Research Topics
| David G FrazerSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
| Collaborators
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Detail Information
Publications
Nonlinear model for offline correction of pulmonary waveform generatorsJeffrey S Reynolds
Engineering and Controls Technology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
IEEE Trans Biomed Eng 49:1567-73. 2002..0%. When loaded with the Micro DiaryCard meter, the uncorrected pump outputs included six waveforms with MSE higher than 0.001 L2/s2. Pump corrections for these six waveforms resulted in a mean decrease in MSE of 58.4%...
Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunctionTimothy R Nurkiewicz
Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, WV, USA
Part Fibre Toxicol 5:1. 2008..abstract:..- Comparison of stainless and mild steel welding fumes in generation of reactive oxygen speciesStephen S Leonard
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
Part Fibre Toxicol 7:32. 2010..An inhalation exposure chamber located at NIOSH was used to collect the welding fume particles... 
Determining when enhanced pause (Penh) is sensitive to changes in specific airway resistanceDavid G Frazer
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
J Toxicol Environ Health A 74:287-95. 2011..That relationship is used to describe the conditions under which whole-body plethysmograph Penh measurements can be used to detect changes in sRaw...- Multi-walled carbon nanotubes: sampling criteria and aerosol characterizationBean T Chen
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505 2888, USA
Inhal Toxicol 24:798-820. 2012..The measurement scheme should be relevant for any carbon nanotube aerosol... - Nanotechnology: toxicologic pathologyAnn F Hubbs
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Toxicol Pathol 41:395-409. 2013..Thus, the pathology assessment is facilitated by understanding the unique features at the nanoscale and the tools that can assist in evaluating nanotoxicology studies... - Alterations in welding process voltage affect the generation of ultrafine particles, fume composition, and pulmonary toxicityJames M Antonini
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Nanotoxicology 5:700-10. 2011..In summary, a modest raise in welding voltage affected fume size and elemental composition and altered the temporal lung toxicity profile... - Neurotoxicity following acute inhalation exposure to the oil dispersant COREXIT EC9500AKrishnan Sriram
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Toxicology and Molecular Biology Branch, Morgantown, West Virginia 26505, USA
J Toxicol Environ Health A 74:1405-18. 2011..Whether such acute molecular aberrations might persist and produce chronic neurological deficits remains to be ascertained... - Short-term inhalation exposure to mild steel welding fume had no effect on lung inflammation and injury but did alter defense responses to bacteria in ratsJames M Antonini
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
Inhal Toxicol 21:182-92. 2009..More chronic inhalation studies are needed to further examine the immune effects and to elucidate the possible mechanisms of the suppressed lung defense response to infection associated with the inhalation of MS welding fume... - Mild steel welding fume causes manganese accumulation and subtle neuroinflammatory changes but not overt neuronal damage in discrete brain regions of rats after short-term inhalation exposureJames M Antonini
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Neurotoxicology 30:915-25. 2009..The neurofunctional significance of these findings currently is being investigated in longer, more chronic welding fume exposure studies... - Persistence of deposited metals in the lungs after stainless steel and mild steel welding fume inhalation in ratsJames M Antonini
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Arch Toxicol 85:487-98. 2011..The potentially more toxic metals (e.g., Mn, Cr) present in the stainless steel fume were cleared from the lungs more quickly than Fe, likely increasing their translocation from the respiratory system to other organs... - Nanoparticles-containing spray can aerosol: characterization, exposure assessment, and generator designBean T Chen
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Inhal Toxicol 22:1072-82. 2010..Future investigations will include an inhalation study to obtain information on dose-response relationships in rats and to use it to establish a No Effect Exposure Level for setting guidelines for this consumer product... - Effect of short-term stainless steel welding fume inhalation exposure on lung inflammation, injury, and defense responses in ratsJames M Antonini
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, Morgantown, WV 26505, USA
Toxicol Appl Pharmacol 223:234-45. 2007..Additional chronic inhalation studies are needed to further examine the lung effects associated with SS welding fume exposure... - Unrestrained acoustic plethysmograph for measuring tidal volume in miceJeffrey S Reynolds
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Ann Biomed Eng 34:1494-9. 2006..The RMS error between measured and delivered volume was 4.43 microL. A volume step test, performed to assess the response time of the system, showed that the plethysmograph responded in less than one millisecond... - Metal working fluids: sub-chronic effects on pulmonary functions in B6C3F1 mice given vitamin E deficient and sufficient dietsAnna A Shvedova
Pathology and Physiology Research Branch, Engineering Control and Technology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Toxicology 177:285-97. 2002..This is the first report that describes the increase of oxidative stress in the lungs after MWF exposure... - Exposure to particulate 1-->3-beta-glucans induces greater pulmonary toxicity than soluble 1-->3-beta-glucans in ratsShih Houng Young
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS 2027, Morgantown, WV 26505, USA
J Toxicol Environ Health A 66:25-38. 2003..Therefore, results demonstrate that particulate zymosan A is more potent in inducing pulmonary inflammation and damage in rats than the soluble form of this beta-glucan... - Effect of asphalt fume inhalation exposure at simulated road paving conditions prior to bacterial infection on lung defense responses in ratsJames M Antonini
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
Inhal Toxicol 15:1347-68. 2003..It was concluded that acute inhalation of asphalt fumes at a high concentration had a minimal effect on lung immune responses to infection in rats... - Characterization of DNA adducts from lung tissue of asphalt fume-exposed mice by nanoflow liquid chromatography quadrupole time-of-flight mass spectrometryJin J Wang
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, U S Department of Health and Human Services, Morgantown, WV 26505, USA
Anal Biochem 322:79-88. 2003..35 pmol/mg DNA by 32P-postlabeling assay. In total, the results indicated that PAH DNA adducts were significantly elevated (p < 0.001) in the lung tissue of asphalt-fume-exposed mice relative to tissue from control animals... - Asymmetric and axisymmetric constant curvature liquid-gas interfaces in pulmonary airwaysWilliam G Lindsley
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
Ann Biomed Eng 33:365-75. 2005.... - Design, construction, and characterization of a novel robotic welding fume generator and inhalation exposure system for laboratory animalsJames M Antonini
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
J Occup Environ Hyg 3:194-203; quiz D45. 2006.... - Short-term inhalation of stainless steel welding fume causes sustained lung toxicity but no tumorigenesis in lung tumor susceptible A/J micePatti C Zeidler-Erdely
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505, USA
Inhal Toxicol 23:112-20. 2011..Under our exposure conditions, GMA-SS exposure resulted in no significant tumor development in A/J mice... - Impairment of coronary arteriolar endothelium-dependent dilation after multi-walled carbon nanotube inhalation: a time-course studyPhoebe A Stapleton
Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, WV 26506, USA
Int J Mol Sci 13:13781-803. 2012..The innovations within the field of nanotechnology, while exciting and novel, can only reach their full potential if toxicity is first properly assessed... - Respiratory and olfactory cytotoxicity of inhaled 2,3-pentanedione in Sprague-Dawley ratsAnn F Hubbs
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Am J Pathol 181:829-44. 2012..Claudin-1 expression increased in the OB and striatum. We conclude that 2,3-pentanedione is a respiratory hazard that can also alter gene expression in the brain... - Noninvasive pulmonary function screening in spontaneously breathing rodents: an engineering systems perspectiveJeffrey S Reynolds
Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA
Pharmacol Ther 131:359-68. 2011..This model is used as a basis to demonstrate the relationship between pulmonary parameters derived from circuit analysis... - Pulmonary effects after acute inhalation of oil dispersant (COREXIT EC9500A) in ratsJenny R Roberts
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
J Toxicol Environ Health A 74:1381-96. 2011..COREXIT inhibited neurogenic contractile responses of strips to electrical field stimulation. Our findings suggest that COREXIT inhalation did not initiate lung inflammation, but may transiently increase the difficulty of breathing... - Pulmonary nanoparticle exposure disrupts systemic microvascular nitric oxide signalingTimothy R Nurkiewicz
Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, West Virginia 26506, USA
Toxicol Sci 110:191-203. 2009..These results indicate that in conjunction with microvascular dysfunction, nanoparticle exposure also decreases NO bioavailability through at least two functionally distinct mechanisms that may mutually increase local reactive species... - Type I interferon and pattern recognition receptor signaling following particulate matter inhalationAaron Erdely
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
Part Fibre Toxicol 9:25. 2012..Whole blood cells, aorta and lung were harvested for global gene expression analysis with subsequent Ingenuity Pathway Analysis and confirmatory qRT-PCR. Serum was collected for protein profiling... - Model predictions of the recruitment of lung units and the lung surface area-volume relationship during inflationDavid G Frazer
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Ann Biomed Eng 32:756-63. 2004..86 and 1. This result supports the theory that, for inflation from EEPs below 4 cmH2O, lung expansion occurs in part by the recruitment of lung units and not solely by the expansion of open units... - Modified endotoxin responses in rats pretreated with 1-->3-beta-glucan (zymosan A)Shih-Houng Young
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Toxicol Appl Pharmacol 178:172-9. 2002..These results suggest that complex interaction of components may exist in exposure to organic dusts. Therefore, hazard may not be defined by measuring endotoxin or 1-->3-beta-glucans alone... - Measurement of airborne nanoparticle surface area using a filter-based gas adsorption method for inhalation toxicology experimentsRyan F LeBuf
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
Nanotoxicology 5:687-99. 2011.... - Nanoparticle inhalation alters systemic arteriolar vasoreactivity through sympathetic and cyclooxygenase-mediated pathwaysTravis L Knuckles
Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, WV, USA
Nanotoxicology 6:724-35. 2012..Furthermore, the enhanced adrenergic receptor sensitivity suggests an augmented sympathetic responsiveness... - Unrestrained acoustic plethysmograph for measuring specific airway resistance in miceJeffrey S Reynolds
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd, ms L2101, Morgantown, WV 26505, USA
J Appl Physiol 105:711-7. 2008..s. A dose-dependent increase in sRaw was shown, with an approximate tripling of sRaw at the highest dose. These results demonstrate the ability of the system to estimate sRaw based on plethysmograph airflow and acoustic amplitude... - Partially opened triple helix is the biologically active conformation of 1-->3-beta-glucans that induces pulmonary inflammation in ratsShih Houng Young
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
J Toxicol Environ Health A 66:551-63. 2003..This study indicates that the partially opened triple helix of 1-->3-beta-glucans is more active than the closed conformation in inducing pulmonary inflammation in rats... - Identification and quantification of urinary benzo[a]pyrene and its metabolites from asphalt fume exposed mice by microflow LC coupled to hybrid quadrupole time-of-flight mass spectrometryJin J Wang
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, US Department of Health and Human Services, Morgantown, West Virginia, 26505, USA
Analyst 128:864-70. 2003..The fragmentation patterns established in this study can also be used to identify and quantify PAH metabolites in other biological fluids...