Jenny R Roberts

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. doi request reprint Pulmonary and cardiovascular responses of rats to inhalation of silver nanoparticles
    Jenny R Roberts
    Health Effects Laboratory Division HELD, National Institute for Occupational Safety and Health NIOSH, Centers for Disease Control and Prevention CDC, 1095 Willowdale Rd M S 2015, Morgantown, WV 26505, USA
    J Toxicol Environ Health A 76:651-68. 2013
  2. ncbi request reprint Soluble metals associated with residual oil fly ash increase morbidity and lung injury after bacterial infection in rats
    Jenny R Roberts
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, and Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 67:251-63. 2004
  3. doi request reprint Pulmonary effects after acute inhalation of oil dispersant (COREXIT EC9500A) in rats
    Jenny R Roberts
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 74:1381-96. 2011
  4. doi request reprint Toxicological evaluation of lung responses after intratracheal exposure to non-dispersed titanium dioxide nanorods
    Jenny R Roberts
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 74:790-810. 2011
  5. ncbi request reprint Soluble metals in residual oil fly ash alter innate and adaptive pulmonary immune responses to bacterial infection in rats
    Jenny R Roberts
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 221:306-19. 2007
  6. doi request reprint The soluble nickel component of residual oil fly ash alters pulmonary host defense in rats
    Jenny R Roberts
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, and West Virginia University, Morgantown, West Virginia 26505, USA
    J Immunotoxicol 6:49-61. 2009
  7. pmc Lung toxicity and biodistribution of Cd/Se-ZnS quantum dots with different surface functional groups after pulmonary exposure in rats
    Jenny R Roberts
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Part Fibre Toxicol 10:5. 2013
  8. ncbi request reprint Exposure of brown Norway rats to diesel exhaust particles prior to ovalbumin (OVA) sensitization elicits IgE adjuvant activity but attenuates OVA-induced airway inflammation
    Caroline C Dong
    School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506 9530, USA
    Toxicol Sci 88:150-60. 2005
  9. ncbi request reprint Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes
    Krishnan Sriram
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Arch Toxicol 84:521-40. 2010
  10. ncbi request reprint Effect of diesel exhaust particles on allergic reactions and airway responsiveness in ovalbumin-sensitized brown Norway rats
    Caroline C Dong
    School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506 9530, USA
    Toxicol Sci 88:202-12. 2005

Collaborators

Detail Information

Publications56

  1. doi request reprint Pulmonary and cardiovascular responses of rats to inhalation of silver nanoparticles
    Jenny R Roberts
    Health Effects Laboratory Division HELD, National Institute for Occupational Safety and Health NIOSH, Centers for Disease Control and Prevention CDC, 1095 Willowdale Rd M S 2015, Morgantown, WV 26505, USA
    J Toxicol Environ Health A 76:651-68. 2013
    ..In summary, short-term inhalation of nano-Ag did not produce apparent marked acute toxicity in this animal model. ..
  2. ncbi request reprint Soluble metals associated with residual oil fly ash increase morbidity and lung injury after bacterial infection in rats
    Jenny R Roberts
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, and Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 67:251-63. 2004
    ..These results suggest that soluble metals present in ROFA may play a key role in increased susceptibility to pulmonary infection in exposed populations...
  3. doi request reprint Pulmonary effects after acute inhalation of oil dispersant (COREXIT EC9500A) in rats
    Jenny R Roberts
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 74:1381-96. 2011
    ..COREXIT inhibited neurogenic contractile responses of strips to electrical field stimulation. Our findings suggest that COREXIT inhalation did not initiate lung inflammation, but may transiently increase the difficulty of breathing...
  4. doi request reprint Toxicological evaluation of lung responses after intratracheal exposure to non-dispersed titanium dioxide nanorods
    Jenny R Roberts
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 74:790-810. 2011
    ..To summarize, non-dispersed TiO₂ nanorods were found to induce radical formation and cellular oxidant production, and to generate transient and reversible pneumotoxic effects, and to not markedly alter pulmonary immune function...
  5. ncbi request reprint Soluble metals in residual oil fly ash alter innate and adaptive pulmonary immune responses to bacterial infection in rats
    Jenny R Roberts
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 221:306-19. 2007
    ..The results suggest that soluble metals in ROFA increase lung injury and inflammation, and alter both innate and adaptive pulmonary immune responses...
  6. doi request reprint The soluble nickel component of residual oil fly ash alters pulmonary host defense in rats
    Jenny R Roberts
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, and West Virginia University, Morgantown, West Virginia 26505, USA
    J Immunotoxicol 6:49-61. 2009
    ..Soluble Ni is likely the primary metal involved in the increased susceptibility to infection observed in rats exposed to the soluble metals of ROFA...
  7. pmc Lung toxicity and biodistribution of Cd/Se-ZnS quantum dots with different surface functional groups after pulmonary exposure in rats
    Jenny R Roberts
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Part Fibre Toxicol 10:5. 2013
    ..The goal of the present study was to assess pulmonary toxicity, clearance, and biodistribution of QD with different functional groups in rats after pulmonary exposure...
  8. ncbi request reprint Exposure of brown Norway rats to diesel exhaust particles prior to ovalbumin (OVA) sensitization elicits IgE adjuvant activity but attenuates OVA-induced airway inflammation
    Caroline C Dong
    School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506 9530, USA
    Toxicol Sci 88:150-60. 2005
    ....
  9. ncbi request reprint Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes
    Krishnan Sriram
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Arch Toxicol 84:521-40. 2010
    ..Whether such perturbations will lead to PD-like neuropathological manifestations remains to be elucidated...
  10. ncbi request reprint Effect of diesel exhaust particles on allergic reactions and airway responsiveness in ovalbumin-sensitized brown Norway rats
    Caroline C Dong
    School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506 9530, USA
    Toxicol Sci 88:202-12. 2005
    ..This DEP effect may be, at least partially, attributed to the elevated generation of ROS in AM and ATII cells, a depletion of GSH in AM and lymphocytes, and an increase in AM and ATII cell production of NO...
  11. ncbi request reprint Sustained effect of inhaled diesel exhaust particles on T-lymphocyte-mediated immune responses against Listeria monocytogenes
    Xuejun J Yin
    School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506 9530, USA
    Toxicol Sci 88:73-81. 2005
    ..The results support the epidemiological observations that exposure to DEP may be responsible for the pulmonary health effects on humans...
  12. ncbi request reprint Intratracheal amiodarone administration to F344 rats directly damages lung airway and parenchymal cells
    Michael D Taylor
    Department of Pharmacology and Toxicology, West Virginia University, Morgantown, WV 26506, USA
    Toxicol Appl Pharmacol 188:92-103. 2003
    ..t. AD treatment are similar to the mechanisms that underlie human AIPT. Therefore these data suggest that investigators should use caution in extrapolating results from animal studies that utilize i.t. administration of AD to human AIPT...
  13. ncbi request reprint Pulmonary exposure to 1 --> 3-beta-glucan alters adaptive immune responses in rats
    Shih Houng Young
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Inhal Toxicol 18:865-74. 2006
    ..In summary, rats exposed to zymosan had an increase in acute inflammation, and the altered lymphocyte profiles were consistent with the findings of epidemiology studies...
  14. ncbi request reprint Effects of welding fumes of differing composition and solubility on free radical production and acute lung injury and inflammation in rats
    Michael D Taylor
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Toxicol Sci 75:181-91. 2003
    ..Additionally, both the soluble and insoluble fractions of the MMA-SS fume were required to produce most effects, indicating that the responses are not dependent exclusively on the soluble metals...
  15. doi request reprint Persistence of deposited metals in the lungs after stainless steel and mild steel welding fume inhalation in rats
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Arch Toxicol 85:487-98. 2011
    ..The potentially more toxic metals (e.g., Mn, Cr) present in the stainless steel fume were cleared from the lungs more quickly than Fe, likely increasing their translocation from the respiratory system to other organs...
  16. ncbi request reprint Welding fume exposure and associated inflammatory and hyperplastic changes in the lungs of tumor susceptible a/j mice
    Claudia Solano-Lopez
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA
    Toxicol Pathol 34:364-72. 2006
    ..Our findings that WF causes persistent bronchiolar and peribronchiolar epithelial changes, suggest a need for studies of bronchiolar changes after WF exposure...
  17. ncbi request reprint Suppression of phagocytic and bactericidal functions of rat alveolar macrophages by the organic component of diesel exhaust particles
    Xuejun J Yin
    School of Medicine, West Virginia University, Morgantown, West Virginia 26506 9203, USA
    J Toxicol Environ Health A 70:820-8. 2007
    ..monocytogenes and an increased susceptibility of the lung to bacterial infection...
  18. ncbi request reprint Metal composition and solubility determine lung toxicity induced by residual oil fly ash collected from different sites within a power plant
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Mol Cell Biochem 255:257-65. 2004
    ..These results are most likely due to differences in metal composition and solubility of the ROFA samples...
  19. ncbi request reprint Suppression in lung defense responses after bacterial infection in rats pretreated with different welding fumes
    James M Antonini
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 200:206-18. 2004
    ....
  20. doi request reprint Manganese accumulation in nail clippings as a biomarker of welding fume exposure and neurotoxicity
    Krishnan Sriram
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Toxicology 291:73-82. 2012
    ..The non-invasive means by which nail clippings can be collected, stored, and transported with relative ease, make it an attractive surrogate for biomonitoring WF exposures in occupational settings...
  21. ncbi request reprint Effect of asphalt fume inhalation exposure at simulated road paving conditions prior to bacterial infection on lung defense responses in rats
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Inhal Toxicol 15:1347-68. 2003
    ..It was concluded that acute inhalation of asphalt fumes at a high concentration had a minimal effect on lung immune responses to infection in rats...
  22. pmc Alteration of pulmonary immunity to Listeria monocytogenes by diesel exhaust particles (DEPs). II. Effects of DEPs on T-cell-mediated immune responses in rats
    Xue Jun Yin
    School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506, USA
    Environ Health Perspect 111:524-30. 2003
    ..This T-cell immune response was sufficient to allow the Brown Norway rats to clear the bacteria at 7 days postinfection and overcome the down-regulation of the innate immunity by the acute DEP exposure...
  23. doi request reprint Pulmonary toxicity and extrapulmonary tissue distribution of metals after repeated exposure to different welding fumes
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virgina 26505, USA
    Inhal Toxicol 22:805-16. 2010
    ..Importantly, increased deposition of Mn, but not other metals, was observed in discrete brain regions, including dopamine-rich areas (e.g., striatum and midbrain)...
  24. ncbi request reprint Short-term inhalation exposure to mild steel welding fume had no effect on lung inflammation and injury but did alter defense responses to bacteria in rats
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Inhal Toxicol 21:182-92. 2009
    ..More chronic inhalation studies are needed to further examine the immune effects and to elucidate the possible mechanisms of the suppressed lung defense response to infection associated with the inhalation of MS welding fume...
  25. doi request reprint Alterations in welding process voltage affect the generation of ultrafine particles, fume composition, and pulmonary toxicity
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Nanotoxicology 5:700-10. 2011
    ..In summary, a modest raise in welding voltage affected fume size and elemental composition and altered the temporal lung toxicity profile...
  26. ncbi request reprint Suppression of cell-mediated immune responses to listeria infection by repeated exposure to diesel exhaust particles in brown Norway rats
    Xuejun J Yin
    School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506, USA
    Toxicol Sci 77:263-71. 2004
    ....
  27. ncbi request reprint Role of metal-induced reactive oxygen species generation in lung responses caused by residual oil fly ash
    Anthony B Lewis
    Department of Safety and Environmental Management, College of Engineering and Mineral Resources, Morgantown, WV 26506, USA
    J Biosci 28:13-8. 2003
    ..particulate forms. ROS generated by ROFA-sol. as measured by ESR appear not to play a major role in the lung injury caused after ROFA exposure...
  28. doi request reprint Transcriptomics analysis of lungs and peripheral blood of crystalline silica-exposed rats
    Rajendran Sellamuthu
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health NIOSH, Morgantown, WV 26505, USA
    Inhal Toxicol 24:570-9. 2012
    ....
  29. ncbi request reprint Effect of stainless steel manual metal arc welding fume on free radical production, DNA damage, and apoptosis induction
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Mol Cell Biochem 279:17-23. 2005
    ..A more comprehensive in vivo animal study is ongoing in the laboratory that is continuing these experiments to try to elucidate the potential mechanisms that may be involved with welding fume-induced lung disease...
  30. ncbi request reprint Pulmonary responses to welding fumes: role of metal constituents
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 67:233-49. 2004
    ..This article reviews the role that metals play in the pulmonary effects associated with welding fume exposure in workers and laboratory animals...
  31. doi request reprint Systemic immune cell response in rats after pulmonary exposure to manganese-containing particles collected from welding aerosols
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Immunotoxicol 9:184-92. 2012
    ....
  32. ncbi request reprint Effect of short-term stainless steel welding fume inhalation exposure on lung inflammation, injury, and defense responses in rats
    James M Antonini
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 223:234-45. 2007
    ..Additional chronic inhalation studies are needed to further examine the lung effects associated with SS welding fume exposure...
  33. doi request reprint Mild steel welding fume causes manganese accumulation and subtle neuroinflammatory changes but not overt neuronal damage in discrete brain regions of rats after short-term inhalation exposure
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Neurotoxicology 30:915-25. 2009
    ..The neurofunctional significance of these findings currently is being investigated in longer, more chronic welding fume exposure studies...
  34. ncbi request reprint Residual oil fly ash increases the susceptibility to infection and severely damages the lungs after pulmonary challenge with a bacterial pathogen
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS 2015, Morgantown, West Virginia 26505, USA
    Toxicol Sci 70:110-9. 2002
    ..These results suggest that pulmonary exposure to ROFA may alter AM function and lead to increased susceptibility to lung infection in exposed populations...
  35. ncbi request reprint Role of lung surfactant in phagocytic clearance of apoptotic cells by macrophages in rats
    Liying Wang
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Lab Invest 86:458-66. 2006
    ....
  36. doi request reprint Acute effects of COREXIT EC9500A on cardiovascular functions in rats
    Kristine Krajnak
    Engineering and Controls Technology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 74:1397-404. 2011
    ..These findings demonstrate that an acute exposure to COREXIT EC9500A exerts transient effects on cardiovascular and peripheral vascular functions...
  37. ncbi request reprint Performance evaluation of cytometric bead assays for the measurement of lung cytokines in two rodent models
    Shih Houng Young
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Immunol Methods 331:59-68. 2008
    ..In the case of the mouse CBA, a companion measurement is recommended if samples with low concentrations of an analyte are reported and extrapolated below sensitivity or zero...
  38. ncbi request reprint Response of alveolar macrophages from inducible nitric oxide synthase knockout or wild-type mice to an in vitro lipopolysaccharide or silica exposure
    Patti C Zeidler
    Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 66:995-1013. 2003
    ..In addition, LPS induced TNF-á and MIP-2 production tend to be higher in AMs from iNOS KO mice. Such compensatory changes in the AM response may affect the response of iNOS KO mice to inflammatory exposures...
  39. pmc Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity
    Anna A Shvedova
    Pathology Physiology Research Branch, HELD, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Am J Respir Cell Mol Biol 38:579-90. 2008
    ..In conclusion, enhanced acute inflammation and pulmonary injury with delayed bacterial clearance after SWCNT exposure may lead to increased susceptibility to lung infection in exposed populations...
  40. pmc Alteration of pulmonary immunity to Listeria monocytogenes by diesel exhaust particles (DEPs). I. Effects of DEPs on early pulmonary responses
    Xue Jun Yin
    School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506 9530, USA
    Environ Health Perspect 110:1105-11. 2002
    ..DEPs may also suppress cell-mediated immunity by inhibiting AM secretion of IL-12, a key cytokine for the initiation of T helper type 1 cell development in Listeria infection...
  41. doi request reprint Comparative microscopic study of human and rat lungs after overexposure to welding fume
    James M Antonini
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS 4020, Morgantown, WV 26505, USA
    Ann Occup Hyg 57:1167-79. 2013
    ..Not only were the lung responses similar in the human and rat lungs, as evidenced by inflammatory cell influx and pulmonary disease, but the composition of individual welding particles and agglomerations in situ was comparable...
  42. doi request reprint Molecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats
    Rajendran Sellamuthu
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Appl Toxicol 33:301-12. 2013
    ..Published 2012. This article is a US Government work and is in the public domain in the USA...
  43. ncbi request reprint PbCrO4 mediates cellular responses via reactive oxygen species
    Stephen S Leonard
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Mol Cell Biochem 255:171-9. 2004
    ..These particles could induce chronic production of ROS and activation of NF-kappaB and AP-1. Such induction of transcription pathways may be involved in the inflammatory and carcinogenic responses induced by Cr(VI)-containing particles...
  44. doi request reprint Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes
    Krishnan Sriram
    Toxicology and Molecular Biology Branch, Mailstop L 3014, CDC NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA
    FASEB J 24:4989-5002. 2010
    ..Whether these molecular alterations culminate in neurobehavioral and neuropathological deficits reminiscent of PD remains to be ascertained...
  45. ncbi request reprint Preexposure to repeated low doses of zymosan increases the susceptibility to pulmonary infection in rats
    Shih Houng Young
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Exp Lung Res 35:570-90. 2009
    ..The innate immune response was down-regulated and a Th2 immune response was preferentially induced rather than a Th1 response, the latter being more effective toward the resolution of a L. monocytogenes infection...
  46. ncbi request reprint Matrix metalloproteinase induction in fibrosis and fibrotic nodule formation due to silica inhalation
    James F Scabilloni
    National Institute for Occupational Safety and Health, Pathology and Physiology Research Branch, 1095 Willowdale Rd, Morgantown, WV 26505, USA
    Am J Physiol Lung Cell Mol Physiol 288:L709-17. 2005
    ..In summary, MMP activity was upregulated at 40 days of silica exposure and progressively increased during ensuing fibrotic responses. Early expression of stromelysin was found in fibrosing alveolar walls and fibrotic nodules...
  47. ncbi request reprint A comparison of the pulmonary inflammatory potential of different components of yeast cell wall
    Shih Houng Young
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 70:1116-24. 2007
    ..There is also evidence that zymosan is more potent than purified 1-->3-beta-glucan alone. Evidence indicates that 1-->3-beta-glucan is the major inflammatory component in yeast and fungal cell walls...
  48. ncbi request reprint Blood gene expression profiling detects silica exposure and toxicity
    Rajendran Sellamuthu
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Toxicol Sci 122:253-64. 2011
    ..However, further research is required to determine the potential application of our findings specifically to monitor human exposure to silica and the resulting pulmonary effects...
  49. doi request reprint Single pre-exposure to a high dose of zymosan enhances lung defense mechanisms and accelerates the pulmonary clearance of a bacterial pathogen in rats
    Shih Houng Young
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Exp Lung Res 34:559-78. 2008
    ....
  50. doi request reprint Adjuvant effect of zymosan after pulmonary treatment in a mouse ovalbumin allergy model
    Shih Houng Young
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Exp Lung Res 39:48-57. 2013
    ..The optimum adjuvant dose of zymosan was 10 μg. This study demonstrated an adjuvant effect of zymosan when exposures occurred during the sensitization phase in an OVA-induced allergy model in BALB/c mice...
  51. pmc Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume
    Patti C Zeidler-Erdely
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, USA
    Part Fibre Toxicol 5:12. 2008
    ..abstract:..
  52. pmc Skin as a route of exposure and sensitization in chronic beryllium disease
    Sally S Tinkle
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Environ Health Perspect 111:1202-8. 2003
    ....
  53. ncbi request reprint Quantitative image analysis of drug-induced lung fibrosis using laser scanning confocal microscopy
    Michael D Taylor
    Department of Pharmacology and Toxicology, Robert C Byrd Health Sciences Center of West Virginia University, Morgantown, WV 26506, USA
    Toxicol Sci 67:295-302. 2002
    ..LSCM could be particularly useful when tissue quantity is limited, such as when tissue has been archived from previous studies, or when analyzing human lung biopsy samples for disease diagnosis, where biochemical analysis is difficult...
  54. ncbi request reprint p38 Signaling-mediated hypoxia-inducible factor 1alpha and vascular endothelial growth factor induction by Cr(VI) in DU145 human prostate carcinoma cells
    Ning Gao
    Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    J Biol Chem 277:45041-8. 2002
    ..These results suggest that the expression of HIF-1 and VEGF induced by Cr(VI) may be an important signaling pathway in the Cr(VI)-induced carcinogenesis...
  55. ncbi request reprint Pulmonary effects of welding fumes: review of worker and experimental animal studies
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Am J Ind Med 43:350-60. 2003
    ..Approximately one million workers worldwide perform welding as part of their work duties. Electric arc welding processes produce metal fumes and gases which may be harmful to exposed workers...
  56. ncbi request reprint Difficulty demonstrating estradiol-mediated Erk1/2 phosphorylation in MCF-7 cells
    Stacey L Brower
    Department of Biochemistry and Molecular Pharmacology, Mary Babb Randolph Cancer Center, West Virginia University Health Sciences Center, Morgantown, WV 26506 9142, USA
    J Steroid Biochem Mol Biol 96:375-85. 2005
    ..It remains important to resolve the basis of conflicting reports regarding E2-induced Erk1/2 activation due to the potential importance of this pathway on breast cancer and other processes...