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
Immunol Res 29:113-24. 2004..Several novel strategies including the use of ISCOM-formulated vaccines, mucosal delivery, or DNA vaccination provided cross-subtype protection that could provide an important component of immunity in the event of a pandemic... - Cutting edge: impaired Toll-like receptor expression and function in agingMary Renshaw
Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Immunol 169:4697-701. 2002..These results support the concept that increased susceptibility to infections and poor adaptive immune responses in aging may be due to the decline in TLR expression and function... - RIG-I goes beyond naked recognitionJ Bradford Bowzard
Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA
Cell Host Microbe 13:247-9. 2013..In this issue of Cell Host & Microbe, Weber et al. show that incoming nucleocapsid-bound genomes are sufficient to bind and activate innate immune sensors... - Improving immunogenicity and effectiveness of influenza vaccine in older adultsWeiping Cao
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Bldg 15, SSB 611 B, 1600 Clifton Road, Atlanta, GA, USA
Expert Rev Vaccines 10:1529-37. 2011..The development history of influenza vaccines, current status, and potential strategies to improve the immunogenicity and vaccine effectiveness in older adults are discussed... - 17β-Estradiol restores antibody responses to an influenza vaccine in a postmenopausal mouse modelDoan C Nguyen
Department of Biology, Georgia State University, Atlanta, GA 30302, USA
Vaccine 29:2515-8. 2011..Our findings suggest that immunogenicity and efficacy of influenza vaccines need to be evaluated in postmenopausal women, including women receiving hormone replacement therapy... - A distal regulatory region is required for constitutive and IFN-beta-induced expression of murine TLR9 geneZhu Guo
Influenza Branch, Division of Viral and Rickettssial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Immunol 175:7407-18. 2005..This study illustrates the crucial roles for AP-1, IRF-1, IRF-2, and STAT1 in the regulation of murine TLR9 expression... - Vaccines against influenza A (H5N1): evidence of progressGregory A Poland
J Infect Dis 198:629-31. 2008 - H5N1 vaccine hits the target, but not the bull's eyeSuryaprakash Sambhara
Lancet Infect Dis 7:503-5. 2007 - Cytotoxic T lymphocyte reactivity to gp100, MelanA/MART-1, and tyrosinase, in HLA-A2-positive vitiligo patientsRochelle L Mandelcorn-Monson
Division of Dermatology, Sunnybrook and Women s College Health Sciences Center, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Invest Dermatol 121:550-6. 2003..Our findings implicate T cell reactivity to gp100 in patients with active disease and support the concept of an immunopathologic mechanism in vitiligo, in which cell-mediated responses to normal melanocyte antigens play a crucial part... - DNA vaccine expressing conserved influenza virus proteins protective against H5N1 challenge infection in miceSuzanne L Epstein
Food and Drug Administration, Rockville, Maryland 20852 1448, USA
Emerg Infect Dis 8:796-801. 2002..In the absence of antigenically matched hemagglutinin-based vaccines, DNA vaccination with conserved influenza genes may provide a useful first line of defense against a rapidly spreading pandemic virus...