Research Topics
Genomes and GenesSpecies | Dale W PorterSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
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Publications
Pulmonary toxicity of Expancel microspheres in the ratDale W Porter
National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA
Toxicol Pathol 35:702-14. 2007..lung (supplementary Figure 1); broncholar epithelium 28 days following exposure to 551 DE 20 microspheres (supplementary Figure 2); membrane ruffling and some instances of phagocytosis within the microspheres (supplementary Figure 3)]..- Enhanced nitric oxide and reactive oxygen species production and damage after inhalation of silicaDale W Porter
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
Am J Physiol Lung Cell Mol Physiol 283:L485-93. 2002.... 
Differential mouse pulmonary dose and time course responses to titanium dioxide nanospheres and nanobeltsDale W Porter
National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Toxicol Sci 131:179-93. 2013..In summary, our data indicate that TiO(2) NP shape alters pulmonary responses, with severity of responses being ranked as NS < NB1 < NB2...- Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodelingPatrick L Apopa
The Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Part Fibre Toxicol 6:1. 2009..abstract:.. - PGJ2 inhibition of LPS-induced inflammatory mediator expression from rat alveolar macrophagesDale W Porter
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
J Toxicol Environ Health A 70:1967-76. 2007..Thus, data in this study established that PGJ2 inhibited LPS-induced inflammatory mediator production in rat AM, and this inhibition is mediated, at least in part, by reducing the expression of NF-kappaB mRNA... 
Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubesDale W Porter
National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Toxicology 269:136-47. 2010..Furthermore, the observation that MWCNT reach the pleura after aspiration exposure indicates that more extensive investigations are needed to fully assess if pleural penetration results in any adverse health outcomes...- Nitric oxide and reactive oxygen species production causes progressive damage in rats after cessation of silica inhalationDale W Porter
National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505, USA
Toxicol Sci 90:188-97. 2006..Future studies will be needed to determine whether the progressive oxidative stress, and iNOS activation and NO production, is a direct result of silica lung burden or a consequence of silica-induced biochemical mediators... - Progression of lung inflammation and damage in rats after cessation of silica inhalationDale W Porter
National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA
Toxicol Sci 79:370-80. 2004.... - Comparative pulmonary toxicity of blasting sand and five substitute abrasive blasting agentsDale W Porter
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, M S 2015, Morgantown, WV 26505, USA
J Toxicol Environ Health A 65:1121-40. 2002..Notwithstanding, the data also suggest that chronic exposure to steel grit may pose a health risk due to its effects on epithelial cell proliferation in the lung... - Comparison of low doses of aged and freshly fractured silica on pulmonary inflammation and damage in the ratDale W Porter
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, National Institutes of Health, 1095 Willowdale Road, M S 2015, Morgantown, WV 26505, USA
Toxicology 175:63-71. 2002.... - Time course of pulmonary response of rats to inhalation of crystalline silica: NF-kappa B activation, inflammation, cytokine production, and damageDale W Porter
National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA
Inhal Toxicol 14:349-67. 2002..This suggests that NF-kappa B activation in BAL cells may play an important role in the initiation and progression of silica-induced pulmonary inflammation, cellular damage, and fibrosis... 
Systemic microvascular dysfunction and inflammation after pulmonary particulate matter exposureTimothy R Nurkiewicz
Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9229, USA
Environ Health Perspect 114:412-9. 2006..Collectively, these microvascular observations are consistent with events that contribute to the disruption of the control of peripheral resistance and/or cardiac dysfunction associated with PM exposure...- Exposure to particulate 1-->3-beta-glucans induces greater pulmonary toxicity than soluble 1-->3-beta-glucans in ratsShih Houng Young
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS 2027, Morgantown, WV 26505, USA
J Toxicol Environ Health A 66:25-38. 2003..Therefore, results demonstrate that particulate zymosan A is more potent in inducing pulmonary inflammation and damage in rats than the soluble form of this beta-glucan... - Pulmonary nanoparticle exposure disrupts systemic microvascular nitric oxide signalingTimothy R Nurkiewicz
Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
Toxicol Sci 110:191-203. 2009..These results indicate that in conjunction with microvascular dysfunction, nanoparticle exposure also decreases NO bioavailability through at least two functionally distinct mechanisms that may mutually increase local reactive species... - Response of alveolar macrophages from inducible nitric oxide synthase knockout or wild-type mice to an in vitro lipopolysaccharide or silica exposurePatti C Zeidler
Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26505, USA
J Toxicol Environ Health A 66:995-1013. 2003..In addition, LPS induced TNF-รก and MIP-2 production tend to be higher in AMs from iNOS KO mice. Such compensatory changes in the AM response may affect the response of iNOS KO mice to inflammatory exposures... - Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubesRobert R Mercer
Pathology and Physiology Research Branch, HELD, NIOSH, Morgantown, WV, USA
Part Fibre Toxicol 8:21. 2011..Morphometric measurement of Sirius Red staining was used to assess the connective tissue response... - Distribution and persistence of pleural penetrations by multi-walled carbon nanotubesRobert R Mercer
Pathology and Physiology Research Branch, HELD, NIOSH, Morgantown, WV, USA
Part Fibre Toxicol 7:28. 2010.... - Modified endotoxin responses in rats pretreated with 1-->3-beta-glucan (zymosan A)Shih-Houng Young
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Toxicol Appl Pharmacol 178:172-9. 2002..These results suggest that complex interaction of components may exist in exposure to organic dusts. Therefore, hazard may not be defined by measuring endotoxin or 1-->3-beta-glucans alone... - Multi-walled carbon nanotubes: sampling criteria and aerosol characterizationBean T Chen
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505 2888, USA
Inhal Toxicol 24:798-820. 2012..The measurement scheme should be relevant for any carbon nanotube aerosol... - The sources of inflammatory mediators in the lung after silica exposureK Murali Krishna Rao
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
Environ Health Perspect 112:1679-86. 2004..Identification of the intercellular communication in vivo is still unresolved. However, fibroblasts appear to be an important source of inflammatory mediators in the lung... - Multiwalled carbon nanotube-induced gene signatures in the mouse lung: potential predictive value for human lung cancer risk and prognosisNancy L Guo
Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia, USA
J Toxicol Environ Health A 75:1129-53. 2012..These results may lead to development of a surveillance approach for early detection of lung cancer and prognosis associated with MWCNT in the workplace... - Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunctionTimothy R Nurkiewicz
Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, WV, USA
Part Fibre Toxicol 5:1. 2008..abstract:.. - Particulate matter exposure impairs systemic microvascular endothelium-dependent dilationTimothy R Nurkiewicz
Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9229, USA
Environ Health Perspect 112:1299-306. 2004.... - Cell- and isoform-specific increases in arginase expression in acute silica-induced pulmonary inflammationMirjana Poljakovic
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Toxicol Environ Health A 70:118-27. 2007....