Yong Qian

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi request reprint Cdc42 regulates arsenic-induced NADPH oxidase activation and cell migration through actin filament reorganization
    Yong Qian
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 280:3875-84. 2005
  2. ncbi request reprint Hydrogen peroxide formation and actin filament reorganization by Cdc42 are essential for ethanol-induced in vitro angiogenesis
    Yong Qian
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Biol Chem 278:16189-97. 2003
  3. pmc Perfluorooctane sulfonate (PFOS) induces reactive oxygen species (ROS) production in human microvascular endothelial cells: role in endothelial permeability
    Yong Qian
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 2888, USA
    J Toxicol Environ Health A 73:819-36. 2010
  4. ncbi request reprint ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling
    Yong Qian
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26506, USA
    Oncogene 24:3154-65. 2005
  5. ncbi request reprint Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity
    Yong Qian
    The Mary Babb Randolph Cancer Center and the Department of Microbiology and Immunology, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    J Cell Biochem 91:602-20. 2004
  6. pmc System-based identification of toxicity pathways associated with multi-walled carbon nanotube-induced pathological responses
    Brandi N Snyder-Talkington
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 272:476-89. 2013
  7. ncbi request reprint Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity
    Min Ding
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 281:17359-68. 2006
  8. ncbi request reprint PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration
    Yong Qian
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health NIH, Morgantown, WV 26506, USA
    Am J Physiol Cell Physiol 286:C153-63. 2004
  9. ncbi request reprint Hydrogen peroxide formation and actin filament reorganization by Cdc42 are essential for ethanol-induced in vitro angiogenesis
    Yong Qian
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Nihon Arukoru Yakubutsu Igakkai Zasshi 42:605-9. 2007
  10. pmc Multi-walled carbon nanotubes induce human microvascular endothelial cellular effects in an alveolar-capillary co-culture with small airway epithelial cells
    Brandi N Snyder-Talkington
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505 2888, USA
    Part Fibre Toxicol 10:35. 2013

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Cdc42 regulates arsenic-induced NADPH oxidase activation and cell migration through actin filament reorganization
    Yong Qian
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 280:3875-84. 2005
    ..Taken together, the results indicate that arsenic is able to activate NADPH oxidase through Cdc42-mediated actin filament reorganization, leading to the induction of an increase in cell migration in SVEC4-10 endothelial cells...
  2. ncbi request reprint Hydrogen peroxide formation and actin filament reorganization by Cdc42 are essential for ethanol-induced in vitro angiogenesis
    Yong Qian
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Biol Chem 278:16189-97. 2003
    ..Taken together, our results suggest that ethanol stimulation can induce H(2)O(2) production through the activation of Cdc42, which results in reorganizing actin filaments and increasing cell motility and in vitro angiogenesis...
  3. pmc Perfluorooctane sulfonate (PFOS) induces reactive oxygen species (ROS) production in human microvascular endothelial cells: role in endothelial permeability
    Yong Qian
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 2888, USA
    J Toxicol Environ Health A 73:819-36. 2010
    ..The results generated from this study may provide a new insight into the potential adverse effects of PFOS exposure on humans at the cellular level...
  4. ncbi request reprint ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling
    Yong Qian
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26506, USA
    Oncogene 24:3154-65. 2005
    ..Taken together, our results identify a mechanism through which ILK can regulate both integrin-associated rearrangements of actin filaments and cell migration and invasion at the integrin receptor-proximal region...
  5. ncbi request reprint Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity
    Yong Qian
    The Mary Babb Randolph Cancer Center and the Department of Microbiology and Immunology, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    J Cell Biochem 91:602-20. 2004
    ..We hypothesize that the intrinsic ability of AFAP-110 to crosslink actin filaments or activate cSrc are distinct functions...
  6. pmc System-based identification of toxicity pathways associated with multi-walled carbon nanotube-induced pathological responses
    Brandi N Snyder-Talkington
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 272:476-89. 2013
    ....
  7. ncbi request reprint Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity
    Min Ding
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 281:17359-68. 2006
    ..These finding demonstrate for the first time that a purified compound of anthocyanin inhibits tumor promoter-induced carcinogenesis and tumor metastasis in vivo...
  8. ncbi request reprint PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration
    Yong Qian
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health NIH, Morgantown, WV 26506, USA
    Am J Physiol Cell Physiol 286:C153-63. 2004
    ..These results demonstrate that activation of PI3K activity alone is sufficient to remodel actin filaments to increase cell migration through the activation of Akt and p70S6K1 in CEF cells...
  9. ncbi request reprint Hydrogen peroxide formation and actin filament reorganization by Cdc42 are essential for ethanol-induced in vitro angiogenesis
    Yong Qian
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Nihon Arukoru Yakubutsu Igakkai Zasshi 42:605-9. 2007
  10. pmc Multi-walled carbon nanotubes induce human microvascular endothelial cellular effects in an alveolar-capillary co-culture with small airway epithelial cells
    Brandi N Snyder-Talkington
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505 2888, USA
    Part Fibre Toxicol 10:35. 2013
    ..This study aimed to determine if an alveolar-capillary co-culture model could determine changes in the vascular endothelium after epithelial exposure to MWCNT...
  11. pmc A breast cancer prognostic signature predicts clinical outcomes in multiple tumor types
    Ying Wooi Wan
    Mary Babb Randolph Cancer Center Community Medicine, West Virginia University, Morgantown, WV 26506 9300, USA
    Oncol Rep 24:489-94. 2010
    ....
  12. pmc A population-based gene signature is predictive of breast cancer survival and chemoresponse
    Shruti Rathnagiriswaran
    Mary Babb Randolph Cancer Center, Morgantown, WV 26506 9300, USA
    Int J Oncol 36:607-16. 2010
    ..This study confirmed the prognostic applicability of the breast cancer gene signature in a broad clinical setting. This prognostic signature is also predictive of drug response in cancer cell lines...
  13. pmc Confirmation of gene expression-based prediction of survival in non-small cell lung cancer
    Nancy L Guo
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    Clin Cancer Res 14:8213-20. 2008
    ..Accurate gene expression signatures are needed to classify patients into high- and low-risk groups to improve the selection of patients for adjuvant therapy...
  14. pmc Systematic analysis of multiwalled carbon nanotube-induced cellular signaling and gene expression in human small airway epithelial cells
    Brandi N Snyder-Talkington
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Toxicol Sci 133:79-89. 2013
    ..Gene expression data derived from MWCNT exposure provide information that may be used to elucidate the underlying mode of action of MWCNT in the small airway and suggest potential prognostic gene signatures for risk assessment...
  15. pmc An integrative genomic and proteomic approach to chemosensitivity prediction
    Yan Ma
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506 9300, USA
    Int J Oncol 34:107-15. 2009
    ..This study presents a new analytical framework to identify integrated gene and protein expression signatures for predicting cellular behavior and clinical outcome in general...
  16. ncbi request reprint Population-based molecular prognosis of breast cancer by transcriptional profiling
    Yan Ma
    Mary Babb Randolph Cancer Center, Department of Statistics, Division of Hematology, West Virginia University, Morgantown, WV 26506 9300, USA
    Clin Cancer Res 13:2014-22. 2007
    ..The purpose of this study is to predict breast cancer recurrence and metastases and to identify gene signatures indicative of clinicopathologic characteristics using gene expression patterns derived from cDNA microarray...
  17. pmc Multiwalled carbon nanotube-induced gene signatures in the mouse lung: potential predictive value for human lung cancer risk and prognosis
    Nancy L Guo
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia, USA
    J Toxicol Environ Health A 75:1129-53. 2012
    ..These results may lead to development of a surveillance approach for early detection of lung cancer and prognosis associated with MWCNT in the workplace...
  18. pmc The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells
    Maricica Pacurari
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26505, USA
    Int J Oncol 43:548-60. 2013
    ..These results provide new insights into miR-200 regulation in lung cancer metastasis and consequent clinical outcome, and may provide a potential basis for innovative therapeutic approaches for the treatment of this deadly disease...
  19. ncbi request reprint Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid
    Rentian Feng
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 280:27888-95. 2005
    ....
  20. pmc A smoking-associated 7-gene signature for lung cancer diagnosis and prognosis
    Ying Wooi Wan
    Mary Randolph Cancer Center, West Virginia University, Morgantown, WV 26506, USA
    Int J Oncol 41:1387-96. 2012
    ....
  21. pmc New perspectives for in vitro risk assessment of multiwalled carbon nanotubes: application of coculture and bioinformatics
    Brandi N Snyder-Talkington
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Toxicol Environ Health B Crit Rev 15:468-92. 2012
    ....
  22. ncbi request reprint New perspectives in arsenic-induced cell signal transduction
    Yong Qian
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26506, USA
    J Inorg Biochem 96:271-8. 2003
    ..This review focuses on recent advances in arsenic-induced signal transduction, including reactive oxygen species (ROS) production, tyrosine phosphorylation, MAPK signaling, NF-kappaB activation, cell cycle arrest, and apoptosis...
  23. ncbi request reprint Protein expression levels of the Src activating protein AFAP are developmentally regulated in brain
    David A Clump
    The Mary Babb Randolph Cancer Center and the Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    J Neurobiol 54:473-85. 2003
    ....
  24. pmc Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling
    Patrick L Apopa
    The Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Part Fibre Toxicol 6:1. 2009
    ..abstract:..
  25. pmc AFAP1L1 is a novel adaptor protein of the AFAP family that interacts with cortactin and localizes to invadosomes
    Brandi N Snyder
    The Mary Babb Randolph Cancer Center and the Department of Cancer Cell Biology, West Virginia University, Morgantown, WV 26505, USA
    Eur J Cell Biol 90:376-89. 2011
    ....
  26. doi request reprint Perfluoroalkyl acids including perfluorooctane sulfonate and perfluorohexane sulfonate in firefighters
    Chuanfang Jin
    Institute for Occupational and Environmental Health and West Virginia University School of Medicine, Department of Community Medicine, Morgantown, WV 26506, USA
    J Occup Environ Med 53:324-8. 2011
    ..The objective of the study is to evaluate serum concentrations of perfluoroalkyl acids (PFAAs) in firefighters...
  27. ncbi request reprint Constructing molecular classifiers for the accurate prognosis of lung adenocarcinoma
    Lan Guo
    Mary Babb Randolph Cancer Center, Department of Community Medicine, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    Clin Cancer Res 12:3344-54. 2006
    ..Here, we propose a computational model system which accurately predicts the clinical outcome of individual patients based on their gene expression profiles...
  28. ncbi request reprint Activation of JNK by vanadate induces a Fas-associated death domain (FADD)-dependent death of cerebellar granule progenitors in vitro
    Jia Luo
    Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Robert C Byrd Health Science Center, Morgantown, West Virginia 26506, USA
    J Biol Chem 278:4542-51. 2003
    ..Thus, JNK signaling plays a major role in vanadate-mediated activation of the Fas-FADD-caspase-8 pathway that accounts for vanadate-induced apoptosis of CGPs...
  29. pmc PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments
    Yong Qian
    The Mary Babb Randolph Cancer Center and the Department of Microbiology and Immunology, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    Mol Biol Cell 13:2311-22. 2002
    ....