Research Topics
Genomes and GenesSpecies | Kathleen KreissSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
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Publications
Flavoring-related bronchiolitis obliteransKathleen Kreiss
Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Curr Opin Allergy Clin Immunol 7:162-7. 2007..Toxicologic and epidemiologic studies in the succeeding 5 years have intervention and research implications...
Cumulative sensitization and disease in a beryllium oxide ceramics worker cohortChristine R Schuler
Division of Respiratory Disease Studies, Field Studies Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WVa 26505, USA
J Occup Environ Med 50:1343-50. 2008..We followed a cohort of 136 beryllium oxide ceramics workers from 1992 to 2003, including those who left employment, for beryllium sensitization and chronic beryllium disease (CBD)...
Occupational causes of constrictive bronchiolitisKathleen Kreiss
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
Curr Opin Allergy Clin Immunol 13:167-72. 2013..Indolent evolution of dyspnea without a recognized hazardous exposure is a more common presentation...
Longitudinal lung function declines among California flavoring manufacturing workersKathleen Kreiss
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health NIOSH, Morgantown, WV 26505, USA
Am J Ind Med 55:657-68. 2012..The California Department of Public Health received serial spirometry data for flavoring manufacturing workers at 20 companies at risk of bronchiolitis obliterans...
Beryllium: a modern industrial hazardKathleen Kreiss
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Annu Rev Public Health 28:259-77. 2007..Beryllium sensitization and disease prevention are paradigms for much broader public health action in both occupational and general population settings...
Clinical bronchiolitis obliterans in workers at a microwave-popcorn plantKathleen Kreiss
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WVa 26505, USA
N Engl J Med 347:330-8. 2002..No recognized cause was identified in the plant. Therefore, we medically evaluated current employees and assessed their occupational exposures...
Sensitization and chronic beryllium disease at a primary manufacturing facility, part 3: exposure-response among short-term workersChristine R Schuler
Division of Respiratory Disease Studies, Field Studies Branch, NIOSH, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Scand J Work Environ Health 38:270-81. 2012..We examined exposure-response relations using personal exposure estimates in a beryllium worker cohort with limited work tenure to minimize exposure misclassification...
Sensitization and chronic beryllium disease at a primary manufacturing facility, part 2: validation of historical exposuresJi Young Park
National Institute for Occupational Safety and Health NIOSH, Division of Respiratory Disease Studies, Morgantown, WV, USA
Scand J Work Environ Health 38:259-69. 2012..The JEM was generated for an epidemiologic study to examine quantitative exposure-response relationships with sensitization and chronic beryllium disease...
Sensitization and chronic beryllium disease at a primary manufacturing facility, part 1: historical exposure reconstructionM Abbas Virji
National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Scand J Work Environ Health 38:247-58. 2012..The objective of this study was to develop historical estimates of size-selective personal exposure to beryllium for an epidemiologic study...
TNF-alpha polymorphisms in chronic beryllium disease and beryllium sensitizationErin C McCanlies
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
J Occup Environ Med 49:446-52. 2007....
Exposure pathway assessment at a copper-beryllium alloy facilityGregory A Day
Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, WV 26505, USA
Ann Occup Hyg 51:67-80. 2007..Based on our current understanding of the multiple exposure pathways that may lead to sensitization, we support prudent control practices such as use of protective gloves to minimize skin exposure to beryllium salts and fine particles...
Impact of negatively charged patches on the surface of MHC class II antigen-presenting proteins on risk of chronic beryllium diseaseJames A Snyder
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
J R Soc Interface 5:749-58. 2008..Together with the calculated high binding affinities for beryllium, these results suggest that an adverse immune response, leading to CBD, is triggered by chemically specific metal-protein interactions...
Efficacy of a program to prevent beryllium sensitization among new employees at a copper-beryllium alloy processing facilityCarrie A Thomas
Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Field Studies Branch, 1095 Willowdale Rd, MS 2800, Morgantown, WV 26505, USA
Public Health Rep 124:112-24. 2009..The facility then implemented a preventive program including particle migration control, respiratory and dermal protection, and process enclosure. We assessed the program's efficacy in preventing beryllium sensitization...
Hydrophilic fungi and ergosterol associated with respiratory illness in a water-damaged buildingJu Hyeong Park
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Environ Health Perspect 116:45-50. 2008..Damp building-related respiratory illnesses are an important public health issue...
Diacetyl emissions and airborne dust from butter flavorings used in microwave popcorn productionRandy Boylstein
National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
J Occup Environ Hyg 3:530-5. 2006..Until controls are fully implemented, companies should institute mandatory respiratory protection for all exposed workers...
Sensitization and chronic beryllium disease among workers in copper-beryllium distribution centersMarcia L Stanton
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, MS H2800, Morgantown, WV 26505, USA
J Occup Environ Med 48:204-11. 2006..In this study, we performed a cross-sectional survey of employees at three copper-beryllium alloy distribution centers...
Enhanced preventive programme at a beryllium oxide ceramics facility reduces beryllium sensitisation among new workersKristin J Cummings
NIOSH, Morgantown, West Virginia 26505, USA
Occup Environ Med 64:134-40. 2007..In response, the facility implemented an enhanced preventive programme to reduce sensitisation, including increased respiratory and dermal protection and particle migration control...
Characteristics of beryllium exposure to small particles at a beryllium production facilityM Abbas Virji
National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Ann Occup Hyg 55:70-85. 2011..Consideration of biologically relevant aspects of exposure such as beryllium particle size distribution, chemical form, and solubility will likely improve exposure assessment...
Rayon flock: a new cause of respiratory morbidity in a card processing plantVinicius C S Antao
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
Am J Ind Med 50:274-84. 2007..Following employee respiratory concerns, we investigated the health effects of rayon flock exposure at a card manufacturing plant...
Evaluation of flavorings-related lung disease risk at six microwave popcorn plantsRichard Kanwal
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA
J Occup Environ Med 48:149-57. 2006..After investigating fixed airways obstruction in butter flavoring-exposed workers at a microwave popcorn plant, we sought to further characterize lung disease risk from airborne butter-flavoring chemicals...
Association between IL-1A single nucleotide polymorphisms and chronic beryllium disease and beryllium sensitizationErin C McCanlies
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
J Occup Environ Med 52:680-4. 2010..To determine if single nucleotide polymorphisms (SNPs) in interleukin (IL) IL-1A, IL-1B, IL-1RN, IL-2, IL-9, and IL-9R were associated with chronic beryllium disease (CBD) and beryllium sensitization (BeS)...
Evaluation of a preventive program to reduce sensitization at a beryllium metal, oxide, and alloy production plantRachel L Bailey
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
J Occup Environ Med 52:505-12. 2010..We evaluated a workplace preventive program's effectiveness, which emphasized skin and respiratory protection, workplace cleanliness, and beryllium migration control in lowering beryllium sensitization...
Post-hire asthma among insect-rearing workersEva Suarthana
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
J Occup Environ Med 54:310-7. 2012..To evaluate the incidence of post-hire asthma (PHA) among insect-rearing workers, defined as asthma, the symptoms of which appeared after hire at the current workplace...
Occupational lung disease risk and exposure to butter-flavoring chemicals after implementation of controls at a microwave popcorn plantRichard Kanwal
Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1095 Willowdale Rd, MS H 2800, Morgantown 26505, USA
Public Health Rep 126:480-94. 2011..After an outbreak of severe lung disease among workers exposed to butter-flavoring chemicals at a microwave popcorn plant, we determined whether or not lung disease risk declined after implementation of exposure controls...
Lung disease in flavoring and food production: learning from butter flavoringNancy Sahakian
Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, West Virginia 26505, USA
Adv Food Nutr Res 55:163-92. 2009....
Identification and measurement of diacetyl substitutes in dry bakery mix productionGregory Day
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 2888, USA
J Occup Environ Hyg 8:93-103. 2011....
Exhaled nitric oxide measurement in workers in a microwave popcorn production plantMuge Akpinar-Elci
CDC NIOSH Division of Respiratory Diseases Studies, Morgantown, West Virginia 26505, USA
Int J Occup Environ Health 12:106-10. 2006..05). There is no indication that FENO is useful as a marker of lung injury in a flavoring-exposed worker population with a substantial lung disease burden, but the finding of low FENO in the high-exposure group should not be dismissed...
The association between HLA-DPB1Glu69 and chronic beryllium disease and beryllium sensitizationErin C McCanlies
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Am J Ind Med 46:95-103. 2004..However, the relationship between HLA-DPB1 and beryllium sensitization, and whether the presence of one or two HLA-DPB1(Glu69) alleles is differentially associated with CBD and beryllium sensitization have not been completely resolved...
Acute upper and lower respiratory effects in wildland firefightersDenise M Gaughan
National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA mail
J Occup Environ Med 50:1019-28. 2008..To assess acute respiratory effects experienced by wildland firefighters...
Asthma arising in flavoring-exposed food production workersNancy Sahakian
Centers for Disease Control and Prevention CDC Field Studies Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
Int J Occup Med Environ Health 21:173-7. 2008....
HLA-DPB1 and chronic beryllium disease: a HuGE reviewErin C McCanlies
Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Am J Epidemiol 157:388-98. 2003..Continued research in the beryllium-exposed population will be important for improving personal risk assessment and identifying high-risk genes associated with disease progression...
A reconsideration of acute Beryllium diseaseKristin J Cummings
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
Environ Health Perspect 117:1250-6. 2009....
Immunogenetic factors in beryllium sensitization and chronic beryllium diseaseAinsley Weston
Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop L 3014, Morgantown, WV 26505 2888, USA
Mutat Res 592:68-78. 2005....
Indium lung diseaseKristin J Cummings
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd, MS 2800, Morgantown, WV 26505, USA
Chest 141:1512-21. 2012..Reports of pulmonary fibrosis, emphysema, and, more recently, pulmonary alveolar proteinosis (PAP) in indium workers suggested that workplace exposure to indium compounds caused several different lung diseases...
Characterization of respiratory exposures at a microwave popcorn plant with cases of bronchiolitis obliteransGreg Kullman
National Institute for Occupational Safety and Health NIOSH, Morgantown, West Virginia 26505, USA
J Occup Environ Hyg 2:169-78. 2005....
Process-related risk of beryllium sensitization and disease in a copper-beryllium alloy facilityChristine R Schuler
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
Am J Ind Med 47:195-205. 2005..At a copper-beryllium alloy strip and wire finishing facility we performed a cross-sectional survey to examine prevalences of beryllium sensitization and CBD, and relationships between sensitization and CBD and work areas/processes...
Induced sputum evaluation in microwave popcorn production workersMuge Akpinar-Elci
NIOSH Division of Respiratory Diseases Studies, Centers for Disease Control and Prevention National Institute for Occupational Safety and Health, Field Studies Branch, Mail Stop H 2800, 1095 Willowdale Rd, Morgantown, WV 26505, USA
Chest 128:991-7. 2005..We investigated whether exposure to flavoring agents is associated with airways inflammation in popcorn production workers...
Markers of upper airway inflammation associated with microbial exposure and symptoms in occupants of a water-damaged buildingMuge Akpinar-Elci
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV Department of Public Health and Preventive Medicine, School of Medicine, St George s University, Grenada, WI
Am J Ind Med 56:522-30. 2013..Water damage in buildings has been associated with reports of upper airway inflammation among occupants...
Serial evaluations at an indium-tin oxide production facilityKristin J Cummings
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Am J Ind Med 56:300-7. 2013..We evaluated the effectiveness of workplace changes to prevent indium lung disease, using 2002-2010 surveillance data collected by an indium-tin oxide production facility...
Identification of mold and dampness-associated respiratory morbidity in 2 schools: comparison of questionnaire survey responses to national dataNancy M Sahakian
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd, Morgantown, WV 26505, USA
J Sch Health 78:32-7. 2008..Approximately one third of US public schools require extensive repairs or need at least 1 building replaced. This study illustrates how national data can be used to identify building-related health risks in school employees and students...
Respiratory morbidity in office workers in a water-damaged buildingJean M Cox-Ganser
Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Environ Health Perspect 113:485-90. 2005..Occupancy of the water-damaged building was associated with onset and exacerbation of respiratory conditions, confirmed by objective medical tests. The morbidity and lost work time burdened both employees and employers...
Silicosis mortality with respiratory tuberculosis in the United States, 1968-2006Muazzam Nasrullah
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
Am J Epidemiol 174:839-48. 2011..8). In the United States, 2006 marked the first year since 1968 with no silicosis-respiratory TB deaths. The substantial decline in silicosis-respiratory TB comortality probably reflects prevention and control measures for both diseases...
Pulmonary alveolar proteinosis in workers at an indium processing facilityKristin J Cummings
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Am J Respir Crit Care Med 181:458-64. 2010..These cases suggest that inhalational exposure to ITO causes pulmonary alveolar proteinosis, which may occur via an autoimmune mechanism...
Health effects of exposure to water-damaged New Orleans homes six months after Hurricanes Katrina and RitaKristin J Cummings
Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, USA
Am J Public Health 98:869-75. 2008..We investigated the relation between respiratory symptoms and exposure to water-damaged homes and the effect of respirator use in posthurricane New Orleans, Louisiana...
Risk factors for asthma among cosmetology professionals in ColoradoKathleen Kreiss
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado, USA
J Occup Environ Med 48:1062-9. 2006..After receiving several reports of occupational asthma among cosmetology professionals, we studied the prevalence, work-attributable risk, and tasks associated with asthma in this industry...
Respirator donning in post-hurricane New OrleansKristin J Cummings
National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Emerg Infect Dis 13:700-7. 2007..99, 95% CI, 1.20-3.28); and having participated in mold clean-up (OR 1.82; 95% CI,1.00-3.41). Interventions to improve respirator donning should be considered in planning for influenza epidemics and disasters...
New-onset asthma associated with exposure to 3-amino-5-mercapto-1,2,4-triazoleEva Hnizdo
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
J Occup Environ Med 46:1246-52. 2004..The authors conducted an investigation of a cluster of eight new-onset asthma cases identified in a chemical plant through the Sentinel Event Notification Systems for Occupational Risks (SENSOR) program...
Improving the health of workers in indoor environments: priority research needs for a national occupational research agendaMark J Mendell
National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Cincinnati, Ohio, USA
Am J Public Health 92:1430-40. 2002..Research on these topics, requiring new collaborations and resources, offers enormous potential health and economic returns...
Increased respiratory disease mortality at a microwave popcorn production facility with worker risk of bronchiolitis obliteransCara N Halldin
Epidemic Intelligence Service Program, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
PLoS ONE 8:e57935. 2013....
Flock workers' exposures and respiratory symptoms in five plantsFeroza Daroowalla
National Institute for Occupational Safety and Health, Division of Respiratory Disease Studies, Morgantown, West Virginia 26505, USA
Am J Ind Med 47:144-52. 2005..Longitudinal follow up may provide guidance for a dust or fiber level without adverse respiratory health effects...
Contingent workers and contingent health: risks of a modern economyKristin J Cummings
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
JAMA 299:448-50. 2008
Respiratory and olfactory cytotoxicity of inhaled 2,3-pentanedione in Sprague-Dawley ratsAnn F Hubbs
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Am J Pathol 181:829-44. 2012..Claudin-1 expression increased in the OB and striatum. We conclude that 2,3-pentanedione is a respiratory hazard that can also alter gene expression in the brain...
Fatal asthma from powdering shark cartilage and review of fatal occupational asthma literatureHector G Ortega
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, HELD/ASB/Mailstop L-4218, 1095 Willowdale Rd, Morgantown, West Virginia 26505, USA
Am J Ind Med 42:50-4. 2002..CONCLUSION: Recognition of occupational causes and triggers of asthma and removal of affected individuals from these exposures is critical and can prevent progression to irreversible or even fatal asthma...
Racial differences in prevalence of a supratypic HLA-genetic marker immaterial to pre-employment testing for susceptibility to chronic beryllium diseaseAinsley Weston
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, CDC, MS L3014, 1095 Willowdale Road, Morgantown, WV 26505 2888, USA
Am J Ind Med 41:457-65. 2002..An important consideration in this regard is the prevalence of this marker in the general population, and its consequent positive predictive value of disease susceptibility...
Occupational bronchiolitis obliterans masquerading as COPDKathleen Kreiss
Am J Respir Crit Care Med 176:427-9. 2007
Costs of occupational COPD and asthmaJ Paul Leigh
Department of Epidemiology and Preventive Medicine, School of Medicine, University of California at Davis, Davis, CA 95616-8638, USA
Chest 121:264-72. 2002..1 to $2.1 billion for asthma. CONCLUSIONS: The estimated $6.6 billion cost of occupational COPD and asthma in 1996 is likely to rise with the increasing prevalence of these diseases and warrants preventive intervention...
Needs and opportunities for research in hypersensitivity pneumonitisJordan N Fink
DLD/NHLBI, Two Rockledge Center, 6701 Rockledge Drive, Bethesda, MD 20892-7952, USA
Am J Respir Crit Care Med 171:792-8. 2005....
American Thoracic Society Statement: Occupational contribution to the burden of airway diseaseJohn Balmes
Am J Respir Crit Care Med 167:787-97. 2003
Emerging opportunities to prevent occupational lung diseaseKathleen Kreiss
Occup Environ Med 64:499-500. 2007
