Research Topics
Genomes and Genes | Larisa V GubarevaSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
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Publications
5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replicationPriya Ranjan
Influenza Division, NCIRD, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Virol J 7:102. 2010..Activation of innate immune pathogen sensor Retinoic Acid Inducible Gene-I (RIG-I) has recently been shown to induce antiviral state...
Comprehensive assessment of 2009 pandemic influenza A (H1N1) virus drug susceptibility in vitroLarisa V Gubareva
Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Antivir Ther 15:1151-9. 2010..Antiviral drugs are an important option for managing infections caused by influenza viruses. This study assessed the drug susceptibility of 2009 pandemic influenza A (H1N1) viruses collected globally between April 2009 and January 2010...- Host cell selection of influenza neuraminidase variants: implications for drug resistance monitoring in A(H1N1) virusesMargaret Okomo-Adhiambo
Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Mail Stop G 16, 1600 Clifton Road Atlanta GA, USA
Antiviral Res 85:381-8. 2010.... - Detection of antiviral resistance and genetic lineage markers in influenza B virus neuraminidase using pyrosequencingTiffany G Sheu
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Antiviral Res 85:354-60. 2010.... - Detection of molecular markers of drug resistance in 2009 pandemic influenza A (H1N1) viruses by pyrosequencingVarough M Deyde
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta Georgia 30333, USA
Antimicrob Agents Chemother 54:1102-10. 2010..Pyrosequencing is well suited for the detection of drug resistance markers and signature mutations in the M and NA gene segments of the pandemic H1N1 influenza viruses... - Pyrosequencing as a tool to detect molecular markers of resistance to neuraminidase inhibitors in seasonal influenza A virusesVarough M Deyde
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Antiviral Res 81:16-24. 2009.... - Dual resistance to adamantanes and oseltamivir among seasonal influenza A(H1N1) viruses: 2008-2010Tiffany G Sheu
Influenza Division, Centers for Disease Control and Prevention, Battelle Memorial Institute, Atlanta, Georgia, USA
J Infect Dis 203:13-7. 2011..Because of limited options for antiviral treatment, emergence of dual-resistant influenza viruses poses a public health concern, and their circulation needs to be closely monitored... - Surveillance for neuraminidase inhibitor resistance among human influenza A and B viruses circulating worldwide from 2004 to 2008Tiffany G Sheu
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Antimicrob Agents Chemother 52:3284-92. 2008..6% (50/579 isolates). The recent increase in oseltamivir resistance among A(H1N1) viruses isolated from untreated patients raises public health concerns and necessitates close monitoring of resistance to NA inhibitors... - Triple-reassortant swine influenza A (H1) in humans in the United States, 2005-2009Vivek Shinde
Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
N Engl J Med 360:2616-25. 2009..Triple-reassortant swine influenza A (H1) viruses--containing genes from avian, human, and swine influenza viruses--emerged and became enzootic among pig herds in North America during the late 1990s... - Analysis of influenza viruses from patients clinically suspected of infection with an oseltamivir resistant virus during the 2009 pandemic in the United StatesHa T Nguyen
Influenza Division, Centers for Disease Control and Prevention, Mail Stop G 16, 1600 Clifton Road, Atlanta, GA 30333, USA
Antiviral Res 93:381-6. 2012..These data suggest that pyrosequencing is a powerful tool for timely detection of NAI resistant viruses and that NI assays are needed for comprehensive testing to detect novel resistance substitutions... - Influenza B viruses with mutation in the neuraminidase active site, North Carolina, USA, 2010-11Katrina Sleeman
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 17:2043-6. 2011.... - Assessment of pandemic and seasonal influenza A (H1N1) virus susceptibility to neuraminidase inhibitors in three enzyme activity inhibition assaysHa T Nguyen
Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Mail Stop G 16, 1600 Clifton Road, Atlanta, GA 30333, USA
Antimicrob Agents Chemother 54:3671-7. 2010..It would be desirable to develop an NI assay which combines the advantages of all three currently available assays but which lacks their shortcomings... - In vitro antiviral activity of favipiravir (T-705) against drug-resistant influenza and 2009 A(H1N1) virusesKatrina Sleeman
Virus Surveillance and Diagnosis Branch, Influenza Division, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329 4018, USA
Antimicrob Agents Chemother 54:2517-24. 2010..This study demonstrates that favipiravir inhibits in vitro replication of a wide range of influenza viruses, including those resistant to currently available drugs... - Detection of E119V and E119I mutations in influenza A (H3N2) viruses isolated from an immunocompromised patient: challenges in diagnosis of oseltamivir resistanceMargaret Okomo-Adhiambo
Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Antimicrob Agents Chemother 54:1834-41. 2010.... 
Correction: okomo-adhiambo, m. Et Al. Neuraminidase inhibitor susceptibility testing in human influenza viruses: a laboratory surveillance perspective. Viruses 2010, 2, 2269-2289Margaret Okomo-Adhiambo
Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop G16, Atlanta, GA 30333, USA E Mails M O A K S K B H T N V P M T G S J S A I K
Viruses 3:1415-6. 2011..This corrects the article on p. 2269 in vol. 2.]...- Rapid identification of oseltamivir-resistant influenza A(H1N1) viruses with H274Y mutation by RT-PCR/restriction fragment length polymorphism assayLizheng Guo
Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS G 16, Atlanta, GA 30333, USA
Antiviral Res 82:29-33. 2009..Our RT-PCR/RFLP assay provides a simple, rapid and sensitive tool to monitor the emergence and spread of H274Y oseltamivir-resistant influenza A(H1N1) viruses... - Detection of molecular markers of antiviral resistance in influenza A (H5N1) viruses using a pyrosequencing methodVarough M Deyde
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Antimicrob Agents Chemother 53:1039-47. 2009..The pyrosequencing approach may provide a valuable tool for rapid detection of markers of drug resistance in H5N1 viruses and facilitate the elucidation of the role of such changes in natural and acquired drug resistance... - Infections with oseltamivir-resistant influenza A(H1N1) virus in the United StatesNila J Dharan
Epidemic Intelligence Service, Office of Workforce and Career Development Assigned to Influenza Division, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS A 32, Atlanta, GA 30333, USA
JAMA 301:1034-41. 2009..Early surveillance data suggest that the prevalence of oseltamivir resistance among A(H1N1) viruses will most likely be higher during the 2008-2009 season... - Neuraminidase inhibitor susceptibility testing in human influenza viruses: a laboratory surveillance perspectiveMargaret Okomo-Adhiambo
Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop G16, Atlanta, GA 30333, USA E Mails M O A K S K B H T N V P M T G S J S A I K
Viruses 2:2269-89. 2010..This study summarizes baseline susceptibility patterns of seasonal and pandemic influenza viruses, and seeks to contribute towards criteria for defining NAI resistance... - Oseltamivir inhibits H7 influenza virus replication in mice inoculated by the ocular routeJessica A Belser
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Antimicrob Agents Chemother 56:1616-8. 2012..We demonstrate that H7 viruses possess sensitivity to neuraminidase inhibitors and that administration of oseltamivir before ocular virus challenge in mice inhibits H7N7 and H7N3 virus replication in ocular and respiratory tissues... - Outbreak of antiviral drug-resistant influenza a in long-term care facility, Illinois, USA, 2008Nila J Dharan
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 15:1973-6. 2009..Initial outbreak response included treatment and prophylaxis with oseltamivir. The outbreak abated, likely because of infection control measures... - The chemiluminescent neuraminidase inhibition assay: a functional method for detection of influenza virus resistance to the neuraminidase inhibitorsMargaret Okomo-Adhiambo
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Methods Mol Biol 865:95-113. 2012.... - Clinical and virologic outcomes in patients with oseltamivir-resistant seasonal influenza A (H1N1) infections: results from a clinical trialNila J Dharan
Epidemic Intelligence Service, Office of Workforce and Career Development Assigned to Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA
Influenza Other Respi Viruses 6:153-8. 2012..While sample size prohibits a strong conclusion, future studies should evaluate for similar trends... - Neuraminidase inhibitor resistance in influenza viruses and laboratory testing methodsHa T Nguyen
Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA
Antivir Ther 17:159-73. 2012..Close monitoring of antiviral resistance among all influenza viruses, both locally and globally, are essential to inform public health strategies for the control of influenza infections... - Detection of hemagglutinin variants of the pandemic influenza A (H1N1) 2009 virus by pyrosequencingMarnie Levine
Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Mail Stop G 16, 1600 Clifton Road, Atlanta, GA 30333, USA
J Clin Microbiol 49:1307-12. 2011..1%) which the standard cyclic nucleotide dispensation protocol failed to detect. The optimized pyrosequencing protocol is expected to provide a more accurate tool in the analysis of virus variant composition... - Genomic signature-based identification of influenza A viruses using RT-PCR/electro-spray ionization mass spectrometry (ESI-MS) technologyVarough M Deyde
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
PLoS ONE 5:e13293. 2010..Combination of the BC signatures represents a "genomic print" of an influenza A virus... - RT-PCR/electrospray ionization mass spectrometry approach in detection and characterization of influenza virusesVarough M Deyde
Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
Expert Rev Mol Diagn 11:41-52. 2011..In this article, we provide a summary of known applications of the RT-PCR/ESI-MS assay in the field of influenza... - Oseltamivir-resistant pandemic (H1N1) 2009 virus infections, United States, 2010-11Aaron D Storms
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 18:308-11. 2012..Of resistant viruses from 2010-11 and 2009-10, 26% and 89%, respectively, were from persons exposed to oseltamivir before specimen collection. Findings suggest limited community transmission of oseltamivir-resistant virus... - Influenza genome analysis using pyrosequencing method: current applications for a moving targetVarough M Deyde
Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Mail Stop G 16, 1600 Clifton Road, Atlanta, GA 30333, USA
Expert Rev Mol Diagn 9:493-509. 2009..The present report summarizes known applications of the pyrosequencing approach for influenza genome analysis with an emphasis on drug-resistance detection... - Assays for monitoring susceptibility of influenza viruses to neuraminidase inhibitorsMargaret Okomo-Adhiambo
Virus Surveillance and Diagnosis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Influenza Other Respi Viruses 7:44-9. 2013..g., surveillance purposes, clinical settings). Optimally, it is desirable to combine functional and genetic analyses of virus isolates and, when possible, the respective clinical specimens... - Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwideVarough M Deyde
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Infect Dis 196:249-57. 2007..The results of the study highlight the necessity of close monitoring of resistance to existing antivirals as wells as the need for new therapeutics...