Research Topics
Genomes and Genes | Qiang MaSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
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Publications
Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cellsPatrick L Apopa
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
J Biochem Mol Toxicol 22:63-76. 2008..The findings demonstrated that phosphorylation of Nrf2 at the TA domains by CK2 is an integral component of Nrf2 activation necessary for the nuclear localization and transcription activation function of Nrf2 in neuroblastoma cells...- Xenobiotic-activated receptors: from transcription to drug metabolism to diseaseQiang Ma
Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
Chem Res Toxicol 21:1651-71. 2008..In this perspective, common features and recent advances in the structures, modes of action, and implications in disease and drug development of XARs are discussed... - Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytesXiaoqing He
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA
J Mol Cell Cardiol 46:47-58. 2009..The findings, for the first time, established Nrf2 as a critical regulator of defense against ROS in normal and diabetic hearts... - Role of nrf2 in oxidative stress and toxicityQiang Ma
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention
Annu Rev Pharmacol Toxicol 53:401-26. 2013..This review discusses the impact of Nrf2 on oxidative stress and toxicity and how Nrf2 senses oxidants and regulates antioxidant defense... - Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2Qiang Ma
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute forOccupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia
Pharmacol Rev 64:1055-81. 2012..Developing potent and specific ARE inducers and Nrf2 inhibitors holds certain new promise for the prevention and therapy against cancer, chronic disease, and toxicity... 
CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studiesQiang Ma
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Drug Metab Dispos 35:1009-16. 2007..This unique path of CYP1A research underscores the importance of whole animal and human studies in chemical safety evaluation...- 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced degradation of aryl hydrocarbon receptor (AhR) by the ubiquitin-proteasome pathway. Role of the transcription activaton and DNA binding of AhRQ Ma
Molecular Toxicology Laboratory, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
J Biol Chem 275:8432-8. 2000..Our findings provide new insights into the regulation of TCDD-activated AhR through ubiquitin-mediated protein degradation... - Aryl hydrocarbon receptor degradation-promoting factor (ADPF) and the control of the xenobiotic responseQiang Ma
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Mol Interv 7:133-7. 2007..The biological machinery that controls the xenobiotic response thus encompasses an elegance deep beneath the traditional recognition of CYPs as catalysts of xenobiotic degradation... - The challenges of dealing with promiscuous drug-metabolizing enzymes, receptors and transportersQiang Ma
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA
Curr Drug Metab 9:374-83. 2008.... - Transcriptional responses to oxidative stress: pathological and toxicological implicationsQiang Ma
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, United States
Pharmacol Ther 125:376-93. 2010.... - Pharmacogenetics, pharmacogenomics, and individualized medicineQiang Ma
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd, Morgantown, WV 26505, USA
Pharmacol Rev 63:437-59. 2011..Overcoming the obstacles holds promise for achieving the ultimate goal of effective and safe medication to targeted patients with appropriate genotypes... - Influence of light on aryl hydrocarbon receptor signaling and consequences in drug metabolism, physiology and diseaseQiang Ma
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mailstop 3014, 1095 Willowdale Rd, Morgantown, WV 26505, USA
Expert Opin Drug Metab Toxicol 7:1267-93. 2011..Such findings suggest AHR as a therapeutic target for cancer, autoimmune dysfunction, inflammatory disease and stem cell therapy... 
Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2Qiang Ma
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch Health Effects Laboratory Division National Institute for Occupational Safety and Health Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Am J Pathol 168:1960-74. 2006..Our findings suggest that Nrf2 mediates important antioxidant functions involved in the control of peripheral lymphocyte homeostasis and autoimmune surveillance...- TCDD-inducible poly(ADP-ribose) polymerase: a novel response to 2,3,7,8-tetrachlorodibenzo-p-dioxinQ Ma
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
Biochem Biophys Res Commun 289:499-506. 2001..Together, these data demonstrate that TiPARP is a novel target of TCDD that may contribute to multiple responses to TCDD by modulating protein function through poly ADP-ribosylation... - Induction and superinduction of 2,3,7,8-tetrachlorodibenzo-rho-dioxin-inducible poly(ADP-ribose) polymerase: role of the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator transcription activation domains and a labile transcription rQiang Ma
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Arch Biochem Biophys 404:309-16. 2002.... - Inhibition of nuclear factor kappaB by phenolic antioxidants: interplay between antioxidant signaling and inflammatory cytokine expressionQiang Ma
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Mol Pharmacol 64:211-9. 2003.... - Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap 'n' collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2): cross-interaction between AhR (aryl hQiang Ma
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Biochem J 377:205-13. 2004..The findings demonstrate a novel role of Nrf2 in the induction of NQO1 by TCDD and provide new insights into the mechanism by which Nrf2 regulates the induction of phase II enzymes by both phenolic antioxidants and AhR ligands... - A cycloheximide-sensitive factor regulates TCDD-induced degradation of the aryl hydrocarbon receptorQiang Ma
Molecular Toxicology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Chemosphere 46:1491-500. 2002..These findings provide new insights into the mechanism by which TCDD-activated AhR is regulated in nucleus through the 26S proteasome protein degradation pathway... - Origins of individual variability in P4501A inductionQiang Ma
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA
Chem Res Toxicol 16:249-60. 2003 - Chemoprotection by phenolic antioxidants. Inhibition of tumor necrosis factor alpha induction in macrophagesQiang Ma
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
J Biol Chem 277:2477-84. 2002..Our findings demonstrate that phenolic antioxidants potently inhibit signal-induced TNF-alpha transcription and suggest a mechanism of anti-inflammation by the antioxidants through control of cytokine induction during inflammation... - Activation of Nrf2 in defense against cadmium-induced oxidative stressXiaoqing He
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
Chem Res Toxicol 21:1375-83. 2008.... - NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activationXiaoqing He
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention Morgantown, Morgantown, WV 26505, USA
Mol Pharmacol 76:1265-78. 2009.... - Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2Xiaoqing He
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
J Pharmacol Exp Ther 332:66-75. 2010..Our findings support a model in which arsenic binds to different sets of Keap1 cysteine residues to regulate divergent functions in Nrf2 signal transduction... - Protection against chromium (VI)-induced oxidative stress and apoptosis by Nrf2. Recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2/Keap1 associationXiaoqing He
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
Toxicol Sci 98:298-309. 2007..Thus, protection against Cr(VI) toxicity involves a transcriptional signaling loop that includes activation of Nrf2 by the toxic metal, transcription of ARE-driven genes, and reduction of ROS production... - Induction of metallothionein I by arsenic via metal-activated transcription factor 1: critical role of C-terminal cysteine residues in arsenic sensingXiaoqing He
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
J Biol Chem 284:12609-21. 2009..The findings demonstrate a critical role of the C-terminal cysteine cluster of MTF1 in arsenic sensing and gene transcription via arsenic-cysteine thiol interaction... - Superinduction of metallothionein I by inhibition of protein synthesis: role of a labile repressor in MTF-1 mediated gene transcriptionYongyi Bi
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mailstop 3014, Morgantown, WV 26505, USA
J Biochem Mol Toxicol 20:57-68. 2006..The findings reveal a new mechanistic aspect of the superinduction of Mt1, in which a labile repressor negatively controls agonist-induced turnover of the MTF-1 protein... - Resveratrol inhibits paraquat-induced oxidative stress and fibrogenic response by activating the nuclear factor erythroid 2-related factor 2 pathwayXiaoqing He
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
J Pharmacol Exp Ther 342:81-90. 2012..The study reveals a new pathway for molecular intervention against pulmonary oxidative injury and fibrosis... - Induction of metallothionein I by phenolic antioxidants requires metal-activated transcription factor 1 (MTF-1) and zincYongyi Bi
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Biochem J 380:695-703. 2004..These findings establish that phenolic antioxidants activate Mt1 transcription by a zinc-dependent mechanism, which involves MTF-1 binding to metal regulator elements in the Mt1 gene promoter... - Redox regulation by nuclear factor erythroid 2-related factor 2: gatekeeping for the basal and diabetes-induced expression of thioredoxin-interacting proteinXiaoqing He
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA
Mol Pharmacol 82:887-97. 2012..The findings revealed, for the first time, that Nrf2 is a key gatekeeper of Txnip transcription, suppressing both its basal expression and MondoA-driven induction to control the thioredoxin redox signaling in diabetes... - Multiwalled carbon nanotubes induce a fibrogenic response by stimulating reactive oxygen species production, activating NF-κB signaling, and promoting fibroblast-to-myofibroblast transformationXiaoqing He
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
Chem Res Toxicol 24:2237-48. 2011.... - Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2Ann F Hubbs
Experimental Pathology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health CDC, 1095 Willowdale Road, Morgantown, WV 26505, USA
Am J Pathol 170:2068-76. 2007..If this role is confirmed, it may suggest new approaches to treating genetically and chemically induced myelin degenerative diseases... - Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancerXiaoqing He
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
J Biol Chem 281:23620-31. 2006.... - Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null miceXiaoming Hu
Receptor Biology Laboratory, TMBB HELD NIOSH CDC, Mailstop 3014, 1095 Willowdale Rd, Morgantown, WV 26505, USA
Mol Cell Biol 26:940-54. 2006..In addition, these findings raise the possibility that exposure to environmental or occupational ovotoxicants plays a role in the premature ovarian failure commonly associated with infertility and premature aging in women... - [Expression of pro-inflammation cytokines and activation of nuclear factor kappab in the intestinal mucosa of mice with ulcerative colitis]Qun-Ying Wang
Institute for Digestive Diseases of PLA, Nanfang Hospital, First Military Medical University, Guangzhou 50515, China
Di Yi Jun Yi Da Xue Xue Bao 23:1202-5. 2003.... - [Protective effect of tert-butylhydroquinone on bone marrow cells in rats from cytotoxicity induced by benzene in vitro]Zhi-wei Zhao
Department of Occupational and Environmental Health, School of Public Health, Wuhan University, Wuhan 430071, China
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 24:143-6. 2006..The tBHQ can protect the bone marrow cells in rats from the cytotoxicity induced by benzene, which can be partly explained by the increase of the NQO1 activity induced by tBHQ... - Effect of protein kinase C on multidrug resistance of multidrug-resistant colorectal cancer LoVo/Adr cellsQiang Ma
Department of Gastroenterology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
Di Yi Jun Yi Da Xue Xue Bao 22:626-8. 2002..To observe the effect of protein kinase C (PKC) on the multidrug resistance of multidrug-resistant colorectal cancer LoVo/Adr cells and explore the mechanism... - [Study of angiogenesis in human colorectal carcinoma and its modulation by p53 and K-ras gene]Shi-Shun Zhong
PLA Institute for Digestive Disease, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
Zhonghua Nei Ke Za Zhi 42:77-80. 2003..01). VEGF expression correlated with both p53 and K-ras gene mutation (P < 0.01). CONCLUSIONS: p53 and K-ras gene upregulated the expression of VEGF. p53 and K-ras gene might play an important role in modulating tumor angiogenesis... - Determination of alkylphenol ethoxylates in textiles by normal-phase liquid chromatography and reversed-phase liquid chromatography/electrospray mass spectrometryChao Wang
Institute of Industrial Product Inspection, Chinese Academy of Inspection and Quarantine, Beijing, 100025, People s Republic of China
J AOAC Int 90:1411-7. 2007..The 2 detection methods were successfully applied to the investigation of various textile samples, and the data of our research suggested actual pollution in real textile products... - Impacts of passive smoking on learning and memory ability of mouse offsprings and intervention by antioxidantsJie Yang
Chinese Center for Disease Control and Prevention, Beijing 100050, China
Biomed Environ Sci 21:144-9. 2008..To determine the impact of passive smoking and the protective effect of antioxidants such as vitamin E and quercetin on learning and memory ability of mouse offsprings...