Charlene S Dezzutti

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. pmc Detection of human T-lymphotropic virus (HTLV) tax sequences in New York City blood donors seronegative for HTLV types 1 and 2
    Charlene S Dezzutti
    Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Diagn Lab Immunol 10:715-7. 2003
  2. pmc In vitro comparison of topical microbicides for prevention of human immunodeficiency virus type 1 transmission
    Charlene S Dezzutti
    Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Mailstop G19, Atlanta, GA 30333, USA
    Antimicrob Agents Chemother 48:3834-44. 2004
  3. ncbi request reprint Prevalence of cryoglobulinemia in hepatitis C virus (HCV) positive patients with and without human immunodeficiency virus (HIV) coinfection
    Charlene S Dezzutti
    Centers for Disease Control and Prevention, Mailstop G19, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
    J Clin Virol 31:210-4. 2004
  4. ncbi request reprint Mucosal innate immune factors in the female genital tract are associated with vaginal HIV-1 shedding independent of plasma viral load
    James E Cummins
    Laboratory Branch, Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 22:788-95. 2006
  5. pmc Preclinical testing of candidate topical microbicides for anti-human immunodeficiency virus type 1 activity and tissue toxicity in a human cervical explant culture
    James E Cummins
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Center for Disease Control and Prevention, Atlanta, GA 30333, USA
    Antimicrob Agents Chemother 51:1770-9. 2007
  6. ncbi request reprint Changes in hepatitis C virus (HCV) viral load and interferon-alpha levels in HIV/HCV-coinfected patients treated with highly active antiretroviral therapy
    William A Bower
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Acquir Immune Defic Syndr 42:293-7. 2006
  7. ncbi request reprint A human colorectal explant culture to evaluate topical microbicides for the prevention of HIV infection
    Sheila R Abner
    HIV and Retrovirology Branch, Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, and Surgical Service, Emory University School of Medicine, Decatur, Georgia, USA
    J Infect Dis 192:1545-56. 2005
  8. ncbi request reprint Mucosal innate immune factors in secretions from high-risk individuals immunized with a bivalent gp120 vaccine
    James E Cummins
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 23:748-54. 2007
  9. pmc Trichomonas vaginalis-induced epithelial monolayer disruption and human immunodeficiency virus type 1 (HIV-1) replication: implications for the sexual transmission of HIV-1
    Patricia C Guenthner
    HIV and Retrovirology Branch, Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Mail Stop G19, Atlanta, Georgia 30333, USA
    Infect Immun 73:4155-60. 2005
  10. pmc Mucosal and systemic antibody responses in humans infected with simian foamy virus
    James E Cummins
    HIV and Retrovirology Branch, Division of AIDS, STD, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 79:13186-9. 2005

Collaborators

Detail Information

Publications15

  1. pmc Detection of human T-lymphotropic virus (HTLV) tax sequences in New York City blood donors seronegative for HTLV types 1 and 2
    Charlene S Dezzutti
    Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Clin Diagn Lab Immunol 10:715-7. 2003
    ..All NYBD tested negative for antibodies to HTLV types 1 and 2 and HTLV Tax. HTLV tax sequences were not detected in the NYBD lymphocytes. These data demonstrate the lack of HTLV-1 tax in this group of NYBD at low risk for HTLV infection...
  2. pmc In vitro comparison of topical microbicides for prevention of human immunodeficiency virus type 1 transmission
    Charlene S Dezzutti
    Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Mailstop G19, Atlanta, GA 30333, USA
    Antimicrob Agents Chemother 48:3834-44. 2004
    ..Moreover, our systematic anti-HIV-1 testing provides a rational basis for making better informed decisions about which products to consider for clinical trials...
  3. ncbi request reprint Prevalence of cryoglobulinemia in hepatitis C virus (HCV) positive patients with and without human immunodeficiency virus (HIV) coinfection
    Charlene S Dezzutti
    Centers for Disease Control and Prevention, Mailstop G19, 1600 Clifton Road, NE, Atlanta, GA 30333, USA
    J Clin Virol 31:210-4. 2004
    ..Coinfection with human immunodeficiency virus (HIV) has been shown to influence the natural history of hepatitis C infection...
  4. ncbi request reprint Mucosal innate immune factors in the female genital tract are associated with vaginal HIV-1 shedding independent of plasma viral load
    James E Cummins
    Laboratory Branch, Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 22:788-95. 2006
    ..In this group of women, these results suggest that the levels of certain innate immune factors are more closely associated with HIV-1 shedding in the genital mucosa than plasma virus concentrations...
  5. pmc Preclinical testing of candidate topical microbicides for anti-human immunodeficiency virus type 1 activity and tissue toxicity in a human cervical explant culture
    James E Cummins
    Laboratory Branch, Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Center for Disease Control and Prevention, Atlanta, GA 30333, USA
    Antimicrob Agents Chemother 51:1770-9. 2007
    ..Collectively, these data suggest that this culture system can be used for evaluating the safety and efficacy of topical microbicides designed for vaginal use...
  6. ncbi request reprint Changes in hepatitis C virus (HCV) viral load and interferon-alpha levels in HIV/HCV-coinfected patients treated with highly active antiretroviral therapy
    William A Bower
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Acquir Immune Defic Syndr 42:293-7. 2006
    ..It is hypothesized that increases in HCV RNA titers may result from changes in endogenous interferon-alpha (IFN-alpha) production...
  7. ncbi request reprint A human colorectal explant culture to evaluate topical microbicides for the prevention of HIV infection
    Sheila R Abner
    HIV and Retrovirology Branch, Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, and Surgical Service, Emory University School of Medicine, Decatur, Georgia, USA
    J Infect Dis 192:1545-56. 2005
    ..These results suggest that this model is useful for evaluating the safety and efficacy of topical microbicides when used rectally...
  8. ncbi request reprint Mucosal innate immune factors in secretions from high-risk individuals immunized with a bivalent gp120 vaccine
    James E Cummins
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    AIDS Res Hum Retroviruses 23:748-54. 2007
    ..Because of the importance of innate immunity in host defense, evaluation of the mucosal innate immune system should be included in future HIV prevention trials...
  9. pmc Trichomonas vaginalis-induced epithelial monolayer disruption and human immunodeficiency virus type 1 (HIV-1) replication: implications for the sexual transmission of HIV-1
    Patricia C Guenthner
    HIV and Retrovirology Branch, Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Mail Stop G19, Atlanta, Georgia 30333, USA
    Infect Immun 73:4155-60. 2005
    ..Collectively, these data suggest the need for more vigilant efforts in the diagnosis and treatment of T. vaginalis in women and men, especially in countries with a high prevalence of HIV-1...
  10. pmc Mucosal and systemic antibody responses in humans infected with simian foamy virus
    James E Cummins
    HIV and Retrovirology Branch, Division of AIDS, STD, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 79:13186-9. 2005
    ..These results provide a first comparative evaluation of SFV-specific host mucosal humoral immunity in infected humans and chimpanzees that is characterized by a predominant IgG response and a virtually absent IgA response...
  11. pmc Detection of infectious human immunodeficiency virus type 1 in female genital secretions by a short-term culture method
    James E Cummins
    Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 41:4081-8. 2003
    ..Accurate measurements of infectious virus in genital secretions will improve studies that evaluate sexual transmission of HIV-1...
  12. pmc Effect of topical microbicides on infectious human immunodeficiency virus type 1 binding to epithelial cells
    Susan Roth
    University of Pittsburgh, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee Womens Research Institute, 204 Craft Avenue, Pittsburgh, PA 15213, USA
    Antimicrob Agents Chemother 51:1972-8. 2007
    ..Therefore, functional virological assays in addition to measuring viral RNA should be included when clinically evaluating topical microbicide use by infected persons...
  13. pmc Cervical shedding of human T cell lymphotropic virus type I is associated with cervicitis
    Joseph R Zunt
    Department of Neurology, University of Washington School of Medicine, Seattle 98104, USA
    J Infect Dis 186:1669-72. 2002
    ..3-4.3) or Neisseria gonorrhoeae (OR, 1.1; 95% CI, 0.6-3.7) were not significantly associated with HTLV-I shedding. Our results suggest that cervicitis may increase cervical HTLV-I shedding and the sexual transmission of this virus...
  14. ncbi request reprint Preventing the sexual transmission of HIV-1 with topical microbicides: another piece of the equation
    Lisa C Rohan
    Department of Pharmaceutical Science, School of Pharmacy, University of Pittsburgh, PA, USA
    J Infect Dis 196:1285-7. 2007
  15. pmc In vitro preclinical testing of nonoxynol-9 as potential anti-human immunodeficiency virus microbicide: a retrospective analysis of results from five laboratories
    Brigitte E Beer
    Southern Research Institute, 431 Aviation Way, Frederick, MD 21701, USA
    Antimicrob Agents Chemother 50:713-23. 2006
    ..This comparative work can be used to develop standardized microbicide testing protocols that will help advance potential microbicides to clinical trials...