Research Topics
| O M KewSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
| Collaborators
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Detail Information
Publications
Polio eradication: the OPV paradoxWalter R Dowdle
Task Force for Child Survival and Development, Decatur, GA 30030, USA
Rev Med Virol 13:277-91. 2003....
Prolonged replication of a type 1 vaccine-derived poliovirus in an immunodeficient patientO M Kew
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Clin Microbiol 36:2893-9. 1998..These findings may have important implications for the strategy to eliminate poliovirus immunization after global polio eradication...
Vaccine-derived polioviruses and the endgame strategy for global polio eradicationOlen M Kew
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Annu Rev Microbiol 59:587-635. 2005..Developing a posteradication strategy to minimize the risks of VDPV emergence and spread has become an urgent WHO priority...
Circulating vaccine-derived polioviruses: current state of knowledgeOlen M Kew
WHO Global Specialized Reference Laboratory, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Bull World Health Organ 82:16-23. 2004..Particular attention must be given to areas where the risks for wild poliovirus circulation have been highest, and where the highest rates of polio vaccine coverage must be maintained to suppress cVDPV emergence...
Group-specific identification of polioviruses by PCR using primers containing mixed-base or deoxyinosine residue at positions of codon degeneracyD R Kilpatrick
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Center for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Clin Microbiol 34:2990-6. 1996..These degenerate PCR primers should aid in the detection of all polioviruses, including those wild poliovirus isolates for which genotype-specific reagents are unavailable...
Molecular evolution of a type 1 wild-vaccine poliovirus recombinant during widespread circulation in ChinaH M Liu
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 74:11153-61. 2000....
Poliovirus vaccine shedding among persons with HIV in Abidjan, Cote d'IvoireKaren A Hennessey
Global Immunization Division, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30309, USA
J Infect Dis 192:2124-8. 2005..The present study was conducted to assess whether persons infected with human immunodeficiency virus (HIV) experience prolonged VDPV shedding and serve as a source of reintroduction of virus into the population...
Risks of paralytic disease due to wild or vaccine-derived poliovirus after eradicationRadboud J Duintjer Tebbens
Kids Risk Project, Harvard School of Public Health, Boston, MA, USA
Risk Anal 26:1471-505. 2006..This article attempts to comprehensively characterize the risks, synthesize the existing data available for modeling them, and present quantitative risk estimates that can provide a starting point for informing policy decisions...
Development and consideration of global policies for managing the future risks of poliovirus outbreaks: insights and lessons learned through modelingKimberly M Thompson
Kids Risk Project, Harvard School of Public Health, 677 Huntington Ave, 3rd Floor, Boston, MA 02115, USA
Risk Anal 26:1571-80. 2006..This analytical journey has provided several key insights and lessons learned that will be useful to future analysts involved in similar complex decision-making processes...
Vaccine-associated paralytic poliomyelitis in a patient with MHC class II deficiencyNima Parvaneh
Department of Pediatrics, Infectious Disease Research Center, Children s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
J Clin Virol 39:145-8. 2007..We describe a fatal case of VAPP in an 8-month-old boy with Major Histocompatibility Class II deficiency. The isolated poliovirus was a Sabin type 2-type 1 recombinant that showed 1.4% VP1 divergence from Sabin type 2...
Molecular epidemiology of wild poliovirus type 1 circulation in West and Central Africa, from 1997 to 1999, using genotyping with a restriction fragment length polymorphism assayIonela Gouandjika-Vasilache
Institut Pasteur de Bangui, PO Box BP 923, Bangui, Central African Republic
Arch Virol 153:409-16. 2008....
The risks, costs, and benefits of possible future global policies for managing poliovirusesKimberly M Thompson
Kids Risk Project, Harvard School of Public Health, 677 Huntington Ave, Third Floor, Boston, MA 02115, USA
Am J Public Health 98:1322-30. 2008..We assessed the costs, risks, and benefits of possible future major policy decisions on vaccination, surveillance, response plans, and containment following global eradication of wild polioviruses...
A dynamic model of poliomyelitis outbreaks: learning from the past to help inform the futureRadboud J Duintjer Tebbens
KidsRisk Project, Harvard School of Public Health, Boston, MA 02115, USA
Am J Epidemiol 162:358-72. 2005..The authors expect that this model can provide important insights into the dynamics of future potential poliomyelitis outbreaks and in this way serve as a useful tool for risk assessment...
Environmental surveillance of wild poliovirus circulation in Egypt--balancing between detection sensitivity and workloadTapani Hovi
Department of Viral Diseases and Immunology, National Public Health Institute KTL, Mannerheimintie 166, 00300 Helsinki, Finland
J Virol Methods 126:127-34. 2005....
Vaccine policy changes and epidemiology of poliomyelitis in the United StatesLorraine Niño Alexander
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
JAMA 292:1696-701. 2004..To reduce the VAPP burden, national vaccination policy changed in 1997 from reliance on OPV to options for a sequential schedule of inactivated poliovirus vaccine (IPV) followed by OPV. In 2000, an exclusive IPV schedule was adopted...
Multiplex PCR method for identifying recombinant vaccine-related poliovirusesDavid R Kilpatrick
Respiratory and Enteric Virus Branch, G 10, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Clin Microbiol 42:4313-5. 2004..Six pairs of Sabin strain-specific recombinant primers were designed to permit rapid screening for VDPV recombinants by PCR...
Search for poliovirus carriers among people with primary immune deficiency diseases in the United States, Mexico, Brazil, and the United KingdomNeal A Halsey
Institute for Vaccine Safety, Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA
Bull World Health Organ 82:3-8. 2004..CONCLUSION: Although chronic poliovirus excretion can occur in immunodeficient persons, it appears to be rare...
Retrospective analysis of a local cessation of vaccination against poliomyelitis: a possible scenario for the futureEkaterina A Korotkova
A. N. Belozersky Institute of Physical-Chemical Biology, Moscow State University, Moscow 119899, Russia
J Virol 77:12460-5. 2003..The high transmissibility of OPV-derived viruses in nonimmune population, documented here, and the known existence of long-term OPV excretors should be also considered in assessing risks of the synchronized global cessation of OPV usage...
Prolonged detection of indigenous wild polioviruses in sewage from communities in EgyptLaila El Bassioni
Egyptian Organization for Biological Products and Vaccine Production, Cairo, Egypt
Am J Epidemiol 158:807-15. 2003..Continued analysis of sewage samples, critical evaluation of immunization coverage, and performance of surveillance for acute flaccid paralysis are proposed as follow-up activities...
Serial recombination during circulation of type 1 wild-vaccine recombinant polioviruses in ChinaHong Mei Liu
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 77:10994-1005. 2003..The appearance within approximately 2.5 years of five recombinant classes derived from a single ancestral infection illustrates the rapid emergence of new recombinants among circulating wild polioviruses...
Uncertainty and sensitivity analyses of a decision analytic model for posteradication polio risk managementRadboud J Duintjer Tebbens
Kids Risk Project, Harvard School of Public Health, Boston, MA 02115, USA
Risk Anal 28:855-76. 2008....
