Research Topics
| Cynthia S GoldsmithSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
| Collaborators
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Detail Information
Publications
Ultrastructural characterization of SARS coronavirusCynthia S Goldsmith
Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 10:320-6. 2004..Electron microscopic studies were critical in identifying the etiologic agent of the SARS outbreak and in guiding subsequent laboratory and epidemiologic investigations...- Ultrastructural characterization of pandemic (H1N1) 2009 virusCynthia S Goldsmith
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 17:2056-9. 2011..Many morphologic characteristics were similar to those previously described for influenza virus. One of the distinctive features was dense tubular structures in the nuclei of infected cells... 
Elucidation of Nipah virus morphogenesis and replication using ultrastructural and molecular approachesCynthia S Goldsmith
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Mailstop G30, 1600 Clifton Road NE, Atlanta, GA 30333, USA
Virus Res 92:89-98. 2003..Ultrastructural ISH studies suggest these inclusions play an important role in the transcription process...- Modern uses of electron microscopy for detection of virusesCynthia S Goldsmith
Infectious Disease Pathology Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Clin Microbiol Rev 22:552-63. 2009..These studies provide information for treatment and vaccine strategies... - A novel coronavirus associated with severe acute respiratory syndromeThomas G Ksiazek
Special Pathogens Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USA
N Engl J Med 348:1953-66. 2003..Because of the death of Dr. Carlo Urbani, we propose that our first isolate be named the Urbani strain of SARS-associated coronavirus... - Immunohistochemical, in situ hybridization, and ultrastructural localization of SARS-associated coronavirus in lung of a fatal case of severe acute respiratory syndrome in TaiwanWun-Ju Shieh
Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, Center for Disease Control and Prevention, Atlanta, GA 30333, USA
Hum Pathol 36:303-9. 2005..These techniques represent valuable laboratory diagnostic modalities and provide insights into the pathogenesis of this emerging infection... 
Reduced virus replication, proinflammatory cytokine production, and delayed macrophage cell death in human PBMCs infected with the newly discovered Bundibugyo ebolavirus relative to Zaire ebolavirusManisha Gupta
Special Pathogens Branch, DVRD, Centers for Disease Control and Prevention, Atlanta, GA, USA
Virology 402:203-8. 2010..The findings of slower Bundibugyo ebolavirus replication, lower production of proinflammatory cytokines and delay in macrophage cell death provide insight into the basis of the lower case fatality observed with Bundibugyo ebolavirus...- Monkeypox transmission and pathogenesis in prairie dogsJeannette Guarner
Infectious Disease Pathology Activity, Centers for Disease Control and Prevention, Mailstop G32, 1600 Clifton Road NE, Atlanta, GA 30333, USA
Emerg Infect Dis 10:426-31. 2004..Prairie dogs offer insights into transmission, pathogenesis, and new vaccine and treatment trials because they are susceptible to severe monkeypox infection... - Human febrile illness caused by encephalomyocarditis virus infection, PeruM Steven Oberste
Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Emerg Infect Dis 15:640-6. 2009..Serum samples from case-patient 2 did not contain antibodies detectable by either assay. Detection of virus in serum strongly supports a role for EMCV in human infection and febrile illness... - Novel deer-associated parapoxvirus infection in deer huntersAmira A Roess
Epidemic Intelligence Service, Epidemiology Program Office, and the Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
N Engl J Med 363:2621-7. 2010..Deer populations continue to increase, leading to the possibility that there will be more deer-associated parapoxvirus infections... - A new phlebovirus associated with severe febrile illness in MissouriLaura K McMullan
Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
N Engl J Med 367:834-41. 2012..Although Koch's postulates have not been completely fulfilled, we believe that this phlebovirus, which is novel in the Americas, is the cause of this clinical syndrome... - SARS-coronavirus replication in human peripheral monocytes/macrophagesMamadi Yilla
Respiratory and Enteric Viruses Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS C22, Atlanta, GA 30333, USA
Virus Res 107:93-101. 2005..Given the importance of monocytes/macrophages to the immune response, it is possible that their infection by SARS-CoV and alteration of this infection by IFN-alpha may be important to the course of the infection in humans... - Pathology and pathogenesis of fatal Bordetella pertussis infection in infantsChristopher D Paddock
Infectious Disease Pathology Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Clin Infect Dis 47:328-38. 2008.... - Tropism and infectivity of influenza virus, including highly pathogenic avian H5N1 virus, in ferret tracheal differentiated primary epithelial cell culturesHui Zeng
Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
J Virol 87:2597-607. 2013..This ferret tracheal differentiated primary epithelial cell culture system provides a valuable in vitro model for studying cellular tropism, infectivity, and the pathogenesis of influenza viruses... - Generation of eGFP expressing recombinant Zaire ebolavirus for analysis of early pathogenesis events and high-throughput antiviral drug screeningJonathan S Towner
Special Pathogens Branch, Division of Viral and Rickettsial Diseases, NCID, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Virology 332:20-7. 2005..We show that Ebola-eGFP virus (EboZ-eGFP) infects known early targets of human infections and serves as an ideal model to screen antiviral compounds in less time than any previously published assay... - Rickettsia parkeri: a newly recognized cause of spotted fever rickettsiosis in the United StatesChristopher D Paddock
Division of Viral and Rickettsial Diseases, Infectious Disease Pathology Activity, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Clin Infect Dis 38:805-11. 2004..parkeri rickettsiosis and possibly other novel SFG rickettsioses in the United States... - 2009 pandemic influenza A (H1N1): pathology and pathogenesis of 100 fatal cases in the United StatesWun Ju Shieh
Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G 32, Atlanta, GA 30333, USA
Am J Pathol 177:166-75. 2010..Underlying medical conditions and bacterial co-infections contributed to the fatal outcome of this infection. More studies are needed to understand the multifactorial pathogenesis of this infection... - Fatal hemorrhagic fever caused by West Nile virus in the United StatesChristopher D Paddock
Infectious Disease Pathology Activity, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Clin Infect Dis 42:1527-35. 2006..We describe a case of fulminant WNV infection in a 59-year-old Florida man who died following a brief illness that resembled hemorrhagic disease caused by Rickettsia reckettsii, dengue virus or yellow fever virus... - Transmission of lymphocytic choriomeningitis virus by organ transplantationStaci A Fischer
Rhode Island Hospital and Brown Medical School, Providence, USA
N Engl J Med 354:2235-49. 2006..One recipient, who received ribavirin and reduced levels of immunosuppressive therapy, survived. CONCLUSIONS: We document two clusters of LCMV infection transmitted through organ transplantation... - Nipah virus infection: pathology and pathogenesis of an emerging paramyxoviral zoonosisKum Thong Wong
University of Malaya, Kuala Lumpur, Malaysia
Am J Pathol 161:2153-67. 2002..Infection of endothelial cells and neurons as well as vasculitis and thrombosis seem to be critical to the pathogenesis of this new human disease... - A new arenavirus in a cluster of fatal transplant-associated diseasesGustavo Palacios
Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
N Engl J Med 358:991-8. 2008..Culture, polymerase-chain-reaction (PCR) and serologic assays, and oligonucleotide microarray analysis for a wide range of infectious agents were not informative...