Research Topics
Species | Brian J McMahonSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
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Publications
The natural history of chronic hepatitis B virus infectionBrian J McMahon
Viral Hepatitis Program, Alaska Native Medical Center, Anchorage, Alaska 99508 5902, USA
Semin Liver Dis 24:17-21. 2004..Future research will help clarify the outcome of chronic HBV infection...- Epidemiology and natural history of hepatitis BBrian J McMahon
Liver Disease and Hepatitis Program, Alaska Native Medical Center, Anchorage, Alaska, USA
Semin Liver Dis 25:3-8. 2005..Persons identified with chronic HBV infection need lifelong, regular monitoring for the development of active liver disease and HCC... 
Elimination of hepatocellular carcinoma and acute hepatitis B in children 25 years after a hepatitis B newborn and catch-up immunization programBrian J McMahon
Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, AK 99508, USA
Hepatology 54:801-7. 2011....- Reinfection after successful eradication of Helicobacter pylori: a 2-year prospective study in Alaska NativesB J McMahon
Department of Internal Medicine, Alaska Native Medical Center, Anchorage, USA
Aliment Pharmacol Ther 23:1215-23. 2006..Limited information exists regarding risk factors for reinfection after cure of Helicobacter pylori infection... - Natural history of chronic hepatitis BBrian J McMahon
Alaska Native Tribal Health Consortium, Anchorage, AK, USA
Clin Liver Dis 14:381-96. 2010..Finally, ways in which the natural history can be altered by hepatitis B vaccination and identification, close monitoring, and appropriate treatment of chronically infected individuals are reviewed... 
Natural history of chronic hepatitis B - clinical implicationsBrian J McMahon
Liver Disease and Hepatitis Program, Alaska Native Medical Center, Anchorage, Alaska, USA
Medscape J Med 10:91. 2008- Implementing evidenced-based practice guidelines for the management of chronic hepatitis B virus infectionBrian J McMahon
Liver Disease and Hepatitis Program, Alaska Native Medical Center, Anchorage, Alaska 99508, USA
Am J Med 121:S45-52. 2008.... - The natural history of chronic hepatitis B virus infectionBrian J McMahon
Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, AK 99508, USA
Hepatology 49:S45-55. 2009..Also, nested case-control studies assessing immunological and host genetic factors among persons with active and inactive disease phases, HCC, and cirrhosis could be conducted using these types of cohorts... - The influence of hepatitis B virus genotype and subgenotype on the natural history of chronic hepatitis BBrian J McMahon
Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium and Arctic Investigations Program, Centers for Disease Control and Prevention, 4315 Diplomacy Drive, Anchorage, AK, 99508, USA
Hepatol Int 3:334-42. 2009..Chronic infection with hepatitis B virus (HBV) is associated with a high lifetime risk of developing hepatocellular carcinoma (HCC) and cirrhosis of the liver... - Antibody levels and protection after hepatitis B vaccine: results of a 22-year follow-up study and response to a booster doseBrian J McMahon
Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, Alaska, USA
J Infect Dis 200:1390-6. 2009..The duration of protection in children and adults (including health care workers) resulting from the hepatitis B vaccine primary series is unknown... - Adverse outcomes in Alaska natives who recovered from or have chronic hepatitis C infectionBrian J McMahon
Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, 4315 Diplomacy Drive, Anchorage, Alaska 99508, USA
Gastroenterology 138:922-31.e1. 2010.... - Antibody levels and protection after hepatitis B vaccination: results of a 15-year follow-upBrian J McMahon
Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, and the Alaska Native Medical Center, Anchorage, Alaska 99508, USA
Ann Intern Med 142:333-41. 2005..The duration of protection afforded by hepatitis B vaccination is unknown... - Viral hepatitis in the ArcticBrian J McMahon
Viral Hepatitis Program, Alaska Native Medical Center Anchorage, Alaska 99508, USA
Int J Circumpolar Health 63:41-8. 2004..Summarize research on viral hepatitis in indigenous populations in the Arctic... - The relationship among previous antimicrobial use, antimicrobial resistance, and treatment outcomes for Helicobacter pylori infectionsBrian J McMahon
Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, and Alaska Native Medical Center, Anchorage, Alaska 99508, USA
Ann Intern Med 139:463-9. 2003..The relationship between previous antimicrobial treatments and infection with drug-resistant Helicobacter pylori is unknown... - Screening for hepatocellular carcinoma in Alaska natives infected with chronic hepatitis B: a 16-year population-based studyB J McMahon
Departments of Internal Medicine and Surgery, Alaska Native Medical Center, Indian Health Service, Public Health Service, U S Department of Health and Human Services, Anchorage, Alaska, USA
Hepatology 32:842-6. 2000..024), respectively. Screening of HBsAg carriers with semiannual AFP was effective in detecting most HCC tumors at a resectable stage and significantly prolonged survival rates when compared with historical controls in this population... - Factors associated with the progression of fibrosis on liver biopsy in Alaska Native and American Indian persons with chronic hepatitis CStephen E Livingston
Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium Liver Disease and Hepatitis Program, Anchorage, Alaska 99508, USA
Can J Gastroenterol 24:445-51. 2010..Various factors influence the development and rate of fibrosis progression in chronic hepatitis C virus (HCV) infection... - Clearance of hepatitis B e antigen in patients with chronic hepatitis B and genotypes A, B, C, D, and FStephen E Livingston
Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, Alaska
Gastroenterology 133:1452-7. 2007..Five hepatitis B virus genotypes were identified in Alaska Native persons; we analyzed clearance of HBeAg by age and genotype... - Clearance of hepatitis B surface antigen and risk of hepatocellular carcinoma in a cohort chronically infected with hepatitis B virusJosephine Simonetti
Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, AK 99508, USA
Hepatology 51:1531-7. 2010..6 years after clearance. CONCLUSION: HCC can occur in persons with chronic hepatitis B who have lost HBsAg, even in the absence of cirrhosis. These persons should still be followed with periodic liver ultrasound to detect HCC early... - Alaska sentinel surveillance for antimicrobial resistance in Helicobacter pylori isolates from Alaska native persons, 1999-2003Michael G Bruce
Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK 99508, USA
Helicobacter 11:581-8. 2006..Previous studies in Alaska have demonstrated elevated proportions of antimicrobial resistance among Helicobacter pylori isolates... - Steatosis and hepatitis C in an Alaska Native/American Indian populationStephen E Livingston
Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, Alaska 99508, USA
Int J Circumpolar Health 65:253-60. 2006..To determine the prevalence and characteristics of steatosis in Alaska Natives/American Indians (AN/AI) with chronic hepatitis C virus (HCV) infection... - Results of a general hepatitis C lookback program for persons who received blood transfusions in a neonatal intensive care unit between January 1975 and July 1992Henry H Cagle
Liver Disease and Hepatitis Program, Division of Community Health, Alaska Native Tribal Health Consortium, Anchorage 99508, USA
Arch Pediatr Adolesc Med 161:125-30. 2007..To notify persons who received a blood transfusion in a neonatal intensive care unit between January 1975 and July 1992 of their risk for hepatitis C infection and to encourage them to seek hepatitis C antibody testing... - Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native populationDana L Bruden
Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging Zoonoses and Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK 99508, United States
World J Gastroenterol 17:4682-8. 2011..High rates of Helicobacter pylori (H. pylori) infection, H. pylori treatment failure, and gastric cancer in this population necessitate documentation of infection status at multiple time points over a patient's life... - Hepatitis C infection in Alaska Natives with persistently normal, persistently elevated or fluctuating alanine aminotransferase levelsMichael G Bruce
Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, Alaska
Liver Int 26:643-9. 2006.... - Persistence of antibody to hepatitis B and protection from disease among Alaska natives immunized at birthCatherine M Dentinger
Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, AK, USA
Pediatr Infect Dis J 24:786-92. 2005..Transient anti-HBc appeared in a small percentage of children; however, none developed clinical signs of hepatitis or chronic HBV infection... - Hepatitis B virus genotypes in Alaska Native people with hepatocellular carcinoma: preponderance of genotype FStephen E Livingston
Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, AK 99508, USA
J Infect Dis 195:5-11. 2007..The development of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection has been associated with specific HBV genotypes and the presence of specific mutations... - Epidemiology and risk factors for hepatitis C in Alaska NativesBrian J McMahon
Viral Hepatitis Program, Alaska Native Medical Center, Anchorage, AK, USA
Hepatology 39:325-32. 2004..S. population. Persons with a history of blood transfusion were more likely to be HCV RNA positive than those without such history. Higher RNA levels found in males may explain the more severe disease previously reported in this group... - Differences in response to a hepatitis B vaccine booster dose among Alaskan children and adolescents vaccinated during infancyTaraz Samandari
Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Pediatrics 120:e373-81. 2007..The duration of protection provided by hepatitis B vaccination is unknown, but the presence of immune memory can be evaluated indirectly by measuring the immune response to a booster dose of vaccine... - Hepatitis B-associated vasculitis in Alaska Natives: viral genotype, clinical and serologic outcomeKathy J Hurlburt
Liver Disease and Hepatitis Program, Alaska Native Tribal Health Consortium, Anchorage, AK 99508, USA
Liver Int 27:627-32. 2007.... - Persistence of antibody to hepatitis A virus 10 years after vaccination among children and adultsLaura L Hammitt
Arctic Investigations Program, National Center for Preparedness, Detection and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
J Infect Dis 198:1776-82. 2008..Hepatitis A vaccination is effective in preventing disease. However, the duration of protection after vaccination is unknown... - Duration of hepatitis B immunity in low risk children receiving hepatitis B vaccinations from birthKenneth M Petersen
Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Alaska Native Tribal Health Consortium, Anchorage, AK 99508, USA
Pediatr Infect Dis J 23:650-5. 2004..Additional long term studies of low risk infants are needed to determine duration of protection and the necessity for or timing of booster doses... - Treatment eligibility in Alaska Native and American Indian persons with hepatitis C virus infectionStephen E Livingston
Alaska Native Tribal Health Consortium, Liver Disease and Hepatitis Program, Anchorage, AK 99508, USA
Int J Circumpolar Health 71:1-7. 2012..We examined treatment eligibility in a cohort of Alaska Native and American Indian persons with chronic HCV infection... - Dynamics of Helicobacter pylori-specific immunoglobulin G for 2 years after successful eradication of Helicobacter pylori infection in an American Indian and Alaska Native populationKaren M Miernyk
Alaska Native Tribal Health Consortium, Arctic Investigations Program, Centers for Disease Control and Prevention, 4055 Tudor Centre Dr, Anchorage, AK 99508, USA
Clin Vaccine Immunol 14:85-6. 2007..Two months after treatment, 82% of H. pylori-negative persons remained seropositive. While there were declines in H. pylori antibodies for 12 months, after 24 months 71% of persons remained seropositive... - The relationship between previous fluoroquinolone use and levofloxacin resistance in Helicobacter pylori infectionJohn J Carothers
Native Medical Center, Anchorage, Alaska, USA
Clin Infect Dis 44:e5-8. 2007..pylori isolates that were resistant to levofloxacin. Levofloxacin resistance was associated with any prior fluoroquinolone use over the previous 10 years and with the total number of fluoroquinolone courses prescribed (P<.001)... - Evaluation of seaFAST, a rapid fluorescent in situ hybridization test, for detection of Helicobacter pylori and resistance to clarithromycin in paraffin-embedded biopsy sectionsJulie M Morris
Arctic Investigations Program, CDC, 4055 Tudor Centre Drive, Anchorage, AK 99508, USA
J Clin Microbiol 43:3494-6. 2005..The FISH method was found to be 97% sensitive, 94% specific for the detection of H. pylori and comparable to agar dilution for the detection of resistance to clarithromycin... - Results of a hepatitis C general transfusion lookback program for patients who received blood products before July 1992James L Williams
Liver Disease and Hepatitis Program and the Community Health Aide Program, Division of Community Health Services, Alaska Native Tribal Health Consortium, Anchorage, Alaska 99508, USA
Transfusion 45:1020-6. 2005..A general transfusion lookback program was implemented to identify, counsel, and screen persons who received transfusions at the Alaska Native Medical Center between January 1980 and July 1992... - Hepatitis B immunity in children vaccinated with recombinant hepatitis B vaccine beginning at birth: a follow-up study at 15 yearsLaura L Hammitt
Arctic Investigations Program, Centers for Disease Control and Prevention, Anchorage, AK, USA
Vaccine 25:6958-64. 2007..These children had protective anti-HBs concentrations when tested after receiving a three-dose series of 2.5 microg recombinant hepatitis B vaccine starting at birth... - Persistence of hepatitis A vaccine induced seropositivity in infants and young children by maternal antibody status: 10-year follow-upUmid M Sharapov
Division of Viral Hepatitis, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
Hepatology 56:516-22. 2012..CONCLUSION: The seropositivity induced by hepatitis A vaccine given to children <2 years of age persists for at least 10 years regardless of presence of maternal anti-HAV... - Chronic liver disease among Alaska-Native people, 2003-2004Gayle E Fischer
Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Am J Gastroenterol 104:363-70. 2009..The objectives of this study were to determine CLD prevalence and to define its etiologies and complications among AN and AI people, who received health care from an urban hospital center... - Estimating the date of hepatitis C virus infection from patient interviews and antibody tests on stored seraDana L Bruden
Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, Alaska 99508, USA
Am J Gastroenterol 99:1517-22. 2004..CONCLUSIONS: Inaccuracies in the length of HCV could occur in outcome studies that rely on patient recall of risk-factor history. Statistical methods that incorporate the uncertainty in assigning infection date are needed... - Immunogenicity of an inactivated hepatitis A vaccine in infants and young childrenBeth P Bell
Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USA
Pediatr Infect Dis J 26:116-22. 2007..We compared HA vaccine immunogenicity among infants born to immune and susceptible mothers, vaccinated on different schedules... - A prospective evaluation of 200 upper endoscopies performed in Alaska Native personsFrank Sacco
Department of Surgery, Alaska Native Medical Center, Anchorage 99508, USA
Int J Circumpolar Health 66:144-52. 2007..To characterize the nature and prevalence of disease in Alaska Native patients referred for evaluation of upper gastrointestinal signs and symptoms... - Hepatitis A vaccine: immunogenicity following administration of a delayed immunization schedule in infants, children and adultsJames L Williams
Viral Hepatitis Program, Alaska Native Medical Center, ANC HEP, 4315 Diplomacy Drive, 99508, Anchorage, AK, USA
Vaccine 21:3208-11. 2003..Findings suggest a booster administered 20-31 months after the primary dose is immunogenic and GMT in persons >2 years of age were comparable to those seen in adults and children who receive hepatitis A vaccine per schedule... - Long-term immunogenicity of hepatitis a virus vaccine in alaska 17 years after initial childhood seriesGregory A Raczniak
Arctic Investigations Program, Division of Preparedness and Emerging Infections, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention
J Infect Dis 207:493-6. 2013..We report HAV antibody concentrations 17 years after childhood immunization, demonstrating that protective antibody levels remain and have stabilized over the past 7 years... - Impact of a statewide childhood vaccine program in controlling hepatitis A virus infections in AlaskaRosalyn J Singleton
Arctic Investigations Program, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention CDC, Anchorage, AK 99508, USA
Vaccine 28:6298-304. 2010..3) in 2002-2007 was lower than the overall U.S. 2007 rate (1.0). Among age groups, the decrease (99.8%) among children aged 0-14 years was the largest. Routine childhood vaccination has nearly eliminated HAV infection in Alaska... - Impact of recurrent epidemics of hepatitis a virus infection on population immunity levels: Bristol Bay, AlaskaDolly Peach
Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 4055 Tudor Centre Drive, Anchorage, AK 99508, USA
J Infect Dis 186:1081-5. 2002..Little transmission occurred between epidemics. Vaccination of children against HAV should prevent future epidemics... - Impact of immunizations on the disease burden of American Indian and Alaska native childrenRosalyn Singleton
Alaska Native Tribal Consortium, Arctic Investigations Program, National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, 4055 Tudor Centre Dr, Anchorage, Alaska 99508, USA
Arch Pediatr Adolesc Med 163:446-53. 2009..Although tremendous strides have been made in eliminating disparities in infectious disease among AI/AN children, further gains will require addressing disparities in adverse living conditions... - Selecting appropriate management strategies for chronic hepatitis B: who to treatBrian J McMahon
Alaska Native Medical Center, 4315 Diplomacy Drive, Anchorage, AK 99508, USA
Am J Gastroenterol 101:S7-12. 2006..However, not all patients with chronic hepatitis B are identified, and many of those who are diagnosed do not receive adequate management and follow-up... - Azathioprine metabolite measurements are not useful in following treatment of autoimmune hepatitis in Alaska Native and other non-Caucasian peopleElizabeth D Ferucci
Alaska Native Tribal Health Consortium, Anchorage, Alaska 99508, USA
Can J Gastroenterol 25:21-7. 2011..In autoimmune hepatitis (AIH) patients treated with azathioprine, the utility of measuring thiopurine methyltransferase (TPMT) and azathioprine metabolites has been limited... - Prevalence of autoimmune liver disease in Alaska NativesKathy J Hurlburt
Viral Hepatitis Program, Alaska Native Medical Center, Anchorage 99508, USA
Am J Gastroenterol 97:2402-7. 2002..7). The prevalence of PBC was 16/100,000 (95% CI = 12.9-25.4). CONCLUSIONS: This population-based study demonstrates that the prevalence rates of AIH and PBC in Alaska natives are comparable with reported rates in other populations... - High rate of spontaneous negativity for hepatitis C virus RNA after establishment of chronic infection in Alaska NativesJohn D Scott
Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA
Clin Infect Dis 42:945-52. 2006..Hepatitis C virus (HCV) leads to chronic infection in 70%-85% of exposed patients. Spontaneous clearance of the virus after chronic infection is believed to occur rarely... - Hepatitis C virus dynamics during natural infection are associated with long-term histological outcome of chronic hepatitis C diseaseDaniel G Sullivan
University of Washington School of Medicine, Seattle, WA, USA
J Infect Dis 196:239-48. 2007..The long-term dynamics of hepatitis C virus (HCV) infection and their association with hepatitis C disease are unknown... - Classification of hepatitis B virus genotype B into 2 major types based on characterization of a novel subgenotype in Arctic indigenous populationsTomoyuki Sakamoto
Department of Clinical Molecular Informative Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Infect Dis 196:1487-92. 2007..The results suggest that HBV/B may be classified into nonrecombinant (Bj/B1 and B6) and recombinant (Ba/B2-B5) types... - Viral hepatitis in the Arctic. A review from a Circumpolar Workshop on Viral hepatitis, ICCH13Andrei Tulisov
Northern State Medical University, Arkhangelsk, Russia
Alaska Med 49:193-203. 2007.... - Investigation of putative multisubtype hepatitis C virus infections in vivo by heteroduplex mobility analysis of core/envelope subgenomesHui Li
Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington, USA
J Virol 82:7524-32. 2008..In summary, a large proportion of mixed-genotype and switching-genotype patterns generated by 5'-UTR analysis were not reproducible using the HMA approach, emphasizing the need for additional study... - Chronic hepatitis BAnna S F Lok
Division of Gastroenterology, University of Michigan Medical Center, 3912 Taubman Center, Box 0362, Ann Arbor, MI 48109-0362, USA
Hepatology 45:507-39. 2007 - Hepatitis C virus envelope glycoprotein co-evolutionary dynamics during chronic hepatitis CHui Li
Department of Laboratory Medicine, University of Washington Medical Center, Seattle, WA, USA
Virology 375:580-91. 2008..44 versus r=0.17, respectively; P=0.01). In summary, HCV envelope quasispecies co-evolution differs during mild versus severe disease... - [AASLD Practice Guidelines. Chronic hepatitis B: update of therapeutic guidelines]Anna S F Lok
Rom J Gastroenterol 13:150-4. 2004 - Chronic hepatitis B: update of recommendationsAnna S F Lok
Division of Gastroenterology, University of Michigan Medical Center, 3912 Taubman Center, Ann Arbor, MI 48109-0362, USA
Hepatology 39:857-61. 2004