H R Pohl

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. doi request reprint Sodium and potassium in health and disease
    Hana R Pohl
    US Department of Health and Human Services, Agency for Toxic Substances and Disease Registry ATSDR, 1600 Clifton Road, Mailstop F 57, Atlanta, GA, 30333, USA
    Met Ions Life Sci 13:29-47. 2013
  2. doi request reprint Joint toxicity of alkoxyethanol mixtures: contribution of in silico applications
    H R Pohl
    Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA, USA
    Regul Toxicol Pharmacol 64:134-42. 2012
  3. doi request reprint Binary weight-of-evidence evaluations of chemical interactions--15 years of experience
    Hana R Pohl
    Agency for Toxic Substances and Disease Registry, U S Department of Health and Human Services, Division of Toxicology and Environmental Medicine, 1600 Clifton Road, F 32, Atlanta, GA 30333, USA
    Regul Toxicol Pharmacol 54:264-71. 2009
  4. ncbi request reprint The role of exposure versus body burden data in deriving health guidance values
    Hana R Pohl
    U S Department of Health and Human Services, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia, USA
    J Toxicol Environ Health B Crit Rev 10:401-15. 2007
  5. ncbi request reprint Health effects classification and its role in the derivation of minimal risk levels: reproductive and endocrine effects
    Hana R Pohl
    Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA, USA
    Regul Toxicol Pharmacol 42:209-17. 2005
  6. ncbi request reprint Risk assessment of chemicals and pharmaceuticals in the pediatric population: a workshop report
    H R Pohl
    Agency for Toxic Substances and Disease Registry ATSDR, US Department of Health and Human Services, Atlanta, GA 30333, USA
    Regul Toxicol Pharmacol 42:83-95. 2005
  7. ncbi request reprint Health effects classification and its role in the derivation of minimal risk levels: hepatic effects
    Hana R Pohl
    Agency for Toxic Substances and Disease Registry, U S Department of Health and Human Services, Atlanta, GA 30333, USA
    Regul Toxicol Pharmacol 42:161-71. 2005
  8. ncbi request reprint Six interaction profiles for simple mixtures
    Hana R Pohl
    Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, 1600 Clifton Road, Atlanta, Georgia 30333, USA
    Chemosphere 53:183-97. 2003
  9. doi request reprint Chemical risk assessment and uncertainty associated with extrapolation across exposure duration
    H R Pohl
    Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA, USA
    Regul Toxicol Pharmacol 57:18-23. 2010
  10. doi request reprint The impact of CYP2E1 genetic variability on risk assessment of VOC mixtures
    Hana R Pohl
    Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA 30333, USA
    Regul Toxicol Pharmacol 59:364-74. 2011

Collaborators

Detail Information

Publications21

  1. doi request reprint Sodium and potassium in health and disease
    Hana R Pohl
    US Department of Health and Human Services, Agency for Toxic Substances and Disease Registry ATSDR, 1600 Clifton Road, Mailstop F 57, Atlanta, GA, 30333, USA
    Met Ions Life Sci 13:29-47. 2013
    ..Similarly, the clinicians recognize hyperkalemia and hypokalemia. Pathologies associated with these states are described and examples of some of the diseases are presented here. ..
  2. doi request reprint Joint toxicity of alkoxyethanol mixtures: contribution of in silico applications
    H R Pohl
    Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA, USA
    Regul Toxicol Pharmacol 64:134-42. 2012
    ..Unique genotypes introduced as a function of migration can alter the genetic makeup of any given population. Hence special consideration should be given to susceptible populations while conducting chemical health risk assessments...
  3. doi request reprint Binary weight-of-evidence evaluations of chemical interactions--15 years of experience
    Hana R Pohl
    Agency for Toxic Substances and Disease Registry, U S Department of Health and Human Services, Division of Toxicology and Environmental Medicine, 1600 Clifton Road, F 32, Atlanta, GA 30333, USA
    Regul Toxicol Pharmacol 54:264-71. 2009
    ..Examples are given regarding the importance of human variability in mixtures' ability to affect human health and regarding the dose versus effect relationships...
  4. ncbi request reprint The role of exposure versus body burden data in deriving health guidance values
    Hana R Pohl
    U S Department of Health and Human Services, Agency for Toxic Substances and Disease Registry, Atlanta, Georgia, USA
    J Toxicol Environ Health B Crit Rev 10:401-15. 2007
    ..This article evaluates the exposure versus body burden approaches using 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and lead as examples...
  5. ncbi request reprint Health effects classification and its role in the derivation of minimal risk levels: reproductive and endocrine effects
    Hana R Pohl
    Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA, USA
    Regul Toxicol Pharmacol 42:209-17. 2005
    ..The paper also describes the ranking of effects into less serious and serious categories according to ATSDR's Guidance for Developing Toxicological Profiles, endpoints used for the MRLs derivation, and the use of uncertainty factors...
  6. ncbi request reprint Risk assessment of chemicals and pharmaceuticals in the pediatric population: a workshop report
    H R Pohl
    Agency for Toxic Substances and Disease Registry ATSDR, US Department of Health and Human Services, Atlanta, GA 30333, USA
    Regul Toxicol Pharmacol 42:83-95. 2005
    ..Topics discussed included clinical trials/toxicity studies, testing in juvenile animals, PBPK modeling in children, and children's risk assessment...
  7. ncbi request reprint Health effects classification and its role in the derivation of minimal risk levels: hepatic effects
    Hana R Pohl
    Agency for Toxic Substances and Disease Registry, U S Department of Health and Human Services, Atlanta, GA 30333, USA
    Regul Toxicol Pharmacol 42:161-71. 2005
    ..It also describes the ranking of effects into less serious and serious categories as described in ATSDR's Guidance for Developing Toxicological Profiles...
  8. ncbi request reprint Six interaction profiles for simple mixtures
    Hana R Pohl
    Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, 1600 Clifton Road, Atlanta, Georgia 30333, USA
    Chemosphere 53:183-97. 2003
    ..Physiologically based pharmacokinetic modeling was used for BTEX. In most cases, a target-organ toxicity dose modification of the hazard index approach is recommended for conducting exposure-based assessments of noncancer health hazards...
  9. doi request reprint Chemical risk assessment and uncertainty associated with extrapolation across exposure duration
    H R Pohl
    Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA, USA
    Regul Toxicol Pharmacol 57:18-23. 2010
    ..In addition, we investigated the impact of chemical structure and chemical structure activity relationship on validation of predictions across exposure durations...
  10. doi request reprint The impact of CYP2E1 genetic variability on risk assessment of VOC mixtures
    Hana R Pohl
    Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA 30333, USA
    Regul Toxicol Pharmacol 59:364-74. 2011
    ..Using examples of three different mixtures, this review paper outlines the variances in CYP2E1 isoenzymes, effect of exposure to such mixtures on sensitive populations, and approaches to mixtures risk assessment...
  11. ncbi request reprint Reducing uncertainty in the derivation and application of health guidance values in public health practice. Dioxin as a case study
    C T De Rosa
    Agency for Toxic Substances and Disease Registry Public Health Service, U S Department of Health and Human Services, Atlanta, Georgia 30333, USA
    Ann N Y Acad Sci 895:348-64. 1999
    ....
  12. ncbi request reprint Public health assessment of hexachlorobenzene
    H R Pohl
    Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA 30333, USA
    Chemosphere 43:903-8. 2001
    ..Based on this fact, it is not necessary to include HCB in the total TEQ count at hazardous waste sites at this time...
  13. ncbi request reprint Metal ions affecting the neurological system
    Hana R Pohl
    Agency for Toxic Substances and Disease Registry, U S Department of Health and Human Services, Atlanta GA 30333, USA
    Met Ions Life Sci 8:247-62. 2011
    ..Therefore, plausible mechanisms of action are also described...
  14. ncbi request reprint Metal ions affecting the hematological system
    Nickolette Roney
    Agency for Toxic Substances and Disease Registry, U S Department of Health and Human Services, Atlanta GA 30333, USA
    Met Ions Life Sci 8:143-55. 2011
    ..For example, copper, iron, and zinc have been shown to have a protective effect on the hematotoxicity of lead. In contrast, co-exposure to manganese may increase the hematotoxicity of lead...
  15. ncbi request reprint Mixtures and their risk assessment in toxicology
    Moiz M Mumtaz
    Agency for Toxic Substances and Disease Registry, U S Department of Health and Human Services, Atlanta GA 30333, USA
    Met Ions Life Sci 8:61-80. 2011
    ..The chapter also provides examples of future trends in chemical mixtures assessment...
  16. ncbi request reprint A regional approach to assess the impact of living in a chemical world
    Christopher T De Rosa
    Division of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, CDC, Atlanta, GA 30333, USA
    Ann N Y Acad Sci 1076:829-38. 2006
    ..In aggregate, our evaluations have demonstrated a need for community-based frameworks and computational techniques to track patterns of environmentally related exposures and associated health effects...
  17. ncbi request reprint Health effects classification and its role in the derivation of minimal risk levels: renal effects
    C H Selene J Chou
    Agency for Toxic Substances and Disease Registry, U S Department of Health and Human Services, Atlanta, GA, USA
    Regul Toxicol Pharmacol 42:202-8. 2005
    ..This article reports on endpoints used to derive the MRLs. It also presents the ranking of effects into less serious and serious categories as described in ATSDR's Guidance for Developing Toxicological Profiles...
  18. ncbi request reprint Agency for Toxic Substances and Disease Registry's 1997 priority list of hazardous substances. Latent effects--carcinogenesis, neurotoxicology, and developmental deficits in humans and animals
    S R Ostrowski
    Division of Toxicology, Agency for Toxic Substances and Disease Registry, U S Department of Health and Human Services, Atlanta, GA 30333, USA
    Toxicol Ind Health 15:602-44. 1999
    ..Latency periods for related chemicals are expected to be similar due to structural and toxicological similarities...
  19. ncbi request reprint Breast-feeding exposure of infants to cadmium, lead, and mercury: a public health viewpoint
    H G Abadin
    Division of Toxicology, Agency for Toxic Substances and Disease Registry, U S Department of Health and Human Services, Atlanta, Georgia 30333, USA
    Toxicol Ind Health 13:495-517. 1997
    ..Research is required to better understand the impact of low-level exposure to heavy metals via breast milk. Breastfeeding should be encouraged under most circumstances...
  20. doi request reprint Chemical mixtures: evaluation of risk for child-specific exposures in a multi-stressor environment
    H R Pohl
    Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, Georgia, USA
    Toxicol Appl Pharmacol 233:116-25. 2008
    ....
  21. pmc Exposures to air pollutants during pregnancy and preterm delivery
    Jong Han Leem
    Department of Occupational and Environmental Medicine, Inha University, Jung Gu, Incheon, Korea
    Environ Health Perspect 114:905-10. 2006
    ..A biologic mechanism through increased prostaglandin levels that are triggered by inflammatory mediators during exposure periods is discussed...