Research Topics
Species | J M KatzSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
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Publications
5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replicationPriya Ranjan
Influenza Division, NCIRD, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Virol J 7:102. 2010..Activation of innate immune pathogen sensor Retinoic Acid Inducible Gene-I (RIG-I) has recently been shown to induce antiviral state...
Serologic assays for influenza surveillance, diagnosis and vaccine evaluationJacqueline M Katz
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Expert Rev Anti Infect Ther 9:669-83. 2011..The use of standardized protocols and antibody standards are important steps to improve reproducibility and interlaboratory comparability of results of serologic assays for influenza viruses...- The public health impact of avian influenza virusesJ M Katz
Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Poult Sci 88:872-9. 2009..Taken together, such studies provide valuable information with which we can assess the public health risk of avian influenza viruses... 
Current methods for assessing T cell responses to influenzaJ M Katz
Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Dev Biol (Basel) 115:85-93. 2003..Although still technically demanding, these modern assays represent important new tools for the quantitative analysis of T cell responses to influenza infection and vaccination...- Immunity to influenza: the challenges of protecting an aging populationJacqueline M Katz
Influenza Branch, Mailstop G 16, Division of Viral and Rickettsial Diseases Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
Immunol Res 29:113-24. 2004..Several novel strategies including the use of ISCOM-formulated vaccines, mucosal delivery, or DNA vaccination provided cross-subtype protection that could provide an important component of immunity in the event of a pandemic... - Molecular correlates of influenza A H5N1 virus pathogenesis in miceJ M Katz
Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 74:10807-10. 2000..Alone or in combination, these specific residues are the likely determinants of virulence of human H5N1 influenza viruses in this model... - Immunity to influenza A H9N2 viruses induced by infection and vaccinationX Lu
Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 75:4896-901. 2001..These results have implications for the development of human vaccines against H9N2 viruses, a priority for pandemic preparedness... - A nonionic block co-polymer adjuvant (CRL1005) enhances the immunogenicity and protective efficacy of inactivated influenza vaccine in young and aged miceJ M Katz
Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
Vaccine 18:2177-87. 2000..These results suggest that the copolymer adjuvant warrants further investigation as a potential adjuvant for use in human vaccination against influenza... - Mucosal delivery of inactivated influenza vaccine induces B-cell-dependent heterosubtypic cross-protection against lethal influenza A H5N1 virus infectionT M Tumpey
Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 75:5141-50. 2001..These results suggest a strategy of mucosal vaccination that stimulates cross-protection against multiple influenza virus subtypes, including viruses with pandemic potential... - Antibody response in individuals infected with avian influenza A (H5N1) viruses and detection of anti-H5 antibody among household and social contactsJ M Katz
Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Infect Dis 180:1763-70. 1999..In contrast, social exposure to case patients was not associated with H5N1 infection... - New pre-pandemic influenza vaccines: an egg- and adjuvant-independent human adenoviral vector strategy induces long-lasting protective immune responses in miceM A Hoelscher
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Clin Pharmacol Ther 82:665-71. 2007..Furthermore, the vaccine-induced humoral and cellular immune responses and protective immunity persisted at least for a year... - Mechanisms of pathogenicity of influenza A (H5N1) viruses in miceR A Bright
Emory University, Atlanta, GA 30329, USA
Avian Dis 47:1131-4. 2003..This study demonstrates the importance of extrapulmonary spread and replication, particularly in the brain, for the lethality of H5N1 viruses... - A mouse model for the evaluation of pathogenesis and immunity to influenza A (H5N1) viruses isolated from humansX Lu
Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 73:5903-11. 1999..These results suggests a strategy of vaccine preparedness for rapid intervention in future influenza pandemics that uses antigenically related nonpathogenic viruses as vaccine candidates... - Pathogenesis of and immunity to a new influenza A (H5N1) virus isolated from duck meatX H Lu
Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, N.E, Atlanta, GA 30333, USA
Avian Dis 47:1135-40. 2003..A/Dkmt virus cross-reacted poorly with ferret antisera raised against human H5N1 viruses, but prior infection with A/Dkmt virus protected mice from death after secondary infection with human H5N1 virus... - Influenza vaccines generated by reverse geneticsK Subbarao
Influenza Branch, Centers for Disease Control and Prevention, Mailstop G-16, 1600 Clifton Road, Atlanta, GA 30333, USA
Curr Top Microbiol Immunol 283:313-42. 2004..The future of influenza prevention and control lies in the application of this powerful technology for the generation of safe and more effective influenza vaccines... - Risk of influenza A (H5N1) infection among health care workers exposed to patients with influenza A (H5N1), Hong KongC Buxton Bridges
Centers for Disease Control and Prevention, Influenza Branch, MS A 32, 1600 Clifton Rd, Atlanta, GA 30333, USA
J Infect Dis 181:344-8. 2000..Human-to-human transmission of avian influenza may increase the chances for the emergence of a novel influenza virus with pandemic potential... - Neurological manifestations of avian influenza viruses in mammalsT Rowe
Influenza Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop G-16, Atlanta, GA 30333, USA
Avian Dis 47:1122-6. 2003..However, HK/486 was able to replicate in the brain and induce lethal disease following direct intracerebral inoculation... - The impact of avian influenza viruses on public healthJ M Katz
Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, G-16, Atlanta, GA 30333, USA
Avian Dis 47:914-20. 2003..Such transmission increases the likelihood of reassortment between a currently circulating human virus and an avian virus and thus the creation of a strain with pandemic potential... - Systemic and cellular immunityJ M Katz
Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Dev Biol (Basel) 115:107-9. 2003 - Sensitivity and specificity of serologic assays for detection of human infection with 2009 pandemic H1N1 virus in U.S. populationsVic Veguilla
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Centers for Disease Control andPrevention, 2 Atlanta, Georgia 30333, USA
J Clin Microbiol 49:2210-5. 2011..S. populations during the first pandemic waves. These studies provide an approach to optimize timely serological investigations for future pandemics or outbreaks of novel influenza viruses among humans... - Contemporary North American influenza H7 viruses possess human receptor specificity: Implications for virus transmissibilityJessica A Belser
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Proc Natl Acad Sci U S A 105:7558-63. 2008..These results indicate that H7 influenza viruses from the North American lineage have acquired sialic acid-binding properties that more closely resemble those of human influenza viruses and have the potential to spread to naïve animals... - DAS181, a novel sialidase fusion protein, protects mice from lethal avian influenza H5N1 virus infectionJessica A Belser
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Infect Dis 196:1493-9. 2007..This notable antiviral activity underscores the potential utility of DAS181 as a new class of drug that is effective against influenza viruses with pandemic potential... - Pathogenesis of avian influenza A (H5N1) viruses in ferretsLois A Zitzow
Influenza Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Virol 76:4420-9. 2002..We propose the ferret as an alternative model system for the study of these highly pathogenic avian viruses... - Highly pathogenic avian influenza H5N1 viruses elicit an attenuated type i interferon response in polarized human bronchial epithelial cellsHui Zeng
Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Virol 81:12439-49. 2007..The attenuation of this critical host innate immune defense may contribute to the virulence of H5N1 viruses observed in humans... - Pathogenesis of avian influenza (H7) virus infection in mice and ferrets: enhanced virulence of Eurasian H7N7 viruses isolated from humansJessica A Belser
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, MS G 16, 1600 Clifton Rd NE, Atlanta, GA 30333, USA
J Virol 81:11139-47. 2007..Therefore, in general, the relative virulence and cell tropism of the H7 viruses in these animal models correlated with the observed virulence in humans... - The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza virusesTerrence M Tumpey
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Virol 81:10818-21. 2007..Thus, the interferon-induced resistance factor Mx1 represents a key component of the murine innate immune system that mediates protection against epidemic and pandemic influenza viruses... - Polygenic virulence factors involved in pathogenesis of 1997 Hong Kong H5N1 influenza viruses in miceHualan Chen
Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, MS G16, Atlanta, GA 30333, USA
Virus Res 128:159-63. 2007..Multiple genes are involved in virulence of Hong Kong H5N1 influenza A viruses for mice with the presence of lysine at aa627 in the PB2 gene exhibiting a significantly larger effect than the HA and NA genes... - Needle-free skin patch delivery of a vaccine for a potentially pandemic influenza virus provides protection against lethal challenge in miceSanjay Garg
Influenza Division, Mail Stop G 16, CCID, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
Clin Vaccine Immunol 14:926-8. 2007.... - No evidence of avian influenza A (H5N1) among returning US travelersJustin R Ortiz
Centers for Disease Control and Prevention, Influenza Division, Atlanta, Georgia 30333, USA
Emerg Infect Dis 13:294-7. 2007..Among the 59 reported patients, no evidence of H5N1 virus infection was found; none had direct contact with poultry, but 42% had evidence of human influenza A... - Lack of evidence of avian-to-human transmission of avian influenza A (H5N1) virus among poultry workers, Kano, Nigeria, 2006Justin R Ortiz
Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA
J Infect Dis 196:1685-91. 2007..In February 2006, poultry outbreaks of highly pathogenic avian influenza A (H5N1) virus were confirmed in Nigeria. A serosurvey was conducted to assess H5N1 transmission among poultry workers and laboratory workers in Nigeria... - Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virusClaudia Pappas
Influenza Division, Mailstop G 16, National Center for Immunization and Respiratory Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road Northeast, Atlanta, GA 30333, USA
Proc Natl Acad Sci U S A 105:3064-9. 2008..These results highlight the importance of the 1918 HA, NA, and PB1 genes for optimal virus replication and virulence of this pandemic strain... - Infectivity studies of influenza virus hemagglutinin receptor binding site mutants in miceJeffrey Meisner
Emory University School of Medicine, Atlanta, GA 30322, USA
J Virol 82:5079-83. 2008..The capacity of the Y98F mutant to induce antibody responses and the structural locations of HA reversion mutations are examined... - Lack of evidence for human-to-human transmission of avian influenza A (H9N2) viruses in Hong Kong, China 1999Timothy M Uyeki
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 8:154-9. 2002..No serologic evidence of H9N2 infection was found in family members or health-care workers who had close contact with the H9N2-infected children, suggesting that these H9N2 viruses were not easily transmitted from person to person... - Risk of influenza A (H5N1) infection among poultry workers, Hong Kong, 1997-1998Carolyn Buxton Bridges
Influenza Branch, Division of Viral and Rickettsial Diseases, MS A 32, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, Georgia 30333, USA
J Infect Dis 185:1005-10. 2002..More-intensive poultry exposure, such as butchering and exposure to ill poultry, was associated with having anti-H5 antibody. These findings suggest an increased risk for avian influenza infection from occupational exposure... - Antigenically distinct MF59-adjuvanted vaccine to boost immunity to H5N1Iain Stephenson
N Engl J Med 359:1631-3. 2008 - Influenza: propagation, quantification, and storageKristy J Szretter
Influenza Branch, Centers for Disease, Control and Prevention, Atlanta, Georgia, USA
Curr Protoc Microbiol . 2006..MDCK cells are the preferred cell line for isolation of human influenza viruses from clinical specimens... - H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of miceLucy A Perrone
Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Collaborating Centers for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
PLoS Pathog 4:e1000115. 2008.... - NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-IZhu Guo
Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Am J Respir Cell Mol Biol 36:263-9. 2007..These results provide further information on the mechanism by which IAV NS1 antagonizes the host antiviral response... - Influenza A virus (H3N8) in dogs with respiratory disease, FloridaSunchai Payungporn
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 14:902-8. 2008..Continued surveillance and antigenic analyses should monitor possible emergence of antigenic variants of canine influenza virus... - A broadly protective vaccine against globally dispersed clade 1 and clade 2 H5N1 influenza virusesMary A Hoelscher
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Infect Dis 197:1185-8. 2008..We developed an adenoviral vector-based vaccine that contains hemagglutinin protein from clade 1 and clade 2 viruses, as well as conserved nucleoprotein, to broaden the vaccine coverage against H5N1 viruses... - Comparison of neutralising antibody assays for detection of antibody to influenza A/H3N2 viruses: an international collaborative studyIain Stephenson
Infectious Diseases Unit, University Hospitals Leicester, Leicester LE1 5WW, UK
Vaccine 25:4056-63. 2007..This study raises concern about comparability of serology results from H5N1 vaccine trials and it is proposed that an International Standard for influenza H5N1 antibody is developed... - A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmissionTerrence M Tumpey
Influenza Branch, Mailstop G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
Science 315:655-9. 2007..These findings confirm an essential role of hemagglutinin receptor specificity for the transmission of influenza viruses among mammals... - Transmission of equine influenza virus to dogsP C Crawford
College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA
Science 310:482-5. 2005..Evidence of infection in pet dogs suggests that this infection may also become enzootic in this population... - Cross-reactivity to highly pathogenic avian influenza H5N1 viruses after vaccination with nonadjuvanted and MF59-adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a potential priming strategyIain Stephenson
Influenza Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
J Infect Dis 191:1210-5. 2005..0004), and 43% (P = .0128) in 14 subjects, respectively, compared with 27%, 27%, 0%, and 0% in 11 who received nonadjuvanted vaccine. These findings have implications for the rational design of pandemic vaccines against influenza H5... - Isolation and characterization of avian influenza viruses, including highly pathogenic H5N1, from poultry in live bird markets in Hanoi, Vietnam, in 2001Doan C Nguyen
Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Virol 79:4201-12. 2005.... - Characterization of highly pathogenic H5N1 avian influenza A viruses isolated from South KoreaChang-Won Lee
Southeast Poultry Research Laboratory, USDA-ARS, 934 College Station Rd, Athens, GA 30605, USA
J Virol 79:3692-702. 2005.... - Seroprevalence of anti-H5 antibody among Thai health care workers after exposure to avian influenza (H5N1) in a tertiary care centerAnucha Apisarnthanarak
Infectious Diseases Division, Thammasart University Hospital, Klong Luang, Pratumthani, Thailand 12120
Clin Infect Dis 40:e16-8. 2005..There was no serologic evidence of anti-H5 antibody reactivity or subclinical infection in either of the groups... - Avian influenza (H5N1) viruses isolated from humans in Asia in 2004 exhibit increased virulence in mammalsTaronna R Maines
Influenza Branch, Mail Stop G-16, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, N.E, Atlanta, GA 30333, USA
J Virol 79:11788-800. 2005..However, the apparent enhancement of virulence of these viruses in humans in 2004 was better reflected in the ferret... - Impact of glycosylation on the immunogenicity of a DNA-based influenza H5 HA vaccineRick A Bright
Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Virology 308:270-8. 2003.... - Confronting the avian influenza threat: vaccine development for a potential pandemicIain Stephenson
Influenza Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Lancet Infect Dis 4:499-509. 2004..Adjuvanted or whole-virus preparations may improve immunogenicity and allow sparing of antigen... - Characterization of the reconstructed 1918 Spanish influenza pandemic virusTerrence M Tumpey
Influenza Branch, Mailstop G 16, Division of Viral and Rickettsial Diseases DVRD, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
Science 310:77-80. 2005..Moreover, the coordinated expression of the 1918 virus genes most certainly confers the unique high-virulence phenotype observed with this pandemic virus... - Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in miceTerrence M Tumpey
Influenza Branch, Mail Stop G 16, DVRD, NCID, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
J Virol 79:14933-44. 2005.... - DNA vaccine expressing conserved influenza virus proteins protective against H5N1 challenge infection in miceSuzanne L Epstein
Food and Drug Administration, Rockville, Maryland 20852 1448, USA
Emerg Infect Dis 8:796-801. 2002..In the absence of antigenically matched hemagglutinin-based vaccines, DNA vaccination with conserved influenza genes may provide a useful first line of defense against a rapidly spreading pandemic virus... - Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in miceKristy J Szretter
Influenza Branch MS G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
J Virol 81:2736-44. 2007..These results suggest that TNF-alpha may contribute to morbidity during H5N1 influenza virus infection, while IL-1 may be important for effective virus clearance in nonlethal H5N1 disease... - Cross-protective immunity in mice induced by live-attenuated or inactivated vaccines against highly pathogenic influenza A (H5N1) virusesXiuhua Lu
Influenza Branch, Centers for Disease Control and Prevention, USA
Vaccine 24:6588-93. 2006..These results demonstrated that vaccination of mice with H5 IIV or LAIV induced a high degree of cross-protection from illness and death following lethal challenges with a heterologous H5N1 virus... - Lack of transmission of H5N1 avian-human reassortant influenza viruses in a ferret modelTaronna R Maines
Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Proc Natl Acad Sci U S A 103:12121-6. 2006..These results highlight the complexity of the genetic basis of influenza virus transmissibility and suggest that H5N1 viruses may require further adaptation to acquire this essential pandemic trait... - Development of adenoviral-vector-based pandemic influenza vaccine against antigenically distinct human H5N1 strains in miceMary A Hoelscher
Influenza Branch, Division of Rickettsial and Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Lancet 367:475-81. 2006..01). INTERPRETATION: Our findings highlight the potential of an Ad-vector-based delivery system, which is both egg-independent and adjuvant-independent and offers stockpiling options for the development of a pandemic influenza vaccine... - Protection of mice and poultry from lethal H5N1 avian influenza virus through adenovirus-based immunizationWentao Gao
Department of Surgery and Medicine, University of Pittsburgh School of Medicine, Molecular Medicine Institute, Suite 412, 300 Technology Drive, Pittsburgh, PA 15219, USA
J Virol 80:1959-64. 2006.... - Mutant Escherichia coli heat-labile enterotoxin [LT(R192G)] enhances protective humoral and cellular immune responses to orally administered inactivated influenza vaccineXiuhua Lu
Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
Vaccine 20:1019-29. 2002..Taken together, these results indicate that LT(R192G), like wtLT, is a potent adjuvant for oral vaccination of mice with influenza vaccine... - Report of a consultation on role of immunological assays to evaluate efficacy of influenza vaccines. Initiative for Vaccine Research and Global Influenza Programme, World Health Organization, Geneva, Switzerland, 25 January 2005Maria Cristina Cassetti
Division of Microbiology and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Vaccine 24:541-3. 2006 - Safety and immunogenicity of nonadjuvanted and MF59-adjuvanted influenza A/H9N2 vaccine preparationsRobert L Atmar
Department of Medicine, Baylor College of Medicine, Houston, TX, USA
Clin Infect Dis 43:1135-42. 2006..Influenza A/H9N2 viruses can infect humans and are considered to be a pandemic threat. Effective vaccines are needed for these and other avian influenza viruses... - Impaired antigen-induced CD8+ T cell clonal expansion in aging is due to defects in antigen presenting cell functionJulie Plowden
Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Cell Immunol 229:86-92. 2004..The aged APCs were defective in costimulatory molecule expression and cytokine and chemokine secretion. These data indicate that defects in APC function lead to poor T cell clonal expansion and function in aging... - A distal regulatory region is required for constitutive and IFN-beta-induced expression of murine TLR9 geneZhu Guo
Influenza Branch, Division of Viral and Rickettssial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Immunol 175:7407-18. 2005..This study illustrates the crucial roles for AP-1, IRF-1, IRF-2, and STAT1 in the regulation of murine TLR9 expression...