Research Topics
| Conrad P QuinnSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
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Detail Information
Publications
A three-dose intramuscular injection schedule of anthrax vaccine adsorbed generates sustained humoral and cellular immune responses to protective antigen and provides long-term protection against inhalation anthrax in rhesus macaquesConrad P Quinn
Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Clin Vaccine Immunol 19:1730-45. 2012..Vaccinated animals surviving inhalation anthrax developed high-magnitude anamnestic anti-PA IgG and TNA responses...
Immune responses to Bacillus anthracis protective antigen in patients with bioterrorism-related cutaneous or inhalation anthraxConrad P Quinn
Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA
J Infect Dis 190:1228-36. 2004..Anti-PA IgG is an important diagnostic marker of anthrax, a predictor of serum anti-toxin activity, and a marker of immunological memory against anthrax...- Specific, sensitive, and quantitative enzyme-linked immunosorbent assay for human immunoglobulin G antibodies to anthrax toxin protective antigenConrad P Quinn
Centers for Desease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 8:1103-10. 2002..The anti-PA ELISAs proved valuable for the confirmation of cases of cutaneous and inhalational anthrax and evaluation of patients in whom the diagnosis of anthrax was being considered... - Inhalational anthrax outbreak among postal workers, Washington, D.C., 2001Puneet K Dewan
Centers for Desease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 8:1066-72. 2002..Prophylaxis was necessary for all employees. To protect postal workers against bioterrorism, measures to reduce the risk of occupational exposure are necessary... - Lethal factor toxemia and anti-protective antigen antibody activity in naturally acquired cutaneous anthraxAnne E Boyer
Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
J Infect Dis 204:1321-7. 2011..This is the first report of quantitative analysis of serum LF in cutaneous anthrax and the first to associate acute stage toxemia with subsequent antitoxin antibody responses... 
Standardized, mathematical model-based and validated in vitro analysis of anthrax lethal toxin neutralizationHan Li
Microbial Pathogenesis and Immune Response Laboratory, Meningitis and Vaccine Preventable Diseases Branch, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States
J Immunol Methods 333:89-106. 2008....- Opening a bacillus anthracis-containing envelope, Capitol Hill, Washington, D.C.: the public health responseVincent P Hsu
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Emerg Infect Dis 8:1039-43. 2002..Early nasal swab testing is a useful epidemiologic tool to assess risk of exposure to aerosolized B. anthracis. Early, wide chemoprophylaxis may have averted an outbreak of anthrax in this population... - No evidence of a mild form of inhalational Bacillus anthracis infection during a bioterrorism-related inhalational anthrax outbreak in Washington, D.C., in 2001Henry C Baggett
Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK, USA
Clin Infect Dis 41:991-7. 2005..anthracis infection. We hypothesized that early antibiotic use could have decreased the sensitivity of diagnostic tests or that bioterrorism-related inhalational anthrax may include mild disease... - Comparison of MALDI-TOF-MS and HPLC-ESI-MS/MS for endopeptidase activity-based quantification of Anthrax lethal factor in serumZsuzsanna Kuklenyik
National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, United States
Anal Chem 83:1760-5. 2011..99 (r(2) = 0.997) and -0.25% mean relative difference (±9% standard deviation). This study shows that isotope dilution MALDI-TOF-MS is a robust and precise quantitative MS platform... - Kinetics of lethal factor and poly-D-glutamic acid antigenemia during inhalation anthrax in rhesus macaquesAnne E Boyer
Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Infect Immun 77:3432-41. 2009..This study emphasizes the value of LF detection as a tool for early diagnosis of inhalation anthrax before the onset of fulminant systemic infection... - A two-stage, multilevel quality control system for serological assays in anthrax vaccine clinical trialsStephen D Soroka
Microbial Pathogenesis and Immune Response Laboratory, Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States
Biologicals 38:675-83. 2010..Assay quality control data establish the functionality of the quality control system and demonstrates the reliability of the serological data generated using these assays... - First case of bioterrorism-related inhalational anthrax in the United States, Palm Beach County, Florida, 2001Marc S Traeger
Centers for Disease Control and Prevention, Atlanta, GA, USA
Emerg Infect Dis 8:1029-34. 2002..Environmental and nasal swab cultures were useful epidemiologic tools that helped direct the investigation towards the infection source and transmission vehicle. We identified 1,114 persons at risk and offered antimicrobial prophylaxis... - Antibody responses to a spore carbohydrate antigen as a marker of nonfatal inhalation anthrax in rhesus macaquesElke Saile
Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Division of Bacterial Diseases, Atlanta, Georgia 30333, USA
Clin Vaccine Immunol 18:743-8. 2011..These data suggest that anti-ATS antibody responses may be used to identify aerosol exposure to B. anthracis spores. The anti-ATS antibody responses were detectable during administration of ciprofloxacin... - Effects of a reduced dose schedule and intramuscular administration of anthrax vaccine adsorbed on immunogenicity and safety at 7 months: a randomized trialNina Marano
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
JAMA 300:1532-43. 2008..In 1999, the US Congress directed the Centers for Disease Control and Prevention to conduct a pivotal safety and efficacy study of anthrax vaccine adsorbed (AVA)... - The critical role of pathology in the investigation of bioterrorism-related cutaneous anthraxWun-Ju Shieh
Infectious Disease Pathology Activity, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Am J Pathol 163:1901-10. 2003..anthracis spores were intentionally released through the United States postal system... - Detection and quantification of anthrax lethal factor in serum by mass spectrometryAnne E Boyer
Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, 4770 Buford Highway, NE, Atlanta, Georgia 30341, USA
Anal Chem 79:8463-70. 2007..This method represents a highly specific and rapid diagnostic tool for early anthrax and has a potential additional role as a research tool for understanding toxemia and effects of medical countermeasures for anthrax... - Rapid, sensitive, and specific lateral-flow immunochromatographic device to measure anti-anthrax protective antigen immunoglobulin g in serum and whole bloodRaymond E Biagini
Division of Applied Research and Technology, Biomonitoring and Health Assessment Branch, Biological Monitoring Research Team, CDC NIOSH MS C 26, Robert A Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Clin Vaccine Immunol 13:541-6. 2006..This kit has utility in determining anti-PA antibody reactivity in the sera of individuals vaccinated with AVA or individuals with clinical anthrax... - Use of anthrax vaccine in the United States: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2009Jennifer Gordon Wright
Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, USA
MMWR Recomm Rep 59:1-30. 2010..anthracis spores... - Comparison of a multiplexed fluorescent covalent microsphere immunoassay and an enzyme-linked immunosorbent assay for measurement of human immunoglobulin G antibodies to anthrax toxinsRaymond E Biagini
Biological Monitoring Laboratory Section, Biomonitoring and Health Assessment Branch, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA
Clin Diagn Lab Immunol 11:50-5. 2004.... - Quantitative mass spectrometry for bacterial protein toxins--a sensitive, specific, high-throughput tool for detection and diagnosisAnne E Boyer
Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Atlanta, GA 30341, USA
Molecules 16:2391-413. 2011..We also describe potential applications to diseases of high public health impact, including Clostridium difficile glucosylating toxins and the Bordetella pertussis adenylyl cyclase... - Quantitative assessment of anthrax vaccine immunogenicity using the dried blood spot matrixJarad M Schiffer
Microbial Pathogenesis and Immune Response Laboratory, Meningitis and Vaccine Preventable Diseases Branch, Division of BacterialDiseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Mail Stop D 01, 1600 Clifton Rd NE, Atlanta, GA 30333, United States
Biologicals 41:98-103. 2013..We have also developed and validated high-throughput data analysis software to facilitate data handling for large clinical trials and emergency response... - Investigation of bioterrorism-related anthrax, United States, 2001: epidemiologic findingsDaniel B Jernigan
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Emerg Infect Dis 8:1019-28. 2002..Continued vigilance for cases is needed among health-care providers and members of the public health and law enforcement communities... - Sensitivity and specificity of serologic assays for detection of human infection with 2009 pandemic H1N1 virus in U.S. populationsVic Veguilla
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Centers for Disease Control andPrevention, 2 Atlanta, Georgia 30333, USA
J Clin Microbiol 49:2210-5. 2011..S. populations during the first pandemic waves. These studies provide an approach to optimize timely serological investigations for future pandemics or outbreaks of novel influenza viruses among humans... - Anthrax lethal toxin paralyzes neutrophil actin-based motilityRussell L During
Department of Medicine/Infectious Diseases, University of Florida, Gainesville, FL 32610, USA
J Infect Dis 192:837-45. 2005..We conclude that 2 h of exposure to LT markedly impairs PMN actin assembly, and reductions in actin filament content are accompanied by a profound paralysis of PMN chemotaxis... - A case of naturally acquired inhalation anthrax: clinical care and analyses of anti-protective antigen immunoglobulin G and lethal factorJames J Walsh
Section of Pulmonary and Critical Care Medicine, Guthrie Clinic, Sayre, PA, USA
Clin Infect Dis 44:968-71. 2007..Clinical correlation of serologic assays for the lethal factor component of lethal toxin and anti-protective antigen immunoglobulin G are also presented... - Human monoclonal antibodies against anthrax lethal factor and protective antigen act independently to protect against Bacillus anthracis infection and enhance endogenous immunity to anthraxMark T Albrecht
Biological Defense Research Directorate, Naval Medical Research Center, 12300 Washington Ave, Silver Spring, MD 20910 7500, USA
Infect Immun 75:5425-33. 2007..Based on these results, IQNPA and IQNLF act independently during prophylactic anthrax treatment and do not interfere with the establishment of endogenous immunity... - Chemical synthesis and immunological properties of oligosaccharides derived from the vegetative cell wall of Bacillus anthracisMahalakshmi Vasan
Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA
Chembiochem 9:1716-20. 2008 - Interlaboratory comparison of results of an anthrax lethal toxin neutralization assay for assessment of functional antibodies in multiple speciesKristian S Omland
Precision Bioassay, Burlington, Vermont, USA
Clin Vaccine Immunol 15:946-53. 2008..This study demonstrates that the TNA is a panspecies assay that can be performed in several different laboratories with a high degree of quantitative agreement and precision... - Cell wall carbohydrate compositions of strains from the Bacillus cereus group of species correlate with phylogenetic relatednessChristine Leoff
Complex Carbohydrate Research Center, University of Georgia, Athens, GA 30602, USA
J Bacteriol 190:112-21. 2008..When plasmid pXO2 was absent, the ManNAc/Gal ratio decreased, while the Glc/Gal ratio increased. Also, deletion of atxA, a global regulatory gene, from a pXO2- strain resulted in cell walls with an even greater level of Glc... - Synthesis and antigenic analysis of the BclA glycoprotein oligosaccharide from the Bacillus anthracis exosporiumAlok S Mehta
Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA
Chemistry 12:9136-49. 2006..Collectively these data provide an important proof-of-concept step in the synthesis and development of spore-specific reagents for detection and targeting of non-protein structures in B. anthracis... - The structure of the major cell wall polysaccharide of Bacillus anthracis is species-specificBiswa Choudhury
Complex Carbohydrate Research Center, University of Georgia, Athens, 30602, USA
J Biol Chem 281:27932-41. 2006..cereus ATCC 14579. The presence of a B. anthracis-specific polysaccharide structure in its vegetative cell wall is discussed with regard to its relationship to those of other Bacillus species... - Application of in vivo induced antigen technology (IVIAT) to Bacillus anthracisSean M Rollins
Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS ONE 3:e1824. 2008..anthracis infection. Identification of L-alanine amidases with B. anthracis specificity may suggest new potential therapeutic targets... - Transcriptional analysis of protective antigen-stimulated PBMC from non-human primates vaccinated with the anthrax vaccine absorbedJames V Rogers
Battelle Memorial Institute, 505 King Avenue, JM-7, Columbus, OH 43201, USA
Vaccine 24:3609-17. 2006..Results were corroborated for several genes by real-time RT-PCR. This study provides information on the potential underlying transcriptional mechanisms in the immune response to PA in AVA-vaccinated rhesus macaques...