Ann Hubbs

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. doi request reprint Nanotechnology: toxicologic pathology
    Ann F Hubbs
    1Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Toxicol Pathol 41:395-409. 2013
  2. doi request reprint Respiratory and olfactory cytotoxicity of inhaled 2,3-pentanedione in Sprague-Dawley rats
    Ann F Hubbs
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Am J Pathol 181:829-44. 2012
  3. pmc Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes
    Robert R Mercer
    Pathology and Physiology Research Branch, HELD, NIOSH, Morgantown, WV, USA
    Part Fibre Toxicol 8:21. 2011
  4. pmc Distribution and persistence of pleural penetrations by multi-walled carbon nanotubes
    Robert R Mercer
    Pathology and Physiology Research Branch, HELD, NIOSH, Morgantown, WV, USA
    Part Fibre Toxicol 7:28. 2010
  5. ncbi request reprint Abrasive blasting agents: designing studies to evaluate relative risk
    Ann Hubbs
    National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    J Toxicol Environ Health A 68:999-1016. 2005
  6. doi request reprint Respiratory toxicologic pathology of inhaled diacetyl in sprague-dawley rats
    Ann F Hubbs
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    Toxicol Pathol 36:330-44. 2008
  7. pmc Coal dust alters beta-naphthoflavone-induced aryl hydrocarbon receptor nuclear translocation in alveolar type II cells
    Mohamed M Ghanem
    Genetics and Developmental Biology Program, West Virginia University, Morgantown, WV 26506, USA
    Part Fibre Toxicol 6:21. 2009
  8. doi request reprint Nanotoxicology--a pathologist's perspective
    Ann F Hubbs
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Toxicol Pathol 39:301-24. 2011
  9. pmc Systemic microvascular dysfunction and inflammation after pulmonary particulate matter exposure
    Timothy R Nurkiewicz
    Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9229, USA
    Environ Health Perspect 114:412-9. 2006
  10. ncbi request reprint Effect of inhaled crystalline silica in a rat model: time course of pulmonary reactions
    Vincent Castranova
    National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Mol Cell Biochem 234:177-84. 2002

Collaborators

Detail Information

Publications34

  1. doi request reprint Nanotechnology: toxicologic pathology
    Ann F Hubbs
    1Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Toxicol Pathol 41:395-409. 2013
    ..Thus, the pathology assessment is facilitated by understanding the unique features at the nanoscale and the tools that can assist in evaluating nanotoxicology studies...
  2. doi request reprint Respiratory and olfactory cytotoxicity of inhaled 2,3-pentanedione in Sprague-Dawley rats
    Ann F Hubbs
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Am J Pathol 181:829-44. 2012
    ..Claudin-1 expression increased in the OB and striatum. We conclude that 2,3-pentanedione is a respiratory hazard that can also alter gene expression in the brain...
  3. pmc Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes
    Robert R Mercer
    Pathology and Physiology Research Branch, HELD, NIOSH, Morgantown, WV, USA
    Part Fibre Toxicol 8:21. 2011
    ..Morphometric measurement of Sirius Red staining was used to assess the connective tissue response...
  4. pmc Distribution and persistence of pleural penetrations by multi-walled carbon nanotubes
    Robert R Mercer
    Pathology and Physiology Research Branch, HELD, NIOSH, Morgantown, WV, USA
    Part Fibre Toxicol 7:28. 2010
    ....
  5. ncbi request reprint Abrasive blasting agents: designing studies to evaluate relative risk
    Ann Hubbs
    National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    J Toxicol Environ Health A 68:999-1016. 2005
    ..This design will facilitate assessment of the pulmonary fibrogenic potential of inhaled abrasive blasting agents at occupationally relevant concentrations...
  6. doi request reprint Respiratory toxicologic pathology of inhaled diacetyl in sprague-dawley rats
    Ann F Hubbs
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    Toxicol Pathol 36:330-44. 2008
    ..Edema and hemorrhage extended into the lamina propria. These findings are consistent with the conclusion that inhaled diacetyl is a respiratory hazard...
  7. pmc Coal dust alters beta-naphthoflavone-induced aryl hydrocarbon receptor nuclear translocation in alveolar type II cells
    Mohamed M Ghanem
    Genetics and Developmental Biology Program, West Virginia University, Morgantown, WV 26506, USA
    Part Fibre Toxicol 6:21. 2009
    ..abstract:..
  8. doi request reprint Nanotoxicology--a pathologist's perspective
    Ann F Hubbs
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Toxicol Pathol 39:301-24. 2011
    ..This review provides an introduction to the pathology and toxicology of nanoparticulates...
  9. pmc Systemic microvascular dysfunction and inflammation after pulmonary particulate matter exposure
    Timothy R Nurkiewicz
    Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9229, USA
    Environ Health Perspect 114:412-9. 2006
    ..Collectively, these microvascular observations are consistent with events that contribute to the disruption of the control of peripheral resistance and/or cardiac dysfunction associated with PM exposure...
  10. ncbi request reprint Effect of inhaled crystalline silica in a rat model: time course of pulmonary reactions
    Vincent Castranova
    National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Mol Cell Biochem 234:177-84. 2002
    ..This suggests an important role for nitric oxide in the initiation of silicosis...
  11. ncbi request reprint Quantitative image analysis of drug-induced lung fibrosis using laser scanning confocal microscopy
    Michael D Taylor
    Department of Pharmacology and Toxicology, Robert C Byrd Health Sciences Center of West Virginia University, Morgantown, WV 26506, USA
    Toxicol Sci 67:295-302. 2002
    ..LSCM could be particularly useful when tissue quantity is limited, such as when tissue has been archived from previous studies, or when analyzing human lung biopsy samples for disease diagnosis, where biochemical analysis is difficult...
  12. ncbi request reprint Role of inducible nitric oxide synthase-derived nitric oxide in silica-induced pulmonary inflammation and fibrosis
    Patti Zeidler
    National Institute for Occupational Safety and Health, Health Effects Laboratory Division, and Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 67:1001-26. 2004
    ..These results suggest that iNOS-derived NO contributes to the pathogenesis of silica-induced lung disease in this mouse model...
  13. pmc Apoptosis and Bax expression are increased by coal dust in the polycyclic aromatic hydrocarbon-exposed lung
    Mohamed M Ghanem
    Genetics and Developmental Biology Program, West Virginia University, Morgantown, West Virginia, USA
    Environ Health Perspect 114:1367-73. 2006
    ..Recently, apoptosis was reported to play a critical role in the development of another pneumoconiosis of miners, silicosis. In addition, CD was reported to suppress cytochrome P450 1A1 (CYP1A1) induction by PAHs...
  14. ncbi request reprint Pulmonary toxicity of Expancel microspheres in the rat
    Dale W Porter
    National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA
    Toxicol Pathol 35:702-14. 2007
    ..lung (supplementary Figure 1); broncholar epithelium 28 days following exposure to 551 DE 20 microspheres (supplementary Figure 2); membrane ruffling and some instances of phagocytosis within the microspheres (supplementary Figure 3)]..
  15. ncbi request reprint Welding fume exposure and associated inflammatory and hyperplastic changes in the lungs of tumor susceptible a/j mice
    Claudia Solano-Lopez
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA
    Toxicol Pathol 34:364-72. 2006
    ..Our findings that WF causes persistent bronchiolar and peribronchiolar epithelial changes, suggest a need for studies of bronchiolar changes after WF exposure...
  16. doi request reprint Crystalline silica is a negative modifier of pulmonary cytochrome P-4501A1 induction
    Lori A Battelli
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 71:521-32. 2008
    ..Our findings suggest that in PAH-exposed rat lung, silica is a negative modifier of CYP1A1 induction and CYP2B1 activity...
  17. doi request reprint Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes
    Dale W Porter
    National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicology 269:136-47. 2010
    ..Furthermore, the observation that MWCNT reach the pleura after aspiration exposure indicates that more extensive investigations are needed to fully assess if pleural penetration results in any adverse health outcomes...
  18. pmc Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2
    Qiang Ma
    Receptor Biology Laboratory, Toxicology and Molecular Biology Branch Health Effects Laboratory Division National Institute for Occupational Safety and Health Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Am J Pathol 168:1960-74. 2006
    ..Our findings suggest that Nrf2 mediates important antioxidant functions involved in the control of peripheral lymphocyte homeostasis and autoimmune surveillance...
  19. ncbi request reprint Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice
    Anna A Shvedova
    Health Effects Laboratory Div, NIOSH, Morgantown, WV, USA
    Am J Physiol Lung Cell Mol Physiol 289:L698-708. 2005
    ..Equal doses of ultrafine carbon black particles or fine crystalline silica (SiO2) did not induce granulomas or alveolar wall thickening and caused a significantly weaker pulmonary inflammation and damage...
  20. ncbi request reprint Comparative pulmonary toxicity of blasting sand and five substitute abrasive blasting agents
    Dale W Porter
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, M S 2015, Morgantown, WV 26505, USA
    J Toxicol Environ Health A 65:1121-40. 2002
    ..Notwithstanding, the data also suggest that chronic exposure to steel grit may pose a health risk due to its effects on epithelial cell proliferation in the lung...
  21. ncbi request reprint Intratracheal amiodarone administration to F344 rats directly damages lung airway and parenchymal cells
    Michael D Taylor
    Department of Pharmacology and Toxicology, West Virginia University, Morgantown, WV 26506, USA
    Toxicol Appl Pharmacol 188:92-103. 2003
    ..t. AD treatment are similar to the mechanisms that underlie human AIPT. Therefore these data suggest that investigators should use caution in extrapolating results from animal studies that utilize i.t. administration of AD to human AIPT...
  22. pmc Inhalation exposure of rats to asphalt fumes generated at paving temperatures alters pulmonary xenobiotic metabolism pathways without lung injury
    Jane Y C Ma
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 2888, USA
    Environ Health Perspect 111:1215-21. 2003
    ..This induction of CYP1A1 and QR with the concomitant down-regulation of CYP2B1 after asphalt fume exposure could alter PAH metabolism and may lead to potential toxic effects in the lung...
  23. ncbi request reprint Progression of lung inflammation and damage in rats after cessation of silica inhalation
    Dale W Porter
    National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA
    Toxicol Sci 79:370-80. 2004
    ....
  24. doi request reprint Evaluation of furfuryl alcohol sensitization potential following dermal and pulmonary exposure: enhancement of airway responsiveness
    Jennifer Franko
    National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA
    Toxicol Sci 125:105-15. 2012
    ..These results suggest that furfuryl alcohol may play a role in the development of allergic airway disease and encourage the need for additional investigation...
  25. ncbi request reprint Respirable coal dust particles modify cytochrome P4501A1 (CYP1A1) expression in rat alveolar cells
    Mohamed M Ghanem
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Am J Respir Cell Mol Biol 31:171-83. 2004
    ..By Western blot, induction of CYP1A1 protein by BNF was significantly reduced by 40 mg CD compared with BNF alone. These findings indicate that CD decreases BNF-induced CYP1A1 protein expression and activity in the lung...
  26. ncbi request reprint Airway responses in Brown Norway rats following inhalation sensitization and challenge with trimellitic anhydride
    Xing Dong Zhang
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Toxicol Sci 94:322-9. 2006
    ....
  27. ncbi request reprint Regulation of eosinophilopoiesis in a murine model of asthma
    Mary Beth Hogan
    Department of Pediatrics, West Virginia University School of Medicine, PO Box 9214, Morgantown, WV 26506, USA
    J Immunol 171:2644-51. 2003
    ..Differentiation of eosinophil progenitor cells and phenotypic eosinophilia is T cell dependent and does not occur in athymic nude mice exposed to intranasal allergen...
  28. ncbi request reprint Cis-4-[(18)F]fluoro-L-proline PET imaging of pulmonary fibrosis in a rabbit model
    William E Wallace
    National Institute for Occupational Safety and Health NIOSH, Centers for Disease Control and Prevention CDC, Morgantown, West Virginia, USA
    J Nucl Med 43:413-20. 2002
    ..The purpose of the study was to determine whether PET imaging with FP is sensitive for detection of pulmonary fibrosis...
  29. pmc Pulmonary nanoparticle exposure disrupts systemic microvascular nitric oxide signaling
    Timothy R Nurkiewicz
    Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
    Toxicol Sci 110:191-203. 2009
    ..These results indicate that in conjunction with microvascular dysfunction, nanoparticle exposure also decreases NO bioavailability through at least two functionally distinct mechanisms that may mutually increase local reactive species...
  30. ncbi request reprint Efficacy of a technique for exposing the mouse lung to particles aspirated from the pharynx
    G V S Rao
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 66:1441-52. 2003
    ..2% of the administered beryllium. These findings demonstrate that following aspiration of pharyngeal deposited particles, exposures to the deep lung are repeatable, technically simple, and highly correlated to the administered dose...
  31. ncbi request reprint Enhanced nitric oxide and reactive oxygen species production and damage after inhalation of silica
    Dale W Porter
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    Am J Physiol Lung Cell Mol Physiol 283:L485-93. 2002
    ....
  32. pmc Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2
    Ann F Hubbs
    Experimental Pathology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health CDC, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Am J Pathol 170:2068-76. 2007
    ..If this role is confirmed, it may suggest new approaches to treating genetically and chemically induced myelin degenerative diseases...
  33. pmc Priorities for development of research methods in occupational cancer
    Elizabeth M Ward
    National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA
    Environ Health Perspect 111:1-12. 2003
    ..Progress in occupational cancer will require interdisciplinary research involving epidemiologists, industrial hygienists, toxicologists, and molecular biologists...
  34. ncbi request reprint IGF-I, IGF-II, and IGF-receptor-1 transcript and IGF-II protein expression in myostatin knockout mice tissues
    Hakan Kocamis
    Division of Histology and Embryology, Kafkas University, Kars, Turkey
    Muscle Nerve 26:55-63. 2002
    ..Reciprocal changes in the expression of myostatin and IGF-II and IGF-R1 may underlie normal growth of skeletal muscle and other organs in mammals, and the changes in these tissues associated with disease...