Affiliation: Centers for Disease Control and Prevention
Hubbs A, Mercer R, Benkovic S, Harkema J, Sriram K, Schwegler Berry D, et al
. Nanotoxicology--a pathologist's perspective. Toxicol Pathol. 2011;39:301-24 pubmed publisher
..This review provides an introduction to the pathology and toxicology of nanoparticulates. ..
Hubbs A, Greskevitch M, Kuempel E, Suarez F, Toraason M. Abrasive blasting agents: designing studies to evaluate relative risk. J Toxicol Environ Health A. 2005;68:999-1016 pubmed
..This design will facilitate assessment of the pulmonary fibrogenic potential of inhaled abrasive blasting agents at occupationally relevant concentrations. ..
Hubbs A, Cumpston A, Goldsmith W, Battelli L, Kashon M, Jackson M, et al
. Respiratory and olfactory cytotoxicity of inhaled 2,3-pentanedione in Sprague-Dawley rats. Am J Pathol. 2012;181:829-44 pubmed publisher
..Claudin-1 expression increased in the OB and striatum. We conclude that 2,3-pentanedione is a respiratory hazard that can also alter gene expression in the brain...
Hubbs A, Goldsmith W, Kashon M, Frazer D, Mercer R, Battelli L, et al
. Respiratory toxicologic pathology of inhaled diacetyl in sprague-dawley rats. Toxicol Pathol. 2008;36:330-44 pubmed publisher
..Edema and hemorrhage extended into the lamina propria. These findings are consistent with the conclusion that inhaled diacetyl is a respiratory hazard. ..
Hubbs A, Fluharty K, Edwards R, Barnabei J, Grantham J, Palmer S, et al
. Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity. Am J Pathol. 2016;186:2887-2908 pubmed publisher
..This suggests the possibility that SQSTM1 or damaged proteins may be transported from the nose to the brain. Together, these findings strongly implicate widespread protein damage in the etiology of flavorings-related lung disease. ..