Pius Joseph

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi request reprint Sodium arsenite-induced inhibition of eukaryotic translation initiation factor 4E (eIF4E) results in cytotoxicity and cell death
    Sreekumar Othumpangat
    Molecular Carcinogenesis Laboratory, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Mol Cell Biochem 279:123-31. 2005
  2. doi request reprint Mechanisms of cadmium carcinogenesis
    Pius Joseph
    Molecular Carcinogenesis Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 238:272-9. 2009
  3. doi request reprint Heme-oxygenase 1 gene expression is a marker for hexavalent chromium-induced stress and toxicity in human dermal fibroblasts
    Pius Joseph
    Molecular Carcinogenesis Laboratory, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health NIOSH, Morgantown, West Virginia 26505, USA
    Toxicol Sci 103:325-34. 2008
  4. doi request reprint Transcriptomics analysis of lungs and peripheral blood of crystalline silica-exposed rats
    Rajendran Sellamuthu
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health NIOSH, Morgantown, WV 26505, USA
    Inhal Toxicol 24:570-9. 2012
  5. ncbi request reprint Up-regulation of expression of translation factors--a novel molecular mechanism for cadmium carcinogenesis
    Pius Joseph
    Molecular Epidemiology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Mol Cell Biochem 255:93-101. 2004
  6. doi request reprint Molecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats
    Rajendran Sellamuthu
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Appl Toxicol 33:301-12. 2013
  7. doi request reprint Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling
    Rajendran Sellamuthu
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health NIOSH, Morgantown, WV 26505, USA
    Inhal Toxicol 23:927-37. 2011
  8. ncbi request reprint Molecular cloning and functional analysis of a novel cadmium-responsive proto-oncogene
    Pius Joseph
    Molecular Epidemiology Laboratory, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Cancer Res 62:703-7. 2002
  9. ncbi request reprint Antisense inhibition of translation initiation factor 3 reverses its oncogenic potential
    Yi Xiong Lei
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia
    Teratog Carcinog Mutagen 22:403-9. 2002
  10. ncbi request reprint Eukaryotic translation initiation factor 4E is a cellular target for toxicity and death due to exposure to cadmium chloride
    Sreekumar Othumpangat
    Molecular Carcinogenesis Laboratory, Toxicology and Molecular Biology Branch, Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 280:25162-9. 2005

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Sodium arsenite-induced inhibition of eukaryotic translation initiation factor 4E (eIF4E) results in cytotoxicity and cell death
    Sreekumar Othumpangat
    Molecular Carcinogenesis Laboratory, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Mol Cell Biochem 279:123-31. 2005
    ....
  2. doi request reprint Mechanisms of cadmium carcinogenesis
    Pius Joseph
    Molecular Carcinogenesis Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 238:272-9. 2009
    ..The available evidence indicates that, perhaps, oxidative stress plays a central role in Cd carcinogenesis because of its involvement in Cd-induced aberrant gene expression, inhibition of DNA damage repair, and apoptosis...
  3. doi request reprint Heme-oxygenase 1 gene expression is a marker for hexavalent chromium-induced stress and toxicity in human dermal fibroblasts
    Pius Joseph
    Molecular Carcinogenesis Laboratory, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health NIOSH, Morgantown, West Virginia 26505, USA
    Toxicol Sci 103:325-34. 2008
    ..Furthermore, the expression level of HO-1 gene is a marker for Cr(VI)-induced cell stress leading to cytotoxicity...
  4. doi request reprint Transcriptomics analysis of lungs and peripheral blood of crystalline silica-exposed rats
    Rajendran Sellamuthu
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health NIOSH, Morgantown, WV 26505, USA
    Inhal Toxicol 24:570-9. 2012
    ....
  5. ncbi request reprint Up-regulation of expression of translation factors--a novel molecular mechanism for cadmium carcinogenesis
    Pius Joseph
    Molecular Epidemiology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Mol Cell Biochem 255:93-101. 2004
    ..These findings demonstrate that the up-regulation of expression of TIF3 and TEF-1delta is a novel molecular mechanism responsible, at least in part, for cadmium carcinogenesis...
  6. doi request reprint Molecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats
    Rajendran Sellamuthu
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Appl Toxicol 33:301-12. 2013
    ..Published 2012. This article is a US Government work and is in the public domain in the USA...
  7. doi request reprint Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling
    Rajendran Sellamuthu
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health NIOSH, Morgantown, WV 26505, USA
    Inhal Toxicol 23:927-37. 2011
    ....
  8. ncbi request reprint Molecular cloning and functional analysis of a novel cadmium-responsive proto-oncogene
    Pius Joseph
    Molecular Epidemiology Laboratory, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Cancer Res 62:703-7. 2002
    ..Taken together, these findings demonstrate for the first time that the cell transformation and tumorigenesis induced by CdCl(2) are due, at least in part, to the overexpression of TIF3, a novel cadmium-responsive proto-oncogene...
  9. ncbi request reprint Antisense inhibition of translation initiation factor 3 reverses its oncogenic potential
    Yi Xiong Lei
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia
    Teratog Carcinog Mutagen 22:403-9. 2002
    ..These results further confirm that overexpression of TIF3 is oncogenic and the antisense TIF3 mRNA expression reverses its oncogenic potential...
  10. ncbi request reprint Eukaryotic translation initiation factor 4E is a cellular target for toxicity and death due to exposure to cadmium chloride
    Sreekumar Othumpangat
    Molecular Carcinogenesis Laboratory, Toxicology and Molecular Biology Branch, Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 280:25162-9. 2005
    ....
  11. ncbi request reprint Expression profile of eukaryotic translation factors in human cancer tissues and cell lines
    Pius Joseph
    Molecular Carcinogenesis Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Mol Carcinog 40:171-9. 2004
    ..These results indicate that human carcinogenesis is often associated with alterations in the expression of various translation factors especially the overexpression of eukaryotic translation elongation factor 1A2...
  12. ncbi request reprint Blood gene expression profiling detects silica exposure and toxicity
    Rajendran Sellamuthu
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Toxicol Sci 122:253-64. 2011
    ..However, further research is required to determine the potential application of our findings specifically to monitor human exposure to silica and the resulting pulmonary effects...
  13. pmc Irritancy and allergic responses induced by topical application of ortho-phthalaldehyde
    Stacey E Anderson
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Toxicol Sci 115:435-43. 2010
    ..The results demonstrate the dermal irritancy and allergic potential of OPA and raise concern about the proposed/intended use of OPA as a safe alternative to glutaraldehyde...
  14. doi request reprint Blood gene expression markers to detect and distinguish target organ toxicity
    Christina Umbright
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Mol Cell Biochem 335:223-34. 2010
    ..In summary, our results demonstrated that blood gene expression markers can detect and distinguish target organ toxicity non-invasively...
  15. ncbi request reprint Oncogenic potential of mouse translation elongation factor-1 delta, a novel cadmium-responsive proto-oncogene
    Pius Joseph
    Molecular Epidemiology Laboratory, Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 277:6131-6. 2002
    ..Our findings demonstrate, for the first time, that the cell transformation and tumorigenesis induced by cadmium are due, at least in part, to the overexpression of TEF-1 delta, a novel cadmium-responsive proto-oncogene...
  16. ncbi request reprint Molecular and cellular mechanisms of cadmium carcinogenesis
    Michael Waisberg
    Department of Land Resource Science, University of Guelph, Guelph, Ont, Canada
    Toxicology 192:95-117. 2003
    ..It becomes clear that there exist multiple mechanisms which contribute to the carcinogenicity of cadmium, although the relative weights of these contributions are difficult to estimate...
  17. ncbi request reprint [Effect of aberrant DNA methylation on the expression of cancer-related genes in Cd-transformed cells]
    Yi Xiong Lei
    Institute of Chemical Carcinogenesis, Guangzhou Medical College, Guangzhou 510182, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 21:114-6. 2003
    ..To study aberrant DNA methylation potentially resulting in changes in the expression of cancer-related genes as a possible epigenetic mechanism for cadmium carcinogenesis...