J T Roehrig

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi Non-structural proteins of dengue 2 virus offer limited protection to interferon-deficient mice after dengue 2 virus challenge
    Amanda E Calvert
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention CDC, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA
    J Gen Virol 87:339-46. 2006
  2. pmc West nile virus in the United States - a historical perspective
    John T Roehrig
    Arboviral Diseases Branch, Division of Vector Borne Diseases, National Center for Zoonotic and Emerging Infectious Diseases, U S Centers for Disease Control and Prevention, 3156 Rampart Road, Fort Collins, CO 80521, USA
    Viruses 5:3088-108. 2013
  3. doi Mutation of the dengue virus type 2 envelope protein heparan sulfate binding sites or the domain III lateral ridge blocks replication in Vero cells prior to membrane fusion
    John T Roehrig
    Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA
    Virology 441:114-25. 2013
  4. pmc Persistence of virus-reactive serum immunoglobulin m antibody in confirmed west nile virus encephalitis cases
    John T Roehrig
    Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Emerg Infect Dis 9:376-9. 2003
  5. ncbi Antibody prophylaxis and therapy for flavivirus encephalitis infections
    J T Roehrig
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Ann N Y Acad Sci 951:286-97. 2001
  6. pmc Contribution of disulfide bridging to epitope expression of the dengue type 2 virus envelope glycoprotein
    John T Roehrig
    Arbovirus Disease Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, Colorado 80522, USA
    J Virol 78:2648-52. 2004
  7. ncbi Identification of Highlands J virus from a Florida horse
    N Karabatsos
    Division of Vector Borne Viral Diseases, Center for Infectious Diseases, U S Department of Health and Human Services, Fort Collins, Colorado 80522
    Am J Trop Med Hyg 39:603-6. 1988
  8. ncbi Synthetic peptides derived from the deduced amino acid sequence of the E-glycoprotein of Murray Valley encephalitis virus elicit antiviral antibody
    J T Roehrig
    Division of Vector Borne Viral Diseases, Public Health Service, Ft Collins, Colorado 80522
    Virology 171:49-60. 1989
  9. pmc Detection of anti-arboviral immunoglobulin G by using a monoclonal antibody-based capture enzyme-linked immunosorbent assay
    A J Johnson
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, Colorado 80522, USA
    J Clin Microbiol 38:1827-31. 2000
  10. ncbi In vitro mechanisms of monoclonal antibody neutralization of alphaviruses
    J T Roehrig
    Division of Vector Borne Viral Diseases, Centers for Disease Control, Fort Collins, Colorado 80522
    Virology 165:66-73. 1988

Collaborators

Detail Information

Publications53

  1. ncbi Non-structural proteins of dengue 2 virus offer limited protection to interferon-deficient mice after dengue 2 virus challenge
    Amanda E Calvert
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention CDC, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA
    J Gen Virol 87:339-46. 2006
    ..These results suggest that, whilst the non-structural proteins were able to enhance mean survival times of AG129 mice, this protection was not as effective as protection mediated by the E protein...
  2. pmc West nile virus in the United States - a historical perspective
    John T Roehrig
    Arboviral Diseases Branch, Division of Vector Borne Diseases, National Center for Zoonotic and Emerging Infectious Diseases, U S Centers for Disease Control and Prevention, 3156 Rampart Road, Fort Collins, CO 80521, USA
    Viruses 5:3088-108. 2013
    ..This paper documents the early events of the introduction into and the spread of WNV in the Western Hemisphere. ..
  3. doi Mutation of the dengue virus type 2 envelope protein heparan sulfate binding sites or the domain III lateral ridge blocks replication in Vero cells prior to membrane fusion
    John T Roehrig
    Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA
    Virology 441:114-25. 2013
    ..Additionally, both mutants were unable to initiate negative-strand vRNA synthesis in Vero cells by 72h post-infection, suggesting that the replication block occurred prior to virus-mediated membrane fusion...
  4. pmc Persistence of virus-reactive serum immunoglobulin m antibody in confirmed west nile virus encephalitis cases
    John T Roehrig
    Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Emerg Infect Dis 9:376-9. 2003
    ..Of those patients bled, 7 (60%) of 12 had anti-WNV IgM at approximately 500 days after onset. Clinicians should be cautious when interpreting serologic results from early season WNV IgM-positive patients...
  5. ncbi Antibody prophylaxis and therapy for flavivirus encephalitis infections
    J T Roehrig
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Ann N Y Acad Sci 951:286-97. 2001
    ..Antiflaviviral human or humanized MAbs might be practical and cost-effective reagents for preventing or modifying flaviviral diseases...
  6. pmc Contribution of disulfide bridging to epitope expression of the dengue type 2 virus envelope glycoprotein
    John T Roehrig
    Arbovirus Disease Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, Colorado 80522, USA
    J Virol 78:2648-52. 2004
    ..If this observation can be confirmed, peptide mimics from this region of E protein might be able to interfere with flavivirus replication...
  7. ncbi Identification of Highlands J virus from a Florida horse
    N Karabatsos
    Division of Vector Borne Viral Diseases, Center for Infectious Diseases, U S Department of Health and Human Services, Fort Collins, Colorado 80522
    Am J Trop Med Hyg 39:603-6. 1988
    ..These tests demonstrate that strain 64A-1519 is a strain of HJ virus distinct from WEE virus...
  8. ncbi Synthetic peptides derived from the deduced amino acid sequence of the E-glycoprotein of Murray Valley encephalitis virus elicit antiviral antibody
    J T Roehrig
    Division of Vector Borne Viral Diseases, Public Health Service, Ft Collins, Colorado 80522
    Virology 171:49-60. 1989
    ..These results indicate that synthetic peptides aid in defining flavivirus antigenic structure, and may serve as possible type-specific diagnostic reagents...
  9. pmc Detection of anti-arboviral immunoglobulin G by using a monoclonal antibody-based capture enzyme-linked immunosorbent assay
    A J Johnson
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, Colorado 80522, USA
    J Clin Microbiol 38:1827-31. 2000
    ..The tests were standardized for laboratory diagnosis of arboviral infections, with the intent that they be used in tandem with the corresponding IgM antibody-capture ELISAs...
  10. ncbi In vitro mechanisms of monoclonal antibody neutralization of alphaviruses
    J T Roehrig
    Division of Vector Borne Viral Diseases, Centers for Disease Control, Fort Collins, Colorado 80522
    Virology 165:66-73. 1988
    ..Once virus had attached to cells, the ability of most MAbs to neutralize infectivity was diminished, except for E2c MAbs. On a molar basis antibody Fab fragments were less efficient than intact antibody at blocking virus attachment...
  11. pmc Widespread West Nile virus activity, eastern United States, 2000
    A A Marfin
    Division of Vector Borne Infections Diseases, Centers for Disease Control and Prevention, P O Box 2087, Fort Collins, CO 80522, USA
    Emerg Infect Dis 7:730-5. 2001
    ..This report summarizes 2000 surveillance data, documents widespread virus activity in 2000, and demonstrates the utility of monitoring virus activity in animals to identify human risk for infection...
  12. pmc West Nile virus recombinant DNA vaccine protects mouse and horse from virus challenge and expresses in vitro a noninfectious recombinant antigen that can be used in enzyme-linked immunosorbent assays
    B S Davis
    Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Fort Collins, Colorado 80522, USA
    J Virol 75:4040-7. 2001
    ..This recombinant antigen has great potential to become the antigen of choice and will facilitate the standardization of reagents and implementation of WN virus surveillance in the United States and elsewhere...
  13. ncbi Monoclonal antibody mapping of the envelope glycoprotein of the dengue 2 virus, Jamaica
    J T Roehrig
    Arbovirus Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Virology 246:317-28. 1998
    ..Domains A and B were spatially associated. As with tick-borne encephalitis virus, determination of domain C was more problematic; however, at least four epitopes had biochemical characteristics consistent with C-domain epitopes...
  14. pmc T-helper cell and associated antibody response to synthetic peptides of the E glycoprotein of Murray Valley encephalitis virus
    J H Mathews
    Division of Vector Borne Infectious Diseases, Centers for Disease Control, Fort Collins, Colorado 80522
    J Virol 65:5141-8. 1991
    ..These results indicate that it may be feasible to design synthetic flavivirus peptides that define T-cell epitopes capable of generating a helper cell response for B-cell epitopes involved in protective immunity...
  15. ncbi Specificity of the murine T helper cell immune response to various alphaviruses
    J H Mathews
    Division of Vector Borne Viral Diseases, Centers for Disease Control, Fort Collins, Colorado 80522
    J Gen Virol 70:2877-86. 1989
    ....
  16. pmc The role of pathology in an investigation of an outbreak of West Nile encephalitis in New York, 1999
    W J Shieh
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 6:370-2. 2000
    ..Histopathologic and immunopathologic examinations performed on human autopsy materials helped guide subsequent laboratory and epidemiologic investigations that led to identification of the etiologic agent...
  17. ncbi West Nile virus in the United States: guidelines for detection, prevention, and control
    D J Gubler
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U S Public Health Service, Department of Health and Human Services, Fort Collins, Colorado 80522, USA
    Viral Immunol 13:469-75. 2000
    ....
  18. pmc Monoclonal antibodies that bind to domain III of dengue virus E glycoprotein are the most efficient blockers of virus adsorption to Vero cells
    W D Crill
    Arbovirus Disease Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, Colorado 80522, USA
    J Virol 75:7769-73. 2001
    ..These results extend our understanding of the structure-function relationships in the E glycoprotein of DEN virus and provide the first direct evidence that domain III encodes the primary flavivirus receptor-binding motif...
  19. ncbi Detection of eastern equine encephalitis virus in infected mosquitoes using a monoclonal antibody-based antigen-capture enzyme-linked immunosorbent assay
    T M Brown
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Am J Trop Med Hyg 65:208-13. 2001
    ..The conversion of this ELISA to a monoclonal antibody-based format should result in a readily standardizable and transferable assay that will permit laboratories lacking virus isolation facilities to conduct EEE virus surveillance...
  20. pmc Identification of an antigenic subtype of eastern equine encephalitis virus isolated from a human
    C H Calisher
    Division of Vector Borne Viral Diseases, Centers for Disease Control, Fort Collins, Colorado 80522
    J Clin Microbiol 28:373-4. 1990
    ..We believe that this is the first evidence of an antigenic subtype of EEE virus...
  21. ncbi Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States
    R S Lanciotti
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80522, USA
    Science 286:2333-7. 1999
    ..This North American WN virus was most closely related to a WN virus isolated from a dead goose in Israel in 1998...
  22. ncbi The emergence of West Nile virus in North America: ecology, epidemiology, and surveillance
    J T Roehrig
    Arbovirus Diseases Branch, Division of Vector Borne Infectious Diseases, National Centers for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, Colorado, USA
    Curr Top Microbiol Immunol 267:223-40. 2002
    ..The valuable lessons learned from the detection and response to the introduction of WN virus into NYC should prove useful if and when subsequent intrusions of new disease agents occur...
  23. ncbi Immunogens of encephalitis viruses
    J T Roehrig
    Division of Vector Borne Infectious Diseases, Centers for Disease Control, Fort Collins, Colorado 80522
    Vet Microbiol 37:273-84. 1993
    ..Recent studies comparing gene sequences from virulent and avirulent VEE viruses have begun to delineate mechanisms of alphavirus attenuation...
  24. pmc New mouse model for dengue virus vaccine testing
    A J Johnson
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, United States Department of Health and Human Services, Fort Collins, Colorado 80522, USA
    J Virol 73:783-6. 1999
    ..These results demonstrate that AG129 mice are a promising small animal model for DEN virus vaccine trials...
  25. pmc Standardization of immunoglobulin M capture enzyme-linked immunosorbent assays for routine diagnosis of arboviral infections
    D A Martin
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, Colorado 80522, USA
    J Clin Microbiol 38:1823-6. 2000
    ..0 as a positive cutoff value. With a blind-coded human serum panel, this combined MAC-ELISA was shown to have test sensitivity and specificity that correlated well with those of other serological techniques...
  26. doi Domain-III FG loop of the dengue virus type 2 envelope protein is important for infection of mammalian cells and Aedes aegypti mosquitoes
    Steven M Erb
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Virology 406:328-35. 2010
    ..Reduced binding of DENV2 type-specific monoclonal antibody 3H5 to mutant viruses confirmed the FG loop motif as its target epitope...
  27. pmc Monoclonal antibodies capable of distinguishing epizootic from enzootic varieties of subtype 1 Venezuelan equine encephalitis viruses in a rapid indirect immunofluorescence assay
    J T Roehrig
    National Center of Infectious Diseases, Centers for Disease Control and Prevention, U S Public Health Service, U S Department of Health and Human Services, Fort Collins, Colorado 80522, USA
    J Clin Microbiol 35:1887-90. 1997
    ..Because VEE virus virulence has been associated in part with the E2 glycoprotein, this observed antigenic change in the 1E virus E2 glycoprotein may explain the apparent equine virulence of this unusual VEE 1E virus...
  28. ncbi West Nile virus encephalitis
    Lyle R Petersen
    Centers for Disease Control and Prevention, Fort Collins, CO 80522, USA
    N Engl J Med 347:1225-6. 2002
  29. ncbi Construction of infectious cDNA clones for dengue 2 virus: strain 16681 and its attenuated vaccine derivative, strain PDK-53
    R M Kinney
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA
    Virology 230:300-8. 1997
    ..Although the NS3-250-Val mutation clearly affected virus replication in vitro, it was not a major determinant of attenuation for PDK-53 virus in suckling mice...
  30. ncbi Enhancing biosynthesis and secretion of premembrane and envelope proteins by the chimeric plasmid of dengue virus type 2 and Japanese encephalitis virus
    Gwong Jen J Chang
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Service, Post Office Box 2087, Fort Collins, CO 80522, USA
    Virology 306:170-80. 2003
    ..Eleven of twelve 2-day-old neonatal mice, derived from a pCB8D2-2J-2-9-1 immunized female mouse, survived intraperitoneal challenge of DEN-2 New Guinea C virus...
  31. ncbi Temporal analyses of the neuropathogenesis of a West Nile virus infection in mice
    Elizabeth A Hunsperger
    Division of Vector Borne Infectious Disease, Centers for Disease Control and Prevention National Center for Infectious Diseases, Ft Collins, Colorado, USA
    J Neurovirol 12:129-39. 2006
    ....
  32. pmc Use of immunoglobulin m cross-reactions in differential diagnosis of human flaviviral encephalitis infections in the United States
    Denise A Martin
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Clin Diagn Lab Immunol 9:544-9. 2002
    ..Infections with SLE virus resulted in antibody that was more cross-reactive, so identification of SLE virus as the infecting agent by use of MAC-ELISA cross-reactivity alone was more problematic...
  33. pmc Development of a human-murine chimeric immunoglobulin M antibody for use in the serological detection of human flavivirus antibodies
    Brett A Thibodeaux
    US Department of Health and Human Services, Division of Vector Borne Infectious Diseases, Arboviral Diseases Branch, National Center for Zoonotic, Fort Collins, Colorado 80521, USA
    Clin Vaccine Immunol 16:679-85. 2009
    ....
  34. ncbi Glycosylation of the dengue 2 virus E protein at N67 is critical for virus growth in vitro but not for growth in intrathoracically inoculated Aedes aegypti mosquitoes
    Juliet E Bryant
    Arboviral Diseases Branch, Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U S Department of Health and Human Services, Fort Collins, CO 80522, USA
    Virology 366:415-23. 2007
    ....
  35. doi The dengue virus type 2 envelope protein fusion peptide is essential for membrane fusion
    Claire Y H Huang
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, 3150 Rampart Rd, Fort Collins, CO 80521, USA
    Virology 396:305-15. 2010
    ..Mutations of the FP also resulted in reduced virus reactivity with flavivirus group-reactive antibodies, confirming earlier reports using virus-like particles...
  36. pmc Development of human-murine chimeric immunoglobulin G for use in the serological detection of human flavivirus and alphavirus antibodies
    Brett A Thibodeaux
    Arboviral Diseases Branch, Division of Vector Borne Diseases, National Center for Zoonotic Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention U S DHHS, 3150 Rampart Road, Fort Collins, CO 80521, USA
    Clin Vaccine Immunol 17:1617-23. 2010
    ..The IgG cMAbs secreted from plasmid-transformed Sp2/0-Ag14 cells had serological activity identical to that of the parent mMAbs, as measured by ELISA using multiple flaviviruses or alphaviruses...
  37. doi Human monoclonal antibodies to West Nile virus identify epitopes on the prM protein
    Amanda E Calvert
    Arboviral Diseases Branch, Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, 3150 Rampart Rd, Fort Collins, CO 80521, USA
    Virology 410:30-7. 2011
    ..Mutations at residue, T20 and T24 affected the binding of hMAbs, 8G8 and 5G12 only. These hMAbs did not significantly protect AG129 interferon-deficient mice or Swiss Webster outbred mice from WNV infection...
  38. ncbi O'Nyong-nyong fever in West Africa
    Drew L Posey
    Centers for Disease Control and Prevention, Division of Global Migration and Quarantine, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 73:32. 2005
  39. ncbi Complete genome sequences and phylogenetic analysis of West Nile virus strains isolated from the United States, Europe, and the Middle East
    Robert S Lanciotti
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U S Department of Health and Human Services, Fort Collins, Colorado 80521, USA
    Virology 298:96-105. 2002
    ..Lineage 2 WN viruses have been isolated only in sub-Saharan Africa and Madagascar. Lineage 1 viruses can be further subdivided into three monophyletic clades...
  40. ncbi Antigenic structure of flavivirus proteins
    John T Roehrig
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, Colorado 80521, USA
    Adv Virus Res 59:141-75. 2003
    ..To prepare effective and inexpensive subunit vaccines, we will need to continue to better understand these structure-function relationships of flavivirus proteins...
  41. ncbi Characterization of West Nile viral replication and maturation in peripheral neurons in culture
    Elizabeth Hunsperger
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Health and Human Services, Fort Collins, CO 80522, USA
    J Neurovirol 11:11-22. 2005
    ..Our studies suggest that even though PC-12 and DRG neurons are mammalian cells, viral protein processing and maturation in these cells more closely resembles replication in C6/36 insect cells than in mammalian Vero cells...
  42. pmc Detection of West Nile virus antigen in mosquitoes and avian tissues by a monoclonal antibody-based capture enzyme immunoassay
    Ann R Hunt
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, Colorado 80522, USA
    J Clin Microbiol 40:2023-30. 2002
    ....
  43. doi Nocodazole delays viral entry into the brain following footpad inoculation with West Nile virus in mice
    E A Hunsperger
    Centers for Disease Control and Prevention, National Center for Infectious Diseases, Division of Vector Borne Infectious Diseases, Dengue Branch, San Juan, Puerto Rico
    J Neurovirol 15:211-8. 2009
    ..These results demonstrate that a single dose of nocodazole delays, but does not block, WNV infection of the brain...
  44. pmc Epitope-blocking enzyme-linked immunosorbent assays for the detection of serum antibodies to west nile virus in multiple avian species
    Bradley J Blitvich
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology Animal Reproduction and Biotechnology Laboratory, Equine Center, Colorado State University, Fort Collins, Colorado 80523, USA
    J Clin Microbiol 41:1041-7. 2003
    ..The blocking assays reported here provide a rapid, reliable, and inexpensive diagnostic and surveillance technique to monitor WNV activity in multiple avian species...
  45. ncbi A humanized murine monoclonal antibody protects mice either before or after challenge with virulent Venezuelan equine encephalomyelitis virus
    Ann R Hunt
    Arbovirus Diseases Branch, Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Fort Collins, CO 80522, USA
    J Gen Virol 87:2467-76. 2006
    ..Importantly, therapeutic administration of the humanized mAb to mice already infected with VEEV cured 90 % of mice treated with Hy4 IgG within 1 h of VEEV inoculation and 75 % of mice treated 24 h after virus infection...
  46. doi Guidelines for Plaque-Reduction Neutralization Testing of Human Antibodies to Dengue Viruses
    John T Roehrig
    National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, U S Department of Health and Human Services, Fort Collins, Colorado, USA
    Viral Immunol 21:123-32. 2008
    ..A more complete version of these guidelines is available on the WHO website: http://www.who.int/immunization/documents/date/en/index.html...
  47. ncbi The envelope glycoproteins of dengue 1 and dengue 2 viruses grown in mosquito cells differ in their utilization of potential glycosylation sites
    A J Johnson
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522
    Virology 203:241-9. 1994
    ..These DEN virus serotypes are thus heterogeneous in their use of glycosylation sites. We also determined by a lectin-binding assay that the attached carbohydrates for both viruses were likely to be of the high-mannose type...
  48. doi Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins
    Shee Mei Lok
    Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, Indiana 47907 2054, USA
    Nat Struct Mol Biol 15:312-7. 2008
    ..The changes in the structure of the viral surface are presumably responsible for inhibiting attachment to cells...
  49. pmc Type- and subcomplex-specific neutralizing antibodies against domain III of dengue virus type 2 envelope protein recognize adjacent epitopes
    Soila Sukupolvi-Petty
    Department of Medicine, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    J Virol 81:12816-26. 2007
    ..Overall, our experiments define adjacent and structurally distinct epitopes on DIII of DENV-2 which elicit type-specific, subcomplex-specific, and cross-reactive antibodies with different neutralizing potentials...
  50. ncbi Dengue virus: molecular basis of cell entry and pathogenesis, 25-27 June 2003, Vienna, Austria
    Scott B Halstead
    Pediatric Dengue Vaccine Initiative, 5824 Edson Lane, Rockville, MD 20852, USA
    Vaccine 23:849-56. 2005
    ..Achievement of this aim will require a better understanding of the basic mechanisms by which dengue viruses recognize, attach, enter and infect relevant human cells and how antibodies protect against dengue infections...
  51. ncbi Recombination and flavivirus vaccines: a commentary
    Thomas P Monath
    Acambis Inc, 38 Sidney Street, Cambridge, MA 02139, USA
    Vaccine 23:2956-8. 2005
  52. ncbi Construction of yellow fever/St. Louis encephalitis chimeric virus and the use of chimeras as a diagnostic tool
    Konstantin V Pugachev
    Acambis Inc, 38 Sidney Street, Cambridge, MA 02139, USA
    Am J Trop Med Hyg 71:639-45. 2004
    ..These chimeras have the potential for use as diagnostic reagents and vaccines against SLE and WN...
  53. doi Flavivirus DNA vaccines--good science, uncertain future
    Lyle R Petersen
    J Infect Dis 196:1721-3. 2007