M J Khoury

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. doi request reprint Dealing with the evidence dilemma in genomics and personalized medicine
    M J Khoury
    National Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Pharmacol Ther 87:635-8. 2010
  2. pmc Race-ethnic differences in the association of genetic loci with HbA1c levels and mortality in U.S. adults: the third National Health and Nutrition Examination Survey (NHANES III)
    Jonna L Grimsby
    General Medicine Division, Massachusetts General Hospital, Boston, MA, USA
    BMC Med Genet 13:30. 2012
  3. doi request reprint A decade of public health genomics in the United States: centers for disease control and prevention 1997-2007
    M J Khoury
    National Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Public Health Genomics 12:20-9. 2009
  4. pmc Transforming epidemiology for 21st century medicine and public health
    Muin J Khoury
    Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
    Cancer Epidemiol Biomarkers Prev 22:508-16. 2013
  5. ncbi request reprint Knowledge integration at the center of genomic medicine
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Genet Med 14:643-7. 2012
  6. pmc Frontiers in cancer epidemiology: a challenge to the research community from the Epidemiology and Genomics Research Program at the National Cancer Institute
    Muin J Khoury
    Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 21:999-1001. 2012
  7. pmc A population approach to precision medicine
    Muin J Khoury
    Office of Public Health Genomics, CDC, Atlanta, GA 30333, USA
    Am J Prev Med 42:639-45. 2012
  8. pmc Multilevel research and the challenges of implementing genomic medicine
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, 1600 Clifton Rd, Mailstop E61, Atlanta, GA 30333, USA
    J Natl Cancer Inst Monogr 2012:112-20. 2012
  9. pmc Beyond base pairs to bedside: a population perspective on how genomics can improve health
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Public Health 102:34-7. 2012
  10. pmc Predictive genetic testing for the identification of high-risk groups: a simulation study on the impact of predictive ability
    Raluca Mihaescu
    Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Genome Med 3:51. 2011

Detail Information

Publications132 found, 100 shown here

  1. doi request reprint Dealing with the evidence dilemma in genomics and personalized medicine
    M J Khoury
    National Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Pharmacol Ther 87:635-8. 2010
    ....
  2. pmc Race-ethnic differences in the association of genetic loci with HbA1c levels and mortality in U.S. adults: the third National Health and Nutrition Examination Survey (NHANES III)
    Jonna L Grimsby
    General Medicine Division, Massachusetts General Hospital, Boston, MA, USA
    BMC Med Genet 13:30. 2012
    ....
  3. doi request reprint A decade of public health genomics in the United States: centers for disease control and prevention 1997-2007
    M J Khoury
    National Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Public Health Genomics 12:20-9. 2009
    ..We also outline a vision for public health genomics for the next decade...
  4. pmc Transforming epidemiology for 21st century medicine and public health
    Muin J Khoury
    Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
    Cancer Epidemiol Biomarkers Prev 22:508-16. 2013
    ..They should lay a strong scientific foundation for accelerated translation of scientific discoveries into individual and population health benefits...
  5. ncbi request reprint Knowledge integration at the center of genomic medicine
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Genet Med 14:643-7. 2012
    ..The ultrarapid production of information requires adequate public and private resources for knowledge integration to support the evidence-based development of genomic medicine...
  6. pmc Frontiers in cancer epidemiology: a challenge to the research community from the Epidemiology and Genomics Research Program at the National Cancer Institute
    Muin J Khoury
    Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 21:999-1001. 2012
    ..grants.cancer.gov/ to develop priorities and the next generation of high-impact studies...
  7. pmc A population approach to precision medicine
    Muin J Khoury
    Office of Public Health Genomics, CDC, Atlanta, GA 30333, USA
    Am J Prev Med 42:639-45. 2012
    ..Balanced strategies that implement both population- and individual-level interventions can best maximize health benefits, minimize harm, and avoid unnecessary healthcare costs...
  8. pmc Multilevel research and the challenges of implementing genomic medicine
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, 1600 Clifton Rd, Mailstop E61, Atlanta, GA 30333, USA
    J Natl Cancer Inst Monogr 2012:112-20. 2012
    ..We synthesize existing information in a framework for future multilevel research for integrating genomic medicine into the cancer care continuum...
  9. pmc Beyond base pairs to bedside: a population perspective on how genomics can improve health
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Public Health 102:34-7. 2012
    ....
  10. pmc Predictive genetic testing for the identification of high-risk groups: a simulation study on the impact of predictive ability
    Raluca Mihaescu
    Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Genome Med 3:51. 2011
    ..We investigated the performance of this risk stratification strategy by examining epidemiological parameters that impact the predictive ability of risk models...
  11. pmc Assessing causal relationships in genomics: From Bradford-Hill criteria to complex gene-environment interactions and directed acyclic graphs
    Sara Geneletti
    Department of Statistics, London School of Economics, Houghton Street, London, UK
    Emerg Themes Epidemiol 8:5. 2011
    ..e., research that integrates knowledge, data, methods, techniques, and reasoning from multiple disciplines, approaches and levels of analysis to generate knowledge that no discipline alone may achieve...
  12. pmc Population sciences, translational research, and the opportunities and challenges for genomics to reduce the burden of cancer in the 21st century
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Cancer Epidemiol Biomarkers Prev 20:2105-14. 2011
    ..An enhanced translational genomics and population sciences agenda is urgently needed to fulfill the promise of genomics in reducing the burden of cancer...
  13. ncbi request reprint Commentary: epidemiology and the continuum from genetic research to genetic testing
    Muin J Khoury
    Office of Genomics and Disease Prevention, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 156:297-9. 2002
  14. ncbi request reprint Will genomics widen or help heal the schism between medicine and public health?
    Muin J Khoury
    National Office of Public Health Genomics, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341, USA
    Am J Prev Med 33:310-7. 2007
    ..A strong medicine-public health partnership in the genomics era is needed for the translation of all scientific discoveries for the benefit of population health...
  15. doi request reprint The evidence dilemma in genomic medicine
    Muin J Khoury
    Centers for Disease Control and Prevention CDC, in Atlanta, Georgia, USA
    Health Aff (Millwood) 27:1600-11. 2008
    ..There is an urgent need for a collaborative process for appropriate transition of genomic discoveries from research to practice...
  16. doi request reprint Current priorities for public health practice in addressing the role of human genomics in improving population health
    Muin J Khoury
    Office of Public Health Genomics, CDC, Atlanta, Georgia 30333, USA
    Am J Prev Med 40:486-93. 2011
    ..Such efforts are needed not only to implement what is known in genomics to improve health but also to reduce potential harm and create the infrastructure needed to derive health benefits in the future...
  17. pmc Invited commentary: from genome-wide association studies to gene-environment-wide interaction studies--challenges and opportunities
    Muin J Khoury
    National Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Epidemiol 169:227-30; discussion 234-5. 2009
    ....
  18. pmc The emergence of translational epidemiology: from scientific discovery to population health impact
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Epidemiol 172:517-24. 2010
    ..02). Epidemiology is increasingly recognized as an important component of TR. By quantifying and integrating knowledge across disciplines, epidemiology provides crucial methods and tools for TR...
  19. ncbi request reprint Do we need genomic research for the prevention of common diseases with environmental causes?
    Muin J Khoury
    Office of Genomics and Disease Prevention, Coordinating Center on Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 161:799-805. 2005
    ..This research is likely to lead to population-wide health promotion and disease prevention efforts, not only to interventions targeted according to genetic susceptibility...
  20. doi request reprint Genetic epidemiology with a capital E, ten years after
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta GA 30333, USA
    Genet Epidemiol 35:845-52. 2011
    ..We extend Duncan Thomas' capital E to include "Evaluation" as the tools of epidemiology are increasingly used to assess how genome-based information can be applied in medicine and public health...
  21. ncbi request reprint Prioritizing genomic applications for action by level of evidence: a horizon-scanning method
    W D Dotson
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Pharmacol Ther 95:394-402. 2014
    ..We illustrate an application of the method to pharmacogenomics tests. ..
  22. ncbi request reprint The return of thalidomide: are birth defects surveillance systems ready?
    Q Yang
    Division of Birth Defects and Developmental Disabilities, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Am J Med Genet 73:251-8. 1997
    ..Our findings highlight the importance of enlarging the monitored population and correct case classification in birth defects surveillance...
  23. pmc Required sample size and nonreplicability thresholds for heterogeneous genetic associations
    Ramal Moonesinghe
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Proc Natl Acad Sci U S A 105:617-22. 2008
    ..Therefore, some true associations may not be practically possible to replicate with consistency, no matter how large studies are conducted. Efforts should be made to minimize between-study heterogeneity in targeted genetic effects...
  24. ncbi request reprint Population-based study of congenital heart defects in Down syndrome
    S B Freeman
    Department of Genetics, Emory University, Atlanta, Georgia 30322, USA
    Am J Med Genet 80:213-7. 1998
    ..This report is unique in that it contains the largest number of trisomy 21 infants ascertained in a population-based study where modern techniques for diagnosing cardiac abnormalities predominate...
  25. ncbi request reprint Tracking the epidemiology of human genes in the literature: the HuGE Published Literature database
    Bruce K Lin
    Office of Genomics and Disease Prevention, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 164:1-4. 2006
    ..Here, the authors provide an overview of the database and its characteristics and uses...
  26. ncbi request reprint An epidemiologic assessment of genomic profiling for measuring susceptibility to common diseases and targeting interventions
    Muin J Khoury
    Office of Genomics and Disease Prevention, Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Genet Med 6:38-47. 2004
    ....
  27. pmc Implications of Internet availability of genomic information for public health practice
    B W Hesse
    National Cancer Institute, National Institutes of Health, 6130 Executive Boulevard, Bethesda, MD 20892 7365, USA
    Public Health Genomics 15:201-8. 2012
    ....
  28. doi request reprint Trends in pharmacogenomic epidemiology: 2001-2007
    I Guessous
    Department of Epidemiology, National Office of Public Health Genomics, Centers for Disease Control and Prevention, Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Public Health Genomics 12:142-8. 2009
    ..Pharmacogenomic epidemiology (PGxE) assesses the range of responses to pharmacologic agents in relation to genetic variation in population groups. We analyzed publication trends to describe the emerging field of PGxE...
  29. pmc Phenopedia and Genopedia: disease-centered and gene-centered views of the evolving knowledge of human genetic associations
    W Yu
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA 30345, USA
    Bioinformatics 26:145-6. 2010
    ..These applications provide user-friendly interfaces for searching summarized information on human genetic associations, using either genes or diseases as the starting point...
  30. ncbi request reprint Risk factors for trisomy 21: maternal cigarette smoking and oral contraceptive use in a population-based case-control study
    Q Yang
    Division of Birth Defects and Developmental Disabilities and the Office of Genetics and Disease Prevention, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Genet Med 1:80-8. 1999
    ..This is the first epidemiological study to categorize cases of trisomy 21 by parent of origin and timing of the meiotic error before assessing possible risk factors...
  31. ncbi request reprint Commentary: facing the challenge of gene-environment interaction: the two-by-four table and beyond
    L D Botto
    Birth Defects and Genetic Diseases Branch, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 153:1016-20. 2001
    ..To highlight the role of gene-environment interaction in disease causation, the authors propose that the two-by-four table is the fundamental unit of epidemiologic analysis...
  32. ncbi request reprint Iron overload, public health, and genetics: evaluating the evidence for hemochromatosis screening
    M E Cogswell
    Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Ann Intern Med 129:971-9. 1998
    ....
  33. ncbi request reprint Vitamin A and cardiac outflow tract defects
    L D Botto
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341, USA
    Epidemiology 12:491-6. 2001
    ..8; 95% confidence interval = 0.1-6.6). Similar intakes of carotenoids and dietary retinol were not associated with an increased risk for either type of outflow tract defect...
  34. ncbi request reprint Informed consent for population-based research involving genetics
    L M Beskow
    Office of Genetics and Disease Prevention, Centers for Disease Control and Prevention, 4770 Buford Hwy NE, MS K 28, Atlanta, GA 30341 3724, USA
    JAMA 286:2315-21. 2001
    ....
  35. ncbi request reprint Prevalence of C282Y and H63D mutations in the hemochromatosis (HFE) gene in the United States
    K K Steinberg
    Molecular Biology Branch, National Center for Environmental Health, Mailstop F 24, Chamblee, GA 30341, USA
    JAMA 285:2216-22. 2001
    ..Population-based estimates of the prevalence of disease-associated mutations, such as hemochromatosis (HFE) gene mutations, are needed to determine the usefulness of genetic screening...
  36. pmc Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994
    Man Huei Chang
    National Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 169:54-66. 2009
    ..These nationally representative data on allele frequency and genotype prevalence provide a valuable resource for future epidemiologic studies in public health in the United States...
  37. pmc GAPscreener: an automatic tool for screening human genetic association literature in PubMed using the support vector machine technique
    Wei Yu
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA
    BMC Bioinformatics 9:205. 2008
    ..The GAPscreener, a free SVM-based software tool, can be used to assist in screening PubMed abstracts for human genetic association studies...
  38. ncbi request reprint The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention?
    Muin J Khoury
    National Office of Public Health Genomics Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Genet Med 9:665-74. 2007
    ..With continued advances in genomic applications, however, the full continuum of translation research needs adequate support to realize the promise of genomics for human health...
  39. pmc Gene Prospector: an evidence gateway for evaluating potential susceptibility genes and interacting risk factors for human diseases
    Wei Yu
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA
    BMC Bioinformatics 9:528. 2008
    ..The application, called Gene Prospector, also provides a comprehensive set of links to additional data sources...
  40. pmc An open source infrastructure for managing knowledge and finding potential collaborators in a domain-specific subset of PubMed, with an example from human genome epidemiology
    Wei Yu
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA
    BMC Bioinformatics 8:436. 2007
    ..The design of this infrastructure makes the system potentially extensible to other data sources...
  41. ncbi request reprint Is family history a useful tool for detecting children at risk for diabetes and cardiovascular diseases? A public health perspective
    Rodolfo Valdez
    National Office of Public Health Genomics, Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Mail Stop K 89, Atlanta, GA 30341, USA
    Pediatrics 120:S78-86. 2007
    ....
  42. ncbi request reprint Family history and prevalence of diabetes in the U.S. population: the 6-year results from the National Health and Nutrition Examination Survey (1999-2004)
    Rodolfo Valdez
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Mailstop K 89, Atlanta, GA 30341, USA
    Diabetes Care 30:2517-22. 2007
    ..We sought to test the association between stratified levels of familial risk of diabetes and the prevalence of the disease in the U.S. population...
  43. pmc An automatic method to generate domain-specific investigator networks using PubMed abstracts
    Wei Yu
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA
    BMC Med Inform Decis Mak 7:17. 2007
    ..We present a novel strategy for building investigator networks dynamically and producing detailed investigator profiles using data available in PubMed abstracts...
  44. ncbi request reprint The emergence of biobanks: practical design considerations for large population-based studies of gene-environment interactions
    Robert L Davis
    Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Community Genet 10:181-5. 2007
    ....
  45. pmc Reporting of human genome epidemiology (HuGE) association studies: an empirical assessment
    Ajay Yesupriya
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, USA
    BMC Med Res Methodol 8:31. 2008
    ..Transparent reporting of study methods and results allows readers to better assess the validity of study findings. Here, we document reporting practices of human genome epidemiology studies...
  46. pmc Most published research findings are false-but a little replication goes a long way
    Ramal Moonesinghe
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Med 4:e28. 2007
  47. pmc Developing Family Healthware, a family history screening tool to prevent common chronic diseases
    Paula W Yoon
    Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Mailstop K47, Atlanta, GA 30341, USA
    Prev Chronic Dis 6:A33. 2009
    ....
  48. pmc The need for genetic variant naming standards in published abstracts of human genetic association studies
    Wei Yu
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    BMC Res Notes 2:56. 2009
    ..The consistent use of rs numbers in abstracts that report genetic associations would enhance knowledge synthesis and translation in this field...
  49. pmc Racial/ethnic differences in association of fasting glucose-associated genomic loci with fasting glucose, HOMA-B, and impaired fasting glucose in the U.S. adult population
    Quanhe Yang
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Diabetes Care 33:2370-7. 2010
    ....
  50. pmc Improvements in ability to detect undiagnosed diabetes by using information on family history among adults in the United States
    Quanhe Yang
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Epidemiol 171:1079-89. 2010
    ..Study findings suggest that adding family history of diabetes can provide significant improvements in detecting undiagnosed diabetes in the US population. Further research is needed to validate the authors' findings...
  51. pmc Application of support vector machine modeling for prediction of common diseases: the case of diabetes and pre-diabetes
    Wei Yu
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA
    BMC Med Inform Decis Mak 10:16. 2010
    ..We illustrate the method to detect persons with diabetes and pre-diabetes in a cross-sectional representative sample of the U.S. population...
  52. doi request reprint A Hardy-Weinberg equilibrium test for analyzing population genetic surveys with complex sample designs
    Ramal Moonesinghe
    Office of Minority Health and Health Disparities, 4770 Buford Highway, Mailstop E 67, Atlanta, GA 30341, USA
    Am J Epidemiol 171:932-41. 2010
    ....
  53. doi request reprint Family history in public health practice: a genomic tool for disease prevention and health promotion
    Rodolfo Valdez
    Office of Public Health Genomics, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Annu Rev Public Health 31:69-87 1 p following 87. 2010
    ..Their goal is to create family history tools that have decision support capabilities and are compatible with electronic health records. These advances will help realize the potential of family history as a public health tool...
  54. pmc Evaluation of the discriminative accuracy of genomic profiling in the prediction of common complex diseases
    Ramal Moonesinghe
    Office of Minority Health and Health Disparities, Centers for Disease Control and Prevention, Mailstop E 67, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
    Eur J Hum Genet 18:485-9. 2010
    ....
  55. pmc Using lifetime risk estimates in personal genomic profiles: estimation of uncertainty
    Quanhe Yang
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Hum Genet 85:786-800. 2009
    ..Epidemiologic parameters involved in computation of disease risk have substantial uncertainty, and cumulative uncertainty should be properly recognized. Reliance on point estimates alone could be seriously misleading...
  56. doi request reprint Steroid 5-{alpha}-reductase Type 2 (SRD5a2) gene polymorphisms and risk of prostate cancer: a HuGE review
    Jun Li
    Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, 4770 Buford Highway, MS K55, Atlanta, GA 30341, USA
    Am J Epidemiol 171:1-13. 2010
    ..Analysis of well-designed population-based studies with pathway-based arrays containing common genetic variants could be useful for identifying genetic factors in prostate cancer...
  57. doi request reprint Comparative effectiveness research and genomic medicine: an evolving partnership for 21st century medicine
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia 3033, USA
    Genet Med 11:707-11. 2009
    ..There is a need to heal the apparent schism between genomic medicine and comparative effectiveness research to enhance knowledge-driven practice of medicine in the 21st century...
  58. doi request reprint Systems-based candidate genes for human response to influenza infection
    Lyna Zhang
    Office of Public Health Genomics, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Infect Genet Evol 9:1148-57. 2009
    ....
  59. pmc The Scientific Foundation for personal genomics: recommendations from a National Institutes of Health-Centers for Disease Control and Prevention multidisciplinary workshop
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Genet Med 11:559-67. 2009
    ..To fulfill the promise of personal genomics, a rigorous multidisciplinary research agenda is needed...
  60. pmc Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases
    Muin J Khoury
    Office of Public Health Genomics, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Epidemiol 170:269-79. 2009
    ..As a next step in the evolution of Human Genome Epidemiology reviews, the authors invite investigators to submit field synopses for possible publication in the American Journal of Epidemiology...
  61. pmc The genomic applications in practice and prevention network
    Muin J Khoury
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Genet Med 11:488-94. 2009
    ....
  62. doi request reprint The association between family history of asthma and the prevalence of asthma among US adults: National Health and Nutrition Examination Survey, 1999-2004
    Tiebin Liu
    Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Genet Med 11:323-8. 2009
    ..To assess the overall prevalence of asthma and the association between family history of asthma and the prevalence of asthma among US adults...
  63. pmc Genome-wide association studies in pharmacogenomics: untapped potential for translation
    Idris Guessous
    Emory University, Rollins School of Public Health Department of Epidemiology, Grace Crum Rollins Building, 1518 Clifton Road, Atlanta, Georgia 30322, USA
    Genome Med 1:46. 2009
    ....
  64. doi request reprint Evaluation of the validity and utility of genetic testing for rare diseases
    Scott D Grosse
    Division of Blood Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Adv Exp Med Biol 686:115-31. 2010
    ..Specific rare disorders addressed include cystic fibrosis, fragile X syndrome, Duchenne and Becker muscular dystrophy, spinal muscular atrophy, Huntington disease, as well as cancer associated with BRCA mutations...
  65. ncbi request reprint On the synthesis and interpretation of consistent but weak gene-disease associations in the era of genome-wide association studies
    Muin J Khoury
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Int J Epidemiol 36:439-45. 2007
    ..Efforts by the Human Genome Epidemiology Network (HuGENet) are currently ongoing to streamline and operationalize these criteria for data on genetic associations with common diseases...
  66. ncbi request reprint Evaluation of family history as a risk factor and screening tool for detecting undiagnosed diabetes in a nationally representative survey population
    Susan Hariri
    Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Genet Med 8:752-9. 2006
    ..We examined the utility of a three-level familial risk stratification system as a screening tool for diabetes in a nationally representative sample of the U.S. adult population...
  67. pmc Improving the prediction of complex diseases by testing for multiple disease-susceptibility genes
    Quanhe Yang
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Am J Hum Genet 72:636-49. 2003
    ..Multiplex genetic testing has the potential to improve the clinical validity of predictive testing for common multifactorial diseases...
  68. ncbi request reprint The emergence of epidemiology in the genomics age
    Muin J Khoury
    Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Int J Epidemiol 33:936-44. 2004
  69. ncbi request reprint From public health emergency to public health service: the implications of evolving criteria for newborn screening panels
    Scott D Grosse
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Pediatrics 117:923-9. 2006
  70. ncbi request reprint Public knowledge regarding the role of genetic susceptibility to environmentally induced health conditions
    Jill Morris
    Office of Genetics and Disease Prevention, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, MS K 28, Atlanta, GA 30341 3724, USA
    Community Genet 6:22-8. 2003
    ..Diseases thought to be caused by exposure to environmental factors are also influenced by genetic susceptibility. It is not clear to what extent the public recognizes the role of genetics in causing these diseases...
  71. ncbi request reprint Genomics and public health in the United States: signposts on the translation highway
    Marta Gwinn
    Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Community Genet 9:21-6. 2006
    ....
  72. ncbi request reprint Family history of type 2 diabetes: a population-based screening tool for prevention?
    Susan Hariri
    Epidemic Intelligence Service Officer, Office of Workforce and Career Development, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Genet Med 8:102-8. 2006
    ..To evaluate the use of self-reported family medical history as a potential screening tool to identify people at-risk for diabetes...
  73. ncbi request reprint Genetics and genomics in practice: the continuum from genetic disease to genetic information in health and disease
    Muin J Khoury
    Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, Mail stop E82, Atlanta, GA 30333, USA
    Genet Med 5:261-8. 2003
    ....
  74. ncbi request reprint The integration of genomics into paediatric and perinatal epidemiology: guidelines for submitting human genome epidemiology (HuGE) reviews
    Muin J Khoury
    Office of Genomics and Disease Prevention, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Paediatr Perinat Epidemiol 19:178-80. 2005
  75. ncbi request reprint From genetics to genomics: using gene-based medicine to prevent disease and promote health in children
    Cynthia A Moore
    Office of Genomics and Disease Prevention, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Semin Perinatol 29:135-43. 2005
    ....
  76. ncbi request reprint How many genes underlie the occurrence of common complex diseases in the population?
    Quanhe Yang
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    Int J Epidemiol 34:1129-37. 2005
    ..It is not clear how many genes are necessary to account for an appreciable population-attributable fraction of these diseases...
  77. ncbi request reprint Mendelian randomisation: a new spin or real progress?
    Julian Little
    Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Lancet 362:930-1. 2003
  78. ncbi request reprint Research priorities for evaluating family history in the prevention of common chronic diseases
    Paula W Yoon
    Office of Genomics and Disease Prevention, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA 39341 3724, USA
    Am J Prev Med 24:128-35. 2003
  79. ncbi request reprint Expanding the definition of a positive family history for early-onset coronary heart disease
    Maren T Scheuner
    Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Genet Med 8:491-501. 2006
    ..To evaluate the impact of additional family history, we examined the associations between various family history definitions and early-onset CHD...
  80. doi request reprint Invited commentary: genes, environment, and hybrid vigor
    Marta Gwinn
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Epidemiol 170:703-7. 2009
    ....
  81. ncbi request reprint DNA banking for epidemiologic studies: a review of current practices
    Karen Steinberg
    Division of Environmental Health Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341 3724, USA
    Epidemiology 13:246-54. 2002
    ..Each of the specimens discussed is useful for epidemiologic studies according to specific needs, which we enumerate in our conclusions...
  82. doi request reprint Awareness and utilization of BRCA1/2 testing among U.S. primary care physicians
    Cecelia A Bellcross
    CDC, Atlanta, Georgia 30333, USA
    Am J Prev Med 40:61-6. 2011
    ..Testing for mutations in the breast and ovarian cancer susceptibility genes BRCA1 and BRCA2 (BRCA) has been commercially available since 1996...
  83. doi request reprint Horizon scanning for new genomic tests
    Marta Gwinn
    McKing Consulting Corporation, Atlanta, Georgia, USA
    Genet Med 13:161-5. 2011
    ..Consequently, it is not easy to determine which tests are in development, currently available, or discontinued. We developed and assessed the usefulness of a systematic approach to identifying new genomic tests on the Internet...
  84. pmc Discriminative accuracy of genomic profiling comparing multiplicative and additive risk models
    Ramal Moonesinghe
    Office of Minority Health and Health Disparities, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Eur J Hum Genet 19:180-5. 2011
    ..Unraveling the exact mode of biological interaction is important when effect sizes of genetic variants are moderate at the least, to prevent the incorrect estimation of risks...
  85. doi request reprint Public health action in genomics is now needed beyond newborn screening
    M S Bowen
    Centers for Disease Control and Prevention, Department of Health and Human Services, Atlanta, GA, USA
    Public Health Genomics 15:327-34. 2012
    ..Enhanced partnerships between genetic and nongenetic providers of clinical medicine and public health are needed to overcome the challenges for implementing genomic medicine applications both now and in the future...
  86. ncbi request reprint Public health impact of genetic tests at the end of the 20th century
    P W Yoon
    Office of Genetics and Disease Prevention, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341-3724, USA
    Genet Med 3:405-10. 2001
    ..However, as more tests are being considered for newborn screening, and associations between genes and common diseases are being discovered, the impact of genetic testing on public health is likely to increase...
  87. pmc Translational research in cancer genetics: the road less traveled
    S D Schully
    Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892, USA
    Public Health Genomics 14:1-8. 2011
    ..In addition to discovery research in cancer genetics, a translational research infrastructure is urgently needed to methodically evaluate and translate gene discoveries for cancer care and prevention...
  88. ncbi request reprint Can family history be used as a tool for public health and preventive medicine?
    Paula W Yoon
    Office of Genomics and Disease Prevention, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
    Genet Med 4:304-10. 2002
  89. ncbi request reprint On the use of population attributable fraction to determine sample size for case-control studies of gene-environment interaction
    Quanhe Yang
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Epidemiology 14:161-7. 2003
    ..In this case, the associated odds ratio for interaction will be weaker and a considerably larger sample size may be needed...
  90. pmc Public awareness and use of direct-to-consumer genetic tests: results from 3 state population-based surveys, 2006
    Katrina A B Goddard
    National Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Am J Public Health 99:442-5. 2009
    ..Less than 1% had used a health-related direct-to-consumer genetic test. Public health systems should increase consumer and provider education and continue surveillance on direct-to-consumer genetic tests...
  91. ncbi request reprint Population screening in the age of genomic medicine
    Muin J Khoury
    Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 348:50-8. 2003
  92. ncbi request reprint Quantifying the health benefits of genetic tests: the importance of a population perspective
    Muin J Khoury
    Office of Genomics and Disease Prevention, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Genet Med 8:191-5. 2006
  93. ncbi request reprint Medium chain acyl-CoA dehydrogenase deficiency human genome epidemiology review
    S S Wang
    Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Genet Med 1:332-9. 1999
    ..State programs are beginning to offer screening in newborns for MCADD using MS/MS. In addition, a private company currently offers voluntary supplemental newborn screening for MCADD to birthing centers...
  94. ncbi request reprint Public attitudes regarding the donation and storage of blood specimens for genetic research
    S S Wang
    Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Community Genet 4:18-26. 2001
    ....
  95. ncbi request reprint Tests of trait-haplotype association when linkage phase is ambiguous, appropriate for matched case-control and cohort studies with competing risks
    W D Flanders
    Department of Epidemiology, Rollins School of Public Health, Emory University, 1599 Clifton Road, Atlanta, GA 30322, USA
    Stat Med 24:2299-316. 2005
    ....
  96. ncbi request reprint A case-control study of maternal alcohol consumption and intrauterine growth retardation
    Q Yang
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 4770 Buford Highway, MS F-45, Atlanta, GA 30341, USA
    Ann Epidemiol 11:497-503. 2001
    ....
  97. doi request reprint Population screening for genetic disorders in the 21st century: evidence, economics, and ethics
    S D Grosse
    National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, U S Department of Health and Human Services, Atlanta, GA 30333, USA
    Public Health Genomics 13:106-15. 2010
    ..Proposals for population screening for genetic diseases require careful scrutiny by decision makers because of the potential for harms and the need to demonstrate benefits commensurate with the opportunity cost of resources expended...
  98. ncbi request reprint Trends and patterns of mortality associated with birth defects and genetic diseases in the United States, 1979-1992: an analysis of multiple-cause mortality data
    Q Yang
    Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Genet Epidemiol 14:493-505. 1997
    ..The upward trend we detected for the deaths with genetic diseases was most likely related to improved recognition and reporting of some genetic diseases rather than to the increased prevalence...
  99. ncbi request reprint Delta-aminolevulinic acid dehydratase genotype and lead toxicity: a HuGE review
    S N Kelada
    Office of Genetics and Disease Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Am J Epidemiol 154:1-13. 2001
    ..No firm evidence exists for an association between ALAD genotype and susceptibility to lead toxicity at background exposure levels; therefore, population testing for the ALAD polymorphism is not justified...
  100. ncbi request reprint HFE genotype and transferrin saturation in the United States
    Mary E Cogswell
    Division of Nutrition and Physical Activity, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, USA
    Genet Med 5:304-10. 2003
    ..Examine the penetrance (defined by high transferrin saturation [TS]) of C282Y and H63D in the U.S. population...
  101. ncbi request reprint Hemochromatosis-associated morbidity in the United States: an analysis of the National Hospital Discharge Survey, 1979-1997
    A S Brown
    Office of Genetics and Disease Prevention, Centers for Disease Control and Prevention, Mailstop K-28, 4770 Buford Hwy NE, Atlanta, GA 30341, USA
    Genet Med 3:109-11. 2001
    ....