Stuart T Nichol

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. pmc Ancient ancestry of KFDV and AHFV revealed by complete genome analyses of viruses isolated from ticks and mammalian hosts
    Kimberly A Dodd
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Negl Trop Dis 5:e1352. 2011
  2. pmc Genetic analysis of viruses associated with emergence of Rift Valley fever in Saudi Arabia and Yemen, 2000-01
    Trevor Shoemaker
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 8:1415-20. 2002
  3. pmc Crimean-Congo hemorrhagic fever, Kazakhstan, 2009-2010
    Barbara Knust
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 18:643-5. 2012
  4. pmc The complete genome sequence of a Crimean-Congo hemorrhagic fever virus isolated from an endemic region in Kosovo
    Darja Duh
    Institute of Microbiology and Immunology, Medical Faculty, Ljubljana, Slovenia
    Virol J 5:7. 2008
  5. pmc Large serological survey showing cocirculation of Ebola and Marburg viruses in Gabonese bat populations, and a high seroprevalence of both viruses in Rousettus aegyptiacus
    Xavier Pourrut
    Institut de Recherche pour le Developpement, UR 178, Marseille, France
    BMC Infect Dis 9:159. 2009
  6. pmc Multiple virus lineages sharing recent common ancestry were associated with a Large Rift Valley fever outbreak among livestock in Kenya during 2006-2007
    Brian H Bird
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 14, Atlanta, GA 30329, USA
    J Virol 82:11152-66. 2008
  7. pmc Complete genome analysis of 33 ecologically and biologically diverse Rift Valley fever virus strains reveals widespread virus movement and low genetic diversity due to recent common ancestry
    Brian H Bird
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road MS G 14, Atlanta, GA 30329, USA
    J Virol 81:2805-16. 2007
  8. pmc Seasonal pulses of Marburg virus circulation in juvenile Rousettus aegyptiacus bats coincide with periods of increased risk of human infection
    Brian R Amman
    Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Pathog 8:e1002877. 2012
  9. pmc Rift Valley fever virus vaccine lacking the NSs and NSm genes is safe, nonteratogenic, and confers protection from viremia, pyrexia, and abortion following challenge in adult and pregnant sheep
    Brian H Bird
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 14, Atlanta, GA 30329, USA
    J Virol 85:12901-9. 2011
  10. pmc Isolation of genetically diverse Marburg viruses from Egyptian fruit bats
    Jonathan S Towner
    Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA
    PLoS Pathog 5:e1000536. 2009

Detail Information

Publications79

  1. pmc Ancient ancestry of KFDV and AHFV revealed by complete genome analyses of viruses isolated from ticks and mammalian hosts
    Kimberly A Dodd
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Negl Trop Dis 5:e1352. 2011
    ..To gain a better understanding of the evolutionary history of AHFV and KFDV, we analyzed the full length genomes of 16 AHFV and 3 KFDV isolates...
  2. pmc Genetic analysis of viruses associated with emergence of Rift Valley fever in Saudi Arabia and Yemen, 2000-01
    Trevor Shoemaker
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 8:1415-20. 2002
    ..These results are consistent with the recent introduction of RVFV into the Arabian Peninsula from East Africa...
  3. pmc Crimean-Congo hemorrhagic fever, Kazakhstan, 2009-2010
    Barbara Knust
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 18:643-5. 2012
    ..Public health measures should center on preventing tick bites, increasing awareness of CCHF signs and symptoms, and adopting hospital infection control practices...
  4. pmc The complete genome sequence of a Crimean-Congo hemorrhagic fever virus isolated from an endemic region in Kosovo
    Darja Duh
    Institute of Microbiology and Immunology, Medical Faculty, Ljubljana, Slovenia
    Virol J 5:7. 2008
    ..9% amino acid difference found between the Kosova Hoti and another strain from Kosovo (9553-01). This suggests that distinct virus strains can coexist in highly endemic areas...
  5. pmc Large serological survey showing cocirculation of Ebola and Marburg viruses in Gabonese bat populations, and a high seroprevalence of both viruses in Rousettus aegyptiacus
    Xavier Pourrut
    Institut de Recherche pour le Developpement, UR 178, Marseille, France
    BMC Infect Dis 9:159. 2009
    ..Recently, bats of multiple species have been identified as possible natural hosts of Zaire ebolavirus (ZEBOV) in Gabon and Republic of Congo, and also of marburgvirus (MARV) in Gabon and Democratic Republic of Congo...
  6. pmc Multiple virus lineages sharing recent common ancestry were associated with a Large Rift Valley fever outbreak among livestock in Kenya during 2006-2007
    Brian H Bird
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 14, Atlanta, GA 30329, USA
    J Virol 82:11152-66. 2008
    ....
  7. pmc Complete genome analysis of 33 ecologically and biologically diverse Rift Valley fever virus strains reveals widespread virus movement and low genetic diversity due to recent common ancestry
    Brian H Bird
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road MS G 14, Atlanta, GA 30329, USA
    J Virol 81:2805-16. 2007
    ..In addition to insights into the evolution and ecology of RVF virus, these genomic data also provide a foundation for the design of molecular detection assays and prototype vaccines useful in combating this important disease...
  8. pmc Seasonal pulses of Marburg virus circulation in juvenile Rousettus aegyptiacus bats coincide with periods of increased risk of human infection
    Brian R Amman
    Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Pathog 8:e1002877. 2012
    ..aegyptiacus bats existing as a large meta-population with associated virus circulation over broad geographic ranges. These findings provide a basis for developing Marburg hemorrhagic fever risk reduction strategies...
  9. pmc Rift Valley fever virus vaccine lacking the NSs and NSm genes is safe, nonteratogenic, and confers protection from viremia, pyrexia, and abortion following challenge in adult and pregnant sheep
    Brian H Bird
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 14, Atlanta, GA 30329, USA
    J Virol 85:12901-9. 2011
    ..As expected, all 3 sham-vaccinated controls experienced viremia, fetal death, and abortion postchallenge. These results demonstrate that the ΔNSs-ΔNSm rRVFV vaccine is safe and nonteratogenic and confers high-level protection in sheep...
  10. pmc Isolation of genetically diverse Marburg viruses from Egyptian fruit bats
    Jonathan S Towner
    Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA
    PLoS Pathog 5:e1000536. 2009
    ..These data indicate common Egyptian fruit bats can represent a major natural reservoir and source of Marburg virus with potential for spillover into humans...
  11. pmc Chloroquine is a potent inhibitor of SARS coronavirus infection and spread
    Martin J Vincent
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Virol J 2:69. 2005
    ..Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available...
  12. pmc Molecular evolution of viruses of the family Filoviridae based on 97 whole-genome sequences
    Serena A Carroll
    Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 87:2608-16. 2013
    ....
  13. pmc Rift valley fever virus lacking the NSs and NSm genes is highly attenuated, confers protective immunity from virulent virus challenge, and allows for differential identification of infected and vaccinated animals
    Brian H Bird
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 14, Atlanta, GA 30329, USA
    J Virol 82:2681-91. 2008
    ....
  14. pmc Reverse genetics generation of chimeric infectious Junin/Lassa virus is dependent on interaction of homologous glycoprotein stable signal peptide and G2 cytoplasmic domains
    Cesar G Albarino
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 14, Atlanta, GA 30329, USA
    J Virol 85:112-22. 2011
    ..These recombinant chimeric viruses shed light on the fundamental requirements of arenavirus GPC maturation and may serve as a strategy for the development of bivalent JUNV and LASV vaccine candidates...
  15. pmc Solid organ transplant-associated lymphocytic choriomeningitis, United States, 2011
    Adam MacNeil
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 18:1256-62. 2012
    ..In this cluster, all recipients developed severe illness, but 2 survived. LCMV infection should be considered as a possible cause of severe posttransplant illness...
  16. pmc Severe hemorrhagic fever in strain 13/N guinea pigs infected with Lujo virus
    Brian H Bird
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Negl Trop Dis 6:e1801. 2012
    ..Establishing an animal LUJV model is an important first step towards understanding the high pathogenicity of LUJV and developing vaccines and antiviral therapeutic drugs for this highly transmissible and lethal emerging pathogen...
  17. pmc Crimean-Congo hemorrhagic fever virus genomics and global diversity
    Varough M Deyde
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Atlanta, GA 30329, USA
    J Virol 80:8834-42. 2006
    ..An analysis of individual segment datasets suggests genetic recombination also occurs. For an arthropod-borne virus, the genomic plasticity of CCHF virus is surprisingly high...
  18. pmc Marburg virus infection detected in a common African bat
    Jonathan S Towner
    Centers for Disease Control and Prevention, Special Pathogens Branch, Atlanta, Georgia, United States of America
    PLoS ONE 2:e764. 2007
    ..These data imply that more areas are at risk for MHF outbreaks than previously realized and correspond well with a recently published report in which three species of fruit bats were demonstrated to be likely reservoirs for Ebola virus...
  19. pmc Efficient reverse genetics generation of infectious junin viruses differing in glycoprotein processing
    Cesar G Albarino
    Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Virol 83:5606-14. 2009
    ....
  20. pmc Reverse genetic generation of recombinant Zaire Ebola viruses containing disrupted IRF-3 inhibitory domains results in attenuated virus growth in vitro and higher levels of IRF-3 activation without inhibiting viral transcription or replication
    Amy L Hartman
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 14, Atlanta, GA 30329, USA
    J Virol 80:6430-40. 2006
    ....
  21. doi request reprint Ancient common ancestry of Crimean-Congo hemorrhagic fever virus
    Serena A Carroll
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 14, Atlanta, GA 30333, USA
    Mol Phylogenet Evol 55:1103-10. 2010
    ..Changes in agricultural practices and climate occurring near the time of the most recent common ancestor of CCHFV may have contributed to its emergence and spread...
  22. pmc Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda
    Jonathan S Towner
    Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Pathog 4:e1000212. 2008
    ....
  23. ncbi request reprint A new phlebovirus associated with severe febrile illness in Missouri
    Laura K McMullan
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 367:834-41. 2012
    ..Although Koch's postulates have not been completely fulfilled, we believe that this phlebovirus, which is novel in the Americas, is the cause of this clinical syndrome...
  24. pmc Reverse genetics recovery of Lujo virus and role of virus RNA secondary structures in efficient virus growth
    Eric Bergeron
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 86:10759-65. 2012
    ..The technology for producing recombinant Lujo virus now provides a method to precisely investigate the molecular determinants of virulence of this newly identified pathogen...
  25. pmc Single-dose immunization with virus replicon particles confers rapid robust protection against Rift Valley fever virus challenge
    Kimberly A Dodd
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 86:4204-12. 2012
    ..These data demonstrate that replicon vaccines successfully bridge the gap between safety and efficacy and provide insights into the kinetics of antiviral protection from RVFV infection...
  26. pmc Crimean-Congo hemorrhagic fever virus-encoded ovarian tumor protease activity is dispensable for virus RNA polymerase function
    Eric Bergeron
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Virol 84:216-26. 2010
    ..These results demonstrated the utility of the minigenome system for use in BSL-2 laboratory settings to analyze CCHFV biology and in antiviral drug discovery programs for this important public health and bioterrorism threat...
  27. pmc Genetic evidence for Rift Valley fever outbreaks in Madagascar resulting from virus introductions from the East African mainland rather than enzootic maintenance
    Serena A Carroll
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, Georgia 30333, USA
    J Virol 85:6162-7. 2011
    ..These data are consistent with the notion that RVFV outbreaks in Madagascar result not from emergence from enzootic cycles within the country but from recurrent virus introductions from the East African mainland...
  28. pmc The major determinant of attenuation in mice of the Candid1 vaccine for Argentine hemorrhagic fever is located in the G2 glycoprotein transmembrane domain
    Cesar G Albarino
    Centers for Disease Control and Prevention, MS G14, Atlanta, GA 30329, USA
    J Virol 85:10404-8. 2011
    ..This work provides insight into the molecular mechanisms of attenuation of the only arenavirus vaccine currently available...
  29. pmc Single-dose replication-defective VSV-based Nipah virus vaccines provide protection from lethal challenge in Syrian hamsters
    Michael K Lo
    Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States Electronic address
    Antiviral Res 101:26-9. 2014
    ..This highly effective single-dose protection coupled with an enhanced safety profile makes these candidates ideal for potential use in livestock and humans. ..
  30. pmc Development of a RVFV ELISA that can distinguish infected from vaccinated animals
    Anita K McElroy
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virol J 6:125. 2009
    ..However, the ability to distinguish infected from vaccinated animals is important for vaccine acceptance by national and international authorities, given regulations restricting movement and export of infected animals...
  31. ncbi request reprint Development of a reverse genetics system to generate recombinant Marburg virus derived from a bat isolate
    Cesar G Albarino
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 446:230-7. 2013
    ..Surprisingly, when these recombinant MARVs were propagated in primary human macrophages, a dramatic difference was found in their ability to grow and to elicit anti-viral cytokine responses. ..
  32. pmc Infection and transmission of Rift Valley fever viruses lacking the NSs and/or NSm genes in mosquitoes: potential role for NSm in mosquito infection
    Mary B Crabtree
    Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, United States of America
    PLoS Negl Trop Dis 6:e1639. 2012
    ....
  33. ncbi request reprint High-throughput molecular detection of hemorrhagic fever virus threats with applications for outbreak settings
    Jonathan S Towner
    Special Pathogens Branch, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 196:S205-12. 2007
    ..Furthermore, the applicability of this method to an outbreak setting was demonstrated by correct analysis of >500 specimens at a field laboratory established during a recent outbreak of Marburg hemorrhagic fever in Angola...
  34. ncbi request reprint Two cases of hantavirus pulmonary syndrome in Randolph County, West Virginia: a coincidence of time and place?
    Julie R Sinclair
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 76:438-42. 2007
    ..These cases emphasize the need to educate the public throughout the United States regarding risks and prevention measures for hantavirus infection...
  35. doi request reprint Hantavirus pulmonary syndrome
    Adam MacNeil
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
    Virus Res 162:138-47. 2011
    ..However, virus infection results in microvascular leakage, which is the hallmark of HPS. This article briefly reviews the knowledge on HPS-associated hantaviruses accumulated since their discovery, less than 20 years ago...
  36. pmc Marburgvirus genomics and association with a large hemorrhagic fever outbreak in Angola
    Jonathan S Towner
    Special Pathogens Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop G14, Atlanta, GA 30333, USA
    J Virol 80:6497-516. 2006
    ..This is in contrast to the 1998 to 2000 marburgvirus outbreak, where evidence of several virus genetic lineages (with up to 21% divergence) and multiple virus introductions into the human population was found...
  37. pmc A shared transcription termination signal on negative and ambisense RNA genome segments of Rift Valley fever, sandfly fever Sicilian, and Toscana viruses
    Cesar G Albarino
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 14, Atlanta, GA 30329, USA
    J Virol 81:5246-56. 2007
    ....
  38. pmc Pet rodents and fatal lymphocytic choriomeningitis in transplant patients
    Brian R Amman
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 13:719-25. 2007
    ..This report details the animal traceback and the supporting laboratory investigations...
  39. pmc Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome
    Jonathan S Towner
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 78:4330-41. 2004
    ..Furthermore, both sequence and epidemiologic data are consistent with the outbreak having originated from a single introduction into the human population...
  40. pmc Crimean-congo hemorrhagic fever virus glycoprotein precursor is cleaved by Furin-like and SKI-1 proteases to generate a novel 38-kilodalton glycoprotein
    Angela J Sanchez
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Mail Stop G 14, 1600 Clifton Rd, Atlanta, GA 30333, USA
    J Virol 80:514-25. 2006
    ..Analogy with soluble glycoproteins and mucin-like proteins encoded by other hemorrhagic fever-associated RNA viruses suggests these proteins could play an important role in viral pathogenesis...
  41. ncbi request reprint RIG-I activation inhibits ebolavirus replication
    Christina F Spiropoulou
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Virology 392:11-5. 2009
    ..These findings indicate that RIG-I-based therapies may provide an attractive approach for antivirals against Ebola hemorrhagic fever, and possibly other HF viruses...
  42. pmc Efficient rescue of recombinant Lassa virus reveals the influence of S segment noncoding regions on virus replication and virulence
    Cesar G Albarino
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G14, Atlanta, GA 30329, USA
    J Virol 85:4020-4. 2011
    ..This work demonstrates that deletions of large portions of these NCRs confer an attenuated phenotype and are a first step toward further insights into the high virulence of LASV...
  43. pmc Highly sensitive and broadly reactive quantitative reverse transcription-PCR assay for high-throughput detection of Rift Valley fever virus
    Brian H Bird
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA
    J Clin Microbiol 45:3506-13. 2007
    ....
  44. pmc High diversity and ancient common ancestry of lymphocytic choriomeningitis virus
    Cesar G Albarino
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 16:1093-100. 2010
    ..Bayesian analysis estimates the most recent common ancestor to be 1,000-5,000 years old, and this long history is consistent with complex phylogeographic relationships of the extant virus isolates...
  45. pmc Crimean-Congo hemorrhagic fever virus glycoprotein processing by the endoprotease SKI-1/S1P is critical for virus infectivity
    Eric Bergeron
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Virol 81:13271-6. 2007
    ..SKI-1/S1P may represent a promising antiviral target...
  46. pmc Inhibition of IRF-3 activation by VP35 is critical for the high level of virulence of ebola virus
    Amy L Hartman
    Centers for Disease Control and Prevention, 1600 Clifton Rd, MS G 14, Atlanta, GA 30329, USA
    J Virol 82:2699-704. 2008
    ..Given that these viruses differ by only a single amino acid in the IRF-3 inhibitory domain of VP35, the level of alteration of virulence is remarkable and highlights the importance of VP35 for the pathogenesis of Ebola virus...
  47. ncbi request reprint N-linked glycosylation of Gn (but not Gc) is important for Crimean Congo hemorrhagic fever virus glycoprotein localization and transport
    Bobbie R Erickson
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA
    Virology 361:348-55. 2007
    ....
  48. pmc Inhibitors of the tick-borne, hemorrhagic Fever-associated flaviviruses
    Mike Flint
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Antimicrob Agents Chemother 58:3206-16. 2014
    ..The S603 and C666 residues were predicted to lie in the active site of the AHFV NS5 polymerase, implicating the catalytic center of the enzyme as the binding site for 2'-CMC. ..
  49. ncbi request reprint The high genetic variation of viruses of the genus Nairovirus reflects the diversity of their predominant tick hosts
    Jessica E Honig
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 318:10-6. 2004
    ..Fossil and phylogenetic data placing the hard tick-soft tick divergence between 120 and 92 million years ago suggest an ancient origin for viruses of the genus Nairovirus...
  50. doi request reprint Filovirus outbreak detection and surveillance: lessons from Bundibugyo
    Adam MacNeil
    Viral Special Pathogens Branch, The Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 204:S761-7. 2011
    ....
  51. ncbi request reprint Marburg hemorrhagic fever associated with multiple genetic lineages of virus
    Daniel G Bausch
    Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 355:909-19. 2006
    ..An outbreak of Marburg hemorrhagic fever was first observed in a gold-mining village in northeastern Democratic Republic of the Congo in October 1998...
  52. pmc Rift Valley fever virus clearance and protection from neurologic disease are dependent on CD4+ T cell and virus-specific antibody responses
    Kimberly A Dodd
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 87:6161-71. 2013
    ..Together, these results indicate CD4(+) T cells are critical determinants of RVFV pathogenesis and play an important role in preventing onset of neurologic disease...
  53. ncbi request reprint Crimean-Congo hemorrhagic fever virus genome L RNA segment and encoded protein
    Jessica E Honig
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 321:29-35. 2004
    ....
  54. pmc Cell culture and electron microscopy for identifying viruses in diseases of unknown cause
    Cynthia S Goldsmith
    Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop G32, Atlanta, GA 30329, USA
    Emerg Infect Dis 19:886-91. 2013
    ..These cases illustrate the importance of the techniques of cell culture and electron microscopy in pathogen identification and recognition of emerging diseases...
  55. ncbi request reprint High-throughput, luciferase-based reverse genetics systems for identifying inhibitors of Marburg and Ebola viruses
    Luke S Uebelhoer
    Centers for Disease Control and Prevention, Atlanta, USA
    Antiviral Res 106:86-94. 2014
    ..We anticipate that both approaches will prove highly useful in the development of anti-filovirus therapies, as well as in basic research on the filovirus life cycle. ..
  56. pmc Deletion of the NSm virulence gene of Rift Valley fever virus inhibits virus replication in and dissemination from the midgut of Aedes aegypti mosquitoes
    Rebekah C Kading
    Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, United States of America
    PLoS Negl Trop Dis 8:e2670. 2014
    ..aegypti infected with reverse genetics-generated wild type RVFV (rRVF-wt) or RVFV lacking the NSm virulence gene (rRVF-ΔNSm) by examining sagittal sections of infected mosquitoes for viral antigen at various time points post-infection...
  57. ncbi request reprint Synthesis, proteolytic processing and complex formation of N-terminally nested precursor proteins of the Rift Valley fever virus glycoproteins
    Sonja R Gerrard
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, MS G 14, Atlanta, GA 30333, USA
    Virology 357:124-33. 2007
    ..Interestingly, Gc can form a complex with a glycoprotein that has been considered nonstructural, a discovery that has implications for both the topology and potential packaging of this glycoprotein...
  58. pmc Ebola hemorrhagic Fever: novel biomarker correlates of clinical outcome
    Anita K McElroy
    Viral Special Pathogens Branch, Centers for Disease Control and Prevention Division of Pediatric Infectious Disease, Emory University School of Medicine, Atlanta, Georgia
    J Infect Dis 210:558-66. 2014
    ..Serum specimens from this outbreak had been preserved in liquid nitrogen from the time of collection and were available for analysis...
  59. doi request reprint Breaking the chain: Rift Valley fever virus control via livestock vaccination
    Brian H Bird
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 14, Atlanta, GA 30333, USA
    Curr Opin Virol 2:315-23. 2012
    ..Preventing RVFV infection of livestock by vaccination is a key element in breaking the chain of human epidemics, and could lead to control of this significant public health threat...
  60. pmc Host mTORC1 signaling regulates andes virus replication
    Shannon McNulty
    Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA
    J Virol 87:912-22. 2013
    ....
  61. pmc Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1
    Martin J Vincent
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, 30333, USA
    J Virol 77:8640-9. 2003
    ....
  62. ncbi request reprint Rift Valley fever virus lacking NSm proteins retains high virulence in vivo and may provide a model of human delayed onset neurologic disease
    Brian H Bird
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road MS G 14, Atlanta, GA 30329, USA
    Virology 362:10-5. 2007
    ..Such infections may provide the basis for study of both RVF acute hepatic disease and delayed onset encephalitic disease in humans...
  63. doi request reprint Rift Valley fever virus inhibits a pro-inflammatory response in experimentally infected human monocyte derived macrophages and a pro-inflammatory cytokine response may be associated with patient survival during natural infection
    Anita K McElroy
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control, MS G14, Atlanta, GA 30333, USA
    Virology 422:6-12. 2012
    ..Finally, analysis of RVF patient samples demonstrated an association between a pro-inflammatory cytokine response and patient survival...
  64. pmc Kyasanur Forest disease virus infection in mice is associated with higher morbidity and mortality than infection with the closely related Alkhurma hemorrhagic fever virus
    Kimberly A Dodd
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America University of California, Davis, School of Veterinary Medicine, Davis, California, United States of America
    PLoS ONE 9:e100301. 2014
    ..Case reports suggest KFDV is more commonly associated with hepatic and gastrointestinal manifestations whereas AHFV is more commonly associated with neurologic disease...
  65. ncbi request reprint A C-terminal basic amino acid motif of Zaire ebolavirus VP35 is essential for type I interferon antagonism and displays high identity with the RNA-binding domain of another interferon antagonist, the NS1 protein of influenza A virus
    Amy L Hartman
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road MS G 14 Atlanta, GA 30329, USA
    Virology 328:177-84. 2004
    ..Remarkably, this basic amino acid motif displayed high sequence identity with part of the N-terminal RNA-binding domain of another interferon-antagonist, the NS1 protein of influenza A virus...
  66. pmc Thottapalayam virus is genetically distant to the rodent-borne hantaviruses, consistent with its isolation from the Asian house shrew (Suncus murinus)
    Pragya D Yadav
    Special Pathogen Branch, Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virol J 4:80. 2007
    ....
  67. ncbi request reprint Hantavirus pulmonary syndrome in Central Bolivia: relationships between reservoir hosts, habitats, and viral genotypes
    Darin S Carroll
    Division of Viral and Rickettsial Diseases, Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 72:42-6. 2005
    ..callosus was 99% identical to viral sequences obtained from the HPS patient in this area, implicating C. callosus as the host and Laguna Negra virus as the agent responsible for the HPS case near Concepcion...
  68. pmc Characterization of the glycoproteins of Crimean-Congo hemorrhagic fever virus
    Angela J Sanchez
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 76:7263-75. 2002
    ....
  69. pmc Proportion of deaths and clinical features in Bundibugyo Ebola virus infection, Uganda
    Adam MacNeil
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 16:1969-72. 2010
    ..Although signs and symptoms were largely nonspecific and similar to those of EHF outbreaks caused by Zaire and Sudan Ebola viruses, proportion of deaths among those infected was lower (≈40%)...
  70. pmc Whole-genome expression profiling reveals that inhibition of host innate immune response pathways by Ebola virus can be reversed by a single amino acid change in the VP35 protein
    Amy L Hartman
    Centers for Disease Control and Prevention, Special Pathogens Branch, Atlanta, Georgia 30329, USA
    J Virol 82:5348-58. 2008
    ..The ability to eliminate this inhibitory effect with a single amino acid change in VP35 demonstrates the critical role this protein must play in the severe aspects this highly fatal disease...
  71. pmc Exposure to lymphocytic choriomeningitis virus, new york, USA
    Barbara Knust
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 17:1324-5. 2011
    ..Human infections can range from mild febrile illness to severe encephalitis and disseminated disease (1). Infection during pregnancy is associated with teratogenic effects, including congenital hydrocephalus and chorioretinitis (2)...
  72. doi request reprint Using next generation sequencing to identify yellow fever virus in Uganda
    Laura K McMullan
    Virus Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA
    Virology 422:1-5. 2012
    ..This finding demonstrated the utility of next generation sequencing and a metagenomic approach to identify an etiological agent and direct the response to a disease outbreak...
  73. pmc Characterization of the Golgi retention motif of Rift Valley fever virus G(N) glycoprotein
    Sonja R Gerrard
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 76:12200-10. 2002
    ....
  74. pmc Seoul virus infection in a Wisconsin patient with recent travel to China, March 2009: first documented case in the Midwestern United States
    Carrie F Nielsen
    Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Trop Med Hyg 83:1266-8. 2010
    ..We describe confirmation of a Seoul virus infection in a 36-year-old scientist who worked with laboratory rats in Milwaukee, Wisconsin, but most likely acquired the infection during a trip to Shenyang, China...
  75. ncbi request reprint Generation of eGFP expressing recombinant Zaire ebolavirus for analysis of early pathogenesis events and high-throughput antiviral drug screening
    Jonathan S Towner
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, NCID, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 332:20-7. 2005
    ..We show that Ebola-eGFP virus (EboZ-eGFP) infects known early targets of human infections and serves as an ideal model to screen antiviral compounds in less time than any previously published assay...
  76. pmc Ngari virus is a Bunyamwera virus reassortant that can be associated with large outbreaks of hemorrhagic fever in Africa
    Sonja R Gerrard
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA 30333, USA
    J Virol 78:8922-6. 2004
    ..Ngari virus should be considered when investigating hemorrhagic fever outbreaks throughout sub-Saharan Africa...
  77. ncbi request reprint Bidirectional infection and release of Rift Valley fever virus in polarized epithelial cells
    Sonja R Gerrard
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Virology 301:226-35. 2002
    ..Furthermore, our results indicate that RVF virus causes disruptions in both the microfilament and the microtubule networks. These disruptions may provide a mechanism for bidirectional release of RVF virions...
  78. ncbi request reprint Analysis of the role of predicted RNA secondary structures in Ebola virus replication
    Sharon M Crary
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 306:210-8. 2003
    ....
  79. ncbi request reprint Nairobi sheep disease virus, an important tick-borne pathogen of sheep and goats in Africa, is also present in Asia
    Beate I Marczinke
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Virology 303:146-51. 2002
    ..Genetic and serologic data demonstrate that Ganjam virus is an Asian variant of NSD virus. These viruses were phylogenetically more closely related to Hazara virus than Dugbe virus...