Research Topics
| Joseph IgietsemeSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
| Collaborators
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Detail Information
Publications
Chlamydia updateJoseph U Igietseme
Molecular Pathogenesis Laboratory, National Center for Infectious Disease, Centers for Disease Control and Prevention (CDC, Atlanta, GA 30333, USA
Expert Rev Vaccines 3:639-42. 2004- Immunogenicity and protection against genital Chlamydia infection and its complications by a multisubunit candidate vaccineGodwin O Ifere
Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
J Microbiol Immunol Infect 40:188-200. 2007..We examined whether a vaccine composed of a combination of the major outer membrane protein (MOMP) and porin B protein (PorB) of C. trachomatis would have a protective advantage over a single subunit construct... - Molecular basis for the potency of IL-10-deficient dendritic cells as a highly efficient APC system for activating Th1 responseQing He
Morehouse School of Medicine, Atlanta, GA 30310, USA
J Immunol 174:4860-9. 2005..Collectively, these results provide a molecular basis for the high Th1-activating capacity of IL-10KO APC and may provide unique immunomodulation targets when designing vaccines against pathogens controlled by T cell immunity... 
Prevention of Chlamydia-induced infertility by inhibition of local caspase activityJoseph U Igietseme
National Center for Emerging Zoonotic and Infectious Diseases, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
J Infect Dis 207:1095-104. 2013..These results provide new insight into the molecular pathogenesis of TFI with significant implications for new strategies for treatment and prevention of chlamydial complications...- CCL5 regulation of mucosal chlamydial immunity and infectionSenthilkumar K Sakthivel
Emory University School of Medicine, Department of Pathology, Atlanta GA, USA
BMC Microbiol 8:136. 2008..These findings suggest the CCR5-CCL5 axis is necessary for optimal chlamydial immunity. We hypothesized CCL5 is required for protective humoral and cellular immunity against Chlamydia... - Delivery of Chlamydia vaccinesJoseph Igietseme
National Center for Infectious Disease CDC, Atlanta, GA 30333, USA
Expert Opin Drug Deliv 2:549-62. 2005..The application of these novel delivery strategies to Chlamydia vaccine design could culminate in timely achievement of an efficacious vaccine... - Developing effective delivery systems for Chlamydia vaccinesJoseph U Igietseme
National Center for Infectious Disease, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
Curr Opin Mol Ther 6:182-94. 2004..These efforts will likely culminate in an efficacious chlamydial vaccine in the near future... - Antibody regulation of Tcell immunity: implications for vaccine strategies against intracellular pathogensJoseph U Igietseme
Molecular Pathogenesis Laboratory, National Center for Infectious Disease, Centers for Disease Control and Prevention CDC, 1600 Clifton Road, Mailstop C17, Atlanta, GA 30333 USA
Expert Rev Vaccines 3:23-34. 2004..The immunobiological implications are discussed in the context of vaccine design, delivery and evaluation against intracellular microbial pathogens of bacteria, fungi and parasitic origin... - Contemporary approaches to designing and evaluating vaccines against ChlamydiaJoseph U Igietseme
Molecular Pathogenesis Laboratory, National Center for Infectious Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Expert Rev Vaccines 2:129-46. 2003.... 
Chlamydia vaccines: recent developments and the role of adjuvants in future formulationsJoseph U Igietseme
National Center for Emerging Zoonotic and Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop G 36, Atlanta, GA 30333, USA
Expert Rev Vaccines 10:1585-96. 2011....- Role of T lymphocytes in the pathogenesis of Chlamydia diseaseJoseph U Igietseme
Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
J Infect Dis 200:926-34. 2009..Furthermore, T cell subsets, especially CD8 T cells, play a major role in Chlamydia-induced infertility. The results have important implications for the immunopathogenesis of chlamydial disease and new vaccine strategies... - Chlamydia trachomatis serovars among strains isolated from members of rural indigenous communities and urban populations in AustraliaClaudiu I Bandea
Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
J Clin Microbiol 46:355-6. 2008..1%), D/Da (n = 4; 8.9%), G (n = 3; 6.7%), and K (n = 1; 2.2%). The distribution of C. trachomatis serovars among members of the indigenous rural and the urban Australian communities appears similar to that in other Western countries... - Live-attenuated influenza viruses as delivery vectors for Chlamydia vaccinesQing He
National Center for Infectious Disease, CDC, Atlanta, GA, USA
Immunology 122:28-37. 2007..Because live attenuated influenza virus vaccines are safe and acceptable for human use, they may provide a new and reliable approach to deliver efficacious vaccines against sexually transmitted diseases... - A recombinant multivalent combination vaccine protects against Chlamydia and genital herpesLuCinda MacMillan
Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
FEMS Immunol Med Microbiol 49:46-55. 2007..Thus, the combination vaccine regimen delivered by rVCG elicited adequate immune effectors that simultaneously protected against the individual pathogens... - Fc receptor regulation of protective immunity against Chlamydia trachomatisTerri Moore
Department of Microbiology and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30320, USA
Immunology 105:213-21. 2002..These findings suggest that a future anti-chlamydial vaccine should elicit both humoral and T-cell-mediated immune responses for optimal memory response and vaccine efficacy... - A novel recombinant multisubunit vaccine against ChlamydiaFrancis O Eko
Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA
J Immunol 173:3375-82. 2004..These results support the operational theory that the ability of a vaccine to confer protective immunity against Chlamydia is a function of the level of Th1 response elicited... - Fc receptor-mediated antibody regulation of T cell immunity against intracellular pathogensTerri Moore
Morehouse School of Medicine, Atlanta, Georgia 30333, USA
J Infect Dis 188:617-24. 2003..Findings offer a paradigm in host defense wherein different effector components function indirectly to maximize the principal effector mechanism... - Recombinant Vibrio cholerae ghosts as a delivery vehicle for vaccinating against Chlamydia trachomatisFrancis O Eko
Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, 720 Westview Dr Atlanta, GA 30310, USA
Vaccine 21:1694-703. 2003..trachomatis infection. Altogether, the potency and relatively low production cost of rVCG offer a significant technical advantage as a chlamydial vaccine... - Chlamydia vaccines: strategies and statusJoseph U Igietseme
Microbiology and Immunology, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, Georgia 30310, USA
BioDrugs 16:19-35. 2002..However, more research efforts and support are needed to achieve the worthy goal of protecting a significant number of the world's population from the devastating consequences of chlamydial invasion of the human mucosal epithelia... - Involvement of LEK1 in dendritic cell regulation of T cell immunity against ChlamydiaQing He
Morehouse School of Medicine, Atlanta, GA 30310, USA
J Immunol 181:4037-42. 2008..Targeted modulation of LEK1 expression provides a novel strategy for augmenting the immunostimulatory function of DCs for inducing an effective immunity against pathogens... - Combination vaccines: design strategies and future trendsJoseph U Igietseme
Expert Rev Vaccines 5:739-45. 2006 - Host inflammatory response and development of complications of Chlamydia trachomatis genital infection in CCR5-deficient mice and subfertile women with the CCR5delta32 gene deletionErika L Barr
Clark Atlanta University, Atlanta, GA 30333, USA
J Microbiol Immunol Infect 38:244-54. 2005..Thus, in mice and humans the inflammation associated with CCR5 function may predispose to development of complications of chlamydial infection, such as TFI... - Does leptin mediate the effect of photoperiod on immune function in mice?Ganapathy K Bhat
Cooperative Reproductive Science Research Center, and Department of Physiology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
Biol Reprod 69:30-6. 2003..The data do not provide definitive support for the hypothesis that photoperiod-induced changes in leptin secretion mediate the effects of season on immune status... - Chemokine and chemokine receptor dynamics during genital chlamydial infectionTesfaye Belay
Department of Microbiology, Biochemistry and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
Infect Immun 70:844-50. 2002..Future studies will focus on how selective modulation of chemokines and their receptors can be used to optimize long-term immunity against CHLAMYDIA:..