Fernando Holguin

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi request reprint Cardiac autonomic changes associated with fish oil vs soy oil supplementation in the elderly
    Fernando Holguin
    Emory University School of Medicine, 1600 Clifton Rd, MS E 17, Atlanta, GA 30333, USA
    Chest 127:1102-7. 2005
  2. pmc The molecular phenotype of severe asthma in children
    Anne M Fitzpatrick
    Emory University School of Medicine, Atlanta, GA, USA
    J Allergy Clin Immunol 125:851-857.e18. 2010
  3. ncbi request reprint Air pollution and heart rate variability among the elderly in Mexico City
    Fernando Holguin
    Emory University School of Medicine, Atlanta, GA 30335, USA
    Epidemiology 14:521-7. 2003
  4. ncbi request reprint Country of birth as a risk factor for asthma among Mexican Americans
    Fernando Holguin
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Respir Crit Care Med 171:103-8. 2005
  5. ncbi request reprint Comorbidity and mortality in COPD-related hospitalizations in the United States, 1979 to 2001
    Fernando Holguin
    Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Chest 128:2005-11. 2005
  6. ncbi request reprint The peroxisome proliferator activated receptor gamma (PPARgamma) ligand rosiglitazone modulates bronchoalveolar lavage levels of leptin, adiponectin, and inflammatory cytokines in lean and obese mice
    Fernando Holguin
    Emory University and the Atlanta Veterans Affairs Medical Center, Atlanta, Georgia 30308, USA
    Lung 185:367-72. 2007
  7. pmc Glutathione oxidation is associated with airway macrophage functional impairment in children with severe asthma
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Pediatr Res 69:154-9. 2011
  8. pmc Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    J Allergy Clin Immunol 124:990-6.e1-9. 2009
  9. doi request reprint Associations between urban air pollution and pediatric asthma control in El Paso, Texas
    Jennifer E Zora
    Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Sci Total Environ 448:56-65. 2013
  10. pmc Airway and plasma leptin and adiponectin in lean and obese asthmatics and controls
    Fernando Holguin
    Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Asthma Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Asthma 48:217-23. 2011

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Cardiac autonomic changes associated with fish oil vs soy oil supplementation in the elderly
    Fernando Holguin
    Emory University School of Medicine, 1600 Clifton Rd, MS E 17, Atlanta, GA 30333, USA
    Chest 127:1102-7. 2005
    ....
  2. pmc The molecular phenotype of severe asthma in children
    Anne M Fitzpatrick
    Emory University School of Medicine, Atlanta, GA, USA
    J Allergy Clin Immunol 125:851-857.e18. 2010
    ..Although the clinical attributes of severe asthma in children have been well described, the differentiating features of the lower airway inflammatory response are less understood...
  3. ncbi request reprint Air pollution and heart rate variability among the elderly in Mexico City
    Fernando Holguin
    Emory University School of Medicine, Atlanta, GA 30335, USA
    Epidemiology 14:521-7. 2003
    ..Suspended particles and ozone have been associated with varying degrees of cardiac autonomic dysfunction...
  4. ncbi request reprint Country of birth as a risk factor for asthma among Mexican Americans
    Fernando Holguin
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Respir Crit Care Med 171:103-8. 2005
    ..6-5.5). In conclusion, the prevalence of asthma was higher in U.S.-born than in Mexican-born Mexican Americans. This finding highlights the importance of environmental exposures in developing asthma in a migratory population...
  5. ncbi request reprint Comorbidity and mortality in COPD-related hospitalizations in the United States, 1979 to 2001
    Fernando Holguin
    Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Chest 128:2005-11. 2005
    ..COPD is one of the leading causes of mortality and morbidity in the United States, yet little is known about the prevalence of comorbid conditions and mortality in hospitalized patients with COPD...
  6. ncbi request reprint The peroxisome proliferator activated receptor gamma (PPARgamma) ligand rosiglitazone modulates bronchoalveolar lavage levels of leptin, adiponectin, and inflammatory cytokines in lean and obese mice
    Fernando Holguin
    Emory University and the Atlanta Veterans Affairs Medical Center, Atlanta, Georgia 30308, USA
    Lung 185:367-72. 2007
    ..These results demonstrate that obesity is associated with alterations in adipokine and cytokine levels in the airways that can be modulated by treatment with roziglitazone...
  7. pmc Glutathione oxidation is associated with airway macrophage functional impairment in children with severe asthma
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Pediatr Res 69:154-9. 2011
    ..Severe asthma in children is characterized by altered airway and intracellular AM GSH homeostasis that translates to impaired AM function. Interventions to restore airway GSH homeostasis may be warranted in children with severe asthma...
  8. pmc Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    J Allergy Clin Immunol 124:990-6.e1-9. 2009
    ..Children with severe allergic asthma have persistent airway inflammation and oxidant stress...
  9. doi request reprint Associations between urban air pollution and pediatric asthma control in El Paso, Texas
    Jennifer E Zora
    Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Sci Total Environ 448:56-65. 2013
    ....
  10. pmc Airway and plasma leptin and adiponectin in lean and obese asthmatics and controls
    Fernando Holguin
    Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Asthma Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Asthma 48:217-23. 2011
    ..However, it is unknown whether obesity induces similar changes in airway levels of these adipokines and whether these changes are associated with increased airway biomarkers of inflammation and oxidative stress...
  11. pmc An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype
    Fernando Holguin
    Asthma Institute, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, MUH 628, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA
    Am J Respir Crit Care Med 187:153-9. 2013
    ..This may be explained by an increase in the concentration of asymmetric dimethyl arginine (ADMA) relative to L-arginine, which can lead to greater nitric oxide synthase uncoupling...
  12. pmc Air pollution and acute respiratory response in a panel of asthmatic children along the U.S.-Mexico border
    Stefanie Ebelt Sarnat
    Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Environ Health Perspect 120:437-44. 2012
    ..Concerns regarding the health impact of urban air pollution on asthmatic children are pronounced along the U.S.-Mexico border because of rapid population growth near busy border highways and roads...
  13. pmc Airway glutathione homeostasis is altered in children with severe asthma: evidence for oxidant stress
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    J Allergy Clin Immunol 123:146-152.e8. 2009
    ..Severe asthma is characterized by persistent airway inflammation and increased formation of reactive oxygen species...
  14. ncbi request reprint Traffic-related exposures, airway function, inflammation, and respiratory symptoms in children
    Fernando Holguin
    Emory University, Atlanta, Georgia, USA
    Am J Respir Crit Care Med 176:1236-42. 2007
    ..Traffic-related emissions have been associated with respiratory symptoms in some studies. However, there is limited information on how traffic-related emissions relate to lung function and airway inflammation...
  15. doi request reprint Racial and ethnic disparities in asthma medication usage and health-care utilization: data from the National Asthma Survey
    Deidre Crocker
    Air Pollution and Respiratory HealthBranch, Centers for Disease Control and Prevention, Atlanta GA 30341, USA
    Chest 136:1063-71. 2009
    ..Our objective was to identify and characterize racial and ethnic disparities in health-care utilization and medication usage among US children with asthma in a large multistate asthma survey...
  16. pmc Prostaglandin Dâ‚‚ pathway upregulation: relation to asthma severity, control, and TH2 inflammation
    Merritt L Fajt
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh Asthma Institute at UPMC University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 131:1504-12. 2013
    ..However, much remains to be understood regarding the presence and activation of these pathway elements in asthmatic patients...
  17. pmc Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics
    Sushma Komakula
    Department of Medicine, Emory University, Atlanta, USA
    Respir Res 8:32. 2007
    ....
  18. ncbi request reprint What is the cost to employers of direct medical care for chronic obstructive pulmonary disease?
    Tursynbek Nurmagambetov
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Environmental Hazards and Health Effects, Air Pollution and Respiratory Health Branch, Atlanta, Georgia 30333, USA
    COPD 3:203-9. 2006
    ..The cost of COPD to employers is high, but the cost could be reduced by programs aimed at preventing new cases of COPD, reducing hospitalizations, and providing more outpatient services to COPD patients...
  19. pmc Epithelial eotaxin-2 and eotaxin-3 expression: relation to asthma severity, luminal eosinophilia and age at onset
    John M Coleman
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh Asthma Institute at UPMC UPSOM, Pittsburgh, PA 15213, USA
    Thorax 67:1061-6. 2012
    ..However, the epithelial and bronchoalveolar lavage (BAL) cell expression of these chemokines in relation to asthma severity and eosinophilic phenotypes has not been addressed...
  20. doi request reprint Trends in hospitalizations for AIDS-associated Pneumocystis jirovecii Pneumonia in the United States (1986 to 2005)
    Colleen F Kelley
    Department of Medicine, Division of Infectious Diseases and the Emory Centerfor AIDS Research, Emory University, Atlanta, GA, USA
    Chest 136:190-7. 2009
    ....
  21. pmc Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    J Allergy Clin Immunol 127:382-389.e1-13. 2011
    ..Although unsupervised cluster analysis is a useful tool for identifying phenotypes, it has not been applied to school-age children with persistent asthma across a wide range of severities...
  22. pmc Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    J Allergy Clin Immunol 121:1372-8, 1378.e1-3. 2008
    ..Lower respiratory tract infection is a differentiating feature of children with poorly controlled asthma...
  23. ncbi request reprint Asthma and air quality
    Jeremy A Sarnat
    Clinical Research Center, Crawford Long Hospital, Emory University, Atlanta, Georgia 30308, USA
    Curr Opin Pulm Med 13:63-6. 2007
    ....
  24. ncbi request reprint Traffic, outdoor air pollution, and asthma
    Fernando Holguin
    Emory University School of Medicine, Division of Pulmonary, Allergy, and Critical Care, Clinical Research Center, Atlanta, GA 30308, USA
    Immunol Allergy Clin North Am 28:577-88, viii-ix. 2008
    ..This article presents an overview of the mechanisms by which outdoor air pollution and traffic-related emissions lead to changes in respiratory health and lung function in subjects with asthma...
  25. doi request reprint Prognostic factors for hospital mortality and ICU admission in patients with ANCA-related pulmonary vasculitis
    Fernando Holguin
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Med Sci 336:321-6. 2008
    ..The objective of this study was to evaluate the factors predictive of 28-day mortality and admission to Intensive Care Unit (ICU) in patients with ANCA-related pulmonary vasculitis...
  26. ncbi request reprint Asthma phenotypes, risk factors, and measures of severity in a national sample of US children
    Colleen F Kelley
    Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    Pediatrics 115:726-31. 2005
    ..To examine a nationally representative sample of US children aged 6 to 16 years old and determine whether there are differences in risk factors and measures of severity between children with different asthma phenotypes...
  27. doi request reprint Acute health effects after exposure to chlorine gas released after a train derailment
    David Van Sickle
    Epidemic Intelligence Service, Air Pollution and Respiratory Health Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Emerg Med 27:1-7. 2009
    ..Pulse oximetry and arterial blood gas analysis provided early indications of outcome severity...