Walid Heneine

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. pmc HIV prevention by oral preexposure prophylaxis
    Walid Heneine
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Cold Spring Harb Perspect Med 2:a007419. 2012
  2. pmc Genetic characterization of the complete genome of a highly divergent simian T-lymphotropic virus (STLV) type 3 from a wild Cercopithecus mona monkey
    David M Sintasath
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore MD 21205, USA
    Retrovirology 6:97. 2009
  3. doi request reprint Intermittent prophylaxis with oral truvada protects macaques from rectal SHIV infection
    J Gerardo Garcia-Lerma
    Division of HIV AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA
    Sci Transl Med 2:14ra4. 2010
  4. pmc Reduced inflammation and CD4 loss in acute SHIV infection during oral pre-exposure prophylaxis
    Ellen N Kersh
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 206:770-9. 2012
  5. doi request reprint Short communication: no evidence of occult SHIV infection as demonstrated by CD8+ cell depletion after chemoprophylaxis-induced protection from mucosal infection in rhesus macaques
    Ellen N Kersh
    Division of HIV AIDS Prevention, NCHHSTP, CCID, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 24:543-6. 2008
  6. pmc Natural substrate concentrations can modulate the prophylactic efficacy of nucleotide HIV reverse transcriptase inhibitors
    J Gerardo Garcia-Lerma
    Division of HIV AIDS Prevention, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA
    J Virol 85:6610-7. 2011
  7. pmc T cell chemo-vaccination effects after repeated mucosal SHIV exposures and oral pre-exposure prophylaxis
    Ellen N Kersh
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 6:e19295. 2011
  8. pmc Protection against rectal transmission of an emtricitabine-resistant simian/human immunodeficiency virus SHIV162p3M184V mutant by intermittent prophylaxis with Truvada
    Mian er Cong
    Laboratory Branch, CDC, Division of HIV AIDS Prevention, MS G45, 1600 Clifton Road, Atlanta, GA 30329, USA
    J Virol 85:7933-6. 2011
  9. pmc Durable protection from vaginal simian-human immunodeficiency virus infection in macaques by tenofovir gel and its relationship to drug levels in tissue
    Charles Dobard
    Laboratory Branch and Quantitative Sciences and Data Management Branch, Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 86:718-25. 2012
  10. pmc Prevention of vaginal SHIV transmission in macaques by a coitally-dependent Truvada regimen
    Jessica Radzio
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 7:e50632. 2012

Collaborators

Detail Information

Publications58

  1. pmc HIV prevention by oral preexposure prophylaxis
    Walid Heneine
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Cold Spring Harb Perspect Med 2:a007419. 2012
    ..Here we outline the preclinical and clinical research on oral PrEP, pharmacologic considerations, and future directions and challenges...
  2. pmc Genetic characterization of the complete genome of a highly divergent simian T-lymphotropic virus (STLV) type 3 from a wild Cercopithecus mona monkey
    David M Sintasath
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore MD 21205, USA
    Retrovirology 6:97. 2009
    ....
  3. doi request reprint Intermittent prophylaxis with oral truvada protects macaques from rectal SHIV infection
    J Gerardo Garcia-Lerma
    Division of HIV AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA
    Sci Transl Med 2:14ra4. 2010
    ..They strengthen the possibility of developing feasible, cost-effective strategies to prevent HIV transmission in humans...
  4. pmc Reduced inflammation and CD4 loss in acute SHIV infection during oral pre-exposure prophylaxis
    Ellen N Kersh
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 206:770-9. 2012
    ..We addressed the hypothesis that SHIV(SF162P3) infection despite active PrEP results in altered early immune parameters, compared with untreated infection...
  5. doi request reprint Short communication: no evidence of occult SHIV infection as demonstrated by CD8+ cell depletion after chemoprophylaxis-induced protection from mucosal infection in rhesus macaques
    Ellen N Kersh
    Division of HIV AIDS Prevention, NCHHSTP, CCID, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 24:543-6. 2008
    ..These data provide important information for PrEP usage to prevent HIV transmission, and fully support the continued pursuit of PrEP prevention measures in humans...
  6. pmc Natural substrate concentrations can modulate the prophylactic efficacy of nucleotide HIV reverse transcriptase inhibitors
    J Gerardo Garcia-Lerma
    Division of HIV AIDS Prevention, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA
    J Virol 85:6610-7. 2011
    ....
  7. pmc T cell chemo-vaccination effects after repeated mucosal SHIV exposures and oral pre-exposure prophylaxis
    Ellen N Kersh
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 6:e19295. 2011
    ..Our findings highlight the importance of monitoring these responses in clinical PrEP trials and suggest that a combination of vaccines and PrEP potentially might enhance efficacy...
  8. pmc Protection against rectal transmission of an emtricitabine-resistant simian/human immunodeficiency virus SHIV162p3M184V mutant by intermittent prophylaxis with Truvada
    Mian er Cong
    Laboratory Branch, CDC, Division of HIV AIDS Prevention, MS G45, 1600 Clifton Road, Atlanta, GA 30329, USA
    J Virol 85:7933-6. 2011
    ..Increased susceptibility to tenofovir due to M184V and other factors, including residual antiviral activity by FTC and/or reduced virus fitness due to M184V, may all have contributed to the observed protection...
  9. pmc Durable protection from vaginal simian-human immunodeficiency virus infection in macaques by tenofovir gel and its relationship to drug levels in tissue
    Charles Dobard
    Laboratory Branch and Quantitative Sciences and Data Management Branch, Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 86:718-25. 2012
    ..The identification of protective TFV-DP concentrations in vaginal lymphocytes may facilitate the evaluation of improved delivery methods of topical TFV and inform clinical studies...
  10. pmc Prevention of vaginal SHIV transmission in macaques by a coitally-dependent Truvada regimen
    Jessica Radzio
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 7:e50632. 2012
    ..Here we examined FTC and tenofovir TFV exposure in vaginal tissues after oral dosing and assessed if peri-coital Truvada also protects macaques against vaginal SHIV infection...
  11. doi request reprint Delayed maturation of antibody avidity but not seroconversion in rhesus macaques infected with simian HIV during oral pre-exposure prophylaxis
    Kelly A Curtis
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Acquir Immune Defic Syndr 57:355-62. 2011
    ....
  12. doi request reprint Minority HIV mutation detection in dried blood spots indicates high specimen integrity and reveals hidden archived drug resistance
    Xierong Wei
    Laboratory Branch, Division of HIV AIDS Prevention, National Centers for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, MS G45 Atlanta, GA 30333, USA
    J Clin Virol 50:148-52. 2011
    ..Dried blood spots (DBS) could serve as an attractive, cost-effective alternative to plasma for HIV drug resistance testing...
  13. doi request reprint Generation and mucosal transmissibility of emtricitabine- and tenofovir-resistant SHIV162P3 mutants in macaques
    Mian er Cong
    Division of HIV AIDS Prevention, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, USA
    Virology 412:435-40. 2011
    ..Our results in limited number of macaques suggest that the reduction in fitness due to M184V and K65R decreases virus transmissibility, and identify in vitro infectivity parameters that associate with mucosal transmissibility...
  14. pmc Complete protection from repeated vaginal simian-human immunodeficiency virus exposures in macaques by a topical gel containing tenofovir alone or with emtricitabine
    Urvi M Parikh
    Laboratory Branch, Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA
    J Virol 83:10358-65. 2009
    ..Thus, single drugs with durable antiviral activity can provide highly effective topical prophylaxis and overcome the need for noncoital use or for drug combinations which are more complex and costly to formulate and approve...
  15. pmc Prophylactic efficacy of oral emtricitabine and tenofovir disoproxil fumarate combination therapy against a tenofovir-resistant simian/human immunodeficiency virus containing the K65R mutation in macaques
    Mian er Cong
    Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
    J Infect Dis 208:463-7. 2013
    ..028), although 4 of 6 FTC/TDF-treated macaques were infected at the end of the challenges. These findings highlight the need to closely monitor PrEP efficacy in areas with prevalent K65R. ..
  16. pmc Susceptibility to repeated, low-dose, rectal SHIVSF162P3 challenge is independent of TRIM5 genotype in rhesus macaques
    Katherine Butler
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    AIDS Res Hum Retroviruses 29:1091-4. 2013
    ..The finding that TRIM5 alleles do not restrict mucosal infection or ensuing replication rates suggests that SHIVSF162P3 is indeed suitable for RLD experimentation...
  17. pmc Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir
    J Gerardo Garcia-Lerma
    Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    PLoS Med 5:e28. 2008
    ..We evaluated daily and intermittent PrEP regimens of increasing antiviral activity in a macaque model that closely resembles human transmission...
  18. pmc Lack of prophylactic efficacy of oral maraviroc in macaques despite high drug concentrations in rectal tissues
    Ivana Massud
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV, Hepatitis, STD, and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 87:8952-61. 2013
    ..The increases in CD3(+)/CCR5(+) cells seen during MVC treatment point to unique immunological effects of CCR5 inhibition by MVC. The implications of these immunological effects on PrEP with MVC require further evaluation. ..
  19. ncbi request reprint High concordance between HIV-1 drug resistance genotypes generated from plasma and dried blood spots in antiretroviral-experienced patients
    Silvina Masciotra
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    AIDS 21:2503-11. 2007
    ..Dried blood spots (DBS) are a convenient alternative to plasma for drug resistance testing in resource-limited settings. We investigated the correlation between resistance genotypes generated from DBS and plasma...
  20. pmc Novel simian foamy virus infections from multiple monkey species in women from the Democratic Republic of Congo
    William M Switzer
    Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Retrovirology 9:100. 2012
    ..Phylogenetic analysis was used to define the NHP species origin of SFV. Participants completed questionnaires to capture NHP exposure information...
  21. doi request reprint High susceptibility to repeated, low-dose, vaginal SHIV exposure late in the luteal phase of the menstrual cycle of pigtail macaques
    Sundaram A Vishwanathan
    Division of HIV AIDS Prevention, CDC, Atlanta, GA 30329, USA
    J Acquir Immune Defic Syndr 57:261-4. 2011
    ..Our data support the findings of higher susceptibility to HIV in women during progesterone-dominated periods including pregnancy and contraceptive use...
  22. pmc Limited SHIV env diversification in macaques failing oral antiretroviral pre-exposure prophylaxis
    Qi Zheng
    National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Retrovirology 9:40. 2012
    ..We investigated viral evolution dynamics in a macaque model of PrEP consisting of repeated rectal exposures to SHIV162P3 in the presence of PrEP...
  23. pmc Simple PCR assays improve the sensitivity of HIV-1 subtype B drug resistance testing and allow linking of resistance mutations
    Jeffrey A Johnson
    Laboratory Branch, Division of HIV ADS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 2:e638. 2007
    ..Sensitive detection of drug-resistant subpopulations, however, requires simple and practical methods for routine testing...
  24. ncbi request reprint On-line coupling of anion exchange and ion-pair chromatography for measurement of intracellular triphosphate metabolites of reverse transcriptase inhibitors
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States
    J Chromatogr B Analyt Technol Biomed Life Sci 877:3659-66. 2009
    ..Limits of detection were 9, 200 and 75 pg per sample for TFV-DP (448/176 m/z), FTC-TP (488/130 m/z) and 3TC-TP (468/119 m/z), respectively...
  25. pmc Evaluation of dried blood spots for human immunodeficiency virus type 1 drug resistance testing
    Amanda McNulty
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA 30333, USA
    J Clin Microbiol 45:517-21. 2007
    ..The amplification of proviral DNA from DBS highlights the need for a wider evaluation of the concordance of resistance genotypes between plasma and DBS...
  26. doi request reprint Clinical and virological characterization of persistent human infection with simian foamy viruses
    Roumiana S Boneva
    HIV and Retrovirology Branch, Division of AIDS, STD and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 23:1330-7. 2007
    ..SFV likely transmits to humans through both percutaneous and mucocutaneous exposures to NHP body fluids. Limited follow-up has not identified SFV-associated illness and secondary transmission among humans...
  27. pmc Rapid decline in the efficiency of HIV drug resistance genotyping from dried blood spots (DBS) and dried plasma spots (DPS) stored at 37 degrees C and high humidity
    J Gerardo Garcia-Lerma
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Antimicrob Chemother 64:33-6. 2009
    ..We sought to investigate how extreme conditions could affect the short-term ability to amplify and genotype HIV from DBS...
  28. pmc The fitness cost of mutations associated with human immunodeficiency virus type 1 drug resistance is modulated by mutational interactions
    Mian er Cong
    Division of HIV AIDS Prevention, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    J Virol 81:3037-41. 2007
    ..We conclude that the persistence of transmitted RT mutants might range widely on the basis of fitness and that the modulation of fitness cost by mutational interactions will be a critical determinant of persistence...
  29. pmc Detection of low-level K65R variants in nucleoside reverse transcriptase inhibitor-naive chronic and acute HIV-1 subtype C infections
    Jin fen Li
    Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 203:798-802. 2011
    ..The frequent appearance of subtype C frameshift deletions at codon 65 supports a propensity for transcription error in this region...
  30. pmc Minority HIV-1 drug resistance mutations are present in antiretroviral treatment-naïve populations and associate with reduced treatment efficacy
    Jeffrey A Johnson
    Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Med 5:e158. 2008
    ..We used sensitive and simple tests to investigate evidence of transmitted drug resistance in antiretroviral drug-naïve persons and assess the clinical implications of minority drug-resistant variants...
  31. pmc Ancient, independent evolution and distinct molecular features of the novel human T-lymphotropic virus type 4
    William M Switzer
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Retrovirology 6:9. 2009
    ..Analysis of full-length genomes can provide basic information on the evolutionary history and replication and pathogenic potential of new viruses...
  32. doi request reprint Coinfection with HIV-1 and simian foamy virus in West Central Africans
    William M Switzer
    Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, Sexually Transmitted Diseases, and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia
    J Infect Dis 197:1389-93. 2008
    ..The findings of the present study suggest opportunities for bloodborne and sexual transmission of SFV and highlight the importance of defining the clinical consequences of dual infections...
  33. doi request reprint Postexposure protection of macaques from Vaginal SHIV infection by topical integrase inhibitors
    Charles Dobard
    Laboratory Branch, Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Sci Transl Med 6:227ra35. 2014
    ..We provide a proof of concept that topically applied integrase inhibitors protect against vaginal SHIV infection when administered shortly before or 3 hours after virus exposure. ..
  34. pmc Absence of evidence of xenotropic murine leukemia virus-related virus infection in persons with chronic fatigue syndrome and healthy controls in the United States
    William M Switzer
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Retrovirology 7:57. 2010
    ..Blinded PCR and serologic testing were performed at the US Centers for Disease Control and Prevention (CDC) and at two additional laboratories...
  35. pmc Emergence of a novel and highly divergent HTLV-3 in a primate hunter in Cameroon
    Haoqiang Zheng
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 401:137-45. 2010
    ....
  36. ncbi request reprint A rapid and sensitive real-time PCR assay for the K65R drug resistance mutation in SIV reverse transcriptase
    Jeffrey A Johnson
    National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30303, USA
    AIDS Res Hum Retroviruses 22:912-6. 2006
    ..4% and 3%, below the detection capability of population sequencing. We propose the SIV K65R real-time PCR assay provides improved sensitivity and simplicity in studying tenofovir resistance in macaque models...
  37. ncbi request reprint The epidemiology of simian immunodeficiency virus infection in a large number of wild- and captive-born chimpanzees: evidence for a recent introduction following chimpanzee divergence
    William M Switzer
    HIV and Retrovirology Branch, Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 21:335-42. 2005
    ..The absence of SIVcpz infection in P. t. verus suggests that SIVcpz may not be endemic to this subspecies and implies that SIVcpz may have been introduced more recently into the chimpanzee subspecies following divergence...
  38. pmc Detection of murine leukemia virus or mouse DNA in commercial RT-PCR reagents and human DNAs
    Haoqiang Zheng
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 6:e29050. 2011
    ..These results identify new sources of MLV contamination and highlight the importance of careful pre-screening of commercial specimens and diagnostic reagents to avoid false-positive MLV PCR results...
  39. pmc Measuring enzymatic HIV-1 susceptibility to two reverse transcriptase inhibitors as a rapid and simple approach to HIV-1 drug-resistance testing
    Dieter Hoffmann
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 6:e22019. 2011
    ..This enzymatic testing is subtype-independent and can assist in the clinical management of diverse populations particularly in resource-limited settings...
  40. doi request reprint Animal models of antiretroviral prophylaxis for HIV prevention
    J Gerardo Garcia-Lerma
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Curr Opin HIV AIDS 7:505-13. 2012
    ....
  41. doi request reprint Short communication: Absence of evidence of HTLV-3 and HTLV-4 in patients with large granular lymphocyte (LGL) leukemia
    Yen T Duong
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    AIDS Res Hum Retroviruses 24:1503-5. 2008
    ..These results suggest that HTLV-3 and HTLV-4 are not the causative agent of LGL leukemia...
  42. pmc No association of xenotropic murine leukemia virus-related viruses with prostate cancer
    William M Switzer
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 6:e19065. 2011
    ..We used broadly reactive PCR and Western blot (WB) assays to detect infection with XMRV and related murine leukemia viruses (MLV)...
  43. ncbi request reprint Natural resistance of human immunodeficiency virus type 2 to zidovudine
    Patrick Reid
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA
    Virology 336:251-64. 2005
    ..Our results demonstrate that the activity of AZT on HIV-2 is lower than previously thought, and emphasize the need for novel antiretroviral drugs specific for HIV-2...
  44. pmc No evidence of murine leukemia virus-related viruses in live attenuated human vaccines
    William M Switzer
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    PLoS ONE 6:e29223. 2011
    ..To address this possibility, we tested eight live attenuated human vaccines using generic PCR for XMRV and MLV sequences. Viral metagenomics using deep sequencing was also done to identify the possibility of other adventitious agents...
  45. doi request reprint Prevalence of transmitted drug resistance associated mutations and HIV-1 subtypes in new HIV-1 diagnoses, U.S.-2006
    William H Wheeler
    Division of HIV AIDS Prevention, National Center for HIV, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS 24:1203-12. 2010
    ..To determine the distribution of HIV-1 subtypes and the prevalence of transmitted drug resistance-associated mutations (TDRM) among persons newly diagnosed with HIV-1 infection in the United States...
  46. ncbi request reprint Physiologic doses of depot-medroxyprogesterone acetate do not increase acute plasma simian HIV viremia or mucosal virus shedding in pigtail macaques
    Jessica Radzio
    aLaboratory Branch, Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention bDepartment of Pathology, Emory University, Atlanta, Georgia, USA
    AIDS 28:1431-9. 2014
    ..Nonhuman primate models may help to determine the effects of DMPA on acute HIV replication...
  47. doi request reprint Oral pre-exposure prophylaxis for HIV prevention
    J Gerardo Garcia-Lerma
    Division of HIV AIDS Prevention, National Center for HIV, Hepatitis, STD, and Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA
    Trends Pharmacol Sci 31:74-81. 2010
    ....
  48. ncbi request reprint Emergence of drug-resistant HIV-1 after intrapartum administration of single-dose nevirapine is substantially underestimated
    Jeffrey A Johnson
    Laboratory Branch, National Center for HIV, STD, and Tuberculosis Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 192:16-23. 2005
    ..These findings indicate that resistance mutations emerged in at least 65% of the women after SD-NVP and emphasize the importance of further research to determine the clinical implications...
  49. pmc Mucosal and systemic antibody responses in humans infected with simian foamy virus
    James E Cummins
    HIV and Retrovirology Branch, Division of AIDS, STD, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 79:13186-9. 2005
    ..These results provide a first comparative evaluation of SFV-specific host mucosal humoral immunity in infected humans and chimpanzees that is characterized by a predominant IgG response and a virtually absent IgA response...
  50. doi request reprint Updated US Public Health Service guidelines for the management of occupational exposures to human immunodeficiency virus and recommendations for postexposure prophylaxis
    David T Kuhar
    Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Infect Control Hosp Epidemiol 34:875-92. 2013
    ....
  51. pmc HIV transmission in a state prison system, 1988-2005
    Krishna Jafa
    Division of HIV AIDS Prevention, National Center for HIV AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    PLoS ONE 4:e5416. 2009
    ..S. prisons is sparsely documented. We investigated 88 HIV seroconversions reported from 1988-2005 among male Georgia prison inmates...
  52. ncbi request reprint Multiprotein HIV type 1 clade B DNA/MVA vaccine: construction, safety, and immunogenicity in Macaques
    James M Smith
    Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    AIDS Res Hum Retroviruses 20:654-65. 2004
    ....
  53. doi request reprint Human T cell lymphotropic virus type 1 infection among U.S. thalassemia patients
    William M Switzer
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    AIDS Res Hum Retroviruses 29:1006-9. 2013
    ..In addition, appropriate counseling and follow-up of HTLV-infected patients are warranted...
  54. ncbi request reprint Updated U.S. Public Health Service guidelines for the management of occupational exposures to HIV and recommendations for postexposure prophylaxis
    Adelisa L Panlilio
    Division of Healthcare Quality Promotion, National Center for Infectious Diseases, CDC, 1600 Clifton Rd, NE, MS E 68, Atlanta, Georgia 30333, USA
    MMWR Recomm Rep 54:1-17. 2005
    ..To ensure timely postexposure management and administration of HIV PEP, clinicians should consider occupational exposures as urgent medical concerns...
  55. pmc Ancient origin and molecular features of the novel human T-lymphotropic virus type 3 revealed by complete genome analysis
    William M Switzer
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 45, Atlanta, GA 30333, USA
    J Virol 80:7427-38. 2006
    ..The ancient origin of HTLV-3, the broad distribution of STLV-3 in Africa, and the propensity of STLVs to cross species into humans all suggest that HTLV-3 may be prevalent and support the need for expanded surveillance for this virus...
  56. ncbi request reprint Effect of mobile phase pH and organic content on LC-MS analysis of nucleoside and nucleotide HIV reverse transcriptase inhibitors
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Chromatogr Sci 47:365-72. 2009
    ..1 mL plasma (10 pg on column) and coefficients of variation from 5% to 15% in the high ng/mL concentration range and from 16% to 20% in the low ng/mL concentration range...
  57. pmc Sensitive tenofovir resistance screening of HIV-1 from the genital and blood compartments of women with breakthrough infections in the CAPRISA 004 tenofovir gel trial
    Xierong Wei
    Centers for Disease Control and Prevention, Atlanta, Georgia
    J Infect Dis 209:1916-20. 2014
    ..The absence of mutation detection suggested little immediate risk of tenofovir-resistant HIV-1 emergence and forward transmission in settings in which gel users are closely monitored for HIV seroconversion. ..
  58. pmc Transmitted human immunodeficiency virus type 1 carrying the D67N or K219Q/E mutation evolves rapidly to zidovudine resistance in vitro and shows a high replicative fitness in the presence of zidovudine
    J Gerardo Garcia-Lerma
    HIV and Retrovirology Branch, Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Virol 78:7545-52. 2004
    ..Our study emphasizes the need for clinical studies to better define the impact of these mutants on treatment responses and evolution of resistance...