Research Topics
| Jon R GentschSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
| Collaborators
|
Detail Information
Publications
Serotype diversity and reassortment between human and animal rotavirus strains: implications for rotavirus vaccine programsJon R Gentsch
Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Infect Dis 192:S146-59. 2005..The enormous diversity and capacity of human rotaviruses for change suggest that rotavirus vaccines must provide good heterotypic protection to be optimally effective...
G and P types of circulating rotavirus strains in the United States during 1996-2005: nine years of prevaccine dataJon R Gentsch
Gastroenteritis and Respiratory Viruses Laboratory Branch, Atlanta, Georgia
J Infect Dis 200:S99-S105. 2009..Rotavirus vaccine was recommended for routine use among US infants in 2006. To provide prevaccine data, we conducted strain surveillance for 9 consecutive seasons during 1996-2005...- United States rotavirus strain surveillance from 2005 to 2008: genotype prevalence before and after vaccine introductionJennifer J Hull
Gastroenteritis and Respiratory Viruses Laboratory Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Pediatr Infect Dis J 30:S42-7. 2011..To monitor the distribution of rotavirus genotypes before and after vaccine introduction, the Centers for Disease Control and Prevention conducted strain surveillance with the National Rotavirus Strain Surveillance System... - Secular variation in United States rotavirus disease rates and serotypes: implications for assessing the rotavirus vaccination programDaniel C Payne
Epidemiology Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Pediatr Infect Dis J 28:948-53. 2009.... - Remaining issues and challenges for rotavirus vaccine in preventing global childhood diarrheal morbidity and mortalityJacqueline E Tate
Centers for Disease Control and Prevention, 1600 Clifton Road, NE MS A34, Atlanta, GA 30333, USA
Expert Rev Vaccines 11:211-20. 2012..The objectives of this paper are to describe the remaining issues and challenges in ensuring the success of the global rotavirus vaccination program and to discuss further research needed to help address them... - Sibling transmission of vaccine-derived rotavirus (RotaTeq) associated with rotavirus gastroenteritisDaniel C Payne
MSPH, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, MS A47, Atlanta, GA 30333, USA
Pediatrics 125:e438-41. 2010..Both children remain healthy 11 months after this event and are without underlying medical conditions... - Uptake, impact, and effectiveness of rotavirus vaccination in the United States: review of the first 3 years of postlicensure dataJacqueline E Tate
Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Pediatr Infect Dis J 30:S56-60. 2011..Rotavirus vaccine was recommended for routine use in US infants in 2006. Before the introduction of vaccine, rotavirus was the most common cause of severe gastroenteritis in children <5 years of age in the United States... 
Novel human rotavirus genotype G5P[7] from child with diarrhea, CameroonMathew D Esona
Gastroenteritis and Respiratory Viruses Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 15:83-6. 2009..This G5P[7] strain exemplifies the importance of heterologous animal rotaviruses in generating HRV genetic diversity through reassortment...- Characterization of VP6 genes from rotavirus strains collected in the United States from 1996-2002Tara K Kerin
National Center for Immunization and Respiratory Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, N E MS G 04, Atlanta, GA 30333, USA
Virus Genes 35:489-95. 2007.... - Detection and characterization of group C rotavirus in Buenos Aires, Argentina, 1997-2003Alejandro A Castello
Division of Viral Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, Georgia, USA
J Med Virol 81:1109-16. 2009..These findings indicate that RVC is a significant cause of diarrhea and it is necessary to develop simple and sensitive serological methods for its detection... - Rotavirus vaccines: current prospects and future challengesRoger I Glass
Viral Gastroenteritis Section, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Lancet 368:323-32. 2006.... - Update on rotavirus vaccinesJoseph S Bresee
Respiratory and Enteric Virus Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Pediatr Infect Dis J 24:947-52. 2005..This update reviews the epidemiology of rotavirus infections, assesses past and current vaccines and presents ideas for implementation of vaccination programs in developed and developing countries... - Intussusception after administration of the rhesus tetravalent rotavirus vaccine (Rotashield): the search for a pathogenic mechanismMaureen Lynch
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Pediatrics 117:e827-32. 2006..The Peyer's patches were not hyperplastic, and we could not establish the pathogenic mechanism for this association... - Global impact of rotavirus vaccinesJacqueline E Tate
National Center for Immunization and Respiratory Diseases, US CDC, 1600 Clifton Rd NE, MS A47, Atlanta, GA 30333, USA
Expert Rev Vaccines 9:395-407. 2010..e., herd protection). Early clinical trial data from Africa and Asia are promising, and further efforts are needed to optimize the benefits of vaccination in developing countries where vaccines are likely to have their greatest impact... - Detection of rotavirus antigenemia in routinely obtained serum specimens to augment surveillance and vaccine effectiveness evaluationsManish Patel
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Pediatr Infect Dis J 29:836-9. 2010..Because obtaining stool specimens is cumbersome, we evaluated whether detection of antigenemia in sera obtained during routine clinical practice could augment rotavirus surveillance to assess the effect of vaccination... - Inactivated rotavirus vaccine induces protective immunity in gnotobiotic pigletsYuhuan Wang
Division of Viral Diseases, Centers for Diseases Control and Prevention, Atlanta, GA, USA
Vaccine 28:5432-6. 2010..Our findings demonstrate the proof of concept for an IRV in a large animal model and provide evidence and justification for further clinical development as an alternative candidate vaccine... - Isolation and characterization of a new simian rotavirus, YK-1Larry E Westerman
Viral Gastroenteritis Team, Respiratory and Enteric Viruses Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Virol J 3:40. 2006..A requirement for an effective animal model is the availability of appropriate rotavirus stocks for challenge... - Reassortant group A rotavirus from straw-colored fruit bat (Eidolon helvum)Mathew D Esona
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 16:1844-52. 2010..Results suggest that several reassortment events have occurred between human, animal, and bat rotaviruses. Several additional rotavirus strains were detected in bats... - Oral rotavirus vaccines: how well will they work where they are needed most?Manish Patel
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
J Infect Dis 200:S39-48. 2009.... - Rotavirus infection alters peripheral T-cell homeostasis in children with acute diarrheaYuhuan Wang
Division of Viral Diseases, Scientific Resources Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Virol 81:3904-12. 2007.... - Development of candidate rotavirus vaccines derived from neonatal strains in IndiaRoger I Glass
Respiratory and Enteric Viruses Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Infect Dis 192:S30-5. 2005..This unique project, which is developing a new rotavirus vaccine in India with the use of Indian strains, an Indian manufacturer, and an Indian clinical development program, aims to expedite introduction of rotavirus vaccines in India... - Active, population-based surveillance for severe rotavirus gastroenteritis in children in the United StatesDaniel C Payne
Epidemiology Branch, Division of Viral Diseases, National Center for Immunizations and Respiratory Disease, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, MS A34, Atlanta, GA 30333, USA
Pediatrics 122:1235-43. 2008..This surveillance system establishes baseline estimates of rotavirus disease burden and allows for the prospective monitoring of rotavirus vaccination impact... - Outbreaks of adult gastroenteritis traced to a single genotype of rotavirusDixie D Griffin
Viral Gastroenteritis Section, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Infect Dis 185:1502-5. 2002..For the rotavirus vaccines under development, special attention may need to be paid to protection against G2 strains... - Rotavirus disease and its preventionMarc Alain Widdowson
Viral Gastroenteritis Section, Respiratory and Enteric Viruses Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Curr Opin Gastroenterol 21:26-31. 2005.... - Inactivated rotavirus vaccines: a priority for accelerated vaccine developmentBaoming Jiang
Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Vaccine 26:6754-8. 2008..Research to develop alternative approaches should be fostered as an insurance policy to protect against suboptimal efficacy or unanticipated adverse events that could hinder global immunization and protection of all children... - Epidemiological profile and burden of rotavirus diarrhea in Vietnam: 5 years of sentinel hospital surveillance, 1998-2003Nguyen Van Man
Poliomyelitis Vaccine Research and Production Center, Hanoi, Vietnam
J Infect Dis 192:S127-32. 2005..Study outcomes will provide information for future testing and potential use of a rotavirus vaccine... - First report from the Asian Rotavirus Surveillance NetworkJoseph Bresee
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 10:988-95. 2004..Such a network should provide increased visibility and advocacy, enable more efficient data collection, facilitate training, and serve as the paradigm for rotavirus surveillance activities in other regions... - The pathology of rotavirus-associated deaths, using new molecular diagnosticsMaureen Lynch
Viral Gastroenteritis Section, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Clin Infect Dis 37:1327-33. 2003..The part played by rotavirus in fatal cases is unclear and requires additional investigation of diarrhea-associated deaths, because a better understanding might alter the approach to treatment and the need for antiviral therapy... - The role of serum antibodies in the protection against rotavirus disease: an overviewBaoming Jiang
Viral Gastroenteritis Section, Respiratory and Enteric Viruses Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Clin Infect Dis 34:1351-61. 2002.... - Protein kinase R mediates intestinal epithelial gene remodeling in response to double-stranded RNA and live rotavirusMatam Vijay-Kumar
Department of Pathology and Laboratory Medicine, Epithelial Pathobiology Unit, Emory University School of Medicine, Atlanta, GA 30322, USA
J Immunol 174:6322-31. 2005.... - The VP7 genes of two G9 rotaviruses isolated in 1980 from diarrheal stool samples collected in Washington, DC, are unique molecularly and serotypicallyDianjun Cao
Epidemiology Section, Laboratory of Infectious Diseases, NIAID, NIH, Building 50, Room 6308, Bethesda, MD 20902, USA
J Virol 82:4175-9. 2008..Unexpectedly, however, the VP7s of the 1980 G9 viruses were more closely related serotypically to lineage 3 VP7s than to lineage 2 VP7, which may be supported by amino acid sequence analyses of the VP7 proteins... - Diversity of rotavirus strains among children with acute diarrhea in China: 1998-2000 surveillance studyZhao Yin Fang
Division of Enteric Viruses, Institute of Virology, Chinese Academy of Preventive Medicine, 100 Ying Xin Jie, Xuan Wu Qu, Beijing 100052, People s Republic of China
J Clin Microbiol 40:1875-8. 2002..Our results indicate that while the common rotavirus strains remain predominant, the diversity of strains is much greater than was previously recognized... - Dominating prevalence of P[8],G1 and P[8],G9 rotavirus strains among children admitted to hospital between 2000 and 2003 in Budapest, HungaryKrisztian Banyai
Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pecs, Hungary
J Med Virol 76:414-23. 2005.... - Genetic variability among serotype G6 human rotaviruses: identification of a novel lineage isolated in HungaryKrisztian Banyai
Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pecs, Hungary
J Med Virol 71:124-34. 2003..Serotype G6-specific primers for each human G6 lineage were also developed. The use of these primers in reverse-transcription polymerase chain reaction genotyping may help determine the epidemiological role of G6 strains in humans... - Molecular epidemiology of human P[8],G9 rotaviruses in Hungary between 1998 and 2001Krisztian Banyai
Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pecs, Hungary
J Med Microbiol 53:791-801. 2004..The unexpected heterogeneity found for G9 VP7 genes from several countries suggests that genetic variation among these strains has not yet been fully explored... - Rotavirus typing methods and algorithmsThea K Fischer
Centre for International Health, University of Bergen, Norway, Laboratorio National de Saude Publica, Bissau, Guinea Bissau and Department of Epidemiology Research, Danish Epidemiology Science Centre, Copenhagen, Denmark
Rev Med Virol 14:71-82. 2004..Improved detection and characterisation of incompletely typed strains will help to develop a comprehensive strain surveillance that may be required for tailoring effective rotavirus vaccines... - Emergence of serotype G12 rotaviruses, HungaryKrisztian Banyai
Baranya County Institute of State Public Health Service, Pecs, Hungary
Emerg Infect Dis 13:916-9. 2007..These findings are consistent with recent reports of the possible global spread and increasing epidemiologic importance of these strains, which may have implications for current rotavirus vaccination strategies... - Rotavirus serotype G9 strains belonging to VP7 gene phylogenetic sequence lineage 1 may be more suitable for serotype G9 vaccine candidates than those belonging to lineage 2 or 3Yasutaka Hoshino
Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8026, USA
J Virol 78:7795-802. 2004..These findings may have important implications for the development of G9 rotavirus vaccine candidates, as the strain with the broadest reactivity (i.e., a prime strain) would certainly be the ideal strain for inclusion in a vaccine... - A porcine G9 rotavirus strain shares neutralization and VP7 phylogenetic sequence lineage 3 characteristics with contemporary human G9 rotavirus strainsYasutaka Hoshino
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Room 6308, 50 South Drive MSC 8026, Bethesda, MD 20892 8026, USA
Virology 332:177-88. 2005..Furthermore, by sequence analysis, the A2 VP7 was shown to belong to lineage 3 G9. These findings raise intriguing questions regarding possible explanations for the emergence of variations among the G9 strains... - Development and validation of DNA microarray for genotyping group A rotavirus VP4 (P[4], P[6], P[8], P[9], and P[14]) and VP7 (G1 to G6, G8 to G10, and G12) genesShinjiro Honma
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 8026, USA
J Clin Microbiol 45:2641-8. 2007..Moreover, because the hybridization patterns exhibited by rotavirus strains of different genotypes can vary, this method may be ideal for analyzing the genetic polymorphisms of the VP7 or VP4 genes of rotaviruses... - Development of a microtiter plate hybridization-based PCR-enzyme-linked immunosorbent assay for identification of clinically relevant human group A rotavirus G and P genotypesNorma Santos
Departamento de Virologia, Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Cidade Universitaria, CCS Bl I, Ilha do Fundao, Rio de Janeiro 21 941 590, Brazil
J Clin Microbiol 46:462-9. 2008.... - Rotavirus epidemiology: the Asian Rotavirus Surveillance NetworkE A S Nelson
Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
Vaccine 26:3192-6. 2008.... - Safety and immunogenicity of two live attenuated human rotavirus vaccine candidates, 116E and I321, in infants: results of a randomised controlled trialNita Bhandari
Society for Applied Studies, New Delhi, India
Vaccine 24:5817-23. 2006..Vaccine virus was shed on days 3, 7 or 28 in 11/30 infants of the 116E and none in the other two groups. The 116E strain is attenuated, clinically safe and highly immunogenic with a single dose... - The expanding diversity of rotavirusesNigel A Cunliffe
Department of Medical Microbiology and Genito-Urinary Medicine, University of Liverpool, Liverpool L69 3GA, UK
Lancet 359:640-2. 2002 - Eight-year survey of human rotavirus strains demonstrates circulation of unusual G and P types in HungaryKrisztian Banyai
Regional Laboratory of Virology, Baranya County Institute of State Public Health Service, Pecs, Hungary
J Clin Microbiol 42:393-7. 2004..Although once considered to be rare, P[9],G6 and P[8],G9 rotavirus strains represent potentially important new serotypes in Hungary... - New oligonucleotide primers for P-typing of rotavirus strains: Strategies for typing previously untypeable strainsMirjam Kühne Simmonds
Enteric Virus Unit, Virus Reference Department, Centre for Infections, Health Protection Agency, London NW9 5EQ, UK
J Clin Virol 42:368-73. 2008....