Alexander I Klimov

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. doi WHO recommendations for the viruses to be used in the 2012 Southern Hemisphere Influenza Vaccine: epidemiology, antigenic and genetic characteristics of influenza A(H1N1)pdm09, A(H3N2) and B influenza viruses collected from February to September 2011
    Alexander I Klimov
    WHO Collaborating Centre for Surveillance, Epidemiology and Control of Influenza, Influenza Division, Centres for Disease Control and Prevention, NE, Atlanta, GA 30333, USA
    Vaccine 30:6461-71. 2012
  2. doi Influenza virus titration, antigenic characterization, and serological methods for antibody detection
    Alexander Klimov
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Methods Mol Biol 865:25-51. 2012
  3. pmc 6-sulfo sialyl Lewis X is the common receptor determinant recognized by H5, H6, H7 and H9 influenza viruses of terrestrial poultry
    Alexandra S Gambaryan
    Chumakov Institute of Poliomyelitis and Viral Encephalitides, RAMS, 142782 Moscow, Russia
    Virol J 5:85. 2008
  4. doi Comprehensive assessment of 2009 pandemic influenza A (H1N1) virus drug susceptibility in vitro
    Larisa V Gubareva
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Antivir Ther 15:1151-9. 2010
  5. doi Host cell selection of influenza neuraminidase variants: implications for drug resistance monitoring in A(H1N1) viruses
    Margaret Okomo-Adhiambo
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Mail Stop G 16, 1600 Clifton Road Atlanta GA, USA
    Antiviral Res 85:381-8. 2010
  6. doi Detection of antiviral resistance and genetic lineage markers in influenza B virus neuraminidase using pyrosequencing
    Tiffany G Sheu
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Antiviral Res 85:354-60. 2010
  7. pmc Detection of molecular markers of drug resistance in 2009 pandemic influenza A (H1N1) viruses by pyrosequencing
    Varough M Deyde
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta Georgia 30333, USA
    Antimicrob Agents Chemother 54:1102-10. 2010
  8. doi Pyrosequencing as a tool to detect molecular markers of resistance to neuraminidase inhibitors in seasonal influenza A viruses
    Varough M Deyde
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Antiviral Res 81:16-24. 2009
  9. pmc In vitro antiviral activity of favipiravir (T-705) against drug-resistant influenza and 2009 A(H1N1) viruses
    Katrina Sleeman
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329 4018, USA
    Antimicrob Agents Chemother 54:2517-24. 2010
  10. pmc Assessment of pandemic and seasonal influenza A (H1N1) virus susceptibility to neuraminidase inhibitors in three enzyme activity inhibition assays
    Ha T Nguyen
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Mail Stop G 16, 1600 Clifton Road, Atlanta, GA 30333, USA
    Antimicrob Agents Chemother 54:3671-7. 2010

Collaborators

Detail Information

Publications31

  1. doi WHO recommendations for the viruses to be used in the 2012 Southern Hemisphere Influenza Vaccine: epidemiology, antigenic and genetic characteristics of influenza A(H1N1)pdm09, A(H3N2) and B influenza viruses collected from February to September 2011
    Alexander I Klimov
    WHO Collaborating Centre for Surveillance, Epidemiology and Control of Influenza, Influenza Division, Centres for Disease Control and Prevention, NE, Atlanta, GA 30333, USA
    Vaccine 30:6461-71. 2012
    ....
  2. doi Influenza virus titration, antigenic characterization, and serological methods for antibody detection
    Alexander Klimov
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Methods Mol Biol 865:25-51. 2012
    ....
  3. pmc 6-sulfo sialyl Lewis X is the common receptor determinant recognized by H5, H6, H7 and H9 influenza viruses of terrestrial poultry
    Alexandra S Gambaryan
    Chumakov Institute of Poliomyelitis and Viral Encephalitides, RAMS, 142782 Moscow, Russia
    Virol J 5:85. 2008
    ..To further characterize these differences, we studied receptor-binding properties of a large panel of influenza A viruses from wild aquatic birds, poultry, pigs and horses...
  4. doi Comprehensive assessment of 2009 pandemic influenza A (H1N1) virus drug susceptibility in vitro
    Larisa V Gubareva
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Antivir Ther 15:1151-9. 2010
    ..Antiviral drugs are an important option for managing infections caused by influenza viruses. This study assessed the drug susceptibility of 2009 pandemic influenza A (H1N1) viruses collected globally between April 2009 and January 2010...
  5. doi Host cell selection of influenza neuraminidase variants: implications for drug resistance monitoring in A(H1N1) viruses
    Margaret Okomo-Adhiambo
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Mail Stop G 16, 1600 Clifton Road Atlanta GA, USA
    Antiviral Res 85:381-8. 2010
    ....
  6. doi Detection of antiviral resistance and genetic lineage markers in influenza B virus neuraminidase using pyrosequencing
    Tiffany G Sheu
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Antiviral Res 85:354-60. 2010
    ....
  7. pmc Detection of molecular markers of drug resistance in 2009 pandemic influenza A (H1N1) viruses by pyrosequencing
    Varough M Deyde
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta Georgia 30333, USA
    Antimicrob Agents Chemother 54:1102-10. 2010
    ..Pyrosequencing is well suited for the detection of drug resistance markers and signature mutations in the M and NA gene segments of the pandemic H1N1 influenza viruses...
  8. doi Pyrosequencing as a tool to detect molecular markers of resistance to neuraminidase inhibitors in seasonal influenza A viruses
    Varough M Deyde
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Antiviral Res 81:16-24. 2009
    ....
  9. pmc In vitro antiviral activity of favipiravir (T-705) against drug-resistant influenza and 2009 A(H1N1) viruses
    Katrina Sleeman
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329 4018, USA
    Antimicrob Agents Chemother 54:2517-24. 2010
    ..This study demonstrates that favipiravir inhibits in vitro replication of a wide range of influenza viruses, including those resistant to currently available drugs...
  10. pmc Assessment of pandemic and seasonal influenza A (H1N1) virus susceptibility to neuraminidase inhibitors in three enzyme activity inhibition assays
    Ha T Nguyen
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Mail Stop G 16, 1600 Clifton Road, Atlanta, GA 30333, USA
    Antimicrob Agents Chemother 54:3671-7. 2010
    ..It would be desirable to develop an NI assay which combines the advantages of all three currently available assays but which lacks their shortcomings...
  11. pmc Dual resistance to adamantanes and oseltamivir among seasonal influenza A(H1N1) viruses: 2008-2010
    Tiffany G Sheu
    Influenza Division, Centers for Disease Control and Prevention, Battelle Memorial Institute, Atlanta, Georgia, USA
    J Infect Dis 203:13-7. 2011
    ..Because of limited options for antiviral treatment, emergence of dual-resistant influenza viruses poses a public health concern, and their circulation needs to be closely monitored...
  12. pmc Detection of molecular markers of antiviral resistance in influenza A (H5N1) viruses using a pyrosequencing method
    Varough M Deyde
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Antimicrob Agents Chemother 53:1039-47. 2009
    ..The pyrosequencing approach may provide a valuable tool for rapid detection of markers of drug resistance in H5N1 viruses and facilitate the elucidation of the role of such changes in natural and acquired drug resistance...
  13. pmc Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans
    Rebecca J Garten
    WHO Collaborating Center for Influenza, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    Science 325:197-201. 2009
    ..Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1)...
  14. doi Rapid identification of oseltamivir-resistant influenza A(H1N1) viruses with H274Y mutation by RT-PCR/restriction fragment length polymorphism assay
    Lizheng Guo
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS G 16, Atlanta, GA 30333, USA
    Antiviral Res 82:29-33. 2009
    ..Our RT-PCR/RFLP assay provides a simple, rapid and sensitive tool to monitor the emergence and spread of H274Y oseltamivir-resistant influenza A(H1N1) viruses...
  15. doi Analysis of influenza viruses from patients clinically suspected of infection with an oseltamivir resistant virus during the 2009 pandemic in the United States
    Ha T Nguyen
    Influenza Division, Centers for Disease Control and Prevention, Mail Stop G 16, 1600 Clifton Road, Atlanta, GA 30333, USA
    Antiviral Res 93:381-6. 2012
    ..These data suggest that pyrosequencing is a powerful tool for timely detection of NAI resistant viruses and that NI assays are needed for comprehensive testing to detect novel resistance substitutions...
  16. ncbi Correction: okomo-adhiambo, m. Et Al. Neuraminidase inhibitor susceptibility testing in human influenza viruses: a laboratory surveillance perspective. Viruses 2010, 2, 2269-2289
    Margaret Okomo-Adhiambo
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop G16, Atlanta, GA 30333, USA E Mails M O A K S K B H T N V P M T G S J S A I K
    Viruses 3:1415-6. 2011
    ..This corrects the article on p. 2269 in vol. 2.]...
  17. pmc Detection of E119V and E119I mutations in influenza A (H3N2) viruses isolated from an immunocompromised patient: challenges in diagnosis of oseltamivir resistance
    Margaret Okomo-Adhiambo
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Antimicrob Agents Chemother 54:1834-41. 2010
    ....
  18. pmc Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004 to 2008
    Tiffany G Sheu
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Antimicrob Agents Chemother 52:3284-92. 2008
    ..6% (50/579 isolates). The recent increase in oseltamivir resistance among A(H1N1) viruses isolated from untreated patients raises public health concerns and necessitates close monitoring of resistance to NA inhibitors...
  19. pmc Neuraminidase inhibitor susceptibility testing in human influenza viruses: a laboratory surveillance perspective
    Margaret Okomo-Adhiambo
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop G16, Atlanta, GA 30333, USA E Mails M O A K S K B H T N V P M T G S J S A I K
    Viruses 2:2269-89. 2010
    ..This study summarizes baseline susceptibility patterns of seasonal and pandemic influenza viruses, and seeks to contribute towards criteria for defining NAI resistance...
  20. doi Neuraminidase inhibitor susceptibility surveillance of influenza viruses circulating worldwide during the 2011 Southern Hemisphere season
    Margaret Okomo-Adhiambo
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, WHO Collaborating Center for Surveillance, Epidemiology and Control of Influenza, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Influenza Other Respir Viruses 7:645-58. 2013
    ..Neuraminidase (NA) inhibitors (NAIs) are currently the only antivirals effective against influenza infections due to widespread resistance to M2 inhibitors...
  21. doi Infections with oseltamivir-resistant influenza A(H1N1) virus in the United States
    Nila J Dharan
    Epidemic Intelligence Service, Office of Workforce and Career Development Assigned to Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS A 32, Atlanta, GA 30333, USA
    JAMA 301:1034-41. 2009
    ..Early surveillance data suggest that the prevalence of oseltamivir resistance among A(H1N1) viruses will most likely be higher during the 2008-2009 season...
  22. doi Influenza: propagation, quantification, and storage
    Amanda L Balish
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Curr Protoc Microbiol . 2013
    ..MDCK cells are the preferred cell line for isolation of human influenza viruses from clinical specimens...
  23. doi Clinical and virologic outcomes in patients with oseltamivir-resistant seasonal influenza A (H1N1) infections: results from a clinical trial
    Nila J Dharan
    Epidemic Intelligence Service, Office of Workforce and Career Development Assigned to Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Influenza Other Respir Viruses 6:153-8. 2012
    ..While sample size prohibits a strong conclusion, future studies should evaluate for similar trends...
  24. doi Seasonality, timing, and climate drivers of influenza activity worldwide
    Eduardo Azziz Baumgartner
    Centers for Disease Control and Prevention, Influenza Division, Atlanta, Georgia 30333, USA
    J Infect Dis 206:838-46. 2012
    ..We analyzed publicly available influenza data to better understand the global circulation of influenza viruses...
  25. pmc Swine Influenza Virus A (H3N2) Infection in Human, Kansas, USA, 2009
    Chad M Cox
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 17:1143-4. 2011
    ..Although an animal source for pandemic (H1N1) 2009 virus has yet to be identified, the pandemic strain resulted from the reassortment of 2 different lineages of SIV (8)...
  26. pmc Genomic signature-based identification of influenza A viruses using RT-PCR/electro-spray ionization mass spectrometry (ESI-MS) technology
    Varough M Deyde
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 5:e13293. 2010
    ..Combination of the BC signatures represents a "genomic print" of an influenza A virus...
  27. ncbi Antigenic and genetic diversity of highly pathogenic avian influenza A (H5N1) viruses isolated in Egypt
    Amanda L Balish
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Avian Dis 54:329-34. 2010
    ..The antigenic changes in Egyptian viruses isolated during 2007-08 necessitated that two of these strains be considered as potential H5N1 pre-pandemic vaccine candidates...
  28. pmc Diagnosis of influenza from respiratory autopsy tissues: detection of virus by real-time reverse transcription-PCR in 222 cases
    Amy M Denison
    Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Mol Diagn 13:123-8. 2011
    ..We also determined that testing of all available respiratory tissues is critical for optimal detection of influenza virus in postmortem tissues...
  29. pmc Structural and Antigenic Variation among Diverse Clade 2 H5N1 Viruses
    David A Shore
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 8:e75209. 2013
    ....
  30. doi Comparative immunogenicity and cross-clade protective efficacy of mammalian cell-grown inactivated and live attenuated H5N1 reassortant vaccines in ferrets
    Kortney M Gustin
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 204:1491-9. 2011
    ..Thus, enhanced respiratory tract antibody responses elicited by LAIV were associated with improved cross-clade protection...
  31. ncbi Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide
    Varough M Deyde
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 196:249-57. 2007
    ..The results of the study highlight the necessity of close monitoring of resistance to existing antivirals as wells as the need for new therapeutics...