Research Topics
| Julian LittleSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
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Detail Information
Publications
Mendelian randomisation: a new spin or real progress?Julian Little
Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Lancet 362:930-1. 2003
Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseasesMuin J Khoury
Office of Public Health Genomics, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Am J Epidemiol 170:269-79. 2009..As a next step in the evolution of Human Genome Epidemiology reviews, the authors invite investigators to submit field synopses for possible publication in the American Journal of Epidemiology...- How many genes underlie the occurrence of common complex diseases in the population?Quanhe Yang
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
Int J Epidemiol 34:1129-37. 2005..It is not clear how many genes are necessary to account for an appreciable population-attributable fraction of these diseases... - The emergence of epidemiology in the genomics ageMuin J Khoury
Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Int J Epidemiol 33:936-44. 2004 - On the synthesis and interpretation of consistent but weak gene-disease associations in the era of genome-wide association studiesMuin J Khoury
National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Int J Epidemiol 36:439-45. 2007..Efforts by the Human Genome Epidemiology Network (HuGENet) are currently ongoing to streamline and operationalize these criteria for data on genetic associations with common diseases... - An epidemiologic assessment of genomic profiling for measuring susceptibility to common diseases and targeting interventionsMuin J Khoury
Office of Genomics and Disease Prevention, Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Genet Med 6:38-47. 2004..CONCLUSION: To assess the value of genomic profiling, well-designed epidemiologic studies are needed to quantify disease risks, in addition to costs, benefits, and risks for testing and interventions... - Turning the pump handle: evolving methods for integrating the evidence on gene-disease associationJulian P T Higgins
Am J Epidemiol 166:863-6. 2007 - A road map for efficient and reliable human genome epidemiologyJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina 45110, Greece
Nat Genet 38:3-5. 2006..Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews... - Reporting, appraising, and integrating data on genotype prevalence and gene-disease associationsJulian Little
Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, Scotland
Am J Epidemiol 156:300-10. 2002.... - Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intakeLinda Sharp
Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen AB25 2ZD, UK
Br J Nutr 99:379-89. 2008..Investigation of particular folate vitamers (for example, tetrahydrofolate, 5,10-methylenetetrahydrofolate) may help clarify carcinogenesis pathways... 
Genome-wide association studies for complex traits: consensus, uncertainty and challengesMark I McCarthy
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Nat Rev Genet 9:356-69. 2008....- A network of investigator networks in human genome epidemiologyJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Am J Epidemiol 162:302-4. 2005.... - Low dose aspirin, COX-inhibition and chemoprevention of colorectal cancerRobert Benamouzig
Department of Gastro enterology, Hopital Avicenne, 125 rue de Stalingrad, 93009 Bobigny Cedex, France
Curr Top Med Chem 5:493-503. 2005..Four RCTs of the effect of aspirin on adenoma recurrence are available. Other trials are currently underway... - Daily soluble aspirin and prevention of colorectal adenoma recurrence: one-year results of the APACC trialRobert Benamouzig
Department of Gastroenterology, Avicenne Hospital, AP-HP, Paris 13 University, Bobigny Cedex, France
Gastroenterology 125:328-36. 2003..01), and initial adenomatous polyp burden less than 10 mm (P = 0.001). CONCLUSIONS: Daily soluble aspirin is associated with a reduction in the risk for recurrent adenomas found at colonoscopy 1 year after starting treatment... - Fetal anticonvulsant syndromes and polymorphisms in MTHFR, MTR, and MTRRJohn Dean
Department of Medical Genetics, Clinical Genetics Centre, University of Aberdeen, Aberdeen, Scotland, United Kingdom
Am J Med Genet A 143:2303-11. 2007..MTR 2756A > G and MTRR 66A > G genotype frequencies in children with FACS and neurodevelopmental disorder were different from those in healthy blood donor controls... - Assessment of cumulative evidence on genetic associations: interim guidelinesJohn P A Ioannidis
Clinical and Molecular Epidemiology Unit, University of Ioannina School of Medicine, Ioannina 45110, Greece
Int J Epidemiol 37:120-32. 2008..Future empirical research and consensus development are needed to develop an integrated model for combining epidemiological and biological evidence in the rapidly evolving field of investigation of genetic factors... - The human genome project is complete. How do we develop a handle for the pump?Julian Little
Am J Epidemiol 157:667-73. 2003 - Asymptomatic colorectal neoplasia and fecal characteristics: a case-control study of subjects participating in the nottingham fecal occult blood screening trialJulian Little
Epidemiology Group, Department of Medicine and Therapeutics, Aberdeen University Medical School, United Kingdom
Dis Colon Rectum 45:1233-41. 2002..CONCLUSION: The study does not support an association between colorectal cancer and fecal bile acids or pH. However, there is evidence that increases in major bile acids are associated with villous adenomas... - [The Strengthening the Reporting of Observational Studies in Epidemiology [STROBE] statement: guidelines for reporting observational studies]Erik von Elm
Institute of Social and Preventive Medicine ISPM, University of Bern, Berna, Switzerland
Gac Sanit 22:144-50. 2008..We hope that the STROBE statement will contribute to improving the quality of reporting of observational studies... - Folate intake, markers of folate status and oral clefts: is the evidence converging?Candice Y Johnson
Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Canada
Int J Epidemiol 37:1041-58. 2008..The purpose of this systematic review and meta-analysis was to assemble evidence on the role of folate in the aetiology of cleft lip with or without cleft palate (CL/P) and cleft palate only (CPO)... - [The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies]Erik von Elm
Institute of Social and Preventive Medicine ISPM, University of Bern, Berna, Suiza
Rev Esp Salud Publica 82:251-9. 2008..We hope that the STROBE statement will contribute to improving the quality of reporting of observational studies... - Reporting of systematic reviews: the challenge of genetic association studiesMuin J Khoury
PLoS Med 4:e211. 2007 - Colon cancer and genetic variation in folate metabolism: the clinical bottom lineJulian Little
Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, UK
J Nutr 133:3758S-3766S. 2003.... - Folate, DNA stability and colo-rectal neoplasiaSusan J Duthie
Division of Cellular Integrity, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
Proc Nutr Soc 63:571-8. 2004..Evidence from animal and human studies is presented here in support of folate acting to maintain genomic stability through both these mechanisms... - The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of ScotlandMairi Macarthur
Department of Medicine and Therapeutics, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
Cancer Epidemiol Biomarkers Prev 14:1613-8. 2005..These results suggest that host genetics may play a role in predicting response to chemopreventive strategies. Confirmation of these findings in other populations is required... - Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivoSabrina Narayanan
Division of Cellular Integrity, Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom
Cancer Epidemiol Biomarkers Prev 13:1436-43. 2004.... - Tobacco smoking and oral clefts: a meta-analysisJulian Little
Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, Scotland
Bull World Health Organ 82:213-8. 2004..CONCLUSION: The evidence of an association between maternal tobacco smoking and orofacial clefts is strong enough to justify its use in anti-smoking campaigns... - Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE reviewLinda Sharp
Epidemiology Group, Department of Medicine and Therapeutics, University of Aberdeen, Scotland, UK
Am J Epidemiol 159:423-43. 2004..Overall, the roles of folate-pathway genes, folate, and related dietary factors in colorectal neoplasia are complex. Research priorities are suggested... - Trial of management of borderline and other low-grade abnormal smears (TOMBOLA): Trial designSeonaidh C Cotton
Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, UK
Contemp Clin Trials 27:449-71. 2006..This paper describes the design of the trial, and discusses the rationale underlying aspects of the design and the challenges faced in designing and implementing the trial... - Colorectal cancer and genetic polymorphisms of CYP1A1, GSTM1 and GSTT1: a case-control study in the Grampian region of ScotlandJulian Little
Epidemiology Group, Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, UK
Int J Cancer 119:2155-64. 2006..There was no evidence of interaction between CYP1A1 and smoking, and no evidence of interaction between the GSTM1 or GSTT1 polymorphisms and smoking, meat intake, green leafy vegetable intake, CYP1A1 variants or each other... - The emergence of networks in human genome epidemiology: challenges and opportunitiesDaniela Seminara
Epidemiology and Genetics Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, NIH, EPN Bldg, Rm. 5142, MSC 7393, 6130 Executive Blvd, Bethesda, MD 20892, USA
Epidemiology 18:1-8. 2007 - CYP17 and breast cancer: no overall effect, but what about interactions?Julian Little
Canada Research Chair in Human Genome Epidemiology, Department of Epidemiology and Community Medicine, University of Ottawa, Ontario, Canada
Breast Cancer Res 7:238-42. 2005....