H Frederick Frasch

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. pmc Analysis of finite dose dermal absorption data: implications for dermal exposure assessment
    H Frederick Frasch
    Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    J Expo Sci Environ Epidemiol 24:65-73. 2014
  2. doi request reprint Dermal permeation of 2-hydroxypropyl acrylate, a model water-miscible compound: Effects of concentration, thermodynamic activity and skin hydration
    H Frederick Frasch
    Health Effects Laboratory Division, National Institute for Ocupational Safety and Health, Morgantown, WV 26505, USA Electronic address
    Int J Pharm 460:240-7. 2014
  3. doi request reprint Application of numerical methods for diffusion-based modeling of skin permeation
    H Frederick Frasch
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Adv Drug Deliv Rev 65:208-20. 2013
  4. doi request reprint Dermal absorption of finite doses of volatile compounds
    H Frederick Frasch
    Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Pharm Sci 101:2616-9. 2012
  5. doi request reprint In vitro human epidermal penetration of 1-bromopropane
    H Frederick Frasch
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 74:1249-60. 2011
  6. doi request reprint Tissue binding affects the kinetics of theophylline diffusion through the stratum corneum barrier layer of skin
    H Frederick Frasch
    Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Pharm Sci 100:2989-95. 2011
  7. doi request reprint In vitro dermal penetration of 4-chloro-3-methylphenol from commercial metal working fluid and aqueous vehicles
    H Frederick Frasch
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    J Toxicol Environ Health A 73:1394-405. 2010
  8. doi request reprint A paired comparison between human skin and hairless guinea pig skin in vitro permeability and lag time measurements for 6 industrial chemicals
    H Frederick Frasch
    Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26508, USA
    Cutan Ocul Toxicol 28:107-13. 2009
  9. ncbi request reprint Transcellular route of diffusion through stratum corneum: results from finite element models
    Ana M Barbero
    Health Effects Laboratory, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA
    J Pharm Sci 95:2186-94. 2006
  10. doi request reprint Pig and guinea pig skin as surrogates for human in vitro penetration studies: a quantitative review
    Ana M Barbero
    Health Effects Laboratory Division, National Institute for Occupational Safety and Heath, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA
    Toxicol In Vitro 23:1-13. 2009

Detail Information

Publications16

  1. pmc Analysis of finite dose dermal absorption data: implications for dermal exposure assessment
    H Frederick Frasch
    Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    J Expo Sci Environ Epidemiol 24:65-73. 2014
    ..Case studies are presented that demonstrate the application of these tools to the assessment of dermal absorption data. ..
  2. doi request reprint Dermal permeation of 2-hydroxypropyl acrylate, a model water-miscible compound: Effects of concentration, thermodynamic activity and skin hydration
    H Frederick Frasch
    Health Effects Laboratory Division, National Institute for Ocupational Safety and Health, Morgantown, WV 26505, USA Electronic address
    Int J Pharm 460:240-7. 2014
    ..The goal of these studies was to measure and interpret the skin permeability characteristics of 2-hydroxypropyl acrylate (HPA) as a model compound that is completely miscible with water...
  3. doi request reprint Application of numerical methods for diffusion-based modeling of skin permeation
    H Frederick Frasch
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Adv Drug Deliv Rev 65:208-20. 2013
    ..Model results support a primarily transcellular pathway with anisotropic lipid transport. Future endeavors would benefit from a fundamental analysis of drug/vehicle/skin interactions...
  4. doi request reprint Dermal absorption of finite doses of volatile compounds
    H Frederick Frasch
    Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Pharm Sci 101:2616-9. 2012
    ..The result may be useful for dermal risk assessment as well as in the evaluation of cosmetic and pharmaceutical product performance...
  5. doi request reprint In vitro human epidermal penetration of 1-bromopropane
    H Frederick Frasch
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 74:1249-60. 2011
    ..1-BP is cytotoxic but not corrosive, based on results from a cultured reconstructed human epidermal model (EpiDerm Skin Corrosivity Test)...
  6. doi request reprint Tissue binding affects the kinetics of theophylline diffusion through the stratum corneum barrier layer of skin
    H Frederick Frasch
    Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Pharm Sci 100:2989-95. 2011
    ..4. The permeability coefficient for TH is 4.86 × 10(-5) cm/h, and the lag time is 20.1 h. Binding occurs as a slow process, significantly affecting the kinetics of dermal penetration...
  7. doi request reprint In vitro dermal penetration of 4-chloro-3-methylphenol from commercial metal working fluid and aqueous vehicles
    H Frederick Frasch
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    J Toxicol Environ Health A 73:1394-405. 2010
    ..2 +/- 1.2 and 7.3 +/- 0.8 microg/cm(2), respectively; these amounts are comparable to amounts predicted using a simple algebraic equation...
  8. doi request reprint A paired comparison between human skin and hairless guinea pig skin in vitro permeability and lag time measurements for 6 industrial chemicals
    H Frederick Frasch
    Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26508, USA
    Cutan Ocul Toxicol 28:107-13. 2009
    ..818 +/- 0.030) and the intercept close to 0 (-0.014 +/- 0.023 h), with r(2) = 0.994. These results suggest that HGP skin may serve as an excellent surrogate for human skin in in vitro dermal penetration studies...
  9. ncbi request reprint Transcellular route of diffusion through stratum corneum: results from finite element models
    Ana M Barbero
    Health Effects Laboratory, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA
    J Pharm Sci 95:2186-94. 2006
    ..The importance of the lag time for identifying the diffusion pathway is demonstrated...
  10. doi request reprint Pig and guinea pig skin as surrogates for human in vitro penetration studies: a quantitative review
    Ana M Barbero
    Health Effects Laboratory Division, National Institute for Occupational Safety and Heath, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA
    Toxicol In Vitro 23:1-13. 2009
    ..Both pig and guinea pig are good models for human skin permeability and have less variability than the human skin model. The skin model of choice will depend on the final purpose of the study and the compound under investigation...
  11. ncbi request reprint The transient dermal exposure: theory and experimental examples using skin and silicone membranes
    H Frederick Frasch
    Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Pharm Sci 97:1578-92. 2008
    ..Possible reasons are explored. The current model may provide a realistic framework for estimating absorption from occupational, environmental and pharmaceutical dermal exposures...
  12. ncbi request reprint Skin penetration and lag times of neat and aqueous diethyl phthalate, 1,2-dichloroethane and naphthalene
    H Frederick Frasch
    Health Effects Laboratory, National Institute for Occupational Safety and Health Morgantown, West Virginia 26505, USA
    Cutan Ocul Toxicol 26:147-60. 2007
    ..9 x) but lower with DCE (0.17 x) and NAP (0.45 x). The three chemicals studied including a dry powder, demonstrate the potential for significant dermal penetration...
  13. ncbi request reprint Steady-state flux and lag time in the stratum corneum lipid pathway: results from finite element models
    H Frederick Frasch
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA
    J Pharm Sci 92:2196-207. 2003
    ..Use of the model equations to predict permeability and lag time of lipophilic solutes is described...
  14. doi request reprint Dermal penetration potential of perfluorooctanoic acid (PFOA) in human and mouse skin
    Jennifer Franko
    Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 75:50-62. 2012
    ..These data suggest that PFOA is dermally absorbed and that under certain conditions the skin may be a significant route of exposure...
  15. ncbi request reprint A random walk model of skin permeation
    H Frederick Frasch
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Risk Anal 22:265-76. 2002
    ..The model provides insight into the contributions of stratum corneum diffusivity and effective path lengths to overall skin permeability and may prove useful in the prediction of non-steady-state diffusion phenomena...
  16. ncbi request reprint Regarding the sources of data analyzed with quantitative structure-skin permeability relationship methods (commentary on 'Investigation of the mechanism of flux across human skin in vitro by quantitative structure-permeability relationships')
    H Frederick Frasch
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, MS L 3030, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Eur J Pharm Sci 15:399-403. 2002
    ..Continued use of these data would lead to biased model selection, underestimation of experimental variability, and overestimation of model predictive ability...