C D Paddock

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. pmc Gulf Coast ticks (Amblyomma maculatum) and Rickettsia parkeri, United States
    John W Sumner
    Infectious Disease Pathology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Emerg Infect Dis 13:751-3. 2007
  2. pmc Rickettsia parkeri in Argentina
    Santiago Nava
    Instituto Nacional de Tecnologia Agropecuaria, Santa Fe, Argentina
    Emerg Infect Dis 14:1894-7. 2008
  3. pmc Experimental infection of cotton rats and bobwhite quail with Rickettsia parkeri
    Gail Miriam Moraru
    Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Wise Center, Spring Street, Mississippi State, MS 39762, USA
    Parasit Vectors 6:70. 2013
  4. doi request reprint Myocardial injury and bacterial pneumonia contribute to the pathogenesis of fatal influenza B virus infection
    Christopher D Paddock
    Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA
    J Infect Dis 205:895-905. 2012
  5. pmc Isolation and characterization of Ehrlichia chaffeensis strains from patients with fatal ehrlichiosis
    C D Paddock
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 35:2496-502. 1997
  6. ncbi request reprint Assessing the magnitude of fatal Rocky Mountain spotted fever in the United States: comparison of two national data sources
    Christopher D Paddock
    Viral and Rickettsial Zoonoses Branch, and Office of the Director, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 67:349-54. 2002
  7. ncbi request reprint Rickettsialpox in New York City: a persistent urban zoonosis
    Christopher D Paddock
    Viral and Rickettsial Zoonoses Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Ann N Y Acad Sci 990:36-44. 2003
  8. ncbi request reprint Rickettsia parkeri as a paradigm for multiple causes of tick-borne spotted fever in the western hemisphere
    Christopher D Paddock
    Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Ann N Y Acad Sci 1063:315-26. 2005
  9. ncbi request reprint Infections with Ehrlichia chaffeensis and Ehrlichia ewingii in persons coinfected with human immunodeficiency virus
    C D Paddock
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 33:1586-94. 2001
  10. ncbi request reprint Ecological havoc, the rise of white-tailed deer, and the emergence of Amblyomma americanum-associated zoonoses in the United States
    C D Paddock
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Curr Top Microbiol Immunol 315:289-324. 2007

Detail Information

Publications79

  1. pmc Gulf Coast ticks (Amblyomma maculatum) and Rickettsia parkeri, United States
    John W Sumner
    Infectious Disease Pathology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Emerg Infect Dis 13:751-3. 2007
    ..maculatum may be responsible for additional cases of R. parkeri rickettsiosis throughout much of its US range...
  2. pmc Rickettsia parkeri in Argentina
    Santiago Nava
    Instituto Nacional de Tecnologia Agropecuaria, Santa Fe, Argentina
    Emerg Infect Dis 14:1894-7. 2008
    ..When evaluated by PCR, 17 (7.6%) of 223 questing adult A. triste ticks, collected from 2 sites in the lower ParanĂ¡ River Delta, contained DNA of Rickettsia parkeri...
  3. pmc Experimental infection of cotton rats and bobwhite quail with Rickettsia parkeri
    Gail Miriam Moraru
    Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Wise Center, Spring Street, Mississippi State, MS 39762, USA
    Parasit Vectors 6:70. 2013
    ..Cotton rats and quail are known hosts for larval and nymphal A. maculatum; however, the role of these hosts in the ecology of R. parkeri is unknown...
  4. doi request reprint Myocardial injury and bacterial pneumonia contribute to the pathogenesis of fatal influenza B virus infection
    Christopher D Paddock
    Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA
    J Infect Dis 205:895-905. 2012
    ....
  5. pmc Isolation and characterization of Ehrlichia chaffeensis strains from patients with fatal ehrlichiosis
    C D Paddock
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 35:2496-502. 1997
    ..chaffeensis...
  6. ncbi request reprint Assessing the magnitude of fatal Rocky Mountain spotted fever in the United States: comparison of two national data sources
    Christopher D Paddock
    Viral and Rickettsial Zoonoses Branch, and Office of the Director, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 67:349-54. 2002
    ....
  7. ncbi request reprint Rickettsialpox in New York City: a persistent urban zoonosis
    Christopher D Paddock
    Viral and Rickettsial Zoonoses Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Ann N Y Acad Sci 990:36-44. 2003
    ....
  8. ncbi request reprint Rickettsia parkeri as a paradigm for multiple causes of tick-borne spotted fever in the western hemisphere
    Christopher D Paddock
    Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Ann N Y Acad Sci 1063:315-26. 2005
    ..parkeri as a cause of disease in humans will hopefully encourage a closer examination for specific etiologies of tick-borne spotted fever rickettsioses in the United States and other countries of the Western Hemisphere...
  9. ncbi request reprint Infections with Ehrlichia chaffeensis and Ehrlichia ewingii in persons coinfected with human immunodeficiency virus
    C D Paddock
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 33:1586-94. 2001
    ....
  10. ncbi request reprint Ecological havoc, the rise of white-tailed deer, and the emergence of Amblyomma americanum-associated zoonoses in the United States
    C D Paddock
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Curr Top Microbiol Immunol 315:289-324. 2007
    ....
  11. pmc Isolation of Rickettsia parkeri and identification of a novel spotted fever group Rickettsia sp. from Gulf Coast ticks (Amblyomma maculatum) in the United States
    Christopher D Paddock
    Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Appl Environ Microbiol 76:2689-96. 2010
    ..This study considerably expanded the number of low-passage, A. maculatum-derived isolates of R. parkeri and characterized a second, sympatric Rickettsia sp. found in Gulf Coast ticks...
  12. pmc Ehrlichia chaffeensis: a prototypical emerging pathogen
    Christopher D Paddock
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Microbiol Rev 16:37-64. 2003
    ..americanum, and improvements in confirmatory diagnostic methods, are also explored...
  13. pmc PCR amplification and phylogenetic analysis of groESL operon sequences from Ehrlichia ewingii and Ehrlichia muris
    J W Sumner
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 38:2746-9. 2000
    ..These sequences provide additional PCR targets for species for which few gene sequences have been determined...
  14. pmc Outcome of diagnostic tests using samples from patients with culture-proven human monocytic ehrlichiosis: implications for surveillance
    J E Childs
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 37:2997-3000. 1999
    ..These data suggest that many, if not most, cases of HME in patients who present early in the course of the disease may be missed and underscore the limitations of serologically based surveillance systems...
  15. ncbi request reprint Detection of antibodies reactive with Ehrlichia chaffeensis in the raccoon
    J A Comer
    Viral and Rickettsial Zoonoses Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Wildl Dis 36:705-12. 2000
    ..additional immunologic, molecular, or culture-based studies will be required to confirm E. chaffeensis infections of raccoons in the southeastern United States...
  16. ncbi request reprint Urban zoonoses caused by Bartonella, Coxiella, Ehrlichia, and Rickettsia species
    J A Comer
    Viral and Rickettsial Zoonoses Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Vector Borne Zoonotic Dis 1:91-118. 2001
    ....
  17. ncbi request reprint Analysis of risk factors for fatal Rocky Mountain Spotted Fever: evidence for superiority of tetracyclines for therapy
    R C Holman
    Office of the Director, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia 30333, USA
    J Infect Dis 184:1437-44. 2001
    ..Despite the availability of effective antibiotics, RMSF-related deaths continue to occur because of delayed diagnosis and failure to use appropriate therapy...
  18. ncbi request reprint Family cluster of Rocky Mountain spotted fever
    T F Jones
    Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Infect Dis 28:853-9. 1999
    ..Because hyperendemic foci and family clusters of RMSF can occur, when a case is suspected clinicians should be vigilant for signs and symptoms consistent with R. rickettsii infection in other persons who may have been similarly exposed...
  19. pmc Molecular cloning and characterization of the Ehrlichia chaffeensis variable-length PCR target: an antigen-expressing gene that exhibits interstrain variation
    J W Sumner
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 37:1447-53. 1999
    ..The resulting amplicons varied in length, containing three to six repeat units. This gene, designated the variable-length PCR target, is useful for PCR detection of E. chaffeensis and differentiation of isolates...
  20. ncbi request reprint Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever, ehrlichioses, and anaplasmosis--United States: a practical guide for physicians and other health-care and public health professionals
    Alice S Chapman
    National Center for Infectious Diseases, CDC, Atlanta, GA 30333, USA
    MMWR Recomm Rep 55:1-27. 2006
    ....
  21. ncbi request reprint Infant and maternal risk factors for pertussis-related infant mortality in the United States, 1999 to 2004
    Dana L Haberling
    Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Pediatr Infect Dis J 28:194-8. 2009
    ..Infants aged <12 months have the highest rates of complications and death from pertussis of any age group. Factors that increase the risk of pertussis-related death in infants are not well defined...
  22. ncbi request reprint Influenza-associated deaths among children in the United States, 2003-2004
    Niranjan Bhat
    Epidemic Intelligence Service, Career Development Division, Office of Workforce and Career Development National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 353:2559-67. 2005
    ..Although influenza is common among children, pediatric mortality related to laboratory-confirmed influenza has not been assessed nationally...
  23. ncbi request reprint Passive surveillance as an instrument to identify risk factors for fatal Rocky Mountain spotted fever: is there more to learn?
    James E Childs
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 66:450-7. 2002
    ..Modified surveillance activities could focus on evaluating the risk for fatal RMSF among special populations, monitoring appropriate antibiotic use, and assessing new diagnostic tests...
  24. pmc Molecular diagnosis of Bordetella pertussis infection by evaluation of formalin-fixed tissue specimens
    Kathleen M Tatti
    Centers for Disease Control and Prevention, National Center for Infectious Diseases, Division of Viral and Rickettsial Disease, Infectious Disease Pathology Activity, 1600 Clifton Rd, NE, Mailstop G30, Atlanta, Georgia 30333, USA
    J Clin Microbiol 44:1074-6. 2006
    ..B. pertussis was confirmed in all cases. PCR can be an invaluable retrospective diagnostic tool for evaluating archival tissues from patients with suspected fatal pertussis...
  25. doi request reprint The science and fiction of emerging rickettsioses
    Christopher D Paddock
    Infectious Disease Pathology Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Ann N Y Acad Sci 1166:133-43. 2009
    ..Close inspection of mild or atypical forms of historically recognized rickettsioses and a greater emphasis on culture- and molecular-based diagnostic techniques are the keys to identifying future rickettsial agents of disease...
  26. ncbi request reprint Fatal hemorrhagic fever caused by West Nile virus in the United States
    Christopher D Paddock
    Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 42:1527-35. 2006
    ..We describe a case of fulminant WNV infection in a 59-year-old Florida man who died following a brief illness that resembled hemorrhagic disease caused by Rickettsia reckettsii, dengue virus or yellow fever virus...
  27. doi request reprint Pathology and pathogenesis of fatal Bordetella pertussis infection in infants
    Christopher D Paddock
    Infectious Disease Pathology Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 47:328-38. 2008
    ....
  28. ncbi request reprint Histopathologic and immunohistochemical features of fatal influenza virus infection in children during the 2003-2004 season
    Jeannette Guarner
    Infectious Disease Pathology Activity, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 43:132-40. 2006
    ..The Centers for Disease Control and Prevention enhanced national surveillance for influenza-associated deaths among children because of early reports of pediatric deaths during the 2003-2004 influenza season...
  29. ncbi request reprint Isolation of Rickettsia akari from eschars of patients with rickettsialpox
    Christopher D Paddock
    Viral and Rickettsial Zoonoses Branch and Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Trop Med Hyg 75:732-8. 2006
    ..This work emphasizes the importance and utility of culture-and molecular-based methods for the diagnosis of rickettsialpox and other eschar-associated illnesses...
  30. ncbi request reprint Rocky Mountain spotted fever in Argentina
    Christopher D Paddock
    Infectious Disease Pathology Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 78:687-92. 2008
    ..These findings show the existence of RMSF in Argentina and emphasize the need for clinicians throughout the Americas to consider RMSF in patients with febrile rash illnesses...
  31. ncbi request reprint Rocky Mountain spotted fever in Arizona: documentation of heavy environmental infestations of Rhipicephalus sanguineus at an endemic site
    William L Nicholson
    Viral and Rickettsial Zoonoses Branch, Centers for Disease Control and Prevention, Mail Stop G 13, 1600 Clifton Road, Atlanta, GA 30333, USA
    Ann N Y Acad Sci 1078:338-41. 2006
    ..It is evident that under certain circumstances, this species does transmit Rickettsia rickettsii to humans and deserves reconsideration as a vector in other geographic areas...
  32. ncbi request reprint Detection of West Nile virus in formalin-fixed, paraffin-embedded human tissues by RT-PCR: a useful adjunct to conventional tissue-based diagnostic methods
    Julu Bhatnagar
    Infectious Disease Pathology Activity, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Mailstop G32, Atlanta, GA 30333, United States
    J Clin Virol 38:106-11. 2007
    ....
  33. doi request reprint Ischemic cardiac events during the Department of Health and Human Services Smallpox Vaccination Program, 2003
    David L Swerdlow
    Smallpox Vaccine Adverse Events Monitoring and Response Activity, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Infect Dis 46:S234-41. 2008
    ..10; 95% PI, 3.5-15.7). After persons with >/=3 cardiac risk factors or known heart disease were deferred from vaccination, no ICEs were reported among an additional 6638 vaccinees...
  34. pmc Isolation and characterization of Bartonella bacilliformis from an expatriate Ecuadorian
    Shari L Lydy
    Rickettsial Zoonoses Branch, Mail Stop G 13, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    J Clin Microbiol 46:627-37. 2008
    ..bacilliformis was not thought to be endemic. This study suggests that the range of B. bacilliformis may be expanding from areas of endemicity in Ecuador and that infection may present as atypical clinical disease...
  35. ncbi request reprint Progressive ORF virus infection in a patient with lymphoma: successful treatment using imiquimod
    Edith R Lederman
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 44:e100-3. 2007
    ..The patient's orf virus infection was successfully treated with topical imiquimod despite progression of her malignancy...
  36. pmc Pet rodents and fatal lymphocytic choriomeningitis in transplant patients
    Brian R Amman
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 13:719-25. 2007
    ..This report details the animal traceback and the supporting laboratory investigations...
  37. ncbi request reprint Rickettsia parkeri: a newly recognized cause of spotted fever rickettsiosis in the United States
    Christopher D Paddock
    Division of Viral and Rickettsial Diseases, Infectious Disease Pathology Activity, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 38:805-11. 2004
    ..parkeri rickettsiosis and possibly other novel SFG rickettsioses in the United States...
  38. doi request reprint Rickettsia parkeri rickettsiosis and its clinical distinction from Rocky Mountain spotted fever
    Christopher D Paddock
    Infectious Diseases Pathology Branch, Mailstop G 32, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
    Clin Infect Dis 47:1188-96. 2008
    ..parkeri and comment on distinctions between R. parkeri rickettsiosis and other United States rickettsioses...
  39. doi request reprint Risk factors for lower respiratory tract infection death among infants in the United States, 1999-2004
    Rosalyn J Singleton
    Alaska Native Tribal Health Consortium, Anchorage, Alaska, USA
    Pediatrics 124:e768-76. 2009
    ..To describe maternal and birth-related risk factors associated with lower respiratory tract infection (LRTI) deaths among infants...
  40. ncbi request reprint Imported spotted fever rickettsioses in United States travelers returning from Africa: a summary of cases confirmed by laboratory testing at the Centers for Disease Control and Prevention, 1999-2002
    Jennifer H McQuiston
    Viral and Rickettsial Zoonoses Branch, and Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, National Center for Infectious Disease, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 70:98-101. 2004
    ....
  41. ncbi request reprint The ascendancy of Amblyomma americanum as a vector of pathogens affecting humans in the United States
    James E Childs
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Annu Rev Entomol 48:307-37. 2003
    ....
  42. pmc Flying squirrel-associated typhus, United States
    Mary G Reynolds
    Centers for Disease Control and Prevention, 1600 Clifton Road, Mail Stop G13, Atlanta, GA 30338, USA
    Emerg Infect Dis 9:1341-3. 2003
  43. pmc Monkeypox transmission and pathogenesis in prairie dogs
    Jeannette Guarner
    Infectious Disease Pathology Activity, Centers for Disease Control and Prevention, Mailstop G32, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    Emerg Infect Dis 10:426-31. 2004
    ..Prairie dogs offer insights into transmission, pathogenesis, and new vaccine and treatment trials because they are susceptible to severe monkeypox infection...
  44. ncbi request reprint Rocky Mountain spotted fever from an unexpected tick vector in Arizona
    Linda J Demma
    National Center for Infectious Diseases, Division of Viral and Rickettsial Diseases, The Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 353:587-94. 2005
    ..This disease is rarely reported in Arizona, and the principal vectors, Dermacentor species ticks, are uncommon in the state. From 2002 through 2004, a focus of Rocky Mountain spotted fever was investigated in rural eastern Arizona...
  45. pmc Isolation of genetically diverse Marburg viruses from Egyptian fruit bats
    Jonathan S Towner
    Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA
    PLoS Pathog 5:e1000536. 2009
    ..These data indicate common Egyptian fruit bats can represent a major natural reservoir and source of Marburg virus with potential for spillover into humans...
  46. ncbi request reprint Human monkeypox infection: a family cluster in the midwestern United States
    James J Sejvar
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30033, USA
    J Infect Dis 190:1833-40. 2004
    ..We describe a cluster of monkeypox in a family with a spectrum of clinical illness, including encephalitis, and outline the laboratory confirmation of monkeypox...
  47. pmc Blastomycosis in man after kinkajou bite
    Julie R Harris
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 17:268-70. 2011
    ..When treating a patient with a recalcitrant infection and a history of an animal bite, early and complete animal necropsy and consideration of nonbacterial etiologies are needed...
  48. ncbi request reprint Tissue diagnosis of Ehrlichia chaffeensis in patients with fatal ehrlichiosis by use of immunohistochemistry, in situ hybridization, and polymerase chain reaction
    J E Dawson
    Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 65:603-9. 2001
    ..Significantly, in 2 of these patients, serologic evidence of infection was absent. Use of IHC, ISH, and PCR to visualize and detect Ehrlichia in tissues can facilitate diagnosis of ehrlichial infections...
  49. ncbi request reprint Usefulness of immunohistochemical diagnosis of streptococcus pneumoniae in formalin-fixed, paraffin-embedded specimens compared with culture and gram stain techniques
    Jeannette Guarner
    Infectious Diseases Pathology Activity, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Clin Pathol 127:612-8. 2007
    ..Compared with culture, the immunohistochemical assay showed 100% sensitivity and 71% specificity. Immunohistochemical analysis has the diagnostic advantage of correlating host inflammatory reaction with presence of pneumococci...
  50. ncbi request reprint Diagnosis of invasive group a streptococcal infections by using immunohistochemical and molecular assays
    Jeannette Guarner
    Infectious Disease Pathology Activity, National Centers for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Clin Pathol 126:148-55. 2006
    ..Eighteen patients had systemic infection. Immunohistochemical analysis and PCR can be used for diagnosis of GAS infections in formalin-fixed, paraffin-embedded samples...
  51. ncbi request reprint Detection of Ehrlichia chaffeensis in adult and nymphal Amblyomma americanum (Acari: Ixodidae) ticks from Long Island, New York
    Tonya R Mixson
    Viral and Rickettsial Zoonoses Branch, Division of Viral and Rickettsial Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Med Entomol 41:1104-10. 2004
    ..chaffeensis is endemic to many areas of Long Island and that HME should be considered among the differential diagnoses of the many distinct tick-borne diseases that occur in this region...
  52. ncbi request reprint Short report: concurrent Rocky Mountain spotted fever in a dog and its owner
    Christopher D Paddock
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 66:197-9. 2002
    ..Previous reports of concurrent RMSF in dogs and their owners are reviewed, and the epidemiologic significance of this occurrence is discussed...
  53. ncbi request reprint A novel coronavirus associated with severe acute respiratory syndrome
    Thomas G Ksiazek
    Special Pathogens Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 348:1953-66. 2003
    ..We conducted studies to identify the etiologic agent of this outbreak...
  54. pmc The human ehrlichioses in the United States
    J H McQuiston
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 5:635-42. 1999
    ..Improved national surveillance would provide a better assessment of the public health importance of ehrlichiosis...
  55. ncbi request reprint Immunohistochemical, in situ hybridization, and ultrastructural localization of SARS-associated coronavirus in lung of a fatal case of severe acute respiratory syndrome in Taiwan
    Wun Ju Shieh
    Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, Center for Disease Control and Prevention, Atlanta, GA 30333, USA
    Hum Pathol 36:303-9. 2005
    ..These techniques represent valuable laboratory diagnostic modalities and provide insights into the pathogenesis of this emerging infection...
  56. ncbi request reprint Clinicopathologic study and laboratory diagnosis of 23 cases with West Nile virus encephalomyelitis
    Jeannette Guarner
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Hum Pathol 35:983-90. 2004
    ..Differences in the amount of viral antigen may be related to underlying medical conditions and length of survival. IHC can be an important diagnostic method, particularly during the 1st week of illness, when antigen levels are high...
  57. ncbi request reprint Identification, cloning, and recombinant expression of procalin, a major triatomine allergen
    C D Paddock
    Viral and Rickettsial Zoonoses Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Immunol 167:2694-9. 2001
    ..Recombinant Ag is also shown to react with sera from an allergic patient but not with control sera. By immunolocalization, the source of the salivary Ag is the salivary gland epithelium and its secretions...
  58. ncbi request reprint Transmission of rabies virus from an organ donor to four transplant recipients
    Arjun Srinivasan
    Division of Healthcare Quality Promotion, National Center for Infectious Diseases, and the Epidemic Intelligence Service Branch, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 352:1103-11. 2005
    ..In 2004, four recipients of kidneys, a liver, and an arterial segment from a common organ donor died of encephalitis of an unknown cause...
  59. ncbi request reprint Fatal malaria infection in travelers: novel immunohistochemical assays for the detection of Plasmodium falciparum in tissues and implications for pathogenesis
    Gillian L Genrich
    Infectious Disease Pathology and Malaria Branches, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 76:251-9. 2007
    ..vivax. Immunostaining patterns were predominately cytoplasmic and membranous. P. falciparum antigens were detected in a variety of organs but were most abundant in the blood vessels of brain, heart, and lung tissues...
  60. doi request reprint A new arenavirus in a cluster of fatal transplant-associated diseases
    Gustavo Palacios
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    N Engl J Med 358:991-8. 2008
    ..Culture, polymerase-chain-reaction (PCR) and serologic assays, and oligonucleotide microarray analysis for a wide range of infectious agents were not informative...
  61. pmc Fatal Rickettsia conorii subsp. israelensis infection, Israel
    Miriam Weinberger
    Infectious Diseases Unit, Assaf Harofeh Medical Center, Zerifin 70300, Israel
    Emerg Infect Dis 14:821-4. 2008
    ..israelensis in a traveler returning to Israel from India...
  62. pmc Molecular heterogeneity of Ehrlichia chaffeensis isolates determined by sequence analysis of the 28-kilodalton outer membrane protein genes and other regions of the genome
    Chuanmin Cheng
    Department of Diagnostic Medicine Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, USA
    Infect Immun 71:187-95. 2003
    ..chaffeensis genome. Diversity in different genomic regions could be the result of a selection process or of independently evolved genes...
  63. pmc Rocky Mountain spotted fever, Panama
    Dora Estripeaut
    Hospital del Nino, Panama City, Panama
    Emerg Infect Dis 13:1763-5. 2007
    ..Molecular typing demonstrated strong relatedness of the isolate to strains of R. rickettsii from Central and South America...
  64. pmc Rickettsia parkeri infection after tick bite, Virginia
    Timothy J Whitman
    US Navy Infectious Diseases Department, National Naval Medical Center, Bethesda, Maryland 20889, USA
    Emerg Infect Dis 13:334-6. 2007
    ..Rickettsia parkeri was detected and isolated from the eschar. This report represents the second documented case of R. parkeri rickettsiosis in a US serviceman in eastern Virginia...
  65. pmc Predominance of Ehrlichia ewingii in Missouri dogs
    Allison M Liddell
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Clin Microbiol 41:4617-22. 2003
    ..E. canis, a widely recognized agent of canine ehrlichiosis, was not detected in any animal. The finding of E. ewingii in asymptomatic dogs suggests that dogs could be a reservoir for this Ehrlichia species...
  66. ncbi request reprint Increased detection of rickettsialpox in a New York City hospital following the anthrax outbreak of 2001: use of immunohistochemistry for the rapid confirmation of cases in an era of bioterrorism
    Tamara Koss
    Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arch Dermatol 139:1545-52. 2003
    ..The cluster of cutaneous anthrax cases from bioterrorism in October 2001 likely heightened awareness of and concern for cutaneous eschars...
  67. ncbi request reprint Survey of ticks collected in Mississippi for Rickettsia, Ehrlichia, and Borrelia species
    Jerome Goddard
    Mississippi Department of Health, Jackson, MS 39215 1700, USA
    J Vector Ecol 28:184-9. 2003
    ..The significance of this finding remains undetermined...
  68. pmc Fatal spotted fever rickettsiosis, Kenya
    Jeremiah S Rutherford
    United States Army Medical Research Unit, Nairobi, Kenya
    Emerg Infect Dis 10:910-3. 2004
    ..Immunohistochemical staining of skin, kidney, and liver demonstrated spotted fever group rickettsiae. The clinical findings, severity, and fatal outcome are most consistent with Rickettsia conorii infection...
  69. ncbi request reprint Pseudoepidemic of Q fever at an animal research facility
    Lisa A Conti
    Florida Department of Health, Tallahassee, Florida, USA
    Vector Borne Zoonotic Dis 4:343-350. 2004
    ..This pseudoepidemic resulted from a lapse in laboratory quality control for testing. Similar errors can be avoided through standardization and improved review of laboratory procedures...
  70. ncbi request reprint Observations on distribution and seasonal activity of the Gulf Coast tick in Mississippi
    Jerome Goddard
    Bureau of General Environmental Services, Mississippi Department of Health, P O Box 1700, Jackson, MS 39215, USA
    J Med Entomol 42:176-9. 2005
    ..Nymphs were collected during February through August, and larvae were collected once during each of June, September, and October. Small sample sizes of the immature stages precluded determination of their peak activity...
  71. ncbi request reprint Rickettsia parkeri infection and other spotted fevers in the United States
    Didier Raoult
    N Engl J Med 353:626-7. 2005
  72. ncbi request reprint Reinfection with Ehrlichia chaffeensis in a liver transplant recipient
    Allison M Liddell
    Department of Medicine, Washington University School of Medicine, St Louis, MO, 63110, USA
    Clin Infect Dis 34:1644-7. 2002
    ..We report a case of reinfection with E. chaffeensis after a 2-year interval in a 56-year-old liver transplant recipient with frequent tick attachments...
  73. ncbi request reprint Transmission of lymphocytic choriomeningitis virus by organ transplantation
    Staci A Fischer
    Rhode Island Hospital and Brown Medical School, Providence, USA
    N Engl J Med 354:2235-49. 2006
    ..Each cluster was investigated because diagnostic evaluations were unrevealing, and in each a common donor was recognized...
  74. pmc Tick-borne rickettsioses around the world: emerging diseases challenging old concepts
    Philippe Parola
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Universite de la Mediterranee, Faculte de Medecine, 13385 Marseille Cedex 5, France
    Clin Microbiol Rev 18:719-56. 2005
    ..We present here the tick-borne rickettsioses described through 2005 and focus on the epidemiological circumstances that have played a role in the emergence of the newly recognized diseases...
  75. ncbi request reprint Fatal case of Brazilian spotted fever confirmed by immunohistochemical staining and sequencing methods on fixed tissues
    Tatiana Rozental
    Lab de Hantaviroses e Rickettsioses, Depto Virologia, Pav Rocha Lima 5 andar, Fiocruz Av Brasil, 4365, Manguinhos, Rio de Janeiro, RJ, Brazil CEP 21045 900
    Ann N Y Acad Sci 1078:257-9. 2006
    ..The authors describe the first characterization of Rickettsia rickettsii in a fatal case occurring in Rio de Janeiro State, Brazil...
  76. pmc Utility of the aged BALB/c mouse model to demonstrate prevention and control strategies for severe acute respiratory syndrome coronavirus (SARS-CoV)
    Leatrice N Vogel
    Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892, USA
    Vaccine 25:2173-9. 2007
    ..This study validates the utility of the aged BALB/c mouse model for evaluation of the efficacy of vaccines and immunoprophylaxis...
  77. pmc Q fever endocarditis in HIV-infected patient
    Miguel G Madariaga
    Division of Infectious Disease, Cook County Hospital, Rush Medical College, Chicago, IL 60612, USA
    Emerg Infect Dis 10:501-4. 2004
    ..We review the current literature on Q fever endocarditis, with an emphasis on the co-infection of HIV and Coxiella burnetii...
  78. ncbi request reprint Rocky Mountain spotted fever: a clinician's dilemma
    Edwin J Masters
    Department of Pediatrics, St Francis Medical Center and Southeast Missouri Hospital, Cape Girardeau, MO, USA
    Arch Intern Med 163:769-74. 2003
    ..Early diagnosis and proper treatment save lives...
  79. ncbi request reprint Rickettsialpox in a patient with HIV infection
    Scott Sanders
    Department of Dermatology, Cornell University Weill Medical Center and Lincoln Hospital, Bronx, NY, USA
    J Am Acad Dermatol 48:286-9. 2003
    ..Rickettsialpox is easily treated and may resemble more serious cutaneous eruptions in patients infected with HIV. This diagnosis should be considered in immunocompromised city-dwellers, with fever and a papulovesicular rash...