Claire Y H Huang

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. pmc Dengue 2 PDK-53 virus as a chimeric carrier for tetravalent dengue vaccine development
    Claire Y H Huang
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, Colorado 80522, USA
    J Virol 77:11436-47. 2003
  2. ncbi request reprint Avian virulence and thermostable replication of the North American strain of West Nile virus
    Richard M Kinney
    Division of Vector Borne Infectious Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA
    J Gen Virol 87:3611-22. 2006
  3. pmc Genetic and phenotypic characterization of manufacturing seeds for a tetravalent dengue vaccine (DENVax)
    Claire Y H Huang
    Arboviral Diseases Branch, Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA
    PLoS Negl Trop Dis 7:e2243. 2013
  4. doi request reprint The dengue virus type 2 envelope protein fusion peptide is essential for membrane fusion
    Claire Y H Huang
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, 3150 Rampart Rd, Fort Collins, CO 80521, USA
    Virology 396:305-15. 2010
  5. pmc Chimeric dengue 2 PDK-53/West Nile NY99 viruses retain the phenotypic attenuation markers of the candidate PDK-53 vaccine virus and protect mice against lethal challenge with West Nile virus
    Claire Y H Huang
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, P O Box 2087, Fort Collins, CO 80522, USA
    J Virol 79:7300-10. 2005
  6. doi request reprint Domain-III FG loop of the dengue virus type 2 envelope protein is important for infection of mammalian cells and Aedes aegypti mosquitoes
    Steven M Erb
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Virology 406:328-35. 2010
  7. doi request reprint Amino acid changes within the E protein hinge region that affect dengue virus type 2 infectivity and fusion
    Siritorn Butrapet
    Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA
    Virology 413:118-27. 2011
  8. doi request reprint Mutation of the dengue virus type 2 envelope protein heparan sulfate binding sites or the domain III lateral ridge blocks replication in Vero cells prior to membrane fusion
    John T Roehrig
    Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA
    Virology 441:114-25. 2013
  9. doi request reprint Mutations in the West Nile prM protein affect VLP and virion secretion in vitro
    Amanda E Calvert
    Arbovirus Diseases Branch, Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Fort Collins, CO 80521, USA
    Virology 433:35-44. 2012
  10. ncbi request reprint Non-structural proteins of dengue 2 virus offer limited protection to interferon-deficient mice after dengue 2 virus challenge
    Amanda E Calvert
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention CDC, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA
    J Gen Virol 87:339-46. 2006

Collaborators

Detail Information

Publications19

  1. pmc Dengue 2 PDK-53 virus as a chimeric carrier for tetravalent dengue vaccine development
    Claire Y H Huang
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, Colorado 80522, USA
    J Virol 77:11436-47. 2003
    ..The results of this study demonstrate that the unique attenuation loci of D2 PDK-53 virus make it an attractive vector for the development of live attenuated flavivirus vaccines...
  2. ncbi request reprint Avian virulence and thermostable replication of the North American strain of West Nile virus
    Richard M Kinney
    Division of Vector Borne Infectious Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA
    J Gen Virol 87:3611-22. 2006
    ..These results indicated that the ability of WNV NY99 to replicate at the high temperatures measured in infected AMCRs could be an important factor leading to the increased avian virulence and emergence of this strain of WNV...
  3. pmc Genetic and phenotypic characterization of manufacturing seeds for a tetravalent dengue vaccine (DENVax)
    Claire Y H Huang
    Arboviral Diseases Branch, Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA
    PLoS Negl Trop Dis 7:e2243. 2013
    ..These viruses, containing the pre-membrane (prM) and envelope (E) genes of dengue serotypes 1-4 in the replicative background of the attenuated dengue-2 PDK-53 vaccine virus candidate, were manufactured under cGMP...
  4. doi request reprint The dengue virus type 2 envelope protein fusion peptide is essential for membrane fusion
    Claire Y H Huang
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, 3150 Rampart Rd, Fort Collins, CO 80521, USA
    Virology 396:305-15. 2010
    ..Mutations of the FP also resulted in reduced virus reactivity with flavivirus group-reactive antibodies, confirming earlier reports using virus-like particles...
  5. pmc Chimeric dengue 2 PDK-53/West Nile NY99 viruses retain the phenotypic attenuation markers of the candidate PDK-53 vaccine virus and protect mice against lethal challenge with West Nile virus
    Claire Y H Huang
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, P O Box 2087, Fort Collins, CO 80522, USA
    J Virol 79:7300-10. 2005
    ....
  6. doi request reprint Domain-III FG loop of the dengue virus type 2 envelope protein is important for infection of mammalian cells and Aedes aegypti mosquitoes
    Steven M Erb
    Arthropod Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Virology 406:328-35. 2010
    ..Reduced binding of DENV2 type-specific monoclonal antibody 3H5 to mutant viruses confirmed the FG loop motif as its target epitope...
  7. doi request reprint Amino acid changes within the E protein hinge region that affect dengue virus type 2 infectivity and fusion
    Siritorn Butrapet
    Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA
    Virology 413:118-27. 2011
    ..Possible interactions between hinge residues 52 and 277, or among 53, 135, 170, 186, 265, and 276 required for hinge function were discovered by sequence analysis to identify compensatory mutations...
  8. doi request reprint Mutation of the dengue virus type 2 envelope protein heparan sulfate binding sites or the domain III lateral ridge blocks replication in Vero cells prior to membrane fusion
    John T Roehrig
    Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA
    Virology 441:114-25. 2013
    ..Additionally, both mutants were unable to initiate negative-strand vRNA synthesis in Vero cells by 72h post-infection, suggesting that the replication block occurred prior to virus-mediated membrane fusion...
  9. doi request reprint Mutations in the West Nile prM protein affect VLP and virion secretion in vitro
    Amanda E Calvert
    Arbovirus Diseases Branch, Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Fort Collins, CO 80521, USA
    Virology 433:35-44. 2012
    ..This difference may be due to the quantity of prM in WN VLPs compared to WNV or to differences in maturation, structure, and symmetry of these particles...
  10. ncbi request reprint Non-structural proteins of dengue 2 virus offer limited protection to interferon-deficient mice after dengue 2 virus challenge
    Amanda E Calvert
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention CDC, Public Health Service, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA
    J Gen Virol 87:339-46. 2006
    ..These results suggest that, whilst the non-structural proteins were able to enhance mean survival times of AG129 mice, this protection was not as effective as protection mediated by the E protein...
  11. ncbi request reprint Determining genetic stabilities of chimeric dengue vaccine candidates based on dengue 2 PDK-53 virus by sequencing and quantitative TaqMAMA
    Siritorn Butrapet
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, P O Box 2087, Fort Collins, CO 80522, USA
    J Virol Methods 131:1-9. 2006
    ..The TaqMAMA can be applied in quality control analyses to ensure that attenuated vaccine seeds contain undetectable or minimal levels of reversion at a given attenuation locus...
  12. ncbi request reprint Glycosylation of the dengue 2 virus E protein at N67 is critical for virus growth in vitro but not for growth in intrathoracically inoculated Aedes aegypti mosquitoes
    Juliet E Bryant
    Arboviral Diseases Branch, Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U S Department of Health and Human Services, Fort Collins, CO 80522, USA
    Virology 366:415-23. 2007
    ....
  13. pmc Inhibition of dengue virus serotypes 1 to 4 in vero cell cultures with morpholino oligomers
    Richard M Kinney
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U S Department of Health and Human Services, Fort Collins, Colorado, USA
    J Virol 79:5116-28. 2005
    ..The 5'SL and 3'CS P4-PMOs did not suppress the replication of West Nile virus NY99 in Vero cells. These data indicate that further evaluation of the 5'SL and 3'CS compounds as potential DEN virus therapeutics is warranted...
  14. doi request reprint Development of DENVax: a chimeric dengue-2 PDK-53-based tetravalent vaccine for protection against dengue fever
    Jorge E Osorio
    Inviragen, Inc, Fort Collins, CO 80525, USA
    Vaccine 29:7251-60. 2011
    ..Based on the safety, immunogenicity and efficacy in preclinical studies, Phase 1 clinical testing of DENVax has been initiated...
  15. doi request reprint Treatment of AG129 mice with antisense morpholino oligomers increases survival time following challenge with dengue 2 virus
    David A Stein
    AVI BioPharma Inc, 4575 SW Research Way, Corvallis, OR 97333, USA
    J Antimicrob Chemother 62:555-65. 2008
    ..To determine the antiviral activity of phosphorodiamidate morpholino oligomers (PMO) and peptide-conjugated PMO (PPMO) in AG129 mice infected with dengue 2 virus (DENV-2)...
  16. pmc A single positively selected West Nile viral mutation confers increased virogenesis in American crows
    Aaron C Brault
    Center for Vector Borne Diseases and Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Nat Genet 39:1162-6. 2007
    ..These phenotypic and evolutionary results provide compelling evidence for the positive selection of a mutation encoding increased viremia potential and virulence in the AMCR sentinel bird species...
  17. ncbi request reprint A mutation in the envelope protein fusion loop attenuates mouse neuroinvasiveness of the NY99 strain of West Nile virus
    Shuliu Zhang
    Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0609, USA
    Virology 353:35-40. 2006
    ..MAb 3D9 was subsequently shown to be broadly cross-reactive with other flaviviruses, consistent with binding near the highly conserved fusion loop...
  18. pmc Envelope protein glycosylation status influences mouse neuroinvasion phenotype of genetic lineage 1 West Nile virus strains
    David W C Beasley
    Department of Pathology, Cancer Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555 0609, USA
    J Virol 79:8339-47. 2005
    ..Therefore, the enhanced virulence of North American WNV strains compared with other Old World lineage 1 strains is at least partly mediated by envelope protein glycosylation...
  19. ncbi request reprint Seroprevalence and distribution of Flaviviridae, Togaviridae, and Bunyaviridae arboviral infections in rural Cameroonian adults
    Mark H Kuniholm
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Am J Trop Med Hyg 74:1078-83. 2006
    ..Seroprevalence rates of YF and CHIK increased with age. These results suggest that inter-epidemic arboviral infection is common in central African populations...