P Ruiz

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. doi request reprint Prediction of the health effects of polychlorinated biphenyls (PCBs) and their metabolites using quantitative structure-activity relationship (QSAR)
    P Ruiz
    Agency for Toxic Substances and Disease Registry, Division of Toxicology and Environmental Medicine, Computational Toxicology and Methods Development Unit, 1600 Clifton Road, MS F32, Atlanta, GA 30333, USA
    Toxicol Lett 181:53-65. 2008
  2. doi request reprint Chemical risk assessment and uncertainty associated with extrapolation across exposure duration
    H R Pohl
    Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA, USA
    Regul Toxicol Pharmacol 57:18-23. 2010
  3. doi request reprint Assessment of hydroxylated metabolites of polychlorinated biphenyls as potential xenoestrogens: a QSAR comparative analysis∗
    P Ruiz
    Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, Atlanta, USA
    SAR QSAR Environ Res 24:393-416. 2013
  4. doi request reprint Prediction of acute mammalian toxicity using QSAR methods: a case study of sulfur mustard and its breakdown products
    Patricia Ruiz
    Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30333, USA
    Molecules 17:8982-9001. 2012
  5. doi request reprint Interpreting NHANES biomonitoring data, cadmium
    Patricia Ruiz
    Agency for Toxic Substances and Disease Registry, Atlanta, GA 30333, USA
    Toxicol Lett 198:44-8. 2010
  6. doi request reprint Assessing the toxic effects of ethylene glycol ethers using Quantitative Structure Toxicity Relationship models
    Patricia Ruiz
    Computational Toxicology Methods Development Laboratory, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30333, USA
    Toxicol Appl Pharmacol 254:198-205. 2011
  7. doi request reprint Physiologically based pharmacokinetic (PBPK) tool kit for environmental pollutants--metals
    P Ruiz
    Computational Toxicology and Methods Development Laboratory, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, Atlanta, GA, USA
    SAR QSAR Environ Res 21:603-18. 2010
  8. doi request reprint Joint toxicity of alkoxyethanol mixtures: contribution of in silico applications
    H R Pohl
    Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA, USA
    Regul Toxicol Pharmacol 64:134-42. 2012
  9. ncbi request reprint Toxicity assessment of unintentional exposure to multiple chemicals
    M M Mumtaz
    Division of Toxicology and Environmental Medicine Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, U S Department of Health and Human Services, Atlanta, GA 30333, USA
    Toxicol Appl Pharmacol 223:104-13. 2007

Detail Information

Publications9

  1. doi request reprint Prediction of the health effects of polychlorinated biphenyls (PCBs) and their metabolites using quantitative structure-activity relationship (QSAR)
    P Ruiz
    Agency for Toxic Substances and Disease Registry, Division of Toxicology and Environmental Medicine, Computational Toxicology and Methods Development Unit, 1600 Clifton Road, MS F32, Atlanta, GA 30333, USA
    Toxicol Lett 181:53-65. 2008
    ..Hence, these data should be considered as priority toxicological testing data needs. As with all computational toxicology analytical findings, these conclusions must yield to empirical data as they become available...
  2. doi request reprint Chemical risk assessment and uncertainty associated with extrapolation across exposure duration
    H R Pohl
    Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA, USA
    Regul Toxicol Pharmacol 57:18-23. 2010
    ..In addition, we investigated the impact of chemical structure and chemical structure activity relationship on validation of predictions across exposure durations...
  3. doi request reprint Assessment of hydroxylated metabolites of polychlorinated biphenyls as potential xenoestrogens: a QSAR comparative analysis∗
    P Ruiz
    Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, Atlanta, USA
    SAR QSAR Environ Res 24:393-416. 2013
    ..Such information will help prioritize such molecules for additional testing, guide future basic laboratory research studies, and help the health/risk assessment community understand the complex nature of chemical mixtures...
  4. doi request reprint Prediction of acute mammalian toxicity using QSAR methods: a case study of sulfur mustard and its breakdown products
    Patricia Ruiz
    Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30333, USA
    Molecules 17:8982-9001. 2012
    ..This evaluation allows for the ranking and toxicity estimation of compounds for which little toxicity information existed; thus leading to better risk decision making in the field...
  5. doi request reprint Interpreting NHANES biomonitoring data, cadmium
    Patricia Ruiz
    Agency for Toxic Substances and Disease Registry, Atlanta, GA 30333, USA
    Toxicol Lett 198:44-8. 2010
    ..The model describes Cd's cumulative nature in humans and accommodates the observed variation in exposure/uptake over the course of a lifetime. Such models may be useful for interpreting biomonitoring data and risk assessment...
  6. doi request reprint Assessing the toxic effects of ethylene glycol ethers using Quantitative Structure Toxicity Relationship models
    Patricia Ruiz
    Computational Toxicology Methods Development Laboratory, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30333, USA
    Toxicol Appl Pharmacol 254:198-205. 2011
    ..The predicted toxicity effects were subjected to reverse QSTR (rQSTR) analysis to identify structural attributes that may be the main drivers of the developmental toxicity potential of these compounds...
  7. doi request reprint Physiologically based pharmacokinetic (PBPK) tool kit for environmental pollutants--metals
    P Ruiz
    Computational Toxicology and Methods Development Laboratory, Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, Atlanta, GA, USA
    SAR QSAR Environ Res 21:603-18. 2010
    ..The PBPK tool kit will enable ATSDR scientists to perform simulations of exposures from contaminated environmental media at sites of concern and to better interpret site-specific biomonitoring data...
  8. doi request reprint Joint toxicity of alkoxyethanol mixtures: contribution of in silico applications
    H R Pohl
    Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA, USA
    Regul Toxicol Pharmacol 64:134-42. 2012
    ..Unique genotypes introduced as a function of migration can alter the genetic makeup of any given population. Hence special consideration should be given to susceptible populations while conducting chemical health risk assessments...
  9. ncbi request reprint Toxicity assessment of unintentional exposure to multiple chemicals
    M M Mumtaz
    Division of Toxicology and Environmental Medicine Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, U S Department of Health and Human Services, Atlanta, GA 30333, USA
    Toxicol Appl Pharmacol 223:104-13. 2007
    ..It is through such collaborations that resources are most effectively leveraged to further develop and apply toxicity assessment methods that advance public health practices in vulnerable communities...