D B Miller

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. doi request reprint Do early-life insults contribute to the late-life development of Parkinson and Alzheimer diseases?
    Diane B Miller
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Metabolism 57:S44-9. 2008
  2. doi request reprint Personalized medicine in major depressive disorder -- opportunities and pitfalls
    Diane B Miller
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Metabolism 62:S34-9. 2013
  3. ncbi request reprint The pharmacology of wakefulness
    Diane B Miller
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Metabolism 55:S13-9. 2006
  4. ncbi request reprint Aging, stress and the hippocampus
    D B Miller
    Chronic Stress and Neurotoxicology Laboratories, TMBB HELD, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health CDC NIOSH, Morgantown, WV 26505, USA
    Ageing Res Rev 4:123-40. 2005
  5. ncbi request reprint Depression, cytokines, and glial function
    Diane B Miller
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Metabolism 54:33-8. 2005
  6. ncbi request reprint Elevated environmental temperature and methamphetamine neurotoxicity
    Diane B Miller
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, Centers for Disease Control, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Environ Res 92:48-53. 2003
  7. ncbi request reprint Age as a susceptibility factor in the striatal dopaminergic neurotoxicity observed in the mouse following substituted amphetamine exposure
    D B Miller
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, NIOSH CDC, Morgantown, West Virginia 26505, USA
    Ann N Y Acad Sci 914:194-207. 2000
  8. ncbi request reprint Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor-alpha
    Krishnan Sriram
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Neurochem 96:706-18. 2006
  9. ncbi request reprint Restraint as a stressor in mice: against the dopaminergic neurotoxicity of D-MDMA, low body weight mitigates restraint-induced hypothermia and consequent neuroprotection
    E A Johnson
    Chronic Stress Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health Centers for Disease Control, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Brain Res 875:107-18. 2000
  10. ncbi request reprint The impact of gender and estrogen on striatal dopaminergic neurotoxicity
    D B Miller
    Toxiology and Molecular Biology Branch, CDC NIOSH, Morgantown, West Virginia 26505 2888, USA
    Ann N Y Acad Sci 844:153-65. 1998

Collaborators

Detail Information

Publications39

  1. doi request reprint Do early-life insults contribute to the late-life development of Parkinson and Alzheimer diseases?
    Diane B Miller
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Metabolism 57:S44-9. 2008
    ..More definitive knowledge of the key risk factors involved will be needed to implement intervention and preventative strategies early in life to dampen or prevent any adverse late-life outcomes...
  2. doi request reprint Personalized medicine in major depressive disorder -- opportunities and pitfalls
    Diane B Miller
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Metabolism 62:S34-9. 2013
    ..In the foreseeable future, further interrogation of the genome may serve as the basis for development of new personalized medicine strategies for diagnosis and treatment of MDD...
  3. ncbi request reprint The pharmacology of wakefulness
    Diane B Miller
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Metabolism 55:S13-9. 2006
    ....
  4. ncbi request reprint Aging, stress and the hippocampus
    D B Miller
    Chronic Stress and Neurotoxicology Laboratories, TMBB HELD, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health CDC NIOSH, Morgantown, WV 26505, USA
    Ageing Res Rev 4:123-40. 2005
    ....
  5. ncbi request reprint Depression, cytokines, and glial function
    Diane B Miller
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Metabolism 54:33-8. 2005
    ..We suggest that glial cells, both as a source and target of cytokines, represent the overlooked targets involved in the etiology of depression...
  6. ncbi request reprint Elevated environmental temperature and methamphetamine neurotoxicity
    Diane B Miller
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, Centers for Disease Control, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Environ Res 92:48-53. 2003
    ..Single-dose regimens may aid in uncovering the as yet unknown mechanism(s) of substituted amphetamine neurotoxicity because they reduce the inherent complexity present in repeated dosage regimens...
  7. ncbi request reprint Age as a susceptibility factor in the striatal dopaminergic neurotoxicity observed in the mouse following substituted amphetamine exposure
    D B Miller
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, NIOSH CDC, Morgantown, West Virginia 26505, USA
    Ann N Y Acad Sci 914:194-207. 2000
    ..These data suggest maturity of striatal dopamine systems may be an essential element in the striatal damage induced by the neurotoxic amphetamines...
  8. ncbi request reprint Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor-alpha
    Krishnan Sriram
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Neurochem 96:706-18. 2006
    ..These findings support the hypothesis that TNF-alpha may play a role in the selective vulnerability of the nigrostriatal pathway associated with dopaminergic neurotoxicity and perhaps Parkinson's disease...
  9. ncbi request reprint Restraint as a stressor in mice: against the dopaminergic neurotoxicity of D-MDMA, low body weight mitigates restraint-induced hypothermia and consequent neuroprotection
    E A Johnson
    Chronic Stress Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health Centers for Disease Control, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Brain Res 875:107-18. 2000
    ..The restraint manipulation is not as straight-forward a procedure as is commonly believed. Our data indicate that consistent application of restraint may require an adjustment of the restrainer device to mouse body weight...
  10. ncbi request reprint The impact of gender and estrogen on striatal dopaminergic neurotoxicity
    D B Miller
    Toxiology and Molecular Biology Branch, CDC NIOSH, Morgantown, West Virginia 26505 2888, USA
    Ann N Y Acad Sci 844:153-65. 1998
    ..Surprisingly, estrogen supplementation did not protect against the neurotoxic effects of MPTP in intact 2-yr-old intact female mice, suggesting that low endogenous levels of estrogen may provide neuroprotection...
  11. ncbi request reprint Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: implications for Parkinson's disease
    Krishnan Sriram
    Centers for Disease Control and Prevention NIOSH, Morgantown, West Virginia 26505, USA
    FASEB J 16:1474-6. 2002
    ..Moreover, because TNF-alpha is synthesized predominantly by microglia and astrocytes, our findings implicate the participation of glial cells in MPTP-induced neurotoxicity. Similar mechanisms may underlie the etiopathogenesis of PD...
  12. ncbi request reprint Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF-alpha
    Krishnan Sriram
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    FASEB J 20:670-82. 2006
    ..Taken together, our results are indicative of a region-specific and dual role for TNF-alpha in the brain: a promoter of neurodegeneration in striatum and a protector against neurodegeneration in hippocampus...
  13. doi request reprint Trimethyltin-induced neurotoxicity: gene expression pathway analysis, q-RT-PCR and immunoblotting reveal early effects associated with hippocampal damage and gliosis
    A R Little
    Molecular Neurotoxicology Laboratory, Health Effects Research Laboratory, Centers for Disease Control and Prevention NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Neurotoxicol Teratol 34:72-82. 2012
    ..These observations provide new insight into early events associated with neuronal degeneration and associated glial activation that may serve as the basis for discovery and development of biomarkers of neurotoxicity...
  14. ncbi request reprint Obesity exacerbates chemically induced neurodegeneration
    K Sriram
    HELD TMBB, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Mailstop L 3014, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Neuroscience 115:1335-46. 2002
    ..These events may underlie the enhanced neurotoxicity seen in the obese mice. In summary, our results implicate obesity as a risk factor associated with chemical- and possibly disease-induced neurodegeneration...
  15. ncbi request reprint Induction of gp130-related cytokines and activation of JAK2/STAT3 pathway in astrocytes precedes up-regulation of glial fibrillary acidic protein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of neurodegeneration: key signaling pathway for ast
    Krishnan Sriram
    HELD TMBB, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    J Biol Chem 279:19936-47. 2004
    ..Taken together, our results suggest that the gp130-mediated activation of JAK2/STAT3 signaling pathway may play a key role in the induction of astrogliosis...
  16. doi request reprint Protracted exposure to supraphysiological levels of corticosterone does not cause neuronal loss or damage and protects against kainic acid-induced neurotoxicity in the hippocampus of C57BL/6J mice
    Stanley A Benkovic
    Toxicology and Molecular Biology Branch, Centers for Disease Control and Prevention National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Neurotoxicology 30:965-76. 2009
    ..Our data indicate supraphysiological levels of CORT do not cause neuronal death or injury in hippocampus of C57BL/6J mice and provide neuroprotection against KA-induced neural damage...
  17. pmc Age exaggerates proinflammatory cytokine signaling and truncates signal transducers and activators of transcription 3 signaling following ischemic stroke in the rat
    V A Dinapoli
    Department of Neurosurgery, West Virginia University School of Medicine, Morgantown, WV 26506, USA
    Neuroscience 170:633-44. 2010
    ..These data provide further evidence of the prominent role played by age in the molecular and cellular responses to ischemic stroke and suggest that astrocytes may represent targets for future therapies aimed at improving stroke outcome...
  18. doi request reprint Spinal glia and chronic pain
    James P O'Callaghan
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Metabolism 59:S21-6. 2010
    ....
  19. ncbi request reprint Area under the curve and other summary indicators of repeated waking cortisol measurements
    Desta B Fekedulegn
    Biostatistics and Epidemiology Branch, National Institute for Occupational Safety and Health, HELD BEB, MS 4050, 1095 Willowdale Rd, Morgantown, WV 26505, USA
    Psychosom Med 69:651-9. 2007
    ..The latter parameters, AUC(I), however, is seldom used by research scientists...
  20. pmc Work, obesity, and occupational safety and health
    Paul A Schulte
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA
    Am J Public Health 97:428-36. 2007
    ....
  21. doi request reprint Mild steel welding fume causes manganese accumulation and subtle neuroinflammatory changes but not overt neuronal damage in discrete brain regions of rats after short-term inhalation exposure
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Neurotoxicology 30:915-25. 2009
    ..The neurofunctional significance of these findings currently is being investigated in longer, more chronic welding fume exposure studies...
  22. doi request reprint Defining "neuroinflammation"
    James P O'Callaghan
    Centers for Disease Control and Prevention NIOSH Morgantown, West Virginia, USA
    Ann N Y Acad Sci 1139:318-30. 2008
    ....
  23. ncbi request reprint Development of an animal model to study the potential neurotoxic effects associated with welding fume inhalation
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Neurotoxicology 27:745-51. 2006
    ..With the development of this novel system, an animal model has been established using controlled welding exposures to investigate the possible mechanisms by which welding fume may affect the central nervous system...
  24. ncbi request reprint Brain concentrations of d-MDMA are increased after stress
    Elizabeth Anne Johnson
    Chronic Stress Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health Centers for Disease Control, 1095 Willowdale Road, Morgantown, VA 26505, USA
    Psychopharmacology (Berl) 173:278-86. 2004
    ..Various stressors and hypothermia protect against d-MDMA-induced neurotoxicity through unknown mechanisms, one of which could be a reduction in the distribution of d-MDMA to the brain...
  25. ncbi request reprint d-MDMA during vitamin E deficiency: effects on dopaminergic neurotoxicity and hepatotoxicity
    Elizabeth Anne Johnson
    Chronic Stress Laboratory, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health Centers for Disease Control, Mailstop 3014, 1095 Willowdale Road, 26505, Morgantown, WV, USA
    Brain Res 933:150-63. 2002
    ....
  26. ncbi request reprint Chronic treatment with supraphysiological levels of corticosterone enhances D-MDMA-induced dopaminergic neurotoxicity in the C57BL/6J female mouse
    Elizabeth Anne Johnson
    Chronic Stress and Molecular Neurotoxicology Laboratories, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health Centers for Disease Control, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Brain Res 933:130-8. 2002
    ..An examination of other mouse strains and models of neurotoxic injury would be useful in determining the general validity of the glucocorticoid neuroendangerment hypothesis...
  27. ncbi request reprint Associations of cortical astrogliosis with cognitive performance and dementia status
    Michael L Kashon
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505, USA
    J Alzheimers Dis 6:595-604; discussion 673-81. 2004
    ..Our findings underscore the need to look beyond standard neuropathological measures putatively linked to specific neuropathological conditions in efforts to identify common cellular and molecular processes that contribute to dementia...
  28. ncbi request reprint Effects of aging and stress on hippocampal structure and function
    D B Miller
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Metabolism 52:17-21. 2003
    ..The general preservation of cells and the plastic potential of the hippocampus provide a focus for the development of pharmacological, nutritional, or life-style strategies to combat age-related declines...
  29. ncbi request reprint Chemically induced neuronal damage and gliosis: enhanced expression of the proinflammatory chemokine, monocyte chemoattractant protein (MCP)-1, without a corresponding increase in proinflammatory cytokines(1)
    A R Little
    TMBB HELD, MS 3014, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505 2888, USA
    Neuroscience 115:307-20. 2002
    ....
  30. doi request reprint A framework for the concurrent consideration of occupational hazards and obesity
    P A Schulte
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, MS C14, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
    Ann Occup Hyg 52:555-66. 2008
    ..Utilizing this framework may advance the efforts to address the major societal health problems of occupational hazards and obesity...
  31. ncbi request reprint Restraint stress applied prior to chemical sensitization modulates the development of allergic contact dermatitis differently than restraint prior to challenge
    M S Flint
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    J Neuroimmunol 113:72-80. 2001
    ..These data show that acute restraint modulates cutaneous sensitization differently than challenge, but the changes are not reflected in TNF-alpha or IL-l beta production...
  32. ncbi request reprint Neuroendocrine aspects of the response to stress
    Diane B Miller
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Metabolism 51:5-10. 2002
    ..Advances in molecular biology provide the tools and new opportunities for identifying these therapeutic targets...
  33. pmc Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2
    Ann F Hubbs
    Experimental Pathology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health CDC, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Am J Pathol 170:2068-76. 2007
    ..If this role is confirmed, it may suggest new approaches to treating genetically and chemically induced myelin degenerative diseases...
  34. ncbi request reprint The Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) pilot study: methods and participant characteristics
    John M Violanti
    School of Public Health and Health Professions, Department of Social and Preventive Medicine, State University of New York at Buffalo 14214 8001, USA
    Ann Epidemiol 16:148-56. 2006
    ..This pilot study was undertaken to establish a methodology and descriptive results for a larger police study...
  35. ncbi request reprint Neuronal and astroglial responses to the serotonin and norepinephrine neurotoxin: 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine
    Beth A Luellen
    The Pennsylvania State University, 152 Davey Laboratory, University Park, PA 16802, USA
    J Pharmacol Exp Ther 307:923-31. 2003
    ....
  36. pmc Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum
    Akinori Nishi
    Department of Pharmacology, Kurume University School of Medicine and Japan Science of Technology Agency, Core Research for Evolutional Science and Technology, Kurume, Fukuoka 830 0011, Japan
    J Neurosci 28:10460-71. 2008
    ..These data underscore the importance of individual brain-enriched cyclic-nucleotide PDE isoforms as therapeutic targets for neuropsychiatric and neurodegenerative disorders affecting dopamine neurotransmission...
  37. ncbi request reprint Selective changes in gene expression in cortical regions sensitive to amphetamine during the neurodegenerative process
    John F Bowyer
    Divisions of Neurotoxicology, Biometry and Risk Assessment and Genetic Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Neurotoxicology 25:555-72. 2004
    ..5-fold of control. Nonetheless, some of these lesser fold-changes appeared to be relevant to the neurotoxic process...
  38. ncbi request reprint Thermoregulation and its influence on toxicity assessment
    Christopher J Gordon
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, B105 04, U S Environmental Protection Agency, 109 S T W Alexander Drive, Research Triangle Park, NC 27711, USA
    Toxicology 244:87-97. 2008
    ..This paper endeavors to summarize the importance of thermoregulation in the study of toxicology and propose recommendations for thermometry that researchers may utilize in their toxicological studies...
  39. ncbi request reprint Differential vulnerability of snake species to MPTP: a behavioral and biochemical comparison in ratsnakes (Elaphe) and watersnakes (Nerodia)
    John G Temple
    Department of Biological Sciences, Mary Washington College, Fredericksburg, VA 22401, USA
    Neurotoxicol Teratol 24:227-33. 2002
    ..o. obsoleta that differs from that in N.f. fasciata. The differential sensitivities to monoaminergic modulation may be related to the contrasting diets of these species...