Larisa V Gubareva

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. pmc 5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication
    Priya Ranjan
    Influenza Division, NCIRD, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virol J 7:102. 2010
  2. doi request reprint Comprehensive assessment of 2009 pandemic influenza A (H1N1) virus drug susceptibility in vitro
    Larisa V Gubareva
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Antivir Ther 15:1151-9. 2010
  3. doi request reprint Host cell selection of influenza neuraminidase variants: implications for drug resistance monitoring in A(H1N1) viruses
    Margaret Okomo-Adhiambo
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Mail Stop G 16, 1600 Clifton Road Atlanta GA, USA
    Antiviral Res 85:381-8. 2010
  4. doi request reprint Detection of antiviral resistance and genetic lineage markers in influenza B virus neuraminidase using pyrosequencing
    Tiffany G Sheu
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Antiviral Res 85:354-60. 2010
  5. pmc Detection of molecular markers of drug resistance in 2009 pandemic influenza A (H1N1) viruses by pyrosequencing
    Varough M Deyde
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta Georgia 30333, USA
    Antimicrob Agents Chemother 54:1102-10. 2010
  6. pmc Dual resistance to adamantanes and oseltamivir among seasonal influenza A(H1N1) viruses: 2008-2010
    Tiffany G Sheu
    Influenza Division, Centers for Disease Control and Prevention, Battelle Memorial Institute, Atlanta, Georgia, USA
    J Infect Dis 203:13-7. 2011
  7. pmc Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004 to 2008
    Tiffany G Sheu
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Antimicrob Agents Chemother 52:3284-92. 2008
  8. doi request reprint Triple-reassortant swine influenza A (H1) in humans in the United States, 2005-2009
    Vivek Shinde
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 360:2616-25. 2009
  9. doi request reprint Pyrosequencing as a tool to detect molecular markers of resistance to neuraminidase inhibitors in seasonal influenza A viruses
    Varough M Deyde
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Antiviral Res 81:16-24. 2009
  10. doi request reprint Analysis of influenza viruses from patients clinically suspected of infection with an oseltamivir resistant virus during the 2009 pandemic in the United States
    Ha T Nguyen
    Influenza Division, Centers for Disease Control and Prevention, Mail Stop G 16, 1600 Clifton Road, Atlanta, GA 30333, USA
    Antiviral Res 93:381-6. 2012

Collaborators

Detail Information

Publications35

  1. pmc 5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication
    Priya Ranjan
    Influenza Division, NCIRD, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virol J 7:102. 2010
    ..Activation of innate immune pathogen sensor Retinoic Acid Inducible Gene-I (RIG-I) has recently been shown to induce antiviral state...
  2. doi request reprint Comprehensive assessment of 2009 pandemic influenza A (H1N1) virus drug susceptibility in vitro
    Larisa V Gubareva
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Antivir Ther 15:1151-9. 2010
    ..Antiviral drugs are an important option for managing infections caused by influenza viruses. This study assessed the drug susceptibility of 2009 pandemic influenza A (H1N1) viruses collected globally between April 2009 and January 2010...
  3. doi request reprint Host cell selection of influenza neuraminidase variants: implications for drug resistance monitoring in A(H1N1) viruses
    Margaret Okomo-Adhiambo
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Mail Stop G 16, 1600 Clifton Road Atlanta GA, USA
    Antiviral Res 85:381-8. 2010
    ....
  4. doi request reprint Detection of antiviral resistance and genetic lineage markers in influenza B virus neuraminidase using pyrosequencing
    Tiffany G Sheu
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Antiviral Res 85:354-60. 2010
    ....
  5. pmc Detection of molecular markers of drug resistance in 2009 pandemic influenza A (H1N1) viruses by pyrosequencing
    Varough M Deyde
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta Georgia 30333, USA
    Antimicrob Agents Chemother 54:1102-10. 2010
    ..Pyrosequencing is well suited for the detection of drug resistance markers and signature mutations in the M and NA gene segments of the pandemic H1N1 influenza viruses...
  6. pmc Dual resistance to adamantanes and oseltamivir among seasonal influenza A(H1N1) viruses: 2008-2010
    Tiffany G Sheu
    Influenza Division, Centers for Disease Control and Prevention, Battelle Memorial Institute, Atlanta, Georgia, USA
    J Infect Dis 203:13-7. 2011
    ..Because of limited options for antiviral treatment, emergence of dual-resistant influenza viruses poses a public health concern, and their circulation needs to be closely monitored...
  7. pmc Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004 to 2008
    Tiffany G Sheu
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Antimicrob Agents Chemother 52:3284-92. 2008
    ..6% (50/579 isolates). The recent increase in oseltamivir resistance among A(H1N1) viruses isolated from untreated patients raises public health concerns and necessitates close monitoring of resistance to NA inhibitors...
  8. doi request reprint Triple-reassortant swine influenza A (H1) in humans in the United States, 2005-2009
    Vivek Shinde
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 360:2616-25. 2009
    ..Triple-reassortant swine influenza A (H1) viruses--containing genes from avian, human, and swine influenza viruses--emerged and became enzootic among pig herds in North America during the late 1990s...
  9. doi request reprint Pyrosequencing as a tool to detect molecular markers of resistance to neuraminidase inhibitors in seasonal influenza A viruses
    Varough M Deyde
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Antiviral Res 81:16-24. 2009
    ....
  10. doi request reprint Analysis of influenza viruses from patients clinically suspected of infection with an oseltamivir resistant virus during the 2009 pandemic in the United States
    Ha T Nguyen
    Influenza Division, Centers for Disease Control and Prevention, Mail Stop G 16, 1600 Clifton Road, Atlanta, GA 30333, USA
    Antiviral Res 93:381-6. 2012
    ..These data suggest that pyrosequencing is a powerful tool for timely detection of NAI resistant viruses and that NI assays are needed for comprehensive testing to detect novel resistance substitutions...
  11. pmc Influenza B viruses with mutation in the neuraminidase active site, North Carolina, USA, 2010-11
    Katrina Sleeman
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 17:2043-6. 2011
    ....
  12. pmc In vitro antiviral activity of favipiravir (T-705) against drug-resistant influenza and 2009 A(H1N1) viruses
    Katrina Sleeman
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329 4018, USA
    Antimicrob Agents Chemother 54:2517-24. 2010
    ..This study demonstrates that favipiravir inhibits in vitro replication of a wide range of influenza viruses, including those resistant to currently available drugs...
  13. pmc Assessment of pandemic and seasonal influenza A (H1N1) virus susceptibility to neuraminidase inhibitors in three enzyme activity inhibition assays
    Ha T Nguyen
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Mail Stop G 16, 1600 Clifton Road, Atlanta, GA 30333, USA
    Antimicrob Agents Chemother 54:3671-7. 2010
    ..It would be desirable to develop an NI assay which combines the advantages of all three currently available assays but which lacks their shortcomings...
  14. doi request reprint Assays for monitoring susceptibility of influenza viruses to neuraminidase inhibitors
    Margaret Okomo-Adhiambo
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Influenza Other Respir Viruses 7:44-9. 2013
    ..g., surveillance purposes, clinical settings). Optimally, it is desirable to combine functional and genetic analyses of virus isolates and, when possible, the respective clinical specimens...
  15. pmc Detection of E119V and E119I mutations in influenza A (H3N2) viruses isolated from an immunocompromised patient: challenges in diagnosis of oseltamivir resistance
    Margaret Okomo-Adhiambo
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Antimicrob Agents Chemother 54:1834-41. 2010
    ....
  16. ncbi request reprint Correction: okomo-adhiambo, m. Et Al. Neuraminidase inhibitor susceptibility testing in human influenza viruses: a laboratory surveillance perspective. Viruses 2010, 2, 2269-2289
    Margaret Okomo-Adhiambo
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop G16, Atlanta, GA 30333, USA E Mails M O A K S K B H T N V P M T G S J S A I K
    Viruses 3:1415-6. 2011
    ..This corrects the article on p. 2269 in vol. 2.]...
  17. doi request reprint Rapid identification of oseltamivir-resistant influenza A(H1N1) viruses with H274Y mutation by RT-PCR/restriction fragment length polymorphism assay
    Lizheng Guo
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS G 16, Atlanta, GA 30333, USA
    Antiviral Res 82:29-33. 2009
    ..Our RT-PCR/RFLP assay provides a simple, rapid and sensitive tool to monitor the emergence and spread of H274Y oseltamivir-resistant influenza A(H1N1) viruses...
  18. pmc Detection of molecular markers of antiviral resistance in influenza A (H5N1) viruses using a pyrosequencing method
    Varough M Deyde
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Antimicrob Agents Chemother 53:1039-47. 2009
    ..The pyrosequencing approach may provide a valuable tool for rapid detection of markers of drug resistance in H5N1 viruses and facilitate the elucidation of the role of such changes in natural and acquired drug resistance...
  19. doi request reprint Infections with oseltamivir-resistant influenza A(H1N1) virus in the United States
    Nila J Dharan
    Epidemic Intelligence Service, Office of Workforce and Career Development Assigned to Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS A 32, Atlanta, GA 30333, USA
    JAMA 301:1034-41. 2009
    ..Early surveillance data suggest that the prevalence of oseltamivir resistance among A(H1N1) viruses will most likely be higher during the 2008-2009 season...
  20. pmc Neuraminidase inhibitor susceptibility testing in human influenza viruses: a laboratory surveillance perspective
    Margaret Okomo-Adhiambo
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop G16, Atlanta, GA 30333, USA E Mails M O A K S K B H T N V P M T G S J S A I K
    Viruses 2:2269-89. 2010
    ..This study summarizes baseline susceptibility patterns of seasonal and pandemic influenza viruses, and seeks to contribute towards criteria for defining NAI resistance...
  21. pmc Bioluminescence-based neuraminidase inhibition assay for monitoring influenza virus drug susceptibility in clinical specimens
    Henju Marjuki
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Antimicrob Agents Chemother 57:5209-15. 2013
    ..Furthermore, The QFlu assay allows detection of the influenza virus A and B isolates carrying established and potential NA inhibitor resistance markers and may become a useful tool for monitoring drug resistance in clinical specimens. ..
  22. doi request reprint Neuraminidase inhibitor susceptibility surveillance of influenza viruses circulating worldwide during the 2011 Southern Hemisphere season
    Margaret Okomo-Adhiambo
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, WHO Collaborating Center for Surveillance, Epidemiology and Control of Influenza, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Influenza Other Respir Viruses 7:645-58. 2013
    ..Neuraminidase (NA) inhibitors (NAIs) are currently the only antivirals effective against influenza infections due to widespread resistance to M2 inhibitors...
  23. pmc Oseltamivir inhibits H7 influenza virus replication in mice inoculated by the ocular route
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Antimicrob Agents Chemother 56:1616-8. 2012
    ..We demonstrate that H7 viruses possess sensitivity to neuraminidase inhibitors and that administration of oseltamivir before ocular virus challenge in mice inhibits H7N7 and H7N3 virus replication in ocular and respiratory tissues...
  24. pmc Outbreak of antiviral drug-resistant influenza a in long-term care facility, Illinois, USA, 2008
    Nila J Dharan
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 15:1973-6. 2009
    ..Initial outbreak response included treatment and prophylaxis with oseltamivir. The outbreak abated, likely because of infection control measures...
  25. pmc Cell culture-selected substitutions in influenza A(H3N2) neuraminidase affect drug susceptibility assessment
    Daisuke Tamura
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Antimicrob Agents Chemother 57:6141-6. 2013
    ..Our findings highlight the current challenges in monitoring susceptibility of influenza A(H3N2) viruses to the NAI class of antiviral drugs. ..
  26. doi request reprint The chemiluminescent neuraminidase inhibition assay: a functional method for detection of influenza virus resistance to the neuraminidase inhibitors
    Margaret Okomo-Adhiambo
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Methods Mol Biol 865:95-113. 2012
    ....
  27. doi request reprint Clinical and virologic outcomes in patients with oseltamivir-resistant seasonal influenza A (H1N1) infections: results from a clinical trial
    Nila J Dharan
    Epidemic Intelligence Service, Office of Workforce and Career Development Assigned to Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Influenza Other Respir Viruses 6:153-8. 2012
    ..While sample size prohibits a strong conclusion, future studies should evaluate for similar trends...
  28. doi request reprint Neuraminidase inhibitor resistance in influenza viruses and laboratory testing methods
    Ha T Nguyen
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Antivir Ther 17:159-73. 2012
    ..Close monitoring of antiviral resistance among all influenza viruses, both locally and globally, are essential to inform public health strategies for the control of influenza infections...
  29. doi request reprint The effect of the MDCK cell selected neuraminidase D151G mutation on the drug susceptibility assessment of influenza A(H3N2) viruses
    Vasiliy P Mishin
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Antiviral Res 101:93-6. 2014
    ..In conclusion, the presence of NA D151G variants in cell culture-grown viruses interferes with drug susceptibility assessment and therefore measures need to be implemented to prevent their emergence. ..
  30. pmc Detection of hemagglutinin variants of the pandemic influenza A (H1N1) 2009 virus by pyrosequencing
    Marnie Levine
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Mail Stop G 16, 1600 Clifton Road, Atlanta, GA 30333, USA
    J Clin Microbiol 49:1307-12. 2011
    ..1%) which the standard cyclic nucleotide dispensation protocol failed to detect. The optimized pyrosequencing protocol is expected to provide a more accurate tool in the analysis of virus variant composition...
  31. doi request reprint RT-PCR/electrospray ionization mass spectrometry approach in detection and characterization of influenza viruses
    Varough M Deyde
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Expert Rev Mol Diagn 11:41-52. 2011
    ..In this article, we provide a summary of known applications of the RT-PCR/ESI-MS assay in the field of influenza...
  32. pmc Genomic signature-based identification of influenza A viruses using RT-PCR/electro-spray ionization mass spectrometry (ESI-MS) technology
    Varough M Deyde
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 5:e13293. 2010
    ..Combination of the BC signatures represents a "genomic print" of an influenza A virus...
  33. pmc Oseltamivir-resistant pandemic (H1N1) 2009 virus infections, United States, 2010-11
    Aaron D Storms
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 18:308-11. 2012
    ..Of resistant viruses from 2010-11 and 2009-10, 26% and 89%, respectively, were from persons exposed to oseltamivir before specimen collection. Findings suggest limited community transmission of oseltamivir-resistant virus...
  34. doi request reprint Influenza genome analysis using pyrosequencing method: current applications for a moving target
    Varough M Deyde
    Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Mail Stop G 16, 1600 Clifton Road, Atlanta, GA 30333, USA
    Expert Rev Mol Diagn 9:493-509. 2009
    ..The present report summarizes known applications of the pyrosequencing approach for influenza genome analysis with an emphasis on drug-resistance detection...
  35. ncbi request reprint Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide
    Varough M Deyde
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 196:249-57. 2007
    ..The results of the study highlight the necessity of close monitoring of resistance to existing antivirals as wells as the need for new therapeutics...