Aaron Erdely

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi request reprint Oxidative stress and reduced responsiveness of challenged circulating leukocytes following pulmonary instillation of metal-rich particulate matter in rats
    Aaron Erdely
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown 26505, WV, USA
    Part Fibre Toxicol 11:34. 2014
  2. pmc Carbon nanotube dosimetry: from workplace exposure assessment to inhalation toxicology
    Aaron Erdely
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Part Fibre Toxicol 10:53. 2013
  3. ncbi request reprint Relationship between pulmonary and systemic markers of exposure to multiple types of welding particulate matter
    Aaron Erdely
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, United States
    Toxicology 287:153-9. 2011
  4. pmc Arginase activities and global arginine bioavailability in wild-type and ApoE-deficient mice: responses to high fat and high cholesterol diets
    Aaron Erdely
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America
    PLoS ONE 5:e15253. 2010
  5. ncbi request reprint Identification of systemic markers from a pulmonary carbon nanotube exposure
    Aaron Erdely
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Occup Environ Med 53:S80-6. 2011
  6. pmc Type I interferon and pattern recognition receptor signaling following particulate matter inhalation
    Aaron Erdely
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Part Fibre Toxicol 9:25. 2012
  7. ncbi request reprint Inhalation exposure of gas-metal arc stainless steel welding fume increased atherosclerotic lesions in apolipoprotein E knockout mice
    Aaron Erdely
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, United States
    Toxicol Lett 204:12-6. 2011
  8. ncbi request reprint Short-term inhalation of stainless steel welding fume causes sustained lung toxicity but no tumorigenesis in lung tumor susceptible A/J mice
    Patti C Zeidler-Erdely
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505, USA
    Inhal Toxicol 23:112-20. 2011
  9. ncbi request reprint Lung tumor production and tissue metal distribution after exposure to manual metal ARC-stainless steel welding fume in A/J and C57BL/6J mice
    Patti C Zeidler-Erdely
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, 1095 Willowdale Road M S L2015, Morgantown, WV 26505, USA
    J Toxicol Environ Health A 74:728-36. 2011
  10. pmc Lung tumor promotion by chromium-containing welding particulate matter in a mouse model
    Patti C Zeidler-Erdely
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road MS L2015, Morgantown, WV 26505, USA
    Part Fibre Toxicol 10:45. 2013

Detail Information

Publications16

  1. ncbi request reprint Oxidative stress and reduced responsiveness of challenged circulating leukocytes following pulmonary instillation of metal-rich particulate matter in rats
    Aaron Erdely
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown 26505, WV, USA
    Part Fibre Toxicol 11:34. 2014
    ..These findings support previous studies of an inadequate pulmonary immune response following a metal-rich exposure and extend those findings showing leukocyte dysfunction occurs systemically...
  2. pmc Carbon nanotube dosimetry: from workplace exposure assessment to inhalation toxicology
    Aaron Erdely
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Part Fibre Toxicol 10:53. 2013
    ..S.-based multi-walled CNT (MWCNT) manufacturers and users were extrapolated to results of an inhalation study in mice...
  3. ncbi request reprint Relationship between pulmonary and systemic markers of exposure to multiple types of welding particulate matter
    Aaron Erdely
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, United States
    Toxicology 287:153-9. 2011
    ..In conclusion, varying types of welding fumes elicit quantitatively different systemic inflammatory and/or stress responses...
  4. pmc Arginase activities and global arginine bioavailability in wild-type and ApoE-deficient mice: responses to high fat and high cholesterol diets
    Aaron Erdely
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America
    PLoS ONE 5:e15253. 2010
    ..These results raise the possibility that systemic changes in arginase activity and global arginine bioavailability may be contributing factors in the initiation and/or progression of cardiovascular disease...
  5. ncbi request reprint Identification of systemic markers from a pulmonary carbon nanotube exposure
    Aaron Erdely
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Occup Environ Med 53:S80-6. 2011
    ..Interest exists for early monitoring of worker exposure to engineered nanomaterials. Here, we highlight quantitative systemic markers of early effects after carbon nanotube (CNT) exposure...
  6. pmc Type I interferon and pattern recognition receptor signaling following particulate matter inhalation
    Aaron Erdely
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Part Fibre Toxicol 9:25. 2012
    ..Whole blood cells, aorta and lung were harvested for global gene expression analysis with subsequent Ingenuity Pathway Analysis and confirmatory qRT-PCR. Serum was collected for protein profiling...
  7. ncbi request reprint Inhalation exposure of gas-metal arc stainless steel welding fume increased atherosclerotic lesions in apolipoprotein E knockout mice
    Aaron Erdely
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, United States
    Toxicol Lett 204:12-6. 2011
    ..These results complement epidemiological and functional human studies that suggest welding may result in adverse cardiovascular effects...
  8. ncbi request reprint Short-term inhalation of stainless steel welding fume causes sustained lung toxicity but no tumorigenesis in lung tumor susceptible A/J mice
    Patti C Zeidler-Erdely
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505, USA
    Inhal Toxicol 23:112-20. 2011
    ..Under our exposure conditions, GMA-SS exposure resulted in no significant tumor development in A/J mice...
  9. ncbi request reprint Lung tumor production and tissue metal distribution after exposure to manual metal ARC-stainless steel welding fume in A/J and C57BL/6J mice
    Patti C Zeidler-Erdely
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, 1095 Willowdale Road M S L2015, Morgantown, WV 26505, USA
    J Toxicol Environ Health A 74:728-36. 2011
    ..In addition, long-term extrapulmonary tissue alterations in metals in the susceptible A/J mouse suggest that the adverse effects of this fume might be cumulative...
  10. pmc Lung tumor promotion by chromium-containing welding particulate matter in a mouse model
    Patti C Zeidler-Erdely
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road MS L2015, Morgantown, WV 26505, USA
    Part Fibre Toxicol 10:45. 2013
    ..Therefore, the capacity of chromium-containing gas metal arc (GMA)-SS welding PM to promote lung tumors was evaluated using a two-stage (initiation-promotion) model in lung tumor susceptible A/J mice...
  11. ncbi request reprint Cross-talk between lung and systemic circulation during carbon nanotube respiratory exposure. Potential biomarkers
    Aaron Erdely
    Toxicology and Molecular Biology Branch and Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Nano Lett 9:36-43. 2009
    ..The approach described here will foster the development of biomarkers for application in human screening of nanoparticle exposure...
  12. ncbi request reprint Systemic immune cell response in rats after pulmonary exposure to manganese-containing particles collected from welding aerosols
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Immunotoxicol 9:184-92. 2012
    ....
  13. ncbi request reprint Engineered nanoparticle respiratory exposure and potential risks for cardiovascular toxicity: predictive tests and biomarkers
    Petia P Simeonova
    Tissue Injury Team, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Inhal Toxicol 21:68-73. 2009
    ..Future studies to evaluate the systemic effects of carbon nanotube exposure under workplace or environmental exposure paradigms should be conducted...
  14. pmc Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume
    Patti C Zeidler-Erdely
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, USA
    Part Fibre Toxicol 5:12. 2008
    ..abstract:..
  15. ncbi request reprint Immunotoxicology of arc welding fume: worker and experimental animal studies
    Patti C Zeidler-Erdely
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Immunotoxicol 9:411-25. 2012
    ..The objective of this report was to review both human and animal studies that have examined the effect of welding fume pulmonary exposure on local and systemic immune responses...
  16. ncbi request reprint Effects of acute inhalation of aerosols generated during resistance spot welding with mild-steel on pulmonary, vascular and immune responses in rats
    Patti C Zeidler-Erdely
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Inhal Toxicol 26:697-707. 2014
    ..Acute inhalation of mild-steel spot welding fumes at occupationally relevant concentrations may act as an irritant as evidenced by the increased RL and result in endothelial dysfunction, but otherwise had minor effects on the lung...