Research Topics
| Zsuzsanna KuklenyikSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
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Detail Information
Publications
Two-dimensional high performance liquid chromatography separation and tandem mass spectrometry detection of atrazine and its metabolic and hydrolysis products in urineZsuzsanna Kuklenyik
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
J Chromatogr B Analyt Technol Biomed Life Sci 901:1-8. 2012..1-0.5 μg/l...
Measurement of 18 perfluorinated organic acids and amides in human serum using on-line solid-phase extractionZsuzsanna Kuklenyik
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Anal Chem 77:6085-91. 2005..The high throughput and low limits of detection (0.05-0.8 ng/mL) using a small sample volume (100 microL of serum) and isotope dilution quantification make this method suitable for large-scale epidemiologic studies...- SPE/SPME-GC/MS approach for measuring musk compounds in serum and breast milkZsuzsanna Kuklenyik
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
J Chromatogr B Analyt Technol Biomed Life Sci 858:177-83. 2007..The method, which requires only 1 mL serum or breast milk to achieve limits of detection of 0.03-0.3 ng/mL, is applicable in biomonitoring studies for human internal dose measurement of polycyclic musk compounds... - Automated solid-phase extraction approaches for large scale biomonitoring studiesZsuzsanna Kuklenyik
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
J Chromatogr Sci 47:12-8. 2009.... - Simultaneous measurement of urinary bisphenol A and alkylphenols by automated solid-phase extractive derivatization gas chromatography/mass spectrometryZsuzsanna Kuklenyik
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Anal Chem 75:6820-5. 2003..The method, validated on spiked pooled urine samples and on urine samples from exposed persons, has limits of detection of approximately 0.1 ng in 1 mL of urine... - Design of online solid phase extraction-liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS) hyphenated systems for quantitative analysis of small organic compounds in biological matricesZsuzsanna Kuklenyik
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
J Sep Sci 34:3606-18. 2011.... - Intermittent prophylaxis with oral truvada protects macaques from rectal SHIV infectionJ Gerardo Garcia-Lerma
Division of HIV AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA
Sci Transl Med 2:14ra4. 2010..They strengthen the possibility of developing feasible, cost-effective strategies to prevent HIV transmission in humans... 
Durable protection from vaginal simian-human immunodeficiency virus infection in macaques by tenofovir gel and its relationship to drug levels in tissueCharles Dobard
Laboratory Branch and Quantitative Sciences and Data Management Branch, Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
J Virol 86:718-25. 2012..The identification of protective TFV-DP concentrations in vaginal lymphocytes may facilitate the evaluation of improved delivery methods of topical TFV and inform clinical studies...- Serum concentrations of 11 polyfluoroalkyl compounds in the u.s. population: data from the national health and nutrition examination survey (NHANES)Antonia M Calafat
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Environ Sci Technol 41:2237-42. 2007.... - Measuring environmental phenols and chlorinated organic chemicals in breast milk using automated on-line column-switching-high performance liquid chromatography-isotope dilution tandem mass spectrometryXiaoyun Ye
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop F17, Atlanta, GA 30341, USA
J Chromatogr B Analyt Technol Biomed Life Sci 831:110-5. 2006..BPA, OPP, and BP-3 were detected in more than 60% of the samples tested. The free species of these compounds appear to be most prevalent in milk... - Comparison of MALDI-TOF-MS and HPLC-ESI-MS/MS for endopeptidase activity-based quantification of Anthrax lethal factor in serumZsuzsanna Kuklenyik
National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, United States
Anal Chem 83:1760-5. 2011..99 (r(2) = 0.997) and -0.25% mean relative difference (±9% standard deviation). This study shows that isotope dilution MALDI-TOF-MS is a robust and precise quantitative MS platform... - Trends in exposure to polyfluoroalkyl chemicals in the U.S. Population: 1999-2008Kayoko Kato
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States
Environ Sci Technol 45:8037-45. 2011..Nonetheless, these NHANES data suggest that sociodemographic factors may influence exposure and also provide unique information on temporal trends of exposure... - Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000Antonia M Calafat
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Environ Health Perspect 115:1596-602. 2007..Exposure of the general U.S. population to PFCs is widespread. Since 2002, the manufacturing practices for PFCs in the United States have changed considerably... - Quantification of the urinary concentrations of parabens in humans by on-line solid phase extraction-high performance liquid chromatography-isotope dilution tandem mass spectrometryXiaoyun Ye
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
J Chromatogr B Analyt Technol Biomed Life Sci 844:53-9. 2006..Using this method, we detected methyl, ethyl, and propyl parabens, mostly as conjugated species, in 22 urine samples collected from anonymous adults... - Human exposure assessment to environmental chemicals using biomonitoringAntonia M Calafat
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Int J Androl 29:166-71; discussion 181-5. 2006..The use of biomonitoring in human risk assessment is not discussed... - Perfluorochemicals in pooled serum samples from United States residents in 2001 and 2002Antonia M Calafat
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Environ Sci Technol 40:2128-34. 2006..These findings indicate different patterns of human exposure to PFCs among the population groups examined and stress the importance of conducting research to identify the environmental sources and pathways of human exposure to PFCs... - Quantification of urinary conjugates of bisphenol A, 2,5-dichlorophenol, and 2-hydroxy-4-methoxybenzophenone in humans by online solid phase extraction-high performance liquid chromatography-tandem mass spectrometryXiaoyun Ye
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Mailstop F17, Atlanta, GA 30341, USA
Anal Bioanal Chem 383:638-44. 2005..To our knowledge, this is the first study describing the distribution of urinary conjugates of BP-3 and 2,5-DCP in humans... - Automated on-line column-switching HPLC-MS/MS method with peak focusing for the determination of nine environmental phenols in urineXiaoyun Ye
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Anal Chem 77:5407-13. 2005..The method can be used for quick and accurate analysis of large numbers of samples in epidemiologic studies for assessing the prevalence of human exposure to environmental phenols... - Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference populationAntonia M Calafat
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Environ Health Perspect 113:391-5. 2005..S. population) and relatively small size, this study provides the first reference range of human internal dose levels of BPA and NP in a demographically diverse human population... - On-line coupling of anion exchange and ion-pair chromatography for measurement of intracellular triphosphate metabolites of reverse transcriptase inhibitorsZsuzsanna Kuklenyik
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States
J Chromatogr B Analyt Technol Biomed Life Sci 877:3659-66. 2009..Limits of detection were 9, 200 and 75 pg per sample for TFV-DP (448/176 m/z), FTC-TP (488/130 m/z) and 3TC-TP (468/119 m/z), respectively... - Automated solid-phase extraction and measurement of perfluorinated organic acids and amides in human serum and milkZsuzsanna Kuklenyik
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Environ Sci Technol 38:3698-704. 2004..Additional studies are needed to determine whether environmental exposure to PFCs can result in PFCs partitioning into milk. Large epidemiological studies to determine the levels of PFCs among the U.S. general population are warranted... - Automated online and off-line solid-phase extraction methods for measuring isoflavones and lignans in urineZsuzsanna Kuklenyik
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
J Chromatogr Sci 42:495-500. 2004..Both methods are adequate for analyzing a large number of samples for epidemiological studies to assess the prevalence of human exposure to isoflavones and lignans... - Perfluorinated chemicals in selected residents of the American continentAntonia M Calafat
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Mailstop F17, Atlanta, GA 30341, USA
Chemosphere 63:490-6. 2006..Genetic variability, diet, lifestyle, or a combination of all these may contribute to the different patterns of human exposure to PFCs in the United States and Peru... - Effect of mobile phase pH and organic content on LC-MS analysis of nucleoside and nucleotide HIV reverse transcriptase inhibitorsZsuzsanna Kuklenyik
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
J Chromatogr Sci 47:365-72. 2009..1 mL plasma (10 pg on column) and coefficients of variation from 5% to 15% in the high ng/mL concentration range and from 16% to 20% in the low ng/mL concentration range... - Urinary levels of trichloroacetic acid, a disinfection by-product in chlorinated drinking water, in a human reference populationAntonia M Calafat
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Environ Health Perspect 111:151-4. 2003.... - Quantitative mass spectrometry for bacterial protein toxins--a sensitive, specific, high-throughput tool for detection and diagnosisAnne E Boyer
Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Atlanta, GA 30341, USA
Molecules 16:2391-413. 2011..We also describe potential applications to diseases of high public health impact, including Clostridium difficile glucosylating toxins and the Bordetella pertussis adenylyl cyclase... - Quantitative detection of trichloroacetic acid in human urine using isotope dilution high-performance liquid chromatography-electrospray ionization tandem mass spectrometryZsuzsanna Kuklenyik
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Anal Chem 74:2058-63. 2002..The method is simple and fast and is not labor intensive (sample preparation and analysis can be performed in approximately 15 min) with a limit of detection of 0.5 ng/mL in 1 mL of urine... - Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, MarylandBenjamin J Apelberg
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Environ Sci Technol 41:3891-7. 2007..Our findings suggest that in utero exposure to PFOS and PFOA is ubiquitous in a population of babies born in Baltimore, MD... - Developmental toxicity of perfluorooctanoic acid in the CD-1 mouse after cross-foster and restricted gestational exposuresCynthia J Wolf
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 95:462-73. 2007..Exposure earlier in gestation produced stronger responses, but further study is needed to determine if this is a function of higher total dose or if there is a developmentally sensitive period... - Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspringSally S White
Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Toxicol Sci 96:133-44. 2007..These findings suggest that in addition to gestational exposure, abnormal lactational development of dams may play a role in early growth retardation of developmentally exposed offspring...