Joseph Igietseme

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi request reprint Chlamydia update
    Joseph U Igietseme
    Molecular Pathogenesis Laboratory, National Center for Infectious Disease, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    Expert Rev Vaccines 3:639-42. 2004
  2. ncbi request reprint Immunogenicity and protection against genital Chlamydia infection and its complications by a multisubunit candidate vaccine
    Godwin O Ifere
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Microbiol Immunol Infect 40:188-200. 2007
  3. ncbi request reprint Molecular basis for the potency of IL-10-deficient dendritic cells as a highly efficient APC system for activating Th1 response
    Qing He
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 174:4860-9. 2005
  4. pmc Prevention of Chlamydia-induced infertility by inhibition of local caspase activity
    Joseph U Igietseme
    National Center for Emerging Zoonotic and Infectious Diseases, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    J Infect Dis 207:1095-104. 2013
  5. pmc CCL5 regulation of mucosal chlamydial immunity and infection
    Senthilkumar K Sakthivel
    Emory University School of Medicine, Department of Pathology, Atlanta GA, USA
    BMC Microbiol 8:136. 2008
  6. ncbi request reprint Delivery of Chlamydia vaccines
    Joseph Igietseme
    National Center for Infectious Disease CDC, Atlanta, GA 30333, USA
    Expert Opin Drug Deliv 2:549-62. 2005
  7. ncbi request reprint Developing effective delivery systems for Chlamydia vaccines
    Joseph U Igietseme
    National Center for Infectious Disease, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Curr Opin Mol Ther 6:182-94. 2004
  8. ncbi request reprint Antibody regulation of Tcell immunity: implications for vaccine strategies against intracellular pathogens
    Joseph U Igietseme
    Molecular Pathogenesis Laboratory, National Center for Infectious Disease, Centers for Disease Control and Prevention CDC, 1600 Clifton Road, Mailstop C17, Atlanta, GA 30333 USA
    Expert Rev Vaccines 3:23-34. 2004
  9. ncbi request reprint Contemporary approaches to designing and evaluating vaccines against Chlamydia
    Joseph U Igietseme
    Molecular Pathogenesis Laboratory, National Center for Infectious Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Expert Rev Vaccines 2:129-46. 2003
  10. doi request reprint Chlamydia vaccines: recent developments and the role of adjuvants in future formulations
    Joseph U Igietseme
    National Center for Emerging Zoonotic and Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop G 36, Atlanta, GA 30333, USA
    Expert Rev Vaccines 10:1585-96. 2011

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Chlamydia update
    Joseph U Igietseme
    Molecular Pathogenesis Laboratory, National Center for Infectious Disease, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    Expert Rev Vaccines 3:639-42. 2004
  2. ncbi request reprint Immunogenicity and protection against genital Chlamydia infection and its complications by a multisubunit candidate vaccine
    Godwin O Ifere
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Microbiol Immunol Infect 40:188-200. 2007
    ..We examined whether a vaccine composed of a combination of the major outer membrane protein (MOMP) and porin B protein (PorB) of C. trachomatis would have a protective advantage over a single subunit construct...
  3. ncbi request reprint Molecular basis for the potency of IL-10-deficient dendritic cells as a highly efficient APC system for activating Th1 response
    Qing He
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 174:4860-9. 2005
    ..Collectively, these results provide a molecular basis for the high Th1-activating capacity of IL-10KO APC and may provide unique immunomodulation targets when designing vaccines against pathogens controlled by T cell immunity...
  4. pmc Prevention of Chlamydia-induced infertility by inhibition of local caspase activity
    Joseph U Igietseme
    National Center for Emerging Zoonotic and Infectious Diseases, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    J Infect Dis 207:1095-104. 2013
    ..These results provide new insight into the molecular pathogenesis of TFI with significant implications for new strategies for treatment and prevention of chlamydial complications...
  5. pmc CCL5 regulation of mucosal chlamydial immunity and infection
    Senthilkumar K Sakthivel
    Emory University School of Medicine, Department of Pathology, Atlanta GA, USA
    BMC Microbiol 8:136. 2008
    ..These findings suggest the CCR5-CCL5 axis is necessary for optimal chlamydial immunity. We hypothesized CCL5 is required for protective humoral and cellular immunity against Chlamydia...
  6. ncbi request reprint Delivery of Chlamydia vaccines
    Joseph Igietseme
    National Center for Infectious Disease CDC, Atlanta, GA 30333, USA
    Expert Opin Drug Deliv 2:549-62. 2005
    ..The application of these novel delivery strategies to Chlamydia vaccine design could culminate in timely achievement of an efficacious vaccine...
  7. ncbi request reprint Developing effective delivery systems for Chlamydia vaccines
    Joseph U Igietseme
    National Center for Infectious Disease, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Curr Opin Mol Ther 6:182-94. 2004
    ..These efforts will likely culminate in an efficacious chlamydial vaccine in the near future...
  8. ncbi request reprint Antibody regulation of Tcell immunity: implications for vaccine strategies against intracellular pathogens
    Joseph U Igietseme
    Molecular Pathogenesis Laboratory, National Center for Infectious Disease, Centers for Disease Control and Prevention CDC, 1600 Clifton Road, Mailstop C17, Atlanta, GA 30333 USA
    Expert Rev Vaccines 3:23-34. 2004
    ..The immunobiological implications are discussed in the context of vaccine design, delivery and evaluation against intracellular microbial pathogens of bacteria, fungi and parasitic origin...
  9. ncbi request reprint Contemporary approaches to designing and evaluating vaccines against Chlamydia
    Joseph U Igietseme
    Molecular Pathogenesis Laboratory, National Center for Infectious Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Expert Rev Vaccines 2:129-46. 2003
    ....
  10. doi request reprint Chlamydia vaccines: recent developments and the role of adjuvants in future formulations
    Joseph U Igietseme
    National Center for Emerging Zoonotic and Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop G 36, Atlanta, GA 30333, USA
    Expert Rev Vaccines 10:1585-96. 2011
    ....
  11. pmc Role of T lymphocytes in the pathogenesis of Chlamydia disease
    Joseph U Igietseme
    Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    J Infect Dis 200:926-34. 2009
    ..Furthermore, T cell subsets, especially CD8 T cells, play a major role in Chlamydia-induced infertility. The results have important implications for the immunopathogenesis of chlamydial disease and new vaccine strategies...
  12. pmc Chlamydia trachomatis serovars among strains isolated from members of rural indigenous communities and urban populations in Australia
    Claudiu I Bandea
    Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
    J Clin Microbiol 46:355-6. 2008
    ..1%), D/Da (n = 4; 8.9%), G (n = 3; 6.7%), and K (n = 1; 2.2%). The distribution of C. trachomatis serovars among members of the indigenous rural and the urban Australian communities appears similar to that in other Western countries...
  13. pmc Live-attenuated influenza viruses as delivery vectors for Chlamydia vaccines
    Qing He
    National Center for Infectious Disease, CDC, Atlanta, GA, USA
    Immunology 122:28-37. 2007
    ..Because live attenuated influenza virus vaccines are safe and acceptable for human use, they may provide a new and reliable approach to deliver efficacious vaccines against sexually transmitted diseases...
  14. ncbi request reprint A recombinant multivalent combination vaccine protects against Chlamydia and genital herpes
    LuCinda MacMillan
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    FEMS Immunol Med Microbiol 49:46-55. 2007
    ..Thus, the combination vaccine regimen delivered by rVCG elicited adequate immune effectors that simultaneously protected against the individual pathogens...
  15. pmc Fc receptor regulation of protective immunity against Chlamydia trachomatis
    Terri Moore
    Department of Microbiology and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30320, USA
    Immunology 105:213-21. 2002
    ..These findings suggest that a future anti-chlamydial vaccine should elicit both humoral and T-cell-mediated immune responses for optimal memory response and vaccine efficacy...
  16. ncbi request reprint A novel recombinant multisubunit vaccine against Chlamydia
    Francis O Eko
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 173:3375-82. 2004
    ..These results support the operational theory that the ability of a vaccine to confer protective immunity against Chlamydia is a function of the level of Th1 response elicited...
  17. ncbi request reprint Fc receptor-mediated antibody regulation of T cell immunity against intracellular pathogens
    Terri Moore
    Morehouse School of Medicine, Atlanta, Georgia 30333, USA
    J Infect Dis 188:617-24. 2003
    ..Findings offer a paradigm in host defense wherein different effector components function indirectly to maximize the principal effector mechanism...
  18. ncbi request reprint Recombinant Vibrio cholerae ghosts as a delivery vehicle for vaccinating against Chlamydia trachomatis
    Francis O Eko
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Dr Atlanta, GA 30310, USA
    Vaccine 21:1694-703. 2003
    ..trachomatis infection. Altogether, the potency and relatively low production cost of rVCG offer a significant technical advantage as a chlamydial vaccine...
  19. ncbi request reprint Chlamydia vaccines: strategies and status
    Joseph U Igietseme
    Microbiology and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, Georgia 30310, USA
    BioDrugs 16:19-35. 2002
    ..However, more research efforts and support are needed to achieve the worthy goal of protecting a significant number of the world's population from the devastating consequences of chlamydial invasion of the human mucosal epithelia...
  20. pmc Involvement of LEK1 in dendritic cell regulation of T cell immunity against Chlamydia
    Qing He
    Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 181:4037-42. 2008
    ..Targeted modulation of LEK1 expression provides a novel strategy for augmenting the immunostimulatory function of DCs for inducing an effective immunity against pathogens...
  21. ncbi request reprint Combination vaccines: design strategies and future trends
    Joseph U Igietseme
    Expert Rev Vaccines 5:739-45. 2006
  22. ncbi request reprint Host inflammatory response and development of complications of Chlamydia trachomatis genital infection in CCR5-deficient mice and subfertile women with the CCR5delta32 gene deletion
    Erika L Barr
    Clark Atlanta University, Atlanta, GA 30333, USA
    J Microbiol Immunol Infect 38:244-54. 2005
    ..Thus, in mice and humans the inflammation associated with CCR5 function may predispose to development of complications of chlamydial infection, such as TFI...
  23. ncbi request reprint Does leptin mediate the effect of photoperiod on immune function in mice?
    Ganapathy K Bhat
    Cooperative Reproductive Science Research Center, and Department of Physiology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Biol Reprod 69:30-6. 2003
    ..The data do not provide definitive support for the hypothesis that photoperiod-induced changes in leptin secretion mediate the effects of season on immune status...
  24. pmc Chemokine and chemokine receptor dynamics during genital chlamydial infection
    Tesfaye Belay
    Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Infect Immun 70:844-50. 2002
    ..Future studies will focus on how selective modulation of chemokines and their receptors can be used to optimize long-term immunity against CHLAMYDIA:..