Research Topics
| R M DonlanSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
| Collaborators
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Detail Information
Publications
Biofilms: survival mechanisms of clinically relevant microorganismsRodney M Donlan
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Clin Microbiol Rev 15:167-93. 2002..In the future, treatments may be based on inhibition of genes involved in cell attachment and biofilm formation...
High-level vancomycin-resistant Staphylococcus aureus isolates associated with a polymicrobial biofilmLinda M Weigel
NCID DHQP ELB MS G 08, Centers for Disease Control and Prevention, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
Antimicrob Agents Chemother 51:231-8. 2007..The potential for interspecies transfer of antimicrobial resistance genes, including resistance to vancomycin, may be enhanced by the microenvironment of a biofilm...
Protocol for detection of biofilms on needleless connectors attached to central venous cathetersR M Donlan
Hospital Infections Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Clin Microbiol 39:750-3. 2001..Sixty-three percent of 24 NCs collected from a bone marrow transplant center contained biofilms comprised primarily of coagulase-negative staphylococci...
Biofilms on central venous catheters: is eradication possible?R M Donlan
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Curr Top Microbiol Immunol 322:133-61. 2008..Promising technologies that incorporate novel approaches such as ultrasound, bacteriophage, quorum-sensing inhibitors, or enzymes may also provide useful approaches in the future...
Legionella pneumophila associated with the protozoan Hartmannella vermiformis in a model multi-species biofilm has reduced susceptibility to disinfectantsR M Donlan
Epidemiology and Laboratory Branch, Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta 30333, USA
Biofouling 21:1-7. 2005..A similar pattern was observed for 15 and 60 min contact times. These results indicate that L. pneumophila was less susceptible to MCA or FRC when associated with biofilm-associated H. vermiformis in a model potable water biofilm...
Biofilm elimination on intravascular catheters: important considerations for the infectious disease practitionerRodney M Donlan
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Clin Infect Dis 52:1038-45. 2011..These approaches have the potential to prevent or eradicate biofilms on indwelling intravascular catheters and prevent or resolve catheter-related infections...
Model system for growing and quantifying Streptococcus pneumoniae biofilms in situ and in real timeR M Donlan
Biofilm Laboratory, ELB DHQP NCID, Centers for Disease Control and Prevention, Mail Stop C 16, 1600 Clifton Rd, N E, Atlanta, GA 30333, USA
Appl Environ Microbiol 70:4980-8. 2004..pneumoniae over time by using multiple, corroborative techniques. This approach could prove useful for the study of biofilm processes of this or other microorganisms of clinical or industrial relevance...
Biofilms: microbial life on surfacesRodney M Donlan
Biofilm Laboratory, Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 8:881-90. 2002..A greater understanding of biofilm processes should lead to novel, effective control strategies for biofilm control and a resulting improvement in patient management...
Biofilms and device-associated infectionsR M Donlan
Centers for Disease Control and Prevention Atlanta, Georgia 30333, USA
Emerg Infect Dis 7:277-81. 2001....
Biofilm formation: a clinically relevant microbiological processR M Donlan
Biofilm Laboratory, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Clin Infect Dis 33:1387-92. 2001..An appreciation of the role of biofilms in infection should enhance the clinical decision-making process...
Role of biofilms in the survival of Legionella pneumophila in a model potable-water systemR Murga
Epidemiology and Laboratory Branch, Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Microbiology 147:3121-6. 2001..pneumophila cells present in the biofilm were monitored for 15 d, with and without the presence of H. vermiformis, and it was found that, although unable to replicate in the absence of H. vermiformis, L. pneumophila was able to persist...
Biofilm formation by gram-negative bacteria on central venous catheter connectors: effect of conditioning films in a laboratory modelR Murga
Biofilm Research Laboratory, Division of Healthcare Quality Promotion, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
J Clin Microbiol 39:2294-7. 2001..Results suggest that a conditioning film of blood components promotes biofilm formation by these organisms in an in vitro system...
Bacteriophage cocktail for the prevention of biofilm formation by Pseudomonas aeruginosa on catheters in an in vitro model systemWeiling Fu
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Mail Stop C 16, 1600 Clifton Rd, Atlanta, GA 30333, USA
Antimicrob Agents Chemother 54:397-404. 2010..These results suggest the potential of applying phages, especially phage cocktails, to the surfaces of indwelling medical devices for mitigating biofilm formation by clinically relevant bacteria...
Chlorine inactivation of bacterial bioterrorism agentsLaura J Rose
Centers for Disease Control and Prevention, 1600 Clifton Rd, C16, Atlanta, GA 30333, USA
Appl Environ Microbiol 71:566-8. 2005..Water contaminated with spores of Bacillus anthracis spores would require further treatment...
Preventing biofilms of clinically relevant organisms using bacteriophageRodney M Donlan
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Mail Stop C 16, 1600 Clifton Road, N E, Atlanta, GA 30333, USA
Trends Microbiol 17:66-72. 2009..Phage mixtures or engineered phages could provide effective strategies to overcome these obstacles. Lytic bacteriophages could become a new class of anti-biofilm agents...
Structural analysis of biofilm formation by rapidly and slowly growing nontuberculous mycobacteriaMargaret M Williams
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Appl Environ Microbiol 75:2091-8. 2009..This indicates that M. avium is better adapted for growth in potable water systems than in laboratory incubation conditions and suggests some advantage that MAC has over RGM in low-nutrient environments...
Using bacteriophages to reduce formation of catheter-associated biofilms by Staphylococcus epidermidisJohn J Curtin
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Mail Stop C-16, 1600 Clifton Road, Atlanta, GA 30333, USA
Antimicrob Agents Chemother 50:1268-75. 2006..epidermidis over a 24-h exposure period, suggesting the potential of bacteriophage for mitigating biofilm formation on indwelling catheters and reducing the incidence of catheter-related infections...
Community-onset methicillin-resistant Staphylococcus aureus associated with antibiotic use and the cytotoxin Panton-Valentine leukocidin during a furunculosis outbreak in rural AlaskaHenry C Baggett
Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, Alaska 99508, USA
J Infect Dis 189:1565-73. 2004..001). The majority of MRSA isolates were closely related by PFGE. CONCLUSION: Selective antibiotic pressure for drug-resistant strains carrying PVL may have led to the emergence and spread of CO-MRSA in rural Alaska...
Tetrasodium EDTA as a novel central venous catheter lock solution against biofilmSteven L Percival
Department of Microbiology, Leeds Teaching Hospitals, Leeds, United Kingdom
Infect Control Hosp Epidemiol 26:515-9. 2005..CONCLUSION: Antimicrobial lock treatment using 40 mg/mL(-1) of tetrasodium EDTA for at least 21 hours could significantly reduce or potentially eradicate CVC-associated biofilms of clinically relevant microorganisms...
Statistical assessment of a laboratory method for growing biofilmsDarla M Goeres
Center for Biofilm Engineering, Montana State University, Bozeman, MT 59717-3980, USA
Microbiology 151:757-62. 2005..These results demonstrate that the CBR system is a reliable experimental tool for growing a standard biofilm in the laboratory and that it can be adapted to study several different micro-organisms...
