Conrad P Quinn

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. pmc Bacillus anthracis' lethal toxin induces broad transcriptional responses in human peripheral monocytes
    Kassidy M Chauncey
    Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
    BMC Immunol 13:33. 2012
  2. pmc A three-dose intramuscular injection schedule of anthrax vaccine adsorbed generates sustained humoral and cellular immune responses to protective antigen and provides long-term protection against inhalation anthrax in rhesus macaques
    Conrad P Quinn
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Vaccine Immunol 19:1730-45. 2012
  3. ncbi request reprint Immune responses to Bacillus anthracis protective antigen in patients with bioterrorism-related cutaneous or inhalation anthrax
    Conrad P Quinn
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA
    J Infect Dis 190:1228-36. 2004
  4. pmc Specific, sensitive, and quantitative enzyme-linked immunosorbent assay for human immunoglobulin G antibodies to anthrax toxin protective antigen
    Conrad P Quinn
    Centers for Desease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 8:1103-10. 2002
  5. pmc Inhalational anthrax outbreak among postal workers, Washington, D.C., 2001
    Puneet K Dewan
    Centers for Desease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 8:1066-72. 2002
  6. pmc Lethal factor toxemia and anti-protective antigen antibody activity in naturally acquired cutaneous anthrax
    Anne E Boyer
    Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Infect Dis 204:1321-7. 2011
  7. doi request reprint Standardized, mathematical model-based and validated in vitro analysis of anthrax lethal toxin neutralization
    Han Li
    Microbial Pathogenesis and Immune Response Laboratory, Meningitis and Vaccine Preventable Diseases Branch, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States
    J Immunol Methods 333:89-106. 2008
  8. pmc Opening a bacillus anthracis-containing envelope, Capitol Hill, Washington, D.C.: the public health response
    Vincent P Hsu
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Emerg Infect Dis 8:1039-43. 2002
  9. ncbi request reprint No evidence of a mild form of inhalational Bacillus anthracis infection during a bioterrorism-related inhalational anthrax outbreak in Washington, D.C., in 2001
    Henry C Baggett
    Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK, USA
    Clin Infect Dis 41:991-7. 2005
  10. doi request reprint Comparison of MALDI-TOF-MS and HPLC-ESI-MS/MS for endopeptidase activity-based quantification of Anthrax lethal factor in serum
    Zsuzsanna Kuklenyik
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, United States
    Anal Chem 83:1760-5. 2011

Detail Information

Publications35

  1. pmc Bacillus anthracis' lethal toxin induces broad transcriptional responses in human peripheral monocytes
    Kassidy M Chauncey
    Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
    BMC Immunol 13:33. 2012
    ..Here, we present the transcriptional responses of LT treated human monocytes in order to further elucidate the mechanisms of LT inhibition on the host immune system...
  2. pmc A three-dose intramuscular injection schedule of anthrax vaccine adsorbed generates sustained humoral and cellular immune responses to protective antigen and provides long-term protection against inhalation anthrax in rhesus macaques
    Conrad P Quinn
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Vaccine Immunol 19:1730-45. 2012
    ..Vaccinated animals surviving inhalation anthrax developed high-magnitude anamnestic anti-PA IgG and TNA responses...
  3. ncbi request reprint Immune responses to Bacillus anthracis protective antigen in patients with bioterrorism-related cutaneous or inhalation anthrax
    Conrad P Quinn
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA
    J Infect Dis 190:1228-36. 2004
    ..Anti-PA IgG is an important diagnostic marker of anthrax, a predictor of serum anti-toxin activity, and a marker of immunological memory against anthrax...
  4. pmc Specific, sensitive, and quantitative enzyme-linked immunosorbent assay for human immunoglobulin G antibodies to anthrax toxin protective antigen
    Conrad P Quinn
    Centers for Desease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 8:1103-10. 2002
    ..The anti-PA ELISAs proved valuable for the confirmation of cases of cutaneous and inhalational anthrax and evaluation of patients in whom the diagnosis of anthrax was being considered...
  5. pmc Inhalational anthrax outbreak among postal workers, Washington, D.C., 2001
    Puneet K Dewan
    Centers for Desease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 8:1066-72. 2002
    ..Prophylaxis was necessary for all employees. To protect postal workers against bioterrorism, measures to reduce the risk of occupational exposure are necessary...
  6. pmc Lethal factor toxemia and anti-protective antigen antibody activity in naturally acquired cutaneous anthrax
    Anne E Boyer
    Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Infect Dis 204:1321-7. 2011
    ..This is the first report of quantitative analysis of serum LF in cutaneous anthrax and the first to associate acute stage toxemia with subsequent antitoxin antibody responses...
  7. doi request reprint Standardized, mathematical model-based and validated in vitro analysis of anthrax lethal toxin neutralization
    Han Li
    Microbial Pathogenesis and Immune Response Laboratory, Meningitis and Vaccine Preventable Diseases Branch, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States
    J Immunol Methods 333:89-106. 2008
    ....
  8. pmc Opening a bacillus anthracis-containing envelope, Capitol Hill, Washington, D.C.: the public health response
    Vincent P Hsu
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Emerg Infect Dis 8:1039-43. 2002
    ..Early nasal swab testing is a useful epidemiologic tool to assess risk of exposure to aerosolized B. anthracis. Early, wide chemoprophylaxis may have averted an outbreak of anthrax in this population...
  9. ncbi request reprint No evidence of a mild form of inhalational Bacillus anthracis infection during a bioterrorism-related inhalational anthrax outbreak in Washington, D.C., in 2001
    Henry C Baggett
    Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK, USA
    Clin Infect Dis 41:991-7. 2005
    ..anthracis infection. We hypothesized that early antibiotic use could have decreased the sensitivity of diagnostic tests or that bioterrorism-related inhalational anthrax may include mild disease...
  10. doi request reprint Comparison of MALDI-TOF-MS and HPLC-ESI-MS/MS for endopeptidase activity-based quantification of Anthrax lethal factor in serum
    Zsuzsanna Kuklenyik
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, United States
    Anal Chem 83:1760-5. 2011
    ..99 (r(2) = 0.997) and -0.25% mean relative difference (±9% standard deviation). This study shows that isotope dilution MALDI-TOF-MS is a robust and precise quantitative MS platform...
  11. pmc Kinetics of lethal factor and poly-D-glutamic acid antigenemia during inhalation anthrax in rhesus macaques
    Anne E Boyer
    Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Infect Immun 77:3432-41. 2009
    ..This study emphasizes the value of LF detection as a tool for early diagnosis of inhalation anthrax before the onset of fulminant systemic infection...
  12. doi request reprint Effects of a reduced dose schedule and intramuscular administration of anthrax vaccine adsorbed on immunogenicity and safety at 7 months: a randomized trial
    Nina Marano
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 300:1532-43. 2008
    ..In 1999, the US Congress directed the Centers for Disease Control and Prevention to conduct a pivotal safety and efficacy study of anthrax vaccine adsorbed (AVA)...
  13. doi request reprint Quantitative assessment of anthrax vaccine immunogenicity using the dried blood spot matrix
    Jarad M Schiffer
    Microbial Pathogenesis and Immune Response Laboratory, Meningitis and Vaccine Preventable Diseases Branch, Division of BacterialDiseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Mail Stop D 01, 1600 Clifton Rd NE, Atlanta, GA 30333, United States
    Biologicals 41:98-103. 2013
    ..We have also developed and validated high-throughput data analysis software to facilitate data handling for large clinical trials and emergency response...
  14. pmc Antibody responses to a spore carbohydrate antigen as a marker of nonfatal inhalation anthrax in rhesus macaques
    Elke Saile
    Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Division of Bacterial Diseases, Atlanta, Georgia 30333, USA
    Clin Vaccine Immunol 18:743-8. 2011
    ..These data suggest that anti-ATS antibody responses may be used to identify aerosol exposure to B. anthracis spores. The anti-ATS antibody responses were detectable during administration of ciprofloxacin...
  15. doi request reprint A two-stage, multilevel quality control system for serological assays in anthrax vaccine clinical trials
    Stephen D Soroka
    Microbial Pathogenesis and Immune Response Laboratory, Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States
    Biologicals 38:675-83. 2010
    ..Assay quality control data establish the functionality of the quality control system and demonstrates the reliability of the serological data generated using these assays...
  16. pmc First case of bioterrorism-related inhalational anthrax in the United States, Palm Beach County, Florida, 2001
    Marc S Traeger
    Centers for Disease Control and Prevention, Atlanta, GA, USA
    Emerg Infect Dis 8:1029-34. 2002
    ..Environmental and nasal swab cultures were useful epidemiologic tools that helped direct the investigation towards the infection source and transmission vehicle. We identified 1,114 persons at risk and offered antimicrobial prophylaxis...
  17. pmc The critical role of pathology in the investigation of bioterrorism-related cutaneous anthrax
    Wun Ju Shieh
    Infectious Disease Pathology Activity, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Pathol 163:1901-10. 2003
    ..anthracis spores were intentionally released through the United States postal system...
  18. ncbi request reprint Detection and quantification of anthrax lethal factor in serum by mass spectrometry
    Anne E Boyer
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, 4770 Buford Highway, NE, Atlanta, Georgia 30341, USA
    Anal Chem 79:8463-70. 2007
    ..This method represents a highly specific and rapid diagnostic tool for early anthrax and has a potential additional role as a research tool for understanding toxemia and effects of medical countermeasures for anthrax...
  19. ncbi request reprint Use of anthrax vaccine in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009
    Jennifer Gordon Wright
    Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, USA
    MMWR Recomm Rep 59:1-30. 2010
    ..anthracis spores...
  20. pmc Rapid, sensitive, and specific lateral-flow immunochromatographic device to measure anti-anthrax protective antigen immunoglobulin g in serum and whole blood
    Raymond E Biagini
    Division of Applied Research and Technology, Biomonitoring and Health Assessment Branch, Biological Monitoring Research Team, CDC NIOSH MS C 26, Robert A Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
    Clin Vaccine Immunol 13:541-6. 2006
    ..This kit has utility in determining anti-PA antibody reactivity in the sera of individuals vaccinated with AVA or individuals with clinical anthrax...
  21. pmc Comparison of a multiplexed fluorescent covalent microsphere immunoassay and an enzyme-linked immunosorbent assay for measurement of human immunoglobulin G antibodies to anthrax toxins
    Raymond E Biagini
    Biological Monitoring Laboratory Section, Biomonitoring and Health Assessment Branch, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA
    Clin Diagn Lab Immunol 11:50-5. 2004
    ....
  22. doi request reprint Quantitative mass spectrometry for bacterial protein toxins--a sensitive, specific, high-throughput tool for detection and diagnosis
    Anne E Boyer
    Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Atlanta, GA 30341, USA
    Molecules 16:2391-413. 2011
    ..We also describe potential applications to diseases of high public health impact, including Clostridium difficile glucosylating toxins and the Bordetella pertussis adenylyl cyclase...
  23. pmc Sensitivity and specificity of serologic assays for detection of human infection with 2009 pandemic H1N1 virus in U.S. populations
    Vic Veguilla
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Centers for Disease Control andPrevention, 2 Atlanta, Georgia 30333, USA
    J Clin Microbiol 49:2210-5. 2011
    ..S. populations during the first pandemic waves. These studies provide an approach to optimize timely serological investigations for future pandemics or outbreaks of novel influenza viruses among humans...
  24. pmc Investigation of bioterrorism-related anthrax, United States, 2001: epidemiologic findings
    Daniel B Jernigan
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Emerg Infect Dis 8:1019-28. 2002
    ..Continued vigilance for cases is needed among health-care providers and members of the public health and law enforcement communities...
  25. doi request reprint Effect of reduced dose schedules and intramuscular injection of anthrax vaccine adsorbed on immunological response and safety profile: A randomized trial
    Jennifer G Wright
    Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, United States Electronic address
    Vaccine 32:1019-28. 2014
    ..AVA's originally licensed schedule was 6 subcutaneous (SQ) priming injections administered at months (m) 0, 0.5, 1, 6, 12 and 18 with annual boosters; a simpler schedule is desired...
  26. pmc Chemical synthesis and immunological properties of oligosaccharides derived from the vegetative cell wall of Bacillus anthracis
    Mahalakshmi Vasan
    Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA
    Chembiochem 9:1716-20. 2008
  27. ncbi request reprint Anthrax lethal toxin paralyzes neutrophil actin-based motility
    Russell L During
    Department of Medicine Infectious Diseases, University of Florida, Gainesville, FL 32610, USA
    J Infect Dis 192:837-45. 2005
    ..We conclude that 2 h of exposure to LT markedly impairs PMN actin assembly, and reductions in actin filament content are accompanied by a profound paralysis of PMN chemotaxis...
  28. ncbi request reprint A case of naturally acquired inhalation anthrax: clinical care and analyses of anti-protective antigen immunoglobulin G and lethal factor
    James J Walsh
    Section of Pulmonary and Critical Care Medicine, Guthrie Clinic, Sayre, PA, USA
    Clin Infect Dis 44:968-71. 2007
    ..Clinical correlation of serologic assays for the lethal factor component of lethal toxin and anti-protective antigen immunoglobulin G are also presented...
  29. pmc Human monoclonal antibodies against anthrax lethal factor and protective antigen act independently to protect against Bacillus anthracis infection and enhance endogenous immunity to anthrax
    Mark T Albrecht
    Biological Defense Research Directorate, Naval Medical Research Center, 12300 Washington Ave, Silver Spring, MD 20910 7500, USA
    Infect Immun 75:5425-33. 2007
    ..Based on these results, IQNPA and IQNLF act independently during prophylactic anthrax treatment and do not interfere with the establishment of endogenous immunity...
  30. pmc Interlaboratory comparison of results of an anthrax lethal toxin neutralization assay for assessment of functional antibodies in multiple species
    Kristian S Omland
    Precision Bioassay, Burlington, Vermont, USA
    Clin Vaccine Immunol 15:946-53. 2008
    ..This study demonstrates that the TNA is a panspecies assay that can be performed in several different laboratories with a high degree of quantitative agreement and precision...
  31. pmc Application of in vivo induced antigen technology (IVIAT) to Bacillus anthracis
    Sean M Rollins
    Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 3:e1824. 2008
    ..anthracis infection. Identification of L-alanine amidases with B. anthracis specificity may suggest new potential therapeutic targets...
  32. ncbi request reprint Synthesis and antigenic analysis of the BclA glycoprotein oligosaccharide from the Bacillus anthracis exosporium
    Alok S Mehta
    Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA
    Chemistry 12:9136-49. 2006
    ..Collectively these data provide an important proof-of-concept step in the synthesis and development of spore-specific reagents for detection and targeting of non-protein structures in B. anthracis...
  33. ncbi request reprint The structure of the major cell wall polysaccharide of Bacillus anthracis is species-specific
    Biswa Choudhury
    Complex Carbohydrate Research Center, University of Georgia, Athens, 30602, USA
    J Biol Chem 281:27932-41. 2006
    ..cereus ATCC 14579. The presence of a B. anthracis-specific polysaccharide structure in its vegetative cell wall is discussed with regard to its relationship to those of other Bacillus species...
  34. ncbi request reprint Transcriptional analysis of protective antigen-stimulated PBMC from non-human primates vaccinated with the anthrax vaccine absorbed
    James V Rogers
    Battelle Memorial Institute, 505 King Avenue, JM 7, Columbus, OH 43201, USA
    Vaccine 24:3609-17. 2006
    ..Results were corroborated for several genes by real-time RT-PCR. This study provides information on the potential underlying transcriptional mechanisms in the immune response to PA in AVA-vaccinated rhesus macaques...
  35. pmc Cell wall carbohydrate compositions of strains from the Bacillus cereus group of species correlate with phylogenetic relatedness
    Christine Leoff
    Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA
    J Bacteriol 190:112-21. 2008
    ..When plasmid pXO2 was absent, the ManNAc/Gal ratio decreased, while the Glc/Gal ratio increased. Also, deletion of atxA, a global regulatory gene, from a pXO2- strain resulted in cell walls with an even greater level of Glc...