Cynthia S Goldsmith

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. pmc Ultrastructural characterization of SARS coronavirus
    Cynthia S Goldsmith
    Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 10:320-6. 2004
  2. doi request reprint Novel deer-associated parapoxvirus infection in deer hunters
    Amira A Roess
    Epidemic Intelligence Service, Epidemiology Program Office, and the Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    N Engl J Med 363:2621-7. 2010
  3. pmc Phenotypic, genomic, and transcriptional characterization of Streptococcus pneumoniae interacting with human pharyngeal cells
    Sheila Z Kimaro Mlacha
    Kenya Medical Research Institute, Wellcome Trust Research Programme, Kilifi, Kenya
    BMC Genomics 14:383. 2013
  4. pmc Cell culture and electron microscopy for identifying viruses in diseases of unknown cause
    Cynthia S Goldsmith
    Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop G32, Atlanta, GA 30329, USA
    Emerg Infect Dis 19:886-91. 2013
  5. pmc Ultrastructural characterization of pandemic (H1N1) 2009 virus
    Cynthia S Goldsmith
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 17:2056-9. 2011
  6. pmc Modern uses of electron microscopy for detection of viruses
    Cynthia S Goldsmith
    Infectious Disease Pathology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Microbiol Rev 22:552-63. 2009
  7. ncbi request reprint Elucidation of Nipah virus morphogenesis and replication using ultrastructural and molecular approaches
    Cynthia S Goldsmith
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Mailstop G30, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    Virus Res 92:89-98. 2003
  8. ncbi request reprint A novel coronavirus associated with severe acute respiratory syndrome
    Thomas G Ksiazek
    Special Pathogens Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 348:1953-66. 2003
  9. pmc Human febrile illness caused by encephalomyocarditis virus infection, Peru
    M Steven Oberste
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 15:640-6. 2009
  10. ncbi request reprint Immunohistochemical, in situ hybridization, and ultrastructural localization of SARS-associated coronavirus in lung of a fatal case of severe acute respiratory syndrome in Taiwan
    Wun Ju Shieh
    Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, Center for Disease Control and Prevention, Atlanta, GA 30333, USA
    Hum Pathol 36:303-9. 2005

Collaborators

Detail Information

Publications23

  1. pmc Ultrastructural characterization of SARS coronavirus
    Cynthia S Goldsmith
    Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 10:320-6. 2004
    ..Electron microscopic studies were critical in identifying the etiologic agent of the SARS outbreak and in guiding subsequent laboratory and epidemiologic investigations...
  2. doi request reprint Novel deer-associated parapoxvirus infection in deer hunters
    Amira A Roess
    Epidemic Intelligence Service, Epidemiology Program Office, and the Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    N Engl J Med 363:2621-7. 2010
    ..Deer populations continue to increase, leading to the possibility that there will be more deer-associated parapoxvirus infections...
  3. pmc Phenotypic, genomic, and transcriptional characterization of Streptococcus pneumoniae interacting with human pharyngeal cells
    Sheila Z Kimaro Mlacha
    Kenya Medical Research Institute, Wellcome Trust Research Programme, Kilifi, Kenya
    BMC Genomics 14:383. 2013
    ..Understanding the molecular interactions between the bacterium and the host will contribute to the control and prevention of pneumococcal disease...
  4. pmc Cell culture and electron microscopy for identifying viruses in diseases of unknown cause
    Cynthia S Goldsmith
    Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop G32, Atlanta, GA 30329, USA
    Emerg Infect Dis 19:886-91. 2013
    ..These cases illustrate the importance of the techniques of cell culture and electron microscopy in pathogen identification and recognition of emerging diseases...
  5. pmc Ultrastructural characterization of pandemic (H1N1) 2009 virus
    Cynthia S Goldsmith
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 17:2056-9. 2011
    ..Many morphologic characteristics were similar to those previously described for influenza virus. One of the distinctive features was dense tubular structures in the nuclei of infected cells...
  6. pmc Modern uses of electron microscopy for detection of viruses
    Cynthia S Goldsmith
    Infectious Disease Pathology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Microbiol Rev 22:552-63. 2009
    ..These studies provide information for treatment and vaccine strategies...
  7. ncbi request reprint Elucidation of Nipah virus morphogenesis and replication using ultrastructural and molecular approaches
    Cynthia S Goldsmith
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Mailstop G30, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    Virus Res 92:89-98. 2003
    ..Ultrastructural ISH studies suggest these inclusions play an important role in the transcription process...
  8. ncbi request reprint A novel coronavirus associated with severe acute respiratory syndrome
    Thomas G Ksiazek
    Special Pathogens Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 348:1953-66. 2003
    ..We conducted studies to identify the etiologic agent of this outbreak...
  9. pmc Human febrile illness caused by encephalomyocarditis virus infection, Peru
    M Steven Oberste
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 15:640-6. 2009
    ..Serum samples from case-patient 2 did not contain antibodies detectable by either assay. Detection of virus in serum strongly supports a role for EMCV in human infection and febrile illness...
  10. ncbi request reprint Immunohistochemical, in situ hybridization, and ultrastructural localization of SARS-associated coronavirus in lung of a fatal case of severe acute respiratory syndrome in Taiwan
    Wun Ju Shieh
    Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, Center for Disease Control and Prevention, Atlanta, GA 30333, USA
    Hum Pathol 36:303-9. 2005
    ..These techniques represent valuable laboratory diagnostic modalities and provide insights into the pathogenesis of this emerging infection...
  11. doi request reprint Reduced virus replication, proinflammatory cytokine production, and delayed macrophage cell death in human PBMCs infected with the newly discovered Bundibugyo ebolavirus relative to Zaire ebolavirus
    Manisha Gupta
    Special Pathogens Branch, DVRD, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Virology 402:203-8. 2010
    ..The findings of slower Bundibugyo ebolavirus replication, lower production of proinflammatory cytokines and delay in macrophage cell death provide insight into the basis of the lower case fatality observed with Bundibugyo ebolavirus...
  12. ncbi request reprint SARS-coronavirus replication in human peripheral monocytes/macrophages
    Mamadi Yilla
    Respiratory and Enteric Viruses Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS C22, Atlanta, GA 30333, USA
    Virus Res 107:93-101. 2005
    ..Given the importance of monocytes/macrophages to the immune response, it is possible that their infection by SARS-CoV and alteration of this infection by IFN-alpha may be important to the course of the infection in humans...
  13. pmc Monkeypox transmission and pathogenesis in prairie dogs
    Jeannette Guarner
    Infectious Disease Pathology Activity, Centers for Disease Control and Prevention, Mailstop G32, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    Emerg Infect Dis 10:426-31. 2004
    ..Prairie dogs offer insights into transmission, pathogenesis, and new vaccine and treatment trials because they are susceptible to severe monkeypox infection...
  14. doi request reprint A new phlebovirus associated with severe febrile illness in Missouri
    Laura K McMullan
    Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 367:834-41. 2012
    ..Although Koch's postulates have not been completely fulfilled, we believe that this phlebovirus, which is novel in the Americas, is the cause of this clinical syndrome...
  15. doi request reprint Pathology and pathogenesis of fatal Bordetella pertussis infection in infants
    Christopher D Paddock
    Infectious Disease Pathology Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 47:328-38. 2008
    ....
  16. ncbi request reprint Rickettsia parkeri: a newly recognized cause of spotted fever rickettsiosis in the United States
    Christopher D Paddock
    Division of Viral and Rickettsial Diseases, Infectious Disease Pathology Activity, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Infect Dis 38:805-11. 2004
    ..parkeri rickettsiosis and possibly other novel SFG rickettsioses in the United States...
  17. ncbi request reprint Fatal hemorrhagic fever caused by West Nile virus in the United States
    Christopher D Paddock
    Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 42:1527-35. 2006
    ..We describe a case of fulminant WNV infection in a 59-year-old Florida man who died following a brief illness that resembled hemorrhagic disease caused by Rickettsia reckettsii, dengue virus or yellow fever virus...
  18. pmc Tropism and infectivity of influenza virus, including highly pathogenic avian H5N1 virus, in ferret tracheal differentiated primary epithelial cell cultures
    Hui Zeng
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 87:2597-607. 2013
    ..This ferret tracheal differentiated primary epithelial cell culture system provides a valuable in vitro model for studying cellular tropism, infectivity, and the pathogenesis of influenza viruses...
  19. pmc 2009 pandemic influenza A (H1N1): pathology and pathogenesis of 100 fatal cases in the United States
    Wun Ju Shieh
    Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 32, Atlanta, GA 30333, USA
    Am J Pathol 177:166-75. 2010
    ..Underlying medical conditions and bacterial co-infections contributed to the fatal outcome of this infection. More studies are needed to understand the multifactorial pathogenesis of this infection...
  20. ncbi request reprint Generation of eGFP expressing recombinant Zaire ebolavirus for analysis of early pathogenesis events and high-throughput antiviral drug screening
    Jonathan S Towner
    Special Pathogens Branch, Division of Viral and Rickettsial Diseases, NCID, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 332:20-7. 2005
    ..We show that Ebola-eGFP virus (EboZ-eGFP) infects known early targets of human infections and serves as an ideal model to screen antiviral compounds in less time than any previously published assay...
  21. pmc Nipah virus infection: pathology and pathogenesis of an emerging paramyxoviral zoonosis
    Kum Thong Wong
    University of Malaya, Kuala Lumpur, Malaysia
    Am J Pathol 161:2153-67. 2002
    ..Infection of endothelial cells and neurons as well as vasculitis and thrombosis seem to be critical to the pathogenesis of this new human disease...
  22. ncbi request reprint Transmission of lymphocytic choriomeningitis virus by organ transplantation
    Staci A Fischer
    Rhode Island Hospital and Brown Medical School, Providence, USA
    N Engl J Med 354:2235-49. 2006
    ..Each cluster was investigated because diagnostic evaluations were unrevealing, and in each a common donor was recognized...
  23. doi request reprint A new arenavirus in a cluster of fatal transplant-associated diseases
    Gustavo Palacios
    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    N Engl J Med 358:991-8. 2008
    ..Culture, polymerase-chain-reaction (PCR) and serologic assays, and oligonucleotide microarray analysis for a wide range of infectious agents were not informative...