James Lara

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi Association of antigenic properties to structure of the hepatitis C virus NS3 protein
    James Lara
    Molecular Epidemiology and Bioinformatics Laboratory, Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USA
    In Silico Biol 11:203-12. 2011
  2. ncbi Coordinated evolution among hepatitis C virus genomic sites is coupled to host factors and resistance to interferon
    James Lara
    Molecular Epidemiology and Bioinformatics Laboratory, Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USA
    In Silico Biol 11:213-24. 2011
  3. ncbi Epistatic connectivity among HCV genomic sites as a genetic marker of interferon resistance
    James Lara
    Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Antivir Ther 17:1471-5. 2012
  4. ncbi Artificial neural network for prediction of antigenic activity for a major conformational epitope in the hepatitis C virus NS3 protein
    James Lara
    Division of Viral Hepatitis and Biotechnology Core Facility, Division of Scientific Resources, Centers for Disease Control and Prevention, 1600 Clifton Road MS A33, Atlanta, GA, 30333, USA
    Bioinformatics 24:1858-64. 2008
  5. ncbi Coevolution of the hepatitis C virus polyprotein sites in patients on combined pegylated interferon and ribavirin therapy
    James Lara
    Molecular Epidemiology and Bioinformatics Laboratory, Laboratory Branch, Division of Viral Hepatitis, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    J Virol 85:3649-63. 2011
  6. ncbi The hepatitis E virus polyproline region is involved in viral adaptation
    Michael A Purdy
    Centers for Disease Control and Prevention, National Center for HIV Hepatitis STD TB Prevention, Division of Viral Hepatitis, Atlanta, Georgia, United States of America
    PLoS ONE 7:e35974. 2012
  7. ncbi Convergence and coevolution of hepatitis B virus drug resistance
    Hong Thai
    Molecular Epidemiology and Bioinformatics Laboratory, Division of Viral Hepatitis, Center for Disease Control and Prevention, Atlanta 30329, Georgia, USA
    Nat Commun 3:789. 2012

Collaborators

Detail Information

Publications7

  1. ncbi Association of antigenic properties to structure of the hepatitis C virus NS3 protein
    James Lara
    Molecular Epidemiology and Bioinformatics Laboratory, Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USA
    In Silico Biol 11:203-12. 2011
    ..The data suggest that the BN models may guide the development of NS3 antigens with improved diagnostically relevant properties...
  2. ncbi Coordinated evolution among hepatitis C virus genomic sites is coupled to host factors and resistance to interferon
    James Lara
    Molecular Epidemiology and Bioinformatics Laboratory, Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USA
    In Silico Biol 11:213-24. 2011
    ..The data indicate host specificity of HCV evolution and suggest the application of these models to predict outcomes of IFN/RBV therapy...
  3. ncbi Epistatic connectivity among HCV genomic sites as a genetic marker of interferon resistance
    James Lara
    Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Antivir Ther 17:1471-5. 2012
    ..HCV genomic co-evolution offers a general framework for the detection of predisposition to IFN resistance, and possibly to resistance to direct-acting antivirals...
  4. ncbi Artificial neural network for prediction of antigenic activity for a major conformational epitope in the hepatitis C virus NS3 protein
    James Lara
    Division of Viral Hepatitis and Biotechnology Core Facility, Division of Scientific Resources, Centers for Disease Control and Prevention, 1600 Clifton Road MS A33, Atlanta, GA, 30333, USA
    Bioinformatics 24:1858-64. 2008
    ....
  5. ncbi Coevolution of the hepatitis C virus polyprotein sites in patients on combined pegylated interferon and ribavirin therapy
    James Lara
    Molecular Epidemiology and Bioinformatics Laboratory, Laboratory Branch, Division of Viral Hepatitis, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    J Virol 85:3649-63. 2011
    ..E2 and NS5A generate broad epistatic connectivity across the HCV polyprotein and essentially shape intrahost HCV evolution toward the IFN-RBV resistance. Both proteins can be used to accurately predict the outcomes of IFN-RBV therapy...
  6. ncbi The hepatitis E virus polyproline region is involved in viral adaptation
    Michael A Purdy
    Centers for Disease Control and Prevention, National Center for HIV Hepatitis STD TB Prevention, Division of Viral Hepatitis, Atlanta, Georgia, United States of America
    PLoS ONE 7:e35974. 2012
    ..Particularly as an IDR, the PPR likely contributes to fine tuning of viral replication through protein-protein interactions and should be considered as a target for development of novel anti-viral drugs...
  7. ncbi Convergence and coevolution of hepatitis B virus drug resistance
    Hong Thai
    Molecular Epidemiology and Bioinformatics Laboratory, Division of Viral Hepatitis, Center for Disease Control and Prevention, Atlanta 30329, Georgia, USA
    Nat Commun 3:789. 2012
    ..These findings have implications for public health and offer a more general framework for understanding drug resistance...