David G Frazer

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi request reprint Nonlinear model for offline correction of pulmonary waveform generators
    Jeffrey S Reynolds
    Engineering and Controls Technology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    IEEE Trans Biomed Eng 49:1567-73. 2002
  2. pmc Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction
    Timothy R Nurkiewicz
    Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, WV, USA
    Part Fibre Toxicol 5:1. 2008
  3. pmc Comparison of stainless and mild steel welding fumes in generation of reactive oxygen species
    Stephen S Leonard
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Part Fibre Toxicol 7:32. 2010
  4. doi request reprint Determining when enhanced pause (Penh) is sensitive to changes in specific airway resistance
    David G Frazer
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 74:287-95. 2011
  5. doi request reprint Popcorn flavoring effects on reactivity of rat airways in vivo and in vitro
    Eric J Zaccone
    Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 76:669-89. 2013
  6. doi request reprint Multi-walled carbon nanotubes: sampling criteria and aerosol characterization
    Bean T Chen
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505 2888, USA
    Inhal Toxicol 24:798-820. 2012
  7. doi request reprint Nanotechnology: toxicologic pathology
    Ann F Hubbs
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Toxicol Pathol 41:395-409. 2013
  8. doi request reprint Alterations in welding process voltage affect the generation of ultrafine particles, fume composition, and pulmonary toxicity
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Nanotoxicology 5:700-10. 2011
  9. doi request reprint Pulmonary and cardiovascular responses of rats to inhalation of silver nanoparticles
    Jenny R Roberts
    Health Effects Laboratory Division HELD, National Institute for Occupational Safety and Health NIOSH, Centers for Disease Control and Prevention CDC, 1095 Willowdale Rd M S 2015, Morgantown, WV 26505, USA
    J Toxicol Environ Health A 76:651-68. 2013
  10. pmc Type I interferon and pattern recognition receptor signaling following particulate matter inhalation
    Aaron Erdely
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Part Fibre Toxicol 9:25. 2012

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Nonlinear model for offline correction of pulmonary waveform generators
    Jeffrey S Reynolds
    Engineering and Controls Technology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    IEEE Trans Biomed Eng 49:1567-73. 2002
    ..0%. When loaded with the Micro DiaryCard meter, the uncorrected pump outputs included six waveforms with MSE higher than 0.001 L2/s2. Pump corrections for these six waveforms resulted in a mean decrease in MSE of 58.4%...
  2. pmc Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction
    Timothy R Nurkiewicz
    Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, WV, USA
    Part Fibre Toxicol 5:1. 2008
    ..abstract:..
  3. pmc Comparison of stainless and mild steel welding fumes in generation of reactive oxygen species
    Stephen S Leonard
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Part Fibre Toxicol 7:32. 2010
    ..An inhalation exposure chamber located at NIOSH was used to collect the welding fume particles...
  4. doi request reprint Determining when enhanced pause (Penh) is sensitive to changes in specific airway resistance
    David G Frazer
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 74:287-95. 2011
    ..That relationship is used to describe the conditions under which whole-body plethysmograph Penh measurements can be used to detect changes in sRaw...
  5. doi request reprint Popcorn flavoring effects on reactivity of rat airways in vivo and in vitro
    Eric J Zaccone
    Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 76:669-89. 2013
    ..Data suggest that the effects of 2,3-pentanedione on airway reactivity are greater than those of diacetyl, and that flavorings are airway smooth muscle relaxants and constrictors, thus indicating a complex mechanism. ..
  6. doi request reprint Multi-walled carbon nanotubes: sampling criteria and aerosol characterization
    Bean T Chen
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505 2888, USA
    Inhal Toxicol 24:798-820. 2012
    ..The measurement scheme should be relevant for any carbon nanotube aerosol...
  7. doi request reprint Nanotechnology: toxicologic pathology
    Ann F Hubbs
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Toxicol Pathol 41:395-409. 2013
    ..Thus, the pathology assessment is facilitated by understanding the unique features at the nanoscale and the tools that can assist in evaluating nanotoxicology studies...
  8. doi request reprint Alterations in welding process voltage affect the generation of ultrafine particles, fume composition, and pulmonary toxicity
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Nanotoxicology 5:700-10. 2011
    ..In summary, a modest raise in welding voltage affected fume size and elemental composition and altered the temporal lung toxicity profile...
  9. doi request reprint Pulmonary and cardiovascular responses of rats to inhalation of silver nanoparticles
    Jenny R Roberts
    Health Effects Laboratory Division HELD, National Institute for Occupational Safety and Health NIOSH, Centers for Disease Control and Prevention CDC, 1095 Willowdale Rd M S 2015, Morgantown, WV 26505, USA
    J Toxicol Environ Health A 76:651-68. 2013
    ..In summary, short-term inhalation of nano-Ag did not produce apparent marked acute toxicity in this animal model. ..
  10. pmc Type I interferon and pattern recognition receptor signaling following particulate matter inhalation
    Aaron Erdely
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Part Fibre Toxicol 9:25. 2012
    ..Whole blood cells, aorta and lung were harvested for global gene expression analysis with subsequent Ingenuity Pathway Analysis and confirmatory qRT-PCR. Serum was collected for protein profiling...
  11. doi request reprint Neurotoxicity following acute inhalation exposure to the oil dispersant COREXIT EC9500A
    Krishnan Sriram
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Toxicology and Molecular Biology Branch, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 74:1405-18. 2011
    ..Whether such acute molecular aberrations might persist and produce chronic neurological deficits remains to be ascertained...
  12. doi request reprint Acute pulmonary dose-responses to inhaled multi-walled carbon nanotubes
    Dale W Porter
    National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Nanotoxicology 7:1179-94. 2013
    ..Acute inhalation of MWCNT induced dose-dependent pulmonary inflammation and damage with rapid development of pulmonary fibrosis, and also demonstrated that MWCNT can reach the pleura after inhalation exposure...
  13. doi request reprint Nanoparticle inhalation alters systemic arteriolar vasoreactivity through sympathetic and cyclooxygenase-mediated pathways
    Travis L Knuckles
    Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, WV, USA
    Nanotoxicology 6:724-35. 2012
    ..Furthermore, the enhanced adrenergic receptor sensitivity suggests an augmented sympathetic responsiveness...
  14. ncbi request reprint Effect of short-term stainless steel welding fume inhalation exposure on lung inflammation, injury, and defense responses in rats
    James M Antonini
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 223:234-45. 2007
    ..Additional chronic inhalation studies are needed to further examine the lung effects associated with SS welding fume exposure...
  15. ncbi request reprint Metal working fluids: sub-chronic effects on pulmonary functions in B6C3F1 mice given vitamin E deficient and sufficient diets
    Anna A Shvedova
    Pathology and Physiology Research Branch, Engineering Control and Technology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Toxicology 177:285-97. 2002
    ..This is the first report that describes the increase of oxidative stress in the lungs after MWF exposure...
  16. ncbi request reprint Exposure to particulate 1-->3-beta-glucans induces greater pulmonary toxicity than soluble 1-->3-beta-glucans in rats
    Shih Houng Young
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS 2027, Morgantown, WV 26505, USA
    J Toxicol Environ Health A 66:25-38. 2003
    ..Therefore, results demonstrate that particulate zymosan A is more potent in inducing pulmonary inflammation and damage in rats than the soluble form of this beta-glucan...
  17. ncbi request reprint Effect of asphalt fume inhalation exposure at simulated road paving conditions prior to bacterial infection on lung defense responses in rats
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Inhal Toxicol 15:1347-68. 2003
    ..It was concluded that acute inhalation of asphalt fumes at a high concentration had a minimal effect on lung immune responses to infection in rats...
  18. ncbi request reprint Characterization of DNA adducts from lung tissue of asphalt fume-exposed mice by nanoflow liquid chromatography quadrupole time-of-flight mass spectrometry
    Jin J Wang
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, U S Department of Health and Human Services, Morgantown, WV 26505, USA
    Anal Biochem 322:79-88. 2003
    ..35 pmol/mg DNA by 32P-postlabeling assay. In total, the results indicated that PAH DNA adducts were significantly elevated (p < 0.001) in the lung tissue of asphalt-fume-exposed mice relative to tissue from control animals...
  19. doi request reprint Persistence of deposited metals in the lungs after stainless steel and mild steel welding fume inhalation in rats
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Arch Toxicol 85:487-98. 2011
    ..The potentially more toxic metals (e.g., Mn, Cr) present in the stainless steel fume were cleared from the lungs more quickly than Fe, likely increasing their translocation from the respiratory system to other organs...
  20. doi request reprint Mild steel welding fume causes manganese accumulation and subtle neuroinflammatory changes but not overt neuronal damage in discrete brain regions of rats after short-term inhalation exposure
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Neurotoxicology 30:915-25. 2009
    ..The neurofunctional significance of these findings currently is being investigated in longer, more chronic welding fume exposure studies...
  21. ncbi request reprint Asymmetric and axisymmetric constant curvature liquid-gas interfaces in pulmonary airways
    William G Lindsley
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Ann Biomed Eng 33:365-75. 2005
    ....
  22. ncbi request reprint Short-term inhalation exposure to mild steel welding fume had no effect on lung inflammation and injury but did alter defense responses to bacteria in rats
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Inhal Toxicol 21:182-92. 2009
    ..More chronic inhalation studies are needed to further examine the immune effects and to elucidate the possible mechanisms of the suppressed lung defense response to infection associated with the inhalation of MS welding fume...
  23. ncbi request reprint Design, construction, and characterization of a novel robotic welding fume generator and inhalation exposure system for laboratory animals
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Occup Environ Hyg 3:194-203; quiz D45. 2006
    ....
  24. ncbi request reprint Unrestrained acoustic plethysmograph for measuring tidal volume in mice
    Jeffrey S Reynolds
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Ann Biomed Eng 34:1494-9. 2006
    ..The RMS error between measured and delivered volume was 4.43 microL. A volume step test, performed to assess the response time of the system, showed that the plethysmograph responded in less than one millisecond...
  25. doi request reprint Nanoparticles-containing spray can aerosol: characterization, exposure assessment, and generator design
    Bean T Chen
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Inhal Toxicol 22:1072-82. 2010
    ..Future investigations will include an inhalation study to obtain information on dose-response relationships in rats and to use it to establish a No Effect Exposure Level for setting guidelines for this consumer product...
  26. doi request reprint Short-term inhalation of stainless steel welding fume causes sustained lung toxicity but no tumorigenesis in lung tumor susceptible A/J mice
    Patti C Zeidler-Erdely
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505, USA
    Inhal Toxicol 23:112-20. 2011
    ..Under our exposure conditions, GMA-SS exposure resulted in no significant tumor development in A/J mice...
  27. doi request reprint Carbon nanotube dosimetry: from workplace exposure assessment to inhalation toxicology
    Aaron Erdely
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Part Fibre Toxicol 10:53. 2013
    ..S.-based multi-walled CNT (MWCNT) manufacturers and users were extrapolated to results of an inhalation study in mice...
  28. doi request reprint Respiratory and olfactory cytotoxicity of inhaled 2,3-pentanedione in Sprague-Dawley rats
    Ann F Hubbs
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Am J Pathol 181:829-44. 2012
    ..Claudin-1 expression increased in the OB and striatum. We conclude that 2,3-pentanedione is a respiratory hazard that can also alter gene expression in the brain...
  29. pmc Impairment of coronary arteriolar endothelium-dependent dilation after multi-walled carbon nanotube inhalation: a time-course study
    Phoebe A Stapleton
    Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, WV 26506, USA
    Int J Mol Sci 13:13781-803. 2012
    ..The innovations within the field of nanotechnology, while exciting and novel, can only reach their full potential if toxicity is first properly assessed...
  30. doi request reprint Noninvasive pulmonary function screening in spontaneously breathing rodents: an engineering systems perspective
    Jeffrey S Reynolds
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Pharmacol Ther 131:359-68. 2011
    ..This model is used as a basis to demonstrate the relationship between pulmonary parameters derived from circuit analysis...
  31. doi request reprint Pulmonary effects after acute inhalation of oil dispersant (COREXIT EC9500A) in rats
    Jenny R Roberts
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 74:1381-96. 2011
    ..COREXIT inhibited neurogenic contractile responses of strips to electrical field stimulation. Our findings suggest that COREXIT inhalation did not initiate lung inflammation, but may transiently increase the difficulty of breathing...
  32. pmc Pulmonary nanoparticle exposure disrupts systemic microvascular nitric oxide signaling
    Timothy R Nurkiewicz
    Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
    Toxicol Sci 110:191-203. 2009
    ..These results indicate that in conjunction with microvascular dysfunction, nanoparticle exposure also decreases NO bioavailability through at least two functionally distinct mechanisms that may mutually increase local reactive species...
  33. ncbi request reprint Model predictions of the recruitment of lung units and the lung surface area-volume relationship during inflation
    David G Frazer
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Ann Biomed Eng 32:756-63. 2004
    ..86 and 1. This result supports the theory that, for inflation from EEPs below 4 cmH2O, lung expansion occurs in part by the recruitment of lung units and not solely by the expansion of open units...
  34. ncbi request reprint Modified endotoxin responses in rats pretreated with 1-->3-beta-glucan (zymosan A)
    Shih Houng Young
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Toxicol Appl Pharmacol 178:172-9. 2002
    ..These results suggest that complex interaction of components may exist in exposure to organic dusts. Therefore, hazard may not be defined by measuring endotoxin or 1-->3-beta-glucans alone...
  35. doi request reprint Measurement of airborne nanoparticle surface area using a filter-based gas adsorption method for inhalation toxicology experiments
    Ryan F LeBuf
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    Nanotoxicology 5:687-99. 2011
    ....
  36. doi request reprint Unrestrained acoustic plethysmograph for measuring specific airway resistance in mice
    Jeffrey S Reynolds
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd, ms L2101, Morgantown, WV 26505, USA
    J Appl Physiol (1985) 105:711-7. 2008
    ..s. A dose-dependent increase in sRaw was shown, with an approximate tripling of sRaw at the highest dose. These results demonstrate the ability of the system to estimate sRaw based on plethysmograph airflow and acoustic amplitude...
  37. ncbi request reprint Partially opened triple helix is the biologically active conformation of 1-->3-beta-glucans that induces pulmonary inflammation in rats
    Shih Houng Young
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    J Toxicol Environ Health A 66:551-63. 2003
    ..This study indicates that the partially opened triple helix of 1-->3-beta-glucans is more active than the closed conformation in inducing pulmonary inflammation in rats...
  38. ncbi request reprint Identification and quantification of urinary benzo[a]pyrene and its metabolites from asphalt fume exposed mice by microflow LC coupled to hybrid quadrupole time-of-flight mass spectrometry
    Jin J Wang
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, US Department of Health and Human Services, Morgantown, West Virginia, 26505, USA
    Analyst 128:864-70. 2003
    ..The fragmentation patterns established in this study can also be used to identify and quantify PAH metabolites in other biological fluids...