Zsuzsanna Kuklenyik

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. doi request reprint Two-dimensional high performance liquid chromatography separation and tandem mass spectrometry detection of atrazine and its metabolic and hydrolysis products in urine
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 901:1-8. 2012
  2. ncbi request reprint Measurement of 18 perfluorinated organic acids and amides in human serum using on-line solid-phase extraction
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Anal Chem 77:6085-91. 2005
  3. ncbi request reprint SPE/SPME-GC/MS approach for measuring musk compounds in serum and breast milk
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 858:177-83. 2007
  4. ncbi request reprint Automated solid-phase extraction approaches for large scale biomonitoring studies
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Chromatogr Sci 47:12-8. 2009
  5. ncbi request reprint Simultaneous measurement of urinary bisphenol A and alkylphenols by automated solid-phase extractive derivatization gas chromatography/mass spectrometry
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Anal Chem 75:6820-5. 2003
  6. doi request reprint Design of online solid phase extraction-liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS) hyphenated systems for quantitative analysis of small organic compounds in biological matrices
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Sep Sci 34:3606-18. 2011
  7. doi request reprint Intermittent prophylaxis with oral truvada protects macaques from rectal SHIV infection
    J Gerardo Garcia-Lerma
    Division of HIV AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA
    Sci Transl Med 2:14ra4. 2010
  8. pmc Durable protection from vaginal simian-human immunodeficiency virus infection in macaques by tenofovir gel and its relationship to drug levels in tissue
    Charles Dobard
    Laboratory Branch and Quantitative Sciences and Data Management Branch, Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 86:718-25. 2012
  9. ncbi request reprint Serum concentrations of 11 polyfluoroalkyl compounds in the u.s. population: data from the national health and nutrition examination survey (NHANES)
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Sci Technol 41:2237-42. 2007
  10. ncbi request reprint Measuring environmental phenols and chlorinated organic chemicals in breast milk using automated on-line column-switching-high performance liquid chromatography-isotope dilution tandem mass spectrometry
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop F17, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 831:110-5. 2006

Collaborators

Detail Information

Publications30

  1. doi request reprint Two-dimensional high performance liquid chromatography separation and tandem mass spectrometry detection of atrazine and its metabolic and hydrolysis products in urine
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 901:1-8. 2012
    ..1-0.5 μg/l...
  2. ncbi request reprint Measurement of 18 perfluorinated organic acids and amides in human serum using on-line solid-phase extraction
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Anal Chem 77:6085-91. 2005
    ..The high throughput and low limits of detection (0.05-0.8 ng/mL) using a small sample volume (100 microL of serum) and isotope dilution quantification make this method suitable for large-scale epidemiologic studies...
  3. ncbi request reprint SPE/SPME-GC/MS approach for measuring musk compounds in serum and breast milk
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 858:177-83. 2007
    ..The method, which requires only 1 mL serum or breast milk to achieve limits of detection of 0.03-0.3 ng/mL, is applicable in biomonitoring studies for human internal dose measurement of polycyclic musk compounds...
  4. ncbi request reprint Automated solid-phase extraction approaches for large scale biomonitoring studies
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Chromatogr Sci 47:12-8. 2009
    ....
  5. ncbi request reprint Simultaneous measurement of urinary bisphenol A and alkylphenols by automated solid-phase extractive derivatization gas chromatography/mass spectrometry
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Anal Chem 75:6820-5. 2003
    ..The method, validated on spiked pooled urine samples and on urine samples from exposed persons, has limits of detection of approximately 0.1 ng in 1 mL of urine...
  6. doi request reprint Design of online solid phase extraction-liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS) hyphenated systems for quantitative analysis of small organic compounds in biological matrices
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Sep Sci 34:3606-18. 2011
    ....
  7. doi request reprint Intermittent prophylaxis with oral truvada protects macaques from rectal SHIV infection
    J Gerardo Garcia-Lerma
    Division of HIV AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA
    Sci Transl Med 2:14ra4. 2010
    ..They strengthen the possibility of developing feasible, cost-effective strategies to prevent HIV transmission in humans...
  8. pmc Durable protection from vaginal simian-human immunodeficiency virus infection in macaques by tenofovir gel and its relationship to drug levels in tissue
    Charles Dobard
    Laboratory Branch and Quantitative Sciences and Data Management Branch, Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 86:718-25. 2012
    ..The identification of protective TFV-DP concentrations in vaginal lymphocytes may facilitate the evaluation of improved delivery methods of topical TFV and inform clinical studies...
  9. ncbi request reprint Serum concentrations of 11 polyfluoroalkyl compounds in the u.s. population: data from the national health and nutrition examination survey (NHANES)
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Sci Technol 41:2237-42. 2007
    ....
  10. ncbi request reprint Measuring environmental phenols and chlorinated organic chemicals in breast milk using automated on-line column-switching-high performance liquid chromatography-isotope dilution tandem mass spectrometry
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop F17, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 831:110-5. 2006
    ..BPA, OPP, and BP-3 were detected in more than 60% of the samples tested. The free species of these compounds appear to be most prevalent in milk...
  11. doi request reprint Comparison of MALDI-TOF-MS and HPLC-ESI-MS/MS for endopeptidase activity-based quantification of Anthrax lethal factor in serum
    Zsuzsanna Kuklenyik
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, United States
    Anal Chem 83:1760-5. 2011
    ..99 (r(2) = 0.997) and -0.25% mean relative difference (±9% standard deviation). This study shows that isotope dilution MALDI-TOF-MS is a robust and precise quantitative MS platform...
  12. doi request reprint Trends in exposure to polyfluoroalkyl chemicals in the U.S. Population: 1999-2008
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States
    Environ Sci Technol 45:8037-45. 2011
    ..Nonetheless, these NHANES data suggest that sociodemographic factors may influence exposure and also provide unique information on temporal trends of exposure...
  13. pmc Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 115:1596-602. 2007
    ..Exposure of the general U.S. population to PFCs is widespread. Since 2002, the manufacturing practices for PFCs in the United States have changed considerably...
  14. ncbi request reprint Quantification of the urinary concentrations of parabens in humans by on-line solid phase extraction-high performance liquid chromatography-isotope dilution tandem mass spectrometry
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 844:53-9. 2006
    ..Using this method, we detected methyl, ethyl, and propyl parabens, mostly as conjugated species, in 22 urine samples collected from anonymous adults...
  15. ncbi request reprint Human exposure assessment to environmental chemicals using biomonitoring
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Int J Androl 29:166-71; discussion 181-5. 2006
    ..The use of biomonitoring in human risk assessment is not discussed...
  16. ncbi request reprint Perfluorochemicals in pooled serum samples from United States residents in 2001 and 2002
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Sci Technol 40:2128-34. 2006
    ..These findings indicate different patterns of human exposure to PFCs among the population groups examined and stress the importance of conducting research to identify the environmental sources and pathways of human exposure to PFCs...
  17. ncbi request reprint Quantification of urinary conjugates of bisphenol A, 2,5-dichlorophenol, and 2-hydroxy-4-methoxybenzophenone in humans by online solid phase extraction-high performance liquid chromatography-tandem mass spectrometry
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Mailstop F17, Atlanta, GA 30341, USA
    Anal Bioanal Chem 383:638-44. 2005
    ..To our knowledge, this is the first study describing the distribution of urinary conjugates of BP-3 and 2,5-DCP in humans...
  18. ncbi request reprint Automated on-line column-switching HPLC-MS/MS method with peak focusing for the determination of nine environmental phenols in urine
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Anal Chem 77:5407-13. 2005
    ..The method can be used for quick and accurate analysis of large numbers of samples in epidemiologic studies for assessing the prevalence of human exposure to environmental phenols...
  19. pmc Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 113:391-5. 2005
    ..S. population) and relatively small size, this study provides the first reference range of human internal dose levels of BPA and NP in a demographically diverse human population...
  20. doi request reprint On-line coupling of anion exchange and ion-pair chromatography for measurement of intracellular triphosphate metabolites of reverse transcriptase inhibitors
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States
    J Chromatogr B Analyt Technol Biomed Life Sci 877:3659-66. 2009
    ..Limits of detection were 9, 200 and 75 pg per sample for TFV-DP (448/176 m/z), FTC-TP (488/130 m/z) and 3TC-TP (468/119 m/z), respectively...
  21. ncbi request reprint Automated solid-phase extraction and measurement of perfluorinated organic acids and amides in human serum and milk
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Sci Technol 38:3698-704. 2004
    ..Additional studies are needed to determine whether environmental exposure to PFCs can result in PFCs partitioning into milk. Large epidemiological studies to determine the levels of PFCs among the U.S. general population are warranted...
  22. ncbi request reprint Automated online and off-line solid-phase extraction methods for measuring isoflavones and lignans in urine
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Chromatogr Sci 42:495-500. 2004
    ..Both methods are adequate for analyzing a large number of samples for epidemiological studies to assess the prevalence of human exposure to isoflavones and lignans...
  23. ncbi request reprint Perfluorinated chemicals in selected residents of the American continent
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Mailstop F17, Atlanta, GA 30341, USA
    Chemosphere 63:490-6. 2006
    ..Genetic variability, diet, lifestyle, or a combination of all these may contribute to the different patterns of human exposure to PFCs in the United States and Peru...
  24. ncbi request reprint Effect of mobile phase pH and organic content on LC-MS analysis of nucleoside and nucleotide HIV reverse transcriptase inhibitors
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Chromatogr Sci 47:365-72. 2009
    ..1 mL plasma (10 pg on column) and coefficients of variation from 5% to 15% in the high ng/mL concentration range and from 16% to 20% in the low ng/mL concentration range...
  25. pmc Urinary levels of trichloroacetic acid, a disinfection by-product in chlorinated drinking water, in a human reference population
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 111:151-4. 2003
    ....
  26. doi request reprint Quantitative mass spectrometry for bacterial protein toxins--a sensitive, specific, high-throughput tool for detection and diagnosis
    Anne E Boyer
    Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Atlanta, GA 30341, USA
    Molecules 16:2391-413. 2011
    ..We also describe potential applications to diseases of high public health impact, including Clostridium difficile glucosylating toxins and the Bordetella pertussis adenylyl cyclase...
  27. ncbi request reprint Quantitative detection of trichloroacetic acid in human urine using isotope dilution high-performance liquid chromatography-electrospray ionization tandem mass spectrometry
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Anal Chem 74:2058-63. 2002
    ..The method is simple and fast and is not labor intensive (sample preparation and analysis can be performed in approximately 15 min) with a limit of detection of 0.5 ng/mL in 1 mL of urine...
  28. ncbi request reprint Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, Maryland
    Benjamin J Apelberg
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Environ Sci Technol 41:3891-7. 2007
    ..Our findings suggest that in utero exposure to PFOS and PFOA is ubiquitous in a population of babies born in Baltimore, MD...
  29. ncbi request reprint Developmental toxicity of perfluorooctanoic acid in the CD-1 mouse after cross-foster and restricted gestational exposures
    Cynthia J Wolf
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 95:462-73. 2007
    ..Exposure earlier in gestation produced stronger responses, but further study is needed to determine if this is a function of higher total dose or if there is a developmentally sensitive period...
  30. ncbi request reprint Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring
    Sally S White
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 96:133-44. 2007
    ..These findings suggest that in addition to gestational exposure, abnormal lactational development of dams may play a role in early growth retardation of developmentally exposed offspring...