Research Topics
| Ann HubbsSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
| Collaborators
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Detail Information
Publications
Nanotechnology: toxicologic pathologyAnn F Hubbs
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Toxicol Pathol 41:395-409. 2013..Thus, the pathology assessment is facilitated by understanding the unique features at the nanoscale and the tools that can assist in evaluating nanotoxicology studies...- Respiratory and olfactory cytotoxicity of inhaled 2,3-pentanedione in Sprague-Dawley ratsAnn F Hubbs
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Am J Pathol 181:829-44. 2012..Claudin-1 expression increased in the OB and striatum. We conclude that 2,3-pentanedione is a respiratory hazard that can also alter gene expression in the brain... 
Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubesRobert R Mercer
Pathology and Physiology Research Branch, HELD, NIOSH, Morgantown, WV, USA
Part Fibre Toxicol 8:21. 2011..Morphometric measurement of Sirius Red staining was used to assess the connective tissue response...- Distribution and persistence of pleural penetrations by multi-walled carbon nanotubesRobert R Mercer
Pathology and Physiology Research Branch, HELD, NIOSH, Morgantown, WV, USA
Part Fibre Toxicol 7:28. 2010.... 
Abrasive blasting agents: designing studies to evaluate relative riskAnn Hubbs
National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
J Toxicol Environ Health A 68:999-1016. 2005..This design will facilitate assessment of the pulmonary fibrogenic potential of inhaled abrasive blasting agents at occupationally relevant concentrations...- Respiratory toxicologic pathology of inhaled diacetyl in sprague-dawley ratsAnn F Hubbs
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
Toxicol Pathol 36:330-44. 2008..Edema and hemorrhage extended into the lamina propria. These findings are consistent with the conclusion that inhaled diacetyl is a respiratory hazard... - Coal dust alters beta-naphthoflavone-induced aryl hydrocarbon receptor nuclear translocation in alveolar type II cellsMohamed M Ghanem
Genetics and Developmental Biology Program, West Virginia University, Morgantown, WV 26506, USA
Part Fibre Toxicol 6:21. 2009..abstract:.. - Nanotoxicology--a pathologist's perspectiveAnn F Hubbs
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
Toxicol Pathol 39:301-24. 2011..This review provides an introduction to the pathology and toxicology of nanoparticulates... - Systemic microvascular dysfunction and inflammation after pulmonary particulate matter exposureTimothy R Nurkiewicz
Department of Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9229, USA
Environ Health Perspect 114:412-9. 2006..Collectively, these microvascular observations are consistent with events that contribute to the disruption of the control of peripheral resistance and/or cardiac dysfunction associated with PM exposure... - Effect of inhaled crystalline silica in a rat model: time course of pulmonary reactionsVincent Castranova
National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Mol Cell Biochem 234:177-84. 2002..This suggests an important role for nitric oxide in the initiation of silicosis... - Quantitative image analysis of drug-induced lung fibrosis using laser scanning confocal microscopyMichael D Taylor
Department of Pharmacology and Toxicology, Robert C. Byrd Health Sciences Center of West Virginia University, Morgantown, WV 26506, USA
Toxicol Sci 67:295-302. 2002..LSCM could be particularly useful when tissue quantity is limited, such as when tissue has been archived from previous studies, or when analyzing human lung biopsy samples for disease diagnosis, where biochemical analysis is difficult... - Role of inducible nitric oxide synthase-derived nitric oxide in silica-induced pulmonary inflammation and fibrosisPatti Zeidler
National Institute for Occupational Safety and Health, Health Effects Laboratory Division, and Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26505, USA
J Toxicol Environ Health A 67:1001-26. 2004..These results suggest that iNOS-derived NO contributes to the pathogenesis of silica-induced lung disease in this mouse model... - Apoptosis and Bax expression are increased by coal dust in the polycyclic aromatic hydrocarbon-exposed lungMohamed M Ghanem
Genetics and Developmental Biology Program, West Virginia University, Morgantown, West Virginia, USA
Environ Health Perspect 114:1367-73. 2006..Recently, apoptosis was reported to play a critical role in the development of another pneumoconiosis of miners, silicosis. In addition, CD was reported to suppress cytochrome P450 1A1 (CYP1A1) induction by PAHs... - Pulmonary toxicity of Expancel microspheres in the ratDale W Porter
National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA
Toxicol Pathol 35:702-14. 2007..lung (supplementary Figure 1); broncholar epithelium 28 days following exposure to 551 DE 20 microspheres (supplementary Figure 2); membrane ruffling and some instances of phagocytosis within the microspheres (supplementary Figure 3)].. - Welding fume exposure and associated inflammatory and hyperplastic changes in the lungs of tumor susceptible a/j miceClaudia Solano-Lopez
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA
Toxicol Pathol 34:364-72. 2006..Our findings that WF causes persistent bronchiolar and peribronchiolar epithelial changes, suggest a need for studies of bronchiolar changes after WF exposure... - Crystalline silica is a negative modifier of pulmonary cytochrome P-4501A1 inductionLori A Battelli
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
J Toxicol Environ Health A 71:521-32. 2008..Our findings suggest that in PAH-exposed rat lung, silica is a negative modifier of CYP1A1 induction and CYP2B1 activity... - Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubesDale W Porter
National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Toxicology 269:136-47. 2010..Furthermore, the observation that MWCNT reach the pleura after aspiration exposure indicates that more extensive investigations are needed to fully assess if pleural penetration results in any adverse health outcomes... - Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2Qiang Ma
Receptor Biology Laboratory, Toxicology and Molecular Biology Branch Health Effects Laboratory Division National Institute for Occupational Safety and Health Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Am J Pathol 168:1960-74. 2006..Our findings suggest that Nrf2 mediates important antioxidant functions involved in the control of peripheral lymphocyte homeostasis and autoimmune surveillance... - Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in miceAnna A Shvedova
Health Effects Laboratory Div, NIOSH, Morgantown, WV, USA
Am J Physiol Lung Cell Mol Physiol 289:L698-708. 2005..Equal doses of ultrafine carbon black particles or fine crystalline silica (SiO2) did not induce granulomas or alveolar wall thickening and caused a significantly weaker pulmonary inflammation and damage... - Comparative pulmonary toxicity of blasting sand and five substitute abrasive blasting agentsDale W Porter
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, M S 2015, Morgantown, WV 26505, USA
J Toxicol Environ Health A 65:1121-40. 2002..Notwithstanding, the data also suggest that chronic exposure to steel grit may pose a health risk due to its effects on epithelial cell proliferation in the lung... - Intratracheal amiodarone administration to F344 rats directly damages lung airway and parenchymal cellsMichael D Taylor
Department of Pharmacology and Toxicology, West Virginia University, Morgantown, WV 26506, USA
Toxicol Appl Pharmacol 188:92-103. 2003..t. AD treatment are similar to the mechanisms that underlie human AIPT. Therefore these data suggest that investigators should use caution in extrapolating results from animal studies that utilize i.t. administration of AD to human AIPT... - Inhalation exposure of rats to asphalt fumes generated at paving temperatures alters pulmonary xenobiotic metabolism pathways without lung injuryJane Y C Ma
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 2888, USA
Environ Health Perspect 111:1215-21. 2003..This induction of CYP1A1 and QR with the concomitant down-regulation of CYP2B1 after asphalt fume exposure could alter PAH metabolism and may lead to potential toxic effects in the lung... - Progression of lung inflammation and damage in rats after cessation of silica inhalationDale W Porter
National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA
Toxicol Sci 79:370-80. 2004.... - Evaluation of furfuryl alcohol sensitization potential following dermal and pulmonary exposure: enhancement of airway responsivenessJennifer Franko
National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA
Toxicol Sci 125:105-15. 2012..These results suggest that furfuryl alcohol may play a role in the development of allergic airway disease and encourage the need for additional investigation... - Respirable coal dust particles modify cytochrome P4501A1 (CYP1A1) expression in rat alveolar cellsMohamed M Ghanem
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Am J Respir Cell Mol Biol 31:171-83. 2004..By Western blot, induction of CYP1A1 protein by BNF was significantly reduced by 40 mg CD compared with BNF alone. These findings indicate that CD decreases BNF-induced CYP1A1 protein expression and activity in the lung... - Airway responses in Brown Norway rats following inhalation sensitization and challenge with trimellitic anhydrideXing-Dong Zhang
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Toxicol Sci 94:322-9. 2006.... - Enhanced nitric oxide and reactive oxygen species production and damage after inhalation of silicaDale W Porter
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
Am J Physiol Lung Cell Mol Physiol 283:L485-93. 2002.... - Regulation of eosinophilopoiesis in a murine model of asthmaMary Beth Hogan
Department of Pediatrics, West Virginia University School of Medicine, PO Box 9214, Morgantown, WV 26506, USA
J Immunol 171:2644-51. 2003..Differentiation of eosinophil progenitor cells and phenotypic eosinophilia is T cell dependent and does not occur in athymic nude mice exposed to intranasal allergen... - Cis-4-[(18)F]fluoro-L-proline PET imaging of pulmonary fibrosis in a rabbit modelWilliam E Wallace
National Institute for Occupational Safety and Health (NIOSH, Centers for Disease Control and Prevention (CDC, Morgantown, West Virginia, USA
J Nucl Med 43:413-20. 2002..Additional studies are needed to determine the specificity of the FP tracer for fibrosis versus inflammatory processes... - Pulmonary nanoparticle exposure disrupts systemic microvascular nitric oxide signalingTimothy R Nurkiewicz
Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
Toxicol Sci 110:191-203. 2009..These results indicate that in conjunction with microvascular dysfunction, nanoparticle exposure also decreases NO bioavailability through at least two functionally distinct mechanisms that may mutually increase local reactive species... - Efficacy of a technique for exposing the mouse lung to particles aspirated from the pharynxG V S Rao
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
J Toxicol Environ Health A 66:1441-52. 2003..2% of the administered beryllium. These findings demonstrate that following aspiration of pharyngeal deposited particles, exposures to the deep lung are repeatable, technically simple, and highly correlated to the administered dose... - Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2Ann F Hubbs
Experimental Pathology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health CDC, 1095 Willowdale Road, Morgantown, WV 26505, USA
Am J Pathol 170:2068-76. 2007..If this role is confirmed, it may suggest new approaches to treating genetically and chemically induced myelin degenerative diseases... - Priorities for development of research methods in occupational cancerElizabeth M Ward
National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA
Environ Health Perspect 111:1-12. 2003..Progress in occupational cancer will require interdisciplinary research involving epidemiologists, industrial hygienists, toxicologists, and molecular biologists... - IGF-I, IGF-II, and IGF-receptor-1 transcript and IGF-II protein expression in myostatin knockout mice tissuesHakan Kocamis
Division of Histology and Embryology, Kafkas University, Kars, Turkey
Muscle Nerve 26:55-63. 2002..Reciprocal changes in the expression of myostatin and IGF-II and IGF-R1 may underlie normal growth of skeletal muscle and other organs in mammals, and the changes in these tissues associated with disease...