Dale W Porter

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi request reprint Pulmonary toxicity of Expancel microspheres in the rat
    Dale W Porter
    National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA
    Toxicol Pathol 35:702-14. 2007
  2. ncbi request reprint Enhanced nitric oxide and reactive oxygen species production and damage after inhalation of silica
    Dale W Porter
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    Am J Physiol Lung Cell Mol Physiol 283:L485-93. 2002
  3. pmc Differential mouse pulmonary dose and time course responses to titanium dioxide nanospheres and nanobelts
    Dale W Porter
    National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Toxicol Sci 131:179-93. 2013
  4. pmc Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling
    Patrick L Apopa
    The Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Part Fibre Toxicol 6:1. 2009
  5. doi request reprint Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes
    Dale W Porter
    National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicology 269:136-47. 2010
  6. ncbi request reprint PGJ2 inhibition of LPS-induced inflammatory mediator expression from rat alveolar macrophages
    Dale W Porter
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 70:1967-76. 2007
  7. ncbi request reprint Nitric oxide and reactive oxygen species production causes progressive damage in rats after cessation of silica inhalation
    Dale W Porter
    National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505, USA
    Toxicol Sci 90:188-97. 2006
  8. ncbi request reprint Progression of lung inflammation and damage in rats after cessation of silica inhalation
    Dale W Porter
    National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA
    Toxicol Sci 79:370-80. 2004
  9. ncbi request reprint Time course of pulmonary response of rats to inhalation of crystalline silica: NF-kappa B activation, inflammation, cytokine production, and damage
    Dale W Porter
    National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA
    Inhal Toxicol 14:349-67. 2002
  10. ncbi request reprint Comparative pulmonary toxicity of blasting sand and five substitute abrasive blasting agents
    Dale W Porter
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, M S 2015, Morgantown, WV 26505, USA
    J Toxicol Environ Health A 65:1121-40. 2002

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Pulmonary toxicity of Expancel microspheres in the rat
    Dale W Porter
    National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA
    Toxicol Pathol 35:702-14. 2007
    ..lung (supplementary Figure 1); broncholar epithelium 28 days following exposure to 551 DE 20 microspheres (supplementary Figure 2); membrane ruffling and some instances of phagocytosis within the microspheres (supplementary Figure 3)]..
  2. ncbi request reprint Enhanced nitric oxide and reactive oxygen species production and damage after inhalation of silica
    Dale W Porter
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    Am J Physiol Lung Cell Mol Physiol 283:L485-93. 2002
    ....
  3. pmc Differential mouse pulmonary dose and time course responses to titanium dioxide nanospheres and nanobelts
    Dale W Porter
    National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Toxicol Sci 131:179-93. 2013
    ..In summary, our data indicate that TiO(2) NP shape alters pulmonary responses, with severity of responses being ranked as NS < NB1 < NB2...
  4. pmc Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling
    Patrick L Apopa
    The Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Part Fibre Toxicol 6:1. 2009
    ..abstract:..
  5. doi request reprint Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes
    Dale W Porter
    National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicology 269:136-47. 2010
    ..Furthermore, the observation that MWCNT reach the pleura after aspiration exposure indicates that more extensive investigations are needed to fully assess if pleural penetration results in any adverse health outcomes...
  6. ncbi request reprint PGJ2 inhibition of LPS-induced inflammatory mediator expression from rat alveolar macrophages
    Dale W Porter
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 70:1967-76. 2007
    ..Thus, data in this study established that PGJ2 inhibited LPS-induced inflammatory mediator production in rat AM, and this inhibition is mediated, at least in part, by reducing the expression of NF-kappaB mRNA...
  7. ncbi request reprint Nitric oxide and reactive oxygen species production causes progressive damage in rats after cessation of silica inhalation
    Dale W Porter
    National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505, USA
    Toxicol Sci 90:188-97. 2006
    ..Future studies will be needed to determine whether the progressive oxidative stress, and iNOS activation and NO production, is a direct result of silica lung burden or a consequence of silica-induced biochemical mediators...
  8. ncbi request reprint Progression of lung inflammation and damage in rats after cessation of silica inhalation
    Dale W Porter
    National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA
    Toxicol Sci 79:370-80. 2004
    ....
  9. ncbi request reprint Time course of pulmonary response of rats to inhalation of crystalline silica: NF-kappa B activation, inflammation, cytokine production, and damage
    Dale W Porter
    National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA
    Inhal Toxicol 14:349-67. 2002
    ..This suggests that NF-kappa B activation in BAL cells may play an important role in the initiation and progression of silica-induced pulmonary inflammation, cellular damage, and fibrosis...
  10. ncbi request reprint Comparative pulmonary toxicity of blasting sand and five substitute abrasive blasting agents
    Dale W Porter
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, M S 2015, Morgantown, WV 26505, USA
    J Toxicol Environ Health A 65:1121-40. 2002
    ..Notwithstanding, the data also suggest that chronic exposure to steel grit may pose a health risk due to its effects on epithelial cell proliferation in the lung...
  11. ncbi request reprint Comparison of low doses of aged and freshly fractured silica on pulmonary inflammation and damage in the rat
    Dale W Porter
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, National Institutes of Health, 1095 Willowdale Road, M S 2015, Morgantown, WV 26505, USA
    Toxicology 175:63-71. 2002
    ....
  12. pmc Systemic microvascular dysfunction and inflammation after pulmonary particulate matter exposure
    Timothy R Nurkiewicz
    Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9229, USA
    Environ Health Perspect 114:412-9. 2006
    ..Collectively, these microvascular observations are consistent with events that contribute to the disruption of the control of peripheral resistance and/or cardiac dysfunction associated with PM exposure...
  13. doi request reprint System-based identification of toxicity pathways associated with multi-walled carbon nanotube-induced pathological responses
    Brandi N Snyder-Talkington
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 272:476-89. 2013
    ....
  14. pmc Pulmonary nanoparticle exposure disrupts systemic microvascular nitric oxide signaling
    Timothy R Nurkiewicz
    Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
    Toxicol Sci 110:191-203. 2009
    ..These results indicate that in conjunction with microvascular dysfunction, nanoparticle exposure also decreases NO bioavailability through at least two functionally distinct mechanisms that may mutually increase local reactive species...
  15. ncbi request reprint Exposure to particulate 1-->3-beta-glucans induces greater pulmonary toxicity than soluble 1-->3-beta-glucans in rats
    Shih Houng Young
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS 2027, Morgantown, WV 26505, USA
    J Toxicol Environ Health A 66:25-38. 2003
    ..Therefore, results demonstrate that particulate zymosan A is more potent in inducing pulmonary inflammation and damage in rats than the soluble form of this beta-glucan...
  16. pmc Lung toxicity and biodistribution of Cd/Se-ZnS quantum dots with different surface functional groups after pulmonary exposure in rats
    Jenny R Roberts
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Part Fibre Toxicol 10:5. 2013
    ..The goal of the present study was to assess pulmonary toxicity, clearance, and biodistribution of QD with different functional groups in rats after pulmonary exposure...
  17. ncbi request reprint Response of alveolar macrophages from inducible nitric oxide synthase knockout or wild-type mice to an in vitro lipopolysaccharide or silica exposure
    Patti C Zeidler
    Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 66:995-1013. 2003
    ..In addition, LPS induced TNF-á and MIP-2 production tend to be higher in AMs from iNOS KO mice. Such compensatory changes in the AM response may affect the response of iNOS KO mice to inflammatory exposures...
  18. doi request reprint Investigation of the pulmonary bioactivity of double-walled carbon nanotubes
    Tina M Sager
    a National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Pathology and Physiology Research Branch, Morgantown, West Virginia, USA
    J Toxicol Environ Health A 76:922-36. 2013
    ..In conclusion, this study provides insight into previously uninvestigated pulmonary bioactivity of DWCNT exposure. Data indicate that DWCNT exposure promotes inflammation, injury, and fibrosis in the lung. ..
  19. doi request reprint Acute pulmonary dose-responses to inhaled multi-walled carbon nanotubes
    Dale W Porter
    National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Nanotoxicology 7:1179-94. 2013
    ..Acute inhalation of MWCNT induced dose-dependent pulmonary inflammation and damage with rapid development of pulmonary fibrosis, and also demonstrated that MWCNT can reach the pleura after inhalation exposure...
  20. pmc Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes
    Robert R Mercer
    Pathology and Physiology Research Branch, HELD, NIOSH, Morgantown, WV, USA
    Part Fibre Toxicol 8:21. 2011
    ..Morphometric measurement of Sirius Red staining was used to assess the connective tissue response...
  21. pmc Distribution and persistence of pleural penetrations by multi-walled carbon nanotubes
    Robert R Mercer
    Pathology and Physiology Research Branch, HELD, NIOSH, Morgantown, WV, USA
    Part Fibre Toxicol 7:28. 2010
    ....
  22. ncbi request reprint Modified endotoxin responses in rats pretreated with 1-->3-beta-glucan (zymosan A)
    Shih Houng Young
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Toxicol Appl Pharmacol 178:172-9. 2002
    ..These results suggest that complex interaction of components may exist in exposure to organic dusts. Therefore, hazard may not be defined by measuring endotoxin or 1-->3-beta-glucans alone...
  23. doi request reprint Multi-walled carbon nanotubes: sampling criteria and aerosol characterization
    Bean T Chen
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505 2888, USA
    Inhal Toxicol 24:798-820. 2012
    ..The measurement scheme should be relevant for any carbon nanotube aerosol...
  24. pmc The sources of inflammatory mediators in the lung after silica exposure
    K Murali Krishna Rao
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Environ Health Perspect 112:1679-86. 2004
    ..Identification of the intercellular communication in vivo is still unresolved. However, fibroblasts appear to be an important source of inflammatory mediators in the lung...
  25. doi request reprint Nanotechnology: toxicologic pathology
    Ann F Hubbs
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Toxicol Pathol 41:395-409. 2013
    ..Thus, the pathology assessment is facilitated by understanding the unique features at the nanoscale and the tools that can assist in evaluating nanotoxicology studies...
  26. pmc Multiwalled carbon nanotube-induced gene signatures in the mouse lung: potential predictive value for human lung cancer risk and prognosis
    Nancy L Guo
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia, USA
    J Toxicol Environ Health A 75:1129-53. 2012
    ..These results may lead to development of a surveillance approach for early detection of lung cancer and prognosis associated with MWCNT in the workplace...
  27. pmc Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction
    Timothy R Nurkiewicz
    Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, WV, USA
    Part Fibre Toxicol 5:1. 2008
    ..abstract:..
  28. pmc Particulate matter exposure impairs systemic microvascular endothelium-dependent dilation
    Timothy R Nurkiewicz
    Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9229, USA
    Environ Health Perspect 112:1299-306. 2004
    ....
  29. doi request reprint Promotion of lung adenocarcinoma following inhalation exposure to multi-walled carbon nanotubes
    Linda M Sargent
    National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop L 3014, Morgantown, WV 26505, USA
    Part Fibre Toxicol 11:3. 2014
    ..p. injections, mice were exposed by inhalation to MWCNT (5 mg/m3, 5 hours/day, 5 days/week) or filtered air (controls) for a total of 15 days. At 17 months post-exposure, mice were euthanized and examined for lung tumor formation...
  30. pmc Pulmonary cerium dioxide nanoparticle exposure differentially impairs coronary and mesenteric arteriolar reactivity
    Valerie C Minarchick
    Center for Cardiovascular and Respiratory Sciences, Robert C Byrd Health Sciences Center, West Virginia University School of Medicine, 1 Medical Center Drive, PO Box 9105, Morgantown, WV, 26506 9105, USA
    Cardiovasc Toxicol 13:323-37. 2013
    ..Taken together, these observed microvascular changes may likely have detrimental effects on local blood flow regulation and contribute to cardiovascular dysfunction associated with particle exposure. ..
  31. doi request reprint Carbon nanotube dosimetry: from workplace exposure assessment to inhalation toxicology
    Aaron Erdely
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Part Fibre Toxicol 10:53. 2013
    ..S.-based multi-walled CNT (MWCNT) manufacturers and users were extrapolated to results of an inhalation study in mice...
  32. pmc Cell- and isoform-specific increases in arginase expression in acute silica-induced pulmonary inflammation
    Mirjana Poljakovic
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Toxicol Environ Health A 70:118-27. 2007
    ....