J M Katz

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. pmc 5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication
    Priya Ranjan
    Influenza Division, NCIRD, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virol J 7:102. 2010
  2. doi request reprint Serologic assays for influenza surveillance, diagnosis and vaccine evaluation
    Jacqueline M Katz
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Expert Rev Anti Infect Ther 9:669-83. 2011
  3. doi request reprint The public health impact of avian influenza viruses
    J M Katz
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Poult Sci 88:872-9. 2009
  4. ncbi request reprint Current methods for assessing T cell responses to influenza
    J M Katz
    Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Dev Biol (Basel) 115:85-93. 2003
  5. ncbi request reprint Immunity to influenza: the challenges of protecting an aging population
    Jacqueline M Katz
    Influenza Branch, Mailstop G 16, Division of Viral and Rickettsial Diseases Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Immunol Res 29:113-24. 2004
  6. pmc Molecular correlates of influenza A H5N1 virus pathogenesis in mice
    J M Katz
    Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 74:10807-10. 2000
  7. pmc Immunity to influenza A H9N2 viruses induced by infection and vaccination
    X Lu
    Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 75:4896-901. 2001
  8. ncbi request reprint A nonionic block co-polymer adjuvant (CRL1005) enhances the immunogenicity and protective efficacy of inactivated influenza vaccine in young and aged mice
    J M Katz
    Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Vaccine 18:2177-87. 2000
  9. pmc Mucosal delivery of inactivated influenza vaccine induces B-cell-dependent heterosubtypic cross-protection against lethal influenza A H5N1 virus infection
    T M Tumpey
    Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 75:5141-50. 2001
  10. ncbi request reprint Antibody response in individuals infected with avian influenza A (H5N1) viruses and detection of anti-H5 antibody among household and social contacts
    J M Katz
    Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 180:1763-70. 1999

Detail Information

Publications63

  1. pmc 5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication
    Priya Ranjan
    Influenza Division, NCIRD, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virol J 7:102. 2010
    ..Activation of innate immune pathogen sensor Retinoic Acid Inducible Gene-I (RIG-I) has recently been shown to induce antiviral state...
  2. doi request reprint Serologic assays for influenza surveillance, diagnosis and vaccine evaluation
    Jacqueline M Katz
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Expert Rev Anti Infect Ther 9:669-83. 2011
    ..The use of standardized protocols and antibody standards are important steps to improve reproducibility and interlaboratory comparability of results of serologic assays for influenza viruses...
  3. doi request reprint The public health impact of avian influenza viruses
    J M Katz
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Poult Sci 88:872-9. 2009
    ..Taken together, such studies provide valuable information with which we can assess the public health risk of avian influenza viruses...
  4. ncbi request reprint Current methods for assessing T cell responses to influenza
    J M Katz
    Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Dev Biol (Basel) 115:85-93. 2003
    ..Although still technically demanding, these modern assays represent important new tools for the quantitative analysis of T cell responses to influenza infection and vaccination...
  5. ncbi request reprint Immunity to influenza: the challenges of protecting an aging population
    Jacqueline M Katz
    Influenza Branch, Mailstop G 16, Division of Viral and Rickettsial Diseases Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Immunol Res 29:113-24. 2004
    ..Several novel strategies including the use of ISCOM-formulated vaccines, mucosal delivery, or DNA vaccination provided cross-subtype protection that could provide an important component of immunity in the event of a pandemic...
  6. pmc Molecular correlates of influenza A H5N1 virus pathogenesis in mice
    J M Katz
    Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 74:10807-10. 2000
    ..Alone or in combination, these specific residues are the likely determinants of virulence of human H5N1 influenza viruses in this model...
  7. pmc Immunity to influenza A H9N2 viruses induced by infection and vaccination
    X Lu
    Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 75:4896-901. 2001
    ..These results have implications for the development of human vaccines against H9N2 viruses, a priority for pandemic preparedness...
  8. ncbi request reprint A nonionic block co-polymer adjuvant (CRL1005) enhances the immunogenicity and protective efficacy of inactivated influenza vaccine in young and aged mice
    J M Katz
    Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Vaccine 18:2177-87. 2000
    ..These results suggest that the copolymer adjuvant warrants further investigation as a potential adjuvant for use in human vaccination against influenza...
  9. pmc Mucosal delivery of inactivated influenza vaccine induces B-cell-dependent heterosubtypic cross-protection against lethal influenza A H5N1 virus infection
    T M Tumpey
    Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 75:5141-50. 2001
    ..These results suggest a strategy of mucosal vaccination that stimulates cross-protection against multiple influenza virus subtypes, including viruses with pandemic potential...
  10. ncbi request reprint Antibody response in individuals infected with avian influenza A (H5N1) viruses and detection of anti-H5 antibody among household and social contacts
    J M Katz
    Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 180:1763-70. 1999
    ..In contrast, social exposure to case patients was not associated with H5N1 infection...
  11. pmc New pre-pandemic influenza vaccines: an egg- and adjuvant-independent human adenoviral vector strategy induces long-lasting protective immune responses in mice
    M A Hoelscher
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Pharmacol Ther 82:665-71. 2007
    ..Furthermore, the vaccine-induced humoral and cellular immune responses and protective immunity persisted at least for a year...
  12. ncbi request reprint Mechanisms of pathogenicity of influenza A (H5N1) viruses in mice
    R A Bright
    Emory University, Atlanta, GA 30329, USA
    Avian Dis 47:1131-4. 2003
    ..This study demonstrates the importance of extrapulmonary spread and replication, particularly in the brain, for the lethality of H5N1 viruses...
  13. pmc A mouse model for the evaluation of pathogenesis and immunity to influenza A (H5N1) viruses isolated from humans
    X Lu
    Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 73:5903-11. 1999
    ..These results suggests a strategy of vaccine preparedness for rapid intervention in future influenza pandemics that uses antigenically related nonpathogenic viruses as vaccine candidates...
  14. ncbi request reprint Pathogenesis of and immunity to a new influenza A (H5N1) virus isolated from duck meat
    X H Lu
    Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
    Avian Dis 47:1135-40. 2003
    ..A/Dkmt virus cross-reacted poorly with ferret antisera raised against human H5N1 viruses, but prior infection with A/Dkmt virus protected mice from death after secondary infection with human H5N1 virus...
  15. ncbi request reprint Influenza vaccines generated by reverse genetics
    K Subbarao
    Influenza Branch, Centers for Disease Control and Prevention, Mailstop G 16, 1600 Clifton Road, Atlanta, GA 30333, USA
    Curr Top Microbiol Immunol 283:313-42. 2004
    ..The future of influenza prevention and control lies in the application of this powerful technology for the generation of safe and more effective influenza vaccines...
  16. ncbi request reprint Risk of influenza A (H5N1) infection among health care workers exposed to patients with influenza A (H5N1), Hong Kong
    C Buxton Bridges
    Centers for Disease Control and Prevention, Influenza Branch, MS A 32, 1600 Clifton Rd, Atlanta, GA 30333, USA
    J Infect Dis 181:344-8. 2000
    ..Human-to-human transmission of avian influenza may increase the chances for the emergence of a novel influenza virus with pandemic potential...
  17. ncbi request reprint Neurological manifestations of avian influenza viruses in mammals
    T Rowe
    Influenza Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop G 16, Atlanta, GA 30333, USA
    Avian Dis 47:1122-6. 2003
    ..However, HK/486 was able to replicate in the brain and induce lethal disease following direct intracerebral inoculation...
  18. ncbi request reprint The impact of avian influenza viruses on public health
    J M Katz
    Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, G 16, Atlanta, GA 30333, USA
    Avian Dis 47:914-20. 2003
    ..Such transmission increases the likelihood of reassortment between a currently circulating human virus and an avian virus and thus the creation of a strain with pandemic potential...
  19. ncbi request reprint Systemic and cellular immunity
    J M Katz
    Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Dev Biol (Basel) 115:107-9. 2003
  20. pmc Sensitivity and specificity of serologic assays for detection of human infection with 2009 pandemic H1N1 virus in U.S. populations
    Vic Veguilla
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Centers for Disease Control andPrevention, 2 Atlanta, Georgia 30333, USA
    J Clin Microbiol 49:2210-5. 2011
    ..S. populations during the first pandemic waves. These studies provide an approach to optimize timely serological investigations for future pandemics or outbreaks of novel influenza viruses among humans...
  21. pmc Contemporary North American influenza H7 viruses possess human receptor specificity: Implications for virus transmissibility
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 105:7558-63. 2008
    ..These results indicate that H7 influenza viruses from the North American lineage have acquired sialic acid-binding properties that more closely resemble those of human influenza viruses and have the potential to spread to naïve animals...
  22. ncbi request reprint DAS181, a novel sialidase fusion protein, protects mice from lethal avian influenza H5N1 virus infection
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 196:1493-9. 2007
    ..This notable antiviral activity underscores the potential utility of DAS181 as a new class of drug that is effective against influenza viruses with pandemic potential...
  23. pmc Pathogenesis of avian influenza A (H5N1) viruses in ferrets
    Lois A Zitzow
    Influenza Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 76:4420-9. 2002
    ..We propose the ferret as an alternative model system for the study of these highly pathogenic avian viruses...
  24. pmc Highly pathogenic avian influenza H5N1 viruses elicit an attenuated type i interferon response in polarized human bronchial epithelial cells
    Hui Zeng
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Virol 81:12439-49. 2007
    ..The attenuation of this critical host innate immune defense may contribute to the virulence of H5N1 viruses observed in humans...
  25. pmc Pathogenesis of avian influenza (H7) virus infection in mice and ferrets: enhanced virulence of Eurasian H7N7 viruses isolated from humans
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, MS G 16, 1600 Clifton Rd NE, Atlanta, GA 30333, USA
    J Virol 81:11139-47. 2007
    ..Therefore, in general, the relative virulence and cell tropism of the H7 viruses in these animal models correlated with the observed virulence in humans...
  26. pmc The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses
    Terrence M Tumpey
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Virol 81:10818-21. 2007
    ..Thus, the interferon-induced resistance factor Mx1 represents a key component of the murine innate immune system that mediates protection against epidemic and pandemic influenza viruses...
  27. ncbi request reprint Polygenic virulence factors involved in pathogenesis of 1997 Hong Kong H5N1 influenza viruses in mice
    Hualan Chen
    Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, MS G16, Atlanta, GA 30333, USA
    Virus Res 128:159-63. 2007
    ..Multiple genes are involved in virulence of Hong Kong H5N1 influenza A viruses for mice with the presence of lysine at aa627 in the PB2 gene exhibiting a significantly larger effect than the HA and NA genes...
  28. pmc Needle-free skin patch delivery of a vaccine for a potentially pandemic influenza virus provides protection against lethal challenge in mice
    Sanjay Garg
    Influenza Division, Mail Stop G 16, CCID, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
    Clin Vaccine Immunol 14:926-8. 2007
    ....
  29. pmc No evidence of avian influenza A (H5N1) among returning US travelers
    Justin R Ortiz
    Centers for Disease Control and Prevention, Influenza Division, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 13:294-7. 2007
    ..Among the 59 reported patients, no evidence of H5N1 virus infection was found; none had direct contact with poultry, but 42% had evidence of human influenza A...
  30. ncbi request reprint Lack of evidence of avian-to-human transmission of avian influenza A (H5N1) virus among poultry workers, Kano, Nigeria, 2006
    Justin R Ortiz
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA
    J Infect Dis 196:1685-91. 2007
    ..In February 2006, poultry outbreaks of highly pathogenic avian influenza A (H5N1) virus were confirmed in Nigeria. A serosurvey was conducted to assess H5N1 transmission among poultry workers and laboratory workers in Nigeria...
  31. pmc Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus
    Claudia Pappas
    Influenza Division, Mailstop G 16, National Center for Immunization and Respiratory Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road Northeast, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 105:3064-9. 2008
    ..These results highlight the importance of the 1918 HA, NA, and PB1 genes for optimal virus replication and virulence of this pandemic strain...
  32. pmc Infectivity studies of influenza virus hemagglutinin receptor binding site mutants in mice
    Jeffrey Meisner
    Emory University School of Medicine, Atlanta, GA 30322, USA
    J Virol 82:5079-83. 2008
    ..The capacity of the Y98F mutant to induce antibody responses and the structural locations of HA reversion mutations are examined...
  33. pmc Lack of evidence for human-to-human transmission of avian influenza A (H9N2) viruses in Hong Kong, China 1999
    Timothy M Uyeki
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 8:154-9. 2002
    ..No serologic evidence of H9N2 infection was found in family members or health-care workers who had close contact with the H9N2-infected children, suggesting that these H9N2 viruses were not easily transmitted from person to person...
  34. ncbi request reprint Risk of influenza A (H5N1) infection among poultry workers, Hong Kong, 1997-1998
    Carolyn Buxton Bridges
    Influenza Branch, Division of Viral and Rickettsial Diseases, MS A 32, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, Georgia 30333, USA
    J Infect Dis 185:1005-10. 2002
    ..More-intensive poultry exposure, such as butchering and exposure to ill poultry, was associated with having anti-H5 antibody. These findings suggest an increased risk for avian influenza infection from occupational exposure...
  35. doi request reprint Antigenically distinct MF59-adjuvanted vaccine to boost immunity to H5N1
    Iain Stephenson
    N Engl J Med 359:1631-3. 2008
  36. doi request reprint Influenza: propagation, quantification, and storage
    Kristy J Szretter
    Influenza Branch, Centers for Disease, Control and Prevention, Atlanta, Georgia, USA
    Curr Protoc Microbiol . 2006
    ..MDCK cells are the preferred cell line for isolation of human influenza viruses from clinical specimens...
  37. pmc H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice
    Lucy A Perrone
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Collaborating Centers for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Pathog 4:e1000115. 2008
    ....
  38. ncbi request reprint NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I
    Zhu Guo
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Respir Cell Mol Biol 36:263-9. 2007
    ..These results provide further information on the mechanism by which IAV NS1 antagonizes the host antiviral response...
  39. pmc Influenza A virus (H3N8) in dogs with respiratory disease, Florida
    Sunchai Payungporn
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 14:902-8. 2008
    ..Continued surveillance and antigenic analyses should monitor possible emergence of antigenic variants of canine influenza virus...
  40. pmc A broadly protective vaccine against globally dispersed clade 1 and clade 2 H5N1 influenza viruses
    Mary A Hoelscher
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 197:1185-8. 2008
    ..We developed an adenoviral vector-based vaccine that contains hemagglutinin protein from clade 1 and clade 2 viruses, as well as conserved nucleoprotein, to broaden the vaccine coverage against H5N1 viruses...
  41. ncbi request reprint Comparison of neutralising antibody assays for detection of antibody to influenza A/H3N2 viruses: an international collaborative study
    Iain Stephenson
    Infectious Diseases Unit, University Hospitals Leicester, Leicester LE1 5WW, UK
    Vaccine 25:4056-63. 2007
    ..This study raises concern about comparability of serology results from H5N1 vaccine trials and it is proposed that an International Standard for influenza H5N1 antibody is developed...
  42. ncbi request reprint A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission
    Terrence M Tumpey
    Influenza Branch, Mailstop G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    Science 315:655-9. 2007
    ..These findings confirm an essential role of hemagglutinin receptor specificity for the transmission of influenza viruses among mammals...
  43. ncbi request reprint Transmission of equine influenza virus to dogs
    P C Crawford
    College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA
    Science 310:482-5. 2005
    ..Evidence of infection in pet dogs suggests that this infection may also become enzootic in this population...
  44. ncbi request reprint Cross-reactivity to highly pathogenic avian influenza H5N1 viruses after vaccination with nonadjuvanted and MF59-adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a potential priming strategy
    Iain Stephenson
    Influenza Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 191:1210-5. 2005
    ..0004), and 43% (P = .0128) in 14 subjects, respectively, compared with 27%, 27%, 0%, and 0% in 11 who received nonadjuvanted vaccine. These findings have implications for the rational design of pandemic vaccines against influenza H5...
  45. pmc Isolation and characterization of avian influenza viruses, including highly pathogenic H5N1, from poultry in live bird markets in Hanoi, Vietnam, in 2001
    Doan C Nguyen
    Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Virol 79:4201-12. 2005
    ....
  46. pmc Characterization of highly pathogenic H5N1 avian influenza A viruses isolated from South Korea
    Chang Won Lee
    Southeast Poultry Research Laboratory, USDA ARS, 934 College Station Rd, Athens, GA 30605, USA
    J Virol 79:3692-702. 2005
    ....
  47. ncbi request reprint Seroprevalence of anti-H5 antibody among Thai health care workers after exposure to avian influenza (H5N1) in a tertiary care center
    Anucha Apisarnthanarak
    Infectious Diseases Division, Thammasart University Hospital, Klong Luang, Pratumthani, Thailand 12120
    Clin Infect Dis 40:e16-8. 2005
    ..There was no serologic evidence of anti-H5 antibody reactivity or subclinical infection in either of the groups...
  48. pmc Avian influenza (H5N1) viruses isolated from humans in Asia in 2004 exhibit increased virulence in mammals
    Taronna R Maines
    Influenza Branch, Mail Stop G 16, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
    J Virol 79:11788-800. 2005
    ..However, the apparent enhancement of virulence of these viruses in humans in 2004 was better reflected in the ferret...
  49. ncbi request reprint Impact of glycosylation on the immunogenicity of a DNA-based influenza H5 HA vaccine
    Rick A Bright
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 308:270-8. 2003
    ....
  50. ncbi request reprint Confronting the avian influenza threat: vaccine development for a potential pandemic
    Iain Stephenson
    Influenza Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Lancet Infect Dis 4:499-509. 2004
    ..Adjuvanted or whole-virus preparations may improve immunogenicity and allow sparing of antigen...
  51. ncbi request reprint Characterization of the reconstructed 1918 Spanish influenza pandemic virus
    Terrence M Tumpey
    Influenza Branch, Mailstop G 16, Division of Viral and Rickettsial Diseases DVRD, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
    Science 310:77-80. 2005
    ..Moreover, the coordinated expression of the 1918 virus genes most certainly confers the unique high-virulence phenotype observed with this pandemic virus...
  52. pmc Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice
    Terrence M Tumpey
    Influenza Branch, Mail Stop G 16, DVRD, NCID, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
    J Virol 79:14933-44. 2005
    ....
  53. pmc DNA vaccine expressing conserved influenza virus proteins protective against H5N1 challenge infection in mice
    Suzanne L Epstein
    Food and Drug Administration, Rockville, Maryland 20852 1448, USA
    Emerg Infect Dis 8:796-801. 2002
    ..In the absence of antigenically matched hemagglutinin-based vaccines, DNA vaccination with conserved influenza genes may provide a useful first line of defense against a rapidly spreading pandemic virus...
  54. pmc Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice
    Kristy J Szretter
    Influenza Branch MS G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    J Virol 81:2736-44. 2007
    ..These results suggest that TNF-alpha may contribute to morbidity during H5N1 influenza virus infection, while IL-1 may be important for effective virus clearance in nonlethal H5N1 disease...
  55. ncbi request reprint Cross-protective immunity in mice induced by live-attenuated or inactivated vaccines against highly pathogenic influenza A (H5N1) viruses
    Xiuhua Lu
    Influenza Branch, Centers for Disease Control and Prevention, USA
    Vaccine 24:6588-93. 2006
    ..These results demonstrated that vaccination of mice with H5 IIV or LAIV induced a high degree of cross-protection from illness and death following lethal challenges with a heterologous H5N1 virus...
  56. pmc Lack of transmission of H5N1 avian-human reassortant influenza viruses in a ferret model
    Taronna R Maines
    Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 103:12121-6. 2006
    ..These results highlight the complexity of the genetic basis of influenza virus transmissibility and suggest that H5N1 viruses may require further adaptation to acquire this essential pandemic trait...
  57. pmc Development of adenoviral-vector-based pandemic influenza vaccine against antigenically distinct human H5N1 strains in mice
    Mary A Hoelscher
    Influenza Branch, Division of Rickettsial and Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Lancet 367:475-81. 2006
    ..However, currently licensed human vaccines are subtype-specific and do not protect against these H5N1 viruses. We aimed to develop an influenza vaccine and assessed its immunogenicity and efficacy to confer protection in BALB/c mice...
  58. pmc Protection of mice and poultry from lethal H5N1 avian influenza virus through adenovirus-based immunization
    Wentao Gao
    Department of Surgery and Medicine, University of Pittsburgh School of Medicine, Molecular Medicine Institute, Suite 412, 300 Technology Drive, Pittsburgh, PA 15219, USA
    J Virol 80:1959-64. 2006
    ....
  59. ncbi request reprint Mutant Escherichia coli heat-labile enterotoxin [LT(R192G)] enhances protective humoral and cellular immune responses to orally administered inactivated influenza vaccine
    Xiuhua Lu
    Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Vaccine 20:1019-29. 2002
    ..Taken together, these results indicate that LT(R192G), like wtLT, is a potent adjuvant for oral vaccination of mice with influenza vaccine...
  60. ncbi request reprint Report of a consultation on role of immunological assays to evaluate efficacy of influenza vaccines. Initiative for Vaccine Research and Global Influenza Programme, World Health Organization, Geneva, Switzerland, 25 January 2005
    Maria Cristina Cassetti
    Division of Microbiology and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Vaccine 24:541-3. 2006
  61. ncbi request reprint Safety and immunogenicity of nonadjuvanted and MF59-adjuvanted influenza A/H9N2 vaccine preparations
    Robert L Atmar
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Clin Infect Dis 43:1135-42. 2006
    ..Influenza A/H9N2 viruses can infect humans and are considered to be a pandemic threat. Effective vaccines are needed for these and other avian influenza viruses...
  62. ncbi request reprint Impaired antigen-induced CD8+ T cell clonal expansion in aging is due to defects in antigen presenting cell function
    Julie Plowden
    Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Cell Immunol 229:86-92. 2004
    ..The aged APCs were defective in costimulatory molecule expression and cytokine and chemokine secretion. These data indicate that defects in APC function lead to poor T cell clonal expansion and function in aging...
  63. ncbi request reprint A distal regulatory region is required for constitutive and IFN-beta-induced expression of murine TLR9 gene
    Zhu Guo
    Influenza Branch, Division of Viral and Rickettssial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Immunol 175:7407-18. 2005
    ..This study illustrates the crucial roles for AP-1, IRF-1, IRF-2, and STAT1 in the regulation of murine TLR9 expression...