Julian Little

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi request reprint Mendelian randomisation: a new spin or real progress?
    Julian Little
    Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Lancet 362:930-1. 2003
  2. pmc Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases
    Muin J Khoury
    Office of Public Health Genomics, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 170:269-79. 2009
  3. ncbi request reprint How many genes underlie the occurrence of common complex diseases in the population?
    Quanhe Yang
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    Int J Epidemiol 34:1129-37. 2005
  4. ncbi request reprint The emergence of epidemiology in the genomics age
    Muin J Khoury
    Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Int J Epidemiol 33:936-44. 2004
  5. ncbi request reprint On the synthesis and interpretation of consistent but weak gene-disease associations in the era of genome-wide association studies
    Muin J Khoury
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Int J Epidemiol 36:439-45. 2007
  6. ncbi request reprint An epidemiologic assessment of genomic profiling for measuring susceptibility to common diseases and targeting interventions
    Muin J Khoury
    Office of Genomics and Disease Prevention, Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Genet Med 6:38-47. 2004
  7. ncbi request reprint Turning the pump handle: evolving methods for integrating the evidence on gene-disease association
    Julian P T Higgins
    Am J Epidemiol 166:863-6. 2007
  8. ncbi request reprint A road map for efficient and reliable human genome epidemiology
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina 45110, Greece
    Nat Genet 38:3-5. 2006
  9. ncbi request reprint Reporting, appraising, and integrating data on genotype prevalence and gene-disease associations
    Julian Little
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, Scotland
    Am J Epidemiol 156:300-10. 2002
  10. ncbi request reprint Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake
    Linda Sharp
    Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Br J Nutr 99:379-89. 2008

Detail Information

Publications32

  1. ncbi request reprint Mendelian randomisation: a new spin or real progress?
    Julian Little
    Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Lancet 362:930-1. 2003
  2. pmc Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases
    Muin J Khoury
    Office of Public Health Genomics, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 170:269-79. 2009
    ..As a next step in the evolution of Human Genome Epidemiology reviews, the authors invite investigators to submit field synopses for possible publication in the American Journal of Epidemiology...
  3. ncbi request reprint How many genes underlie the occurrence of common complex diseases in the population?
    Quanhe Yang
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    Int J Epidemiol 34:1129-37. 2005
    ..It is not clear how many genes are necessary to account for an appreciable population-attributable fraction of these diseases...
  4. ncbi request reprint The emergence of epidemiology in the genomics age
    Muin J Khoury
    Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Int J Epidemiol 33:936-44. 2004
  5. ncbi request reprint On the synthesis and interpretation of consistent but weak gene-disease associations in the era of genome-wide association studies
    Muin J Khoury
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Int J Epidemiol 36:439-45. 2007
    ..Efforts by the Human Genome Epidemiology Network (HuGENet) are currently ongoing to streamline and operationalize these criteria for data on genetic associations with common diseases...
  6. ncbi request reprint An epidemiologic assessment of genomic profiling for measuring susceptibility to common diseases and targeting interventions
    Muin J Khoury
    Office of Genomics and Disease Prevention, Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Genet Med 6:38-47. 2004
    ....
  7. ncbi request reprint Turning the pump handle: evolving methods for integrating the evidence on gene-disease association
    Julian P T Higgins
    Am J Epidemiol 166:863-6. 2007
  8. ncbi request reprint A road map for efficient and reliable human genome epidemiology
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina 45110, Greece
    Nat Genet 38:3-5. 2006
    ..Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews...
  9. ncbi request reprint Reporting, appraising, and integrating data on genotype prevalence and gene-disease associations
    Julian Little
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, Scotland
    Am J Epidemiol 156:300-10. 2002
    ....
  10. ncbi request reprint Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake
    Linda Sharp
    Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Br J Nutr 99:379-89. 2008
    ..Investigation of particular folate vitamers (for example, tetrahydrofolate, 5,10-methylenetetrahydrofolate) may help clarify carcinogenesis pathways...
  11. doi request reprint Genome-wide association studies for complex traits: consensus, uncertainty and challenges
    Mark I McCarthy
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Rev Genet 9:356-69. 2008
    ....
  12. ncbi request reprint A network of investigator networks in human genome epidemiology
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Am J Epidemiol 162:302-4. 2005
    ....
  13. ncbi request reprint Low dose aspirin, COX-inhibition and chemoprevention of colorectal cancer
    Robert Benamouzig
    Department of Gastro enterology, Hopital Avicenne, 125 rue de Stalingrad, 93009 Bobigny Cedex, France
    Curr Top Med Chem 5:493-503. 2005
    ..Four RCTs of the effect of aspirin on adenoma recurrence are available. Other trials are currently underway...
  14. ncbi request reprint Daily soluble aspirin and prevention of colorectal adenoma recurrence: one-year results of the APACC trial
    Robert Benamouzig
    Department of Gastroenterology, Avicenne Hospital, AP HP, Paris 13 University, Bobigny Cedex, France
    Gastroenterology 125:328-36. 2003
    ..Epidemiologic and experimental studies have suggested that aspirin intake reduces the risk for colorectal carcinogenesis. However, the available data are not sufficient to serve as the basis for firm recommendations...
  15. ncbi request reprint Fetal anticonvulsant syndromes and polymorphisms in MTHFR, MTR, and MTRR
    John Dean
    Department of Medical Genetics, Clinical Genetics Centre, University of Aberdeen, Aberdeen, Scotland, United Kingdom
    Am J Med Genet A 143:2303-11. 2007
    ..MTR 2756A > G and MTRR 66A > G genotype frequencies in children with FACS and neurodevelopmental disorder were different from those in healthy blood donor controls...
  16. ncbi request reprint Assessment of cumulative evidence on genetic associations: interim guidelines
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, University of Ioannina School of Medicine, Ioannina 45110, Greece
    Int J Epidemiol 37:120-32. 2008
    ..Future empirical research and consensus development are needed to develop an integrated model for combining epidemiological and biological evidence in the rapidly evolving field of investigation of genetic factors...
  17. ncbi request reprint The human genome project is complete. How do we develop a handle for the pump?
    Julian Little
    Am J Epidemiol 157:667-73. 2003
  18. ncbi request reprint Asymptomatic colorectal neoplasia and fecal characteristics: a case-control study of subjects participating in the nottingham fecal occult blood screening trial
    Julian Little
    Epidemiology Group, Department of Medicine and Therapeutics, Aberdeen University Medical School, United Kingdom
    Dis Colon Rectum 45:1233-41. 2002
    ..We sought to test hypotheses relating to fecal bile acids, calcium, and pH in a large sample of asymptomatic subjects who had participated in fecal occult blood screening...
  19. ncbi request reprint [The Strengthening the Reporting of Observational Studies in Epidemiology [STROBE] statement: guidelines for reporting observational studies]
    Erik von Elm
    Institute of Social and Preventive Medicine ISPM, University of Bern, Berna, Switzerland
    Gac Sanit 22:144-50. 2008
    ..We hope that the STROBE statement will contribute to improving the quality of reporting of observational studies...
  20. doi request reprint Folate intake, markers of folate status and oral clefts: is the evidence converging?
    Candice Y Johnson
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Canada
    Int J Epidemiol 37:1041-58. 2008
    ..The purpose of this systematic review and meta-analysis was to assemble evidence on the role of folate in the aetiology of cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO)...
  21. ncbi request reprint [The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies]
    Erik von Elm
    Institute of Social and Preventive Medicine ISPM, University of Bern, Berna, Suiza
    Rev Esp Salud Publica 82:251-9. 2008
    ..We hope that the STROBE statement will contribute to improving the quality of reporting of observational studies...
  22. pmc Reporting of systematic reviews: the challenge of genetic association studies
    Muin J Khoury
    PLoS Med 4:e211. 2007
  23. ncbi request reprint Colon cancer and genetic variation in folate metabolism: the clinical bottom line
    Julian Little
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, UK
    J Nutr 133:3758S-3766S. 2003
    ....
  24. ncbi request reprint Folate, DNA stability and colo-rectal neoplasia
    Susan J Duthie
    Division of Cellular Integrity, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Proc Nutr Soc 63:571-8. 2004
    ..Evidence from animal and human studies is presented here in support of folate acting to maintain genomic stability through both these mechanisms...
  25. ncbi request reprint The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of Scotland
    Mairi Macarthur
    Department of Medicine and Therapeutics, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:1613-8. 2005
    ..These results suggest that host genetics may play a role in predicting response to chemopreventive strategies. Confirmation of these findings in other populations is required...
  26. ncbi request reprint Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo
    Sabrina Narayanan
    Division of Cellular Integrity, Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom
    Cancer Epidemiol Biomarkers Prev 13:1436-43. 2004
    ....
  27. pmc Tobacco smoking and oral clefts: a meta-analysis
    Julian Little
    Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, Scotland
    Bull World Health Organ 82:213-8. 2004
    ..To examine the association between maternal smoking and non-syndromic orofacial clefts in infants...
  28. ncbi request reprint Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review
    Linda Sharp
    Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Scotland, UK
    Am J Epidemiol 159:423-43. 2004
    ..Overall, the roles of folate-pathway genes, folate, and related dietary factors in colorectal neoplasia are complex. Research priorities are suggested...
  29. ncbi request reprint Trial of management of borderline and other low-grade abnormal smears (TOMBOLA): Trial design
    Seonaidh C Cotton
    Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, UK
    Contemp Clin Trials 27:449-71. 2006
    ..This paper describes the design of the trial, and discusses the rationale underlying aspects of the design and the challenges faced in designing and implementing the trial...
  30. ncbi request reprint Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1: a case-control study in the Grampian region of Scotland
    Julian Little
    Epidemiology Group, Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, UK
    Int J Cancer 119:2155-64. 2006
    ..There was no evidence of interaction between CYP1A1 and smoking, and no evidence of interaction between the GSTM1 or GSTT1 polymorphisms and smoking, meat intake, green leafy vegetable intake, CYP1A1 variants or each other...
  31. ncbi request reprint The emergence of networks in human genome epidemiology: challenges and opportunities
    Daniela Seminara
    Epidemiology and Genetics Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, EPN Bldg, Rm 5142, MSC 7393, 6130 Executive Blvd, Bethesda, MD 20892, USA
    Epidemiology 18:1-8. 2007
  32. pmc CYP17 and breast cancer: no overall effect, but what about interactions?
    Julian Little
    Canada Research Chair in Human Genome Epidemiology, Department of Epidemiology and Community Medicine, University of Ottawa, Ontario, Canada
    Breast Cancer Res 7:238-42. 2005
    ....