Suryaprakash Sambhara

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi request reprint Avian influenza vaccines: what's all the flap?
    Suryaprakash Sambhara
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Lancet 367:1636-8. 2006
  2. ncbi request reprint NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I
    Zhu Guo
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Respir Cell Mol Biol 36:263-9. 2007
  3. pmc Increased MDSC accumulation and Th2 biased response to influenza A virus infection in the absence of TLR7 in mice
    Victoria Jeisy-Scott
    Influenza Division, National Center for Immunization and Respiratory, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 6:e25242. 2011
  4. pmc Impact of preexisting adenovirus vector immunity on immunogenicity and protection conferred with an adenovirus-based H5N1 influenza vaccine
    Aseem Pandey
    Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, United States of America
    PLoS ONE 7:e33428. 2012
  5. ncbi request reprint Breaking the immunogenicity barrier of bird flu vaccines
    Suryaprakash Sambhara
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Lancet 370:544-5. 2007
  6. doi request reprint H5N1 Avian influenza: preventive and therapeutic strategies against a pandemic
    Suryaprakash Sambhara
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Annu Rev Med 61:187-98. 2010
  7. doi request reprint Immunosenescence and influenza vaccine efficacy
    Suryaprakash Sambhara
    Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Curr Top Microbiol Immunol 333:413-29. 2009
  8. pmc A broadly protective vaccine against globally dispersed clade 1 and clade 2 H5N1 influenza viruses
    Mary A Hoelscher
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 197:1185-8. 2008
  9. pmc 5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication
    Priya Ranjan
    Influenza Division, NCIRD, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virol J 7:102. 2010
  10. pmc Broadly protective adenovirus-based multivalent vaccines against highly pathogenic avian influenza viruses for pandemic preparedness
    Sai V Vemula
    Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, United States of America
    PLoS ONE 8:e62496. 2013

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Avian influenza vaccines: what's all the flap?
    Suryaprakash Sambhara
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Lancet 367:1636-8. 2006
  2. ncbi request reprint NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I
    Zhu Guo
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Respir Cell Mol Biol 36:263-9. 2007
    ..These results provide further information on the mechanism by which IAV NS1 antagonizes the host antiviral response...
  3. pmc Increased MDSC accumulation and Th2 biased response to influenza A virus infection in the absence of TLR7 in mice
    Victoria Jeisy-Scott
    Influenza Division, National Center for Immunization and Respiratory, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 6:e25242. 2011
    ..Our findings indicate that TLR7 modulates the accumulation of MDSCs during an IAV infection in mice, and that lack of TLR7 signaling leads to a Th2-biased response...
  4. pmc Impact of preexisting adenovirus vector immunity on immunogenicity and protection conferred with an adenovirus-based H5N1 influenza vaccine
    Aseem Pandey
    Department of Comparative Pathobiology, Purdue University, West Lafayette, Indiana, United States of America
    PLoS ONE 7:e33428. 2012
    ..f.u. allowed only partial protection. These results suggest possible strategies to overcome the variable levels of human immunity against adenoviruses, leading to better utilization of HAd vector-based vaccines...
  5. ncbi request reprint Breaking the immunogenicity barrier of bird flu vaccines
    Suryaprakash Sambhara
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Lancet 370:544-5. 2007
  6. doi request reprint H5N1 Avian influenza: preventive and therapeutic strategies against a pandemic
    Suryaprakash Sambhara
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Annu Rev Med 61:187-98. 2010
    ....
  7. doi request reprint Immunosenescence and influenza vaccine efficacy
    Suryaprakash Sambhara
    Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Curr Top Microbiol Immunol 333:413-29. 2009
    ....
  8. pmc A broadly protective vaccine against globally dispersed clade 1 and clade 2 H5N1 influenza viruses
    Mary A Hoelscher
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 197:1185-8. 2008
    ..We developed an adenoviral vector-based vaccine that contains hemagglutinin protein from clade 1 and clade 2 viruses, as well as conserved nucleoprotein, to broaden the vaccine coverage against H5N1 viruses...
  9. pmc 5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication
    Priya Ranjan
    Influenza Division, NCIRD, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virol J 7:102. 2010
    ..Activation of innate immune pathogen sensor Retinoic Acid Inducible Gene-I (RIG-I) has recently been shown to induce antiviral state...
  10. pmc Broadly protective adenovirus-based multivalent vaccines against highly pathogenic avian influenza viruses for pandemic preparedness
    Sai V Vemula
    Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, United States of America
    PLoS ONE 8:e62496. 2013
    ..These results suggest that a multivalent vaccine strategy may provide reasonable protection in the event of a pandemic caused by H5, H7, or H9 avian influenza virus before a strain-matched vaccine can be produced...
  11. pmc Adenoviral vector expressing murine β-defensin 2 enhances immunogenicity of an adenoviral vector based H5N1 influenza vaccine in aged mice
    Sai V Vemula
    Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA
    Virus Res 177:55-61. 2013
    ..Overall, our results highlight the potential utility of Mbd2 as a molecular adjuvant to enhance the immunogenicity and protective efficacy of vaccines for the elderly...
  12. pmc Significant impact of sequence variations in the nucleoprotein on CD8 T cell-mediated cross-protection against influenza A virus infections
    Weimin Zhong
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 5:e10583. 2010
    ..However, it is not clear to what extent such pre-existing cellular immunity can provide cross-subtype protection against novel emerging influenza A viruses...
  13. pmc Needle-free skin patch delivery of a vaccine for a potentially pandemic influenza virus provides protection against lethal challenge in mice
    Sanjay Garg
    Influenza Division, Mail Stop G 16, CCID, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
    Clin Vaccine Immunol 14:926-8. 2007
    ....
  14. pmc Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice
    Kristy J Szretter
    Influenza Branch MS G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    J Virol 81:2736-44. 2007
    ..These results suggest that TNF-alpha may contribute to morbidity during H5N1 influenza virus infection, while IL-1 may be important for effective virus clearance in nonlethal H5N1 disease...
  15. pmc TLR7 recognition is dispensable for influenza virus A infection but important for the induction of hemagglutinin-specific antibodies in response to the 2009 pandemic split vaccine in mice
    Victoria Jeisy-Scott
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 86:10988-98. 2012
    ..Taken together, our data demonstrate that TLR7 plays an important role in vaccine-induced humoral immune responses to influenza virus through the interaction with viral RNA present in the split vaccine...
  16. pmc The 3' untranslated regions of influenza genomic sequences are 5'PPP-independent ligands for RIG-I
    William G Davis
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 7:e32661. 2012
    ..Our findings demonstrated that RNA sequence, length, and secondary structure all contributed to whether or not the 5'PPP moiety is needed for interferon induction by RIG-I...
  17. pmc Early control of H5N1 influenza virus replication by the type I interferon response in mice
    Kristy J Szretter
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 303331, USA
    J Virol 83:5825-34. 2009
    ..These results suggest a role for the IFN-alpha/beta response in the control of H5N1 virus replication both in vivo and in vitro, and as such it may provide some degree of protection to the host in the early stages of infection...
  18. pmc Strategies to alleviate original antigenic sin responses to influenza viruses
    Jin Hyang Kim
    Department of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Center, Emory University, Atlanta, GA 30329, USA
    Proc Natl Acad Sci U S A 109:13751-6. 2012
    ..Taken together, our studies provide at least three ways of overcoming original antigenic sin...
  19. pmc Beta-defensin 2 enhances immunogenicity and protection of an adenovirus-based H5N1 influenza vaccine at an early time
    Sai V Vemula
    Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA
    Virus Res 178:398-403. 2013
    ..These results highlight the potential of Mbd2 as a genetic adjuvant in inducing rapid and robust immune responses to a HAd-based vaccine...
  20. doi request reprint Protein energy malnutrition decreases immunity and increases susceptibility to influenza infection in mice
    Andrew K Taylor
    Influenza Division, National Center for Immunization and Respiratory Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 207:501-10. 2013
    ..Protein energy malnutrition (PEM), a common cause of secondary immune deficiency in children, is associated with an increased risk of infections. Very few studies have addressed the relevance of PEM as a risk factor for influenza...
  21. doi request reprint Rapid differentiation of monocytes into type I IFN-producing myeloid dendritic cells as an antiviral strategy against influenza virus infection
    Weiping Cao
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Immunol 189:2257-65. 2012
    ..Taken together, our results demonstrate that the host responds to influenza virus infection by initiating rapid differentiation of circulating monocytes into IFN-producing mDCs, which contribute to innate antiviral immune responses...
  22. ncbi request reprint Impaired antigen-induced CD8+ T cell clonal expansion in aging is due to defects in antigen presenting cell function
    Julie Plowden
    Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Cell Immunol 229:86-92. 2004
    ..The aged APCs were defective in costimulatory molecule expression and cytokine and chemokine secretion. These data indicate that defects in APC function lead to poor T cell clonal expansion and function in aging...
  23. pmc Development of adenoviral-vector-based pandemic influenza vaccine against antigenically distinct human H5N1 strains in mice
    Mary A Hoelscher
    Influenza Branch, Division of Rickettsial and Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Lancet 367:475-81. 2006
    ..However, currently licensed human vaccines are subtype-specific and do not protect against these H5N1 viruses. We aimed to develop an influenza vaccine and assessed its immunogenicity and efficacy to confer protection in BALB/c mice...
  24. doi request reprint Infection of lung epithelial cells with pandemic 2009 A(H1N1) influenza viruses reveals isolate-specific differences in infectivity and host cellular responses
    Jenish R Patel
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Viral Immunol 24:89-99. 2011
    ....
  25. ncbi request reprint Innate immunity in aging: impact on macrophage function
    Julie Plowden
    Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Aging Cell 3:161-7. 2004
    ..In this paper, we review the literature addressing the impact of aging on the macrophage population...
  26. ncbi request reprint Vaccines against epidemic and pandemic influenza
    Mary Hoelscher
    National Center for Immunization and Respiratory Diseases, Influenza Division, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Mail Stop G47, 1600 Clifton Road, Atlanta, GA 30333, USA
    Expert Opin Drug Deliv 5:1139-57. 2008
    ..2% only [1] . In addition, H5N1 avian influenza viruses have the potential to cause a pandemic. However, H5N1 vaccines currently licensed in the US are poorly immunogenic in high doses in the absence of an adjuvant even in healthy adults...
  27. ncbi request reprint Antiviral defense: RIG-Ing the immune system to STING
    J Bradford Bowzard
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Cytokine Growth Factor Rev 20:1-5. 2009
    ..Here we discuss results of recent investigations into the initiation and transmission of signals through the RIG-I pathway...
  28. pmc Immunosenescence and Challenges of Vaccination against Influenza in the Aging Population
    Adrian J Reber
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA
    Aging Dis 3:68-90. 2012
    ..This review focuses on the status of immunity, responses to influenza vaccination, and strategies that are currently being explored to elicit enhanced immune responses in this high risk population...
  29. doi request reprint PAMPer and tRIGer: ligand-induced activation of RIG-I
    J Bradford Bowzard
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta GA, 30333, United States
    Trends Biochem Sci 36:314-9. 2011
    ..Recent work has begun to clarify the required characteristics of RIG-I activators and is setting the stage for the identification of authentic ligands used during viral infection...
  30. ncbi request reprint Immunity to influenza: the challenges of protecting an aging population
    Jacqueline M Katz
    Influenza Branch, Mailstop G 16, Division of Viral and Rickettsial Diseases Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Immunol Res 29:113-24. 2004
    ..Several novel strategies including the use of ISCOM-formulated vaccines, mucosal delivery, or DNA vaccination provided cross-subtype protection that could provide an important component of immunity in the event of a pandemic...
  31. doi request reprint Cytoplasmic nucleic acid sensors in antiviral immunity
    Priya Ranjan
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Trends Mol Med 15:359-68. 2009
    ..An increased understanding of these molecular aspects of innate immunity will guide the development of novel antiviral therapeutics...
  32. pmc Egg-independent vaccine strategies for highly pathogenic H5N1 influenza viruses
    Aseem Pandey
    Department of Comparative Pathobiology, School of Veterinary Medicine, and Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA
    Hum Vaccin 6:178-88. 2010
    ..The present review will highlight the various egg-independent alternative vaccine approaches for pandemic influenza...
  33. doi request reprint RIG-I activation inhibits ebolavirus replication
    Christina F Spiropoulou
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Virology 392:11-5. 2009
    ..These findings indicate that RIG-I-based therapies may provide an attractive approach for antivirals against Ebola hemorrhagic fever, and possibly other HF viruses...
  34. ncbi request reprint Cutting edge: impaired Toll-like receptor expression and function in aging
    Mary Renshaw
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Immunol 169:4697-701. 2002
    ..These results support the concept that increased susceptibility to infections and poor adaptive immune responses in aging may be due to the decline in TLR expression and function...
  35. doi request reprint RIG-I goes beyond naked recognition
    J Bradford Bowzard
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA
    Cell Host Microbe 13:247-9. 2013
    ..In this issue of Cell Host & Microbe, Weber et al. show that incoming nucleocapsid-bound genomes are sufficient to bind and activate innate immune sensors...
  36. doi request reprint Improving immunogenicity and effectiveness of influenza vaccine in older adults
    Weiping Cao
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Bldg 15, SSB 611 B, 1600 Clifton Road, Atlanta, GA, USA
    Expert Rev Vaccines 10:1529-37. 2011
    ..The development history of influenza vaccines, current status, and potential strategies to improve the immunogenicity and vaccine effectiveness in older adults are discussed...
  37. ncbi request reprint A distal regulatory region is required for constitutive and IFN-beta-induced expression of murine TLR9 gene
    Zhu Guo
    Influenza Branch, Division of Viral and Rickettssial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Immunol 175:7407-18. 2005
    ..This study illustrates the crucial roles for AP-1, IRF-1, IRF-2, and STAT1 in the regulation of murine TLR9 expression...
  38. doi request reprint 17β-Estradiol restores antibody responses to an influenza vaccine in a postmenopausal mouse model
    Doan C Nguyen
    Department of Biology, Georgia State University, Atlanta, GA 30302, USA
    Vaccine 29:2515-8. 2011
    ..Our findings suggest that immunogenicity and efficacy of influenza vaccines need to be evaluated in postmenopausal women, including women receiving hormone replacement therapy...
  39. ncbi request reprint H5N1 vaccine hits the target, but not the bull's eye
    Suryaprakash Sambhara
    Lancet Infect Dis 7:503-5. 2007
  40. doi request reprint Vaccines against influenza A (H5N1): evidence of progress
    Gregory A Poland
    J Infect Dis 198:629-31. 2008
  41. ncbi request reprint Cytotoxic T lymphocyte reactivity to gp100, MelanA/MART-1, and tyrosinase, in HLA-A2-positive vitiligo patients
    Rochelle L Mandelcorn-Monson
    Division of Dermatology, Sunnybrook and Women s College Health Sciences Center, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Invest Dermatol 121:550-6. 2003
    ..Our findings implicate T cell reactivity to gp100 in patients with active disease and support the concept of an immunopathologic mechanism in vitiligo, in which cell-mediated responses to normal melanocyte antigens play a crucial part...
  42. pmc DNA vaccine expressing conserved influenza virus proteins protective against H5N1 challenge infection in mice
    Suzanne L Epstein
    Food and Drug Administration, Rockville, Maryland 20852 1448, USA
    Emerg Infect Dis 8:796-801. 2002
    ..In the absence of antigenically matched hemagglutinin-based vaccines, DNA vaccination with conserved influenza genes may provide a useful first line of defense against a rapidly spreading pandemic virus...