Muin J Khoury

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi request reprint The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention?
    Muin J Khoury
    National Office of Public Health Genomics Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Genet Med 9:665-74. 2007
  2. doi request reprint How can polygenic inheritance be used in population screening for common diseases?
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Genet Med 15:437-43. 2013
  3. pmc Genomics and the prevention and control of common chronic diseases: emerging priorities for public health action
    Muin J Khoury
    Prev Chronic Dis 2:A05. 2005
  4. ncbi request reprint The emergence of epidemiology in the genomics age
    Muin J Khoury
    Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Int J Epidemiol 33:936-44. 2004
  5. pmc The Scientific Foundation for personal genomics: recommendations from a National Institutes of Health-Centers for Disease Control and Prevention multidisciplinary workshop
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Genet Med 11:559-67. 2009
  6. ncbi request reprint The integration of genomics into paediatric and perinatal epidemiology: guidelines for submitting human genome epidemiology (HuGE) reviews
    Muin J Khoury
    Office of Genomics and Disease Prevention, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Paediatr Perinat Epidemiol 19:178-80. 2005
  7. ncbi request reprint On the synthesis and interpretation of consistent but weak gene-disease associations in the era of genome-wide association studies
    Muin J Khoury
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Int J Epidemiol 36:439-45. 2007
  8. ncbi request reprint Comparative effectiveness research and genomic medicine: an evolving partnership for 21st century medicine
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia 3033, USA
    Genet Med 11:707-11. 2009
  9. pmc The genomic applications in practice and prevention network
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Genet Med 11:488-94. 2009
  10. pmc Influence of familial risk on diabetes risk-reducing behaviors among U.S. adults without diabetes
    Man Huei Chang
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Diabetes Care 34:2393-9. 2011

Detail Information

Publications111 found, 100 shown here

  1. ncbi request reprint The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention?
    Muin J Khoury
    National Office of Public Health Genomics Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Genet Med 9:665-74. 2007
    ..With continued advances in genomic applications, however, the full continuum of translation research needs adequate support to realize the promise of genomics for human health...
  2. doi request reprint How can polygenic inheritance be used in population screening for common diseases?
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Genet Med 15:437-43. 2013
    ..In an era of direct-to-consumer availability of personal genomic information, the public health and health-care systems need to prepare for an evidence-based integration of this information into population screening...
  3. pmc Genomics and the prevention and control of common chronic diseases: emerging priorities for public health action
    Muin J Khoury
    Prev Chronic Dis 2:A05. 2005
  4. ncbi request reprint The emergence of epidemiology in the genomics age
    Muin J Khoury
    Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Int J Epidemiol 33:936-44. 2004
  5. pmc The Scientific Foundation for personal genomics: recommendations from a National Institutes of Health-Centers for Disease Control and Prevention multidisciplinary workshop
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Genet Med 11:559-67. 2009
    ..To fulfill the promise of personal genomics, a rigorous multidisciplinary research agenda is needed...
  6. ncbi request reprint The integration of genomics into paediatric and perinatal epidemiology: guidelines for submitting human genome epidemiology (HuGE) reviews
    Muin J Khoury
    Office of Genomics and Disease Prevention, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Paediatr Perinat Epidemiol 19:178-80. 2005
  7. ncbi request reprint On the synthesis and interpretation of consistent but weak gene-disease associations in the era of genome-wide association studies
    Muin J Khoury
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Int J Epidemiol 36:439-45. 2007
    ..Efforts by the Human Genome Epidemiology Network (HuGENet) are currently ongoing to streamline and operationalize these criteria for data on genetic associations with common diseases...
  8. ncbi request reprint Comparative effectiveness research and genomic medicine: an evolving partnership for 21st century medicine
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia 3033, USA
    Genet Med 11:707-11. 2009
    ..There is a need to heal the apparent schism between genomic medicine and comparative effectiveness research to enhance knowledge-driven practice of medicine in the 21st century...
  9. pmc The genomic applications in practice and prevention network
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Genet Med 11:488-94. 2009
    ....
  10. pmc Influence of familial risk on diabetes risk-reducing behaviors among U.S. adults without diabetes
    Man Huei Chang
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Diabetes Care 34:2393-9. 2011
    ..To test the association of family history of diabetes with the adoption of diabetes risk-reducing behaviors and whether this association is strengthened by physician advice or commonly known factors associated with diabetes risk...
  11. doi request reprint A Hardy-Weinberg equilibrium test for analyzing population genetic surveys with complex sample designs
    Ramal Moonesinghe
    Office of Minority Health and Health Disparities, 4770 Buford Highway, Mailstop E 67, Atlanta, GA 30341, USA
    Am J Epidemiol 171:932-41. 2010
    ....
  12. pmc Developing Family Healthware, a family history screening tool to prevent common chronic diseases
    Paula W Yoon
    Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Mailstop K47, Atlanta, GA 30341, USA
    Prev Chronic Dis 6:A33. 2009
    ....
  13. doi request reprint Family history in public health practice: a genomic tool for disease prevention and health promotion
    Rodolfo Valdez
    Office of Public Health Genomics, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Annu Rev Public Health 31:69-87 1 p following 87. 2010
    ..Their goal is to create family history tools that have decision support capabilities and are compatible with electronic health records. These advances will help realize the potential of family history as a public health tool...
  14. pmc Required sample size and nonreplicability thresholds for heterogeneous genetic associations
    Ramal Moonesinghe
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Proc Natl Acad Sci U S A 105:617-22. 2008
    ..Therefore, some true associations may not be practically possible to replicate with consistency, no matter how large studies are conducted. Efforts should be made to minimize between-study heterogeneity in targeted genetic effects...
  15. pmc Multilevel research and the challenges of implementing genomic medicine
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, 1600 Clifton Rd, Mailstop E61, Atlanta, GA 30333, USA
    J Natl Cancer Inst Monogr 2012:112-20. 2012
    ..We synthesize existing information in a framework for future multilevel research for integrating genomic medicine into the cancer care continuum...
  16. pmc An open source infrastructure for managing knowledge and finding potential collaborators in a domain-specific subset of PubMed, with an example from human genome epidemiology
    Wei Yu
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA
    BMC Bioinformatics 8:436. 2007
    ..The design of this infrastructure makes the system potentially extensible to other data sources...
  17. pmc GAPscreener: an automatic tool for screening human genetic association literature in PubMed using the support vector machine technique
    Wei Yu
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA
    BMC Bioinformatics 9:205. 2008
    ..The GAPscreener, a free SVM-based software tool, can be used to assist in screening PubMed abstracts for human genetic association studies...
  18. pmc Improvements in ability to detect undiagnosed diabetes by using information on family history among adults in the United States
    Quanhe Yang
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Epidemiol 171:1079-89. 2010
    ..Study findings suggest that adding family history of diabetes can provide significant improvements in detecting undiagnosed diabetes in the US population. Further research is needed to validate the authors' findings...
  19. pmc Discriminative accuracy of genomic profiling comparing multiplicative and additive risk models
    Ramal Moonesinghe
    Office of Minority Health and Health Disparities, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Eur J Hum Genet 19:180-5. 2011
    ..Unraveling the exact mode of biological interaction is important when effect sizes of genetic variants are moderate at the least, to prevent the incorrect estimation of risks...
  20. pmc Using lifetime risk estimates in personal genomic profiles: estimation of uncertainty
    Quanhe Yang
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Hum Genet 85:786-800. 2009
    ..Epidemiologic parameters involved in computation of disease risk have substantial uncertainty, and cumulative uncertainty should be properly recognized. Reliance on point estimates alone could be seriously misleading...
  21. pmc GWAS Integrator: a bioinformatics tool to explore human genetic associations reported in published genome-wide association studies
    Wei Yu
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Eur J Hum Genet 19:1095-9. 2011
    ..hugenavigator.net/HuGENavigator/gWAHitStartPage.do). The GWAS Integrator may help enhance inference on potential genetic associations identified from GWAS studies...
  22. doi request reprint Sodium and potassium intake and mortality among US adults: prospective data from the Third National Health and Nutrition Examination Survey
    Quanhe Yang
    Division for Heart Diseases and Stroke Prevention, Centers for Disease Control and Prevention, 4770 Buford Hwy NE, Mail Stop K 47, Atlanta, GA 30341, USA
    Arch Intern Med 171:1183-91. 2011
    ..Few studies have examined joint effects of dietary sodium and potassium intake on risk of mortality...
  23. doi request reprint The association between family history of asthma and the prevalence of asthma among US adults: National Health and Nutrition Examination Survey, 1999-2004
    Tiebin Liu
    Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Genet Med 11:323-8. 2009
    ..To assess the overall prevalence of asthma and the association between family history of asthma and the prevalence of asthma among US adults...
  24. pmc Gene Prospector: an evidence gateway for evaluating potential susceptibility genes and interacting risk factors for human diseases
    Wei Yu
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA
    BMC Bioinformatics 9:528. 2008
    ..The application, called Gene Prospector, also provides a comprehensive set of links to additional data sources...
  25. ncbi request reprint Is family history a useful tool for detecting children at risk for diabetes and cardiovascular diseases? A public health perspective
    Rodolfo Valdez
    National Office of Public Health Genomics, Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Mail Stop K 89, Atlanta, GA 30341, USA
    Pediatrics 120:S78-86. 2007
    ....
  26. pmc Estimating the contribution of genetic variants to difference in incidence of disease between population groups
    Ramal Moonesinghe
    Office of Minority Health and Health Disparities, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Eur J Hum Genet 20:831-6. 2012
    ..Any estimate of genetic contribution to the disparity in incidence of disease between two populations at this stage seems to be an elusive goal...
  27. pmc Reporting of human genome epidemiology (HuGE) association studies: an empirical assessment
    Ajay Yesupriya
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, USA
    BMC Med Res Methodol 8:31. 2008
    ..Transparent reporting of study methods and results allows readers to better assess the validity of study findings. Here, we document reporting practices of human genome epidemiology studies...
  28. ncbi request reprint How many genes underlie the occurrence of common complex diseases in the population?
    Quanhe Yang
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    Int J Epidemiol 34:1129-37. 2005
    ..It is not clear how many genes are necessary to account for an appreciable population-attributable fraction of these diseases...
  29. pmc Racial/ethnic differences in association of fasting glucose-associated genomic loci with fasting glucose, HOMA-B, and impaired fasting glucose in the U.S. adult population
    Quanhe Yang
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Diabetes Care 33:2370-7. 2010
    ....
  30. ncbi request reprint An epidemiologic assessment of genomic profiling for measuring susceptibility to common diseases and targeting interventions
    Muin J Khoury
    Office of Genomics and Disease Prevention, Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Genet Med 6:38-47. 2004
    ....
  31. ncbi request reprint Will genomics widen or help heal the schism between medicine and public health?
    Muin J Khoury
    National Office of Public Health Genomics, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341, USA
    Am J Prev Med 33:310-7. 2007
    ..A strong medicine-public health partnership in the genomics era is needed for the translation of all scientific discoveries for the benefit of population health...
  32. ncbi request reprint Evaluation of family history as a risk factor and screening tool for detecting undiagnosed diabetes in a nationally representative survey population
    Susan Hariri
    Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Genet Med 8:752-9. 2006
    ..We examined the utility of a three-level familial risk stratification system as a screening tool for diabetes in a nationally representative sample of the U.S. adult population...
  33. doi request reprint Family history as a risk factor for early-onset stroke/transient ischemic attack among adults in the United States
    Mercy Mvundura
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Public Health Genomics 13:13-20. 2010
    ..We tested the association between familial risk for stroke and prevalence of the disease among US adults and assessed the use of family history of stroke as a risk assessment tool for the disease...
  34. pmc Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994
    Man Huei Chang
    National Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 169:54-66. 2009
    ..These nationally representative data on allele frequency and genotype prevalence provide a valuable resource for future epidemiologic studies in public health in the United States...
  35. ncbi request reprint Research priorities for evaluating family history in the prevention of common chronic diseases
    Paula W Yoon
    Office of Genomics and Disease Prevention, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA 39341 3724, USA
    Am J Prev Med 24:128-35. 2003
  36. pmc Transforming epidemiology for 21st century medicine and public health
    Muin J Khoury
    Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
    Cancer Epidemiol Biomarkers Prev 22:508-16. 2013
    ..They should lay a strong scientific foundation for accelerated translation of scientific discoveries into individual and population health benefits...
  37. pmc Application of support vector machine modeling for prediction of common diseases: the case of diabetes and pre-diabetes
    Wei Yu
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA
    BMC Med Inform Decis Mak 10:16. 2010
    ..We illustrate the method to detect persons with diabetes and pre-diabetes in a cross-sectional representative sample of the U.S. population...
  38. pmc An automatic method to generate domain-specific investigator networks using PubMed abstracts
    Wei Yu
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA
    BMC Med Inform Decis Mak 7:17. 2007
    ..We present a novel strategy for building investigator networks dynamically and producing detailed investigator profiles using data available in PubMed abstracts...
  39. pmc Evaluation of the discriminative accuracy of genomic profiling in the prediction of common complex diseases
    Ramal Moonesinghe
    Office of Minority Health and Health Disparities, Centers for Disease Control and Prevention, Mailstop E 67, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
    Eur J Hum Genet 18:485-9. 2010
    ....
  40. pmc Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases
    Muin J Khoury
    Office of Public Health Genomics, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 170:269-79. 2009
    ..As a next step in the evolution of Human Genome Epidemiology reviews, the authors invite investigators to submit field synopses for possible publication in the American Journal of Epidemiology...
  41. doi request reprint Awareness and utilization of BRCA1/2 testing among U.S. primary care physicians
    Cecelia A Bellcross
    CDC, Atlanta, Georgia 30333, USA
    Am J Prev Med 40:61-6. 2011
    ..Testing for mutations in the breast and ovarian cancer susceptibility genes BRCA1 and BRCA2 (BRCA) has been commercially available since 1996...
  42. ncbi request reprint On the use of population attributable fraction to determine sample size for case-control studies of gene-environment interaction
    Quanhe Yang
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Epidemiology 14:161-7. 2003
    ..In this case, the associated odds ratio for interaction will be weaker and a considerably larger sample size may be needed...
  43. ncbi request reprint Knowledge integration at the center of genomic medicine
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Genet Med 14:643-7. 2012
    ..The ultrarapid production of information requires adequate public and private resources for knowledge integration to support the evidence-based development of genomic medicine...
  44. doi request reprint Public awareness and use of direct-to-consumer personal genomic tests from four state population-based surveys, and implications for clinical and public health practice
    Katherine Kolor
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Genet Med 14:860-7. 2012
    ..Direct-to-consumer personal genomic tests are widely available, but population-based data are limited on awareness and use of these tests among the general public in the United States...
  45. doi request reprint Prospective study of methylenetetrahydrofolate reductase (MTHFR) variant C677T and risk of all-cause and cardiovascular disease mortality among 6000 US adults
    Quanhe Yang
    Office of Public Health Genomics, CDC, Atlanta, GA 30341, USA
    Am J Clin Nutr 95:1245-53. 2012
    ....
  46. ncbi request reprint Family history and prevalence of diabetes in the U.S. population: the 6-year results from the National Health and Nutrition Examination Survey (1999-2004)
    Rodolfo Valdez
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Mailstop K 89, Atlanta, GA 30341, USA
    Diabetes Care 30:2517-22. 2007
    ..We sought to test the association between stratified levels of familial risk of diabetes and the prevalence of the disease in the U.S. population...
  47. pmc Invited commentary: from genome-wide association studies to gene-environment-wide interaction studies--challenges and opportunities
    Muin J Khoury
    National Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Epidemiol 169:227-30; discussion 234-5. 2009
    ....
  48. doi request reprint The evidence dilemma in genomic medicine
    Muin J Khoury
    Centers for Disease Control and Prevention CDC, in Atlanta, Georgia, USA
    Health Aff (Millwood) 27:1600-11. 2008
    ..There is an urgent need for a collaborative process for appropriate transition of genomic discoveries from research to practice...
  49. doi request reprint Current priorities for public health practice in addressing the role of human genomics in improving population health
    Muin J Khoury
    Office of Public Health Genomics, CDC, Atlanta, Georgia 30333, USA
    Am J Prev Med 40:486-93. 2011
    ..Such efforts are needed not only to implement what is known in genomics to improve health but also to reduce potential harm and create the infrastructure needed to derive health benefits in the future...
  50. ncbi request reprint Prevalence, family history, and prevention of reported osteoporosis in U.S. women
    Julie Robitaille
    CDC, The National Center on Birth Defects and Developmental Disabilities, Atlanta, Georgia, USA
    Am J Prev Med 35:47-54. 2008
    ..S. women, examine whether osteoporosis risk factors account for this relationship, and evaluate the likelihood that women at high risk of osteoporosis due to family history report preventive behaviors...
  51. ncbi request reprint Family history of type 2 diabetes: a population-based screening tool for prevention?
    Susan Hariri
    Epidemic Intelligence Service Officer, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Genet Med 8:102-8. 2006
    ..To evaluate the use of self-reported family medical history as a potential screening tool to identify people at-risk for diabetes...
  52. doi request reprint Genetic epidemiology with a capital E, ten years after
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta GA 30333, USA
    Genet Epidemiol 35:845-52. 2011
    ..We extend Duncan Thomas' capital E to include "Evaluation" as the tools of epidemiology are increasingly used to assess how genome-based information can be applied in medicine and public health...
  53. pmc Implementing screening for Lynch syndrome among patients with newly diagnosed colorectal cancer: summary of a public health/clinical collaborative meeting
    Cecelia A Bellcross
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Genet Med 14:152-62. 2012
    ..Such endeavors will require multilevel and multidisciplinary approaches building on collaborative public health and clinical partnerships...
  54. ncbi request reprint Do we need genomic research for the prevention of common diseases with environmental causes?
    Muin J Khoury
    Office of Genomics and Disease Prevention, Coordinating Center on Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 161:799-805. 2005
    ..This research is likely to lead to population-wide health promotion and disease prevention efforts, not only to interventions targeted according to genetic susceptibility...
  55. ncbi request reprint Mendelian randomisation: a new spin or real progress?
    Julian Little
    Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Lancet 362:930-1. 2003
  56. ncbi request reprint Tracking the epidemiology of human genes in the literature: the HuGE Published Literature database
    Bruce K Lin
    Office of Genomics and Disease Prevention, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 164:1-4. 2006
    ..Here, the authors provide an overview of the database and its characteristics and uses...
  57. ncbi request reprint The emergence of biobanks: practical design considerations for large population-based studies of gene-environment interactions
    Robert L Davis
    Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Community Genet 10:181-5. 2007
    ....
  58. ncbi request reprint From genetics to genomics: using gene-based medicine to prevent disease and promote health in children
    Cynthia A Moore
    Office of Genomics and Disease Prevention, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Semin Perinatol 29:135-43. 2005
    ....
  59. ncbi request reprint Quantifying the health benefits of genetic tests: the importance of a population perspective
    Muin J Khoury
    Office of Genomics and Disease Prevention, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Genet Med 8:191-5. 2006
  60. pmc Public awareness and use of direct-to-consumer genetic tests: results from 3 state population-based surveys, 2006
    Katrina A B Goddard
    National Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Am J Public Health 99:442-5. 2009
    ..Less than 1% had used a health-related direct-to-consumer genetic test. Public health systems should increase consumer and provider education and continue surveillance on direct-to-consumer genetic tests...
  61. doi request reprint Steroid 5-{alpha}-reductase Type 2 (SRD5a2) gene polymorphisms and risk of prostate cancer: a HuGE review
    Jun Li
    Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, 4770 Buford Highway, MS K55, Atlanta, GA 30341, USA
    Am J Epidemiol 171:1-13. 2010
    ..Analysis of well-designed population-based studies with pathway-based arrays containing common genetic variants could be useful for identifying genetic factors in prostate cancer...
  62. ncbi request reprint Genetics and genomics in practice: the continuum from genetic disease to genetic information in health and disease
    Muin J Khoury
    Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, Mail stop E82, Atlanta, GA 30333, USA
    Genet Med 5:261-8. 2003
    ....
  63. doi request reprint Horizon scanning for new genomic tests
    Marta Gwinn
    McKing Consulting Corporation, Atlanta, Georgia, USA
    Genet Med 13:161-5. 2011
    ..Consequently, it is not easy to determine which tests are in development, currently available, or discontinued. We developed and assessed the usefulness of a systematic approach to identifying new genomic tests on the Internet...
  64. pmc Most published research findings are false-but a little replication goes a long way
    Ramal Moonesinghe
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Med 4:e28. 2007
  65. pmc Beyond base pairs to bedside: a population perspective on how genomics can improve health
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Public Health 102:34-7. 2012
    ....
  66. pmc The need for genetic variant naming standards in published abstracts of human genetic association studies
    Wei Yu
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    BMC Res Notes 2:56. 2009
    ..The consistent use of rs numbers in abstracts that report genetic associations would enhance knowledge synthesis and translation in this field...
  67. doi request reprint Evaluation of the validity and utility of genetic testing for rare diseases
    Scott D Grosse
    Division of Blood Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Adv Exp Med Biol 686:115-31. 2010
    ..Specific rare disorders addressed include cystic fibrosis, fragile X syndrome, Duchenne and Becker muscular dystrophy, spinal muscular atrophy, Huntington disease, as well as cancer associated with BRCA mutations...
  68. ncbi request reprint Genomics and public health in the United States: signposts on the translation highway
    Marta Gwinn
    Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Community Genet 9:21-6. 2006
    ....
  69. pmc The emergence of translational epidemiology: from scientific discovery to population health impact
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Epidemiol 172:517-24. 2010
    ..02). Epidemiology is increasingly recognized as an important component of TR. By quantifying and integrating knowledge across disciplines, epidemiology provides crucial methods and tools for TR...
  70. ncbi request reprint HFE genotype and transferrin saturation in the United States
    Mary E Cogswell
    Division of Nutrition and Physical Activity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, USA
    Genet Med 5:304-10. 2003
    ..Examine the penetrance (defined by high transferrin saturation [TS]) of C282Y and H63D in the U.S. population...
  71. pmc Population sciences, translational research, and the opportunities and challenges for genomics to reduce the burden of cancer in the 21st century
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Cancer Epidemiol Biomarkers Prev 20:2105-14. 2011
    ..An enhanced translational genomics and population sciences agenda is urgently needed to fulfill the promise of genomics in reducing the burden of cancer...
  72. ncbi request reprint Public knowledge regarding the role of genetic susceptibility to environmentally induced health conditions
    Jill Morris
    Office of Genetics and Disease Prevention, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, MS K 28, Atlanta, GA 30341 3724, USA
    Community Genet 6:22-8. 2003
    ..Diseases thought to be caused by exposure to environmental factors are also influenced by genetic susceptibility. It is not clear to what extent the public recognizes the role of genetics in causing these diseases...
  73. pmc Improving the prediction of complex diseases by testing for multiple disease-susceptibility genes
    Quanhe Yang
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Hum Genet 72:636-49. 2003
    ..Multiplex genetic testing has the potential to improve the clinical validity of predictive testing for common multifactorial diseases...
  74. ncbi request reprint From public health emergency to public health service: the implications of evolving criteria for newborn screening panels
    Scott D Grosse
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Pediatrics 117:923-9. 2006
  75. pmc Genome-wide association studies in pharmacogenomics: untapped potential for translation
    Idris Guessous
    Emory University, Rollins School of Public Health Department of Epidemiology, Grace Crum Rollins Building, 1518 Clifton Road, Atlanta, Georgia 30322, USA
    Genome Med 1:46. 2009
    ....
  76. ncbi request reprint Commentary: epidemiology and the continuum from genetic research to genetic testing
    Muin J Khoury
    Office of Genomics and Disease Prevention, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 156:297-9. 2002
  77. ncbi request reprint DNA banking for epidemiologic studies: a review of current practices
    Karen Steinberg
    Division of Environmental Health Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341 3724, USA
    Epidemiology 13:246-54. 2002
    ..Each of the specimens discussed is useful for epidemiologic studies according to specific needs, which we enumerate in our conclusions...
  78. doi request reprint Primary immunodeficiency diseases: practice among primary care providers and awareness among the general public, United States, 2008
    Rachel Waltenburg
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Genet Med 12:792-800. 2010
    ..Delayed primary immunodeficiency disorder diagnosis leads to increased morbidity and mortality. This study assessed current primary immunodeficiency disorder practice among physicians and awareness among the public...
  79. doi request reprint Invited commentary: genes, environment, and hybrid vigor
    Marta Gwinn
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Epidemiol 170:703-7. 2009
    ....
  80. doi request reprint Systems-based candidate genes for human response to influenza infection
    Lyna Zhang
    Office of Public Health Genomics, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Infect Genet Evol 9:1148-57. 2009
    ....
  81. ncbi request reprint Expanding the definition of a positive family history for early-onset coronary heart disease
    Maren T Scheuner
    Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Genet Med 8:491-501. 2006
    ..To evaluate the impact of additional family history, we examined the associations between various family history definitions and early-onset CHD...
  82. ncbi request reprint Population screening in the age of genomic medicine
    Muin J Khoury
    Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 348:50-8. 2003
  83. ncbi request reprint Can family history be used as a tool for public health and preventive medicine?
    Paula W Yoon
    Office of Genomics and Disease Prevention, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
    Genet Med 4:304-10. 2002
  84. ncbi request reprint What is the clinical utility of genetic testing?
    Scott D Grosse
    National Center on Birth Defects and Developmental Disabilities, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Genet Med 8:448-50. 2006
  85. ncbi request reprint A road map for efficient and reliable human genome epidemiology
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina 45110, Greece
    Nat Genet 38:3-5. 2006
    ..Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews...
  86. ncbi request reprint Evidence based medicine meets genomic medicine
    Jim Evans
    Departments of Genetics and Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7264, USA
    Genet Med 9:799-800. 2007
  87. ncbi request reprint Genomics, epidemiology, and common complex diseases: let's not throw out the baby with the bathwater!
    Muin J Khoury
    Int J Epidemiol 35:1363-4; author reply 1364-5. 2006
  88. ncbi request reprint The human genome project is complete. How do we develop a handle for the pump?
    Julian Little
    Am J Epidemiol 157:667-73. 2003
  89. ncbi request reprint The integration of genomics into obstetrics and gynecology: a HuGE challenge
    Muin J Khoury
    Am J Obstet Gynecol 195:1503-5. 2006
  90. ncbi request reprint Dermatology and the human genome: an epidemiologic approach
    Marta Gwinn
    Arch Dermatol 143:1194-6. 2007
  91. ncbi request reprint Familial risk assessment for early-onset coronary heart disease
    Maren T Scheuner
    RAND Corporation, Santa Monica, CA 90407 2138, USA
    Genet Med 8:525-31. 2006
    ....
  92. ncbi request reprint Turning the pump handle: evolving methods for integrating the evidence on gene-disease association
    Julian P T Higgins
    Am J Epidemiol 166:863-6. 2007
  93. ncbi request reprint Research priorities for public health sciences in the postgenomic era
    Marta Gwinn
    Genet Med 4:410-1. 2002
  94. ncbi request reprint Genomics and public health research
    Muin J Khoury
    JAMA 297:2347; author reply 2347-8. 2007
  95. ncbi request reprint Helping high-risk families: medical and public health approaches
    Ann M Malarcher
    Genet Med 4:239-40. 2002
  96. ncbi request reprint Letting the genome out of the bottle--will we get our wish?
    David J Hunter
    Department of Epidemiology, Harvard School of Public Health, Boston, USA
    N Engl J Med 358:105-7. 2008
  97. doi request reprint A navigator for human genome epidemiology
    Wei Yu
    Nat Genet 40:124-5. 2008
  98. ncbi request reprint Impact of violations and deviations in Hardy-Weinberg equilibrium on postulated gene-disease associations
    Thomas A Trikalinos
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45100, Greece
    Am J Epidemiol 163:300-9. 2006
    ..Postulated genetic associations with modest-sized odds ratios and borderline statistical significance may not be robust in such sensitivity analyses...
  99. pmc Does genetic testing really improve the prediction of future type 2 diabetes?
    A Cecile J W Janssens
    PLoS Med 3:e114; author reply e127. 2006
  100. pmc Family history assessment to detect increased risk for colorectal cancer: conceptual considerations and a preliminary economic analysis
    Scott D Ramsey
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North M2 B230, P O Box 19024, Seattle, WA 98109, USA
    Cancer Epidemiol Biomarkers Prev 14:2494-500. 2005
    ..Although the rationale for earlier screening of persons with a family history of colorectal cancer is plausible, there is no direct evidence that earlier assessment is either effective or cost-effective...
  101. ncbi request reprint A public health approach to pharmacogenomics and gene-based diagnostic tests
    Robert L Davis
    Group Health Cooperative, Center for Health Studies, Seattle, Washington, USA
    Pharmacogenomics 7:331-7. 2006
    ....