Research Topics
| F DeStefanoSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
| Collaborators
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Detail Information
Publications
Childhood vaccinations and risk of asthmaFrank Destefano
Centers for Disease Control and Prevention, Atlanta, GA, USA
Pediatr Infect Dis J 21:498-504. 2002..The weak associations for Hib and hepatitis B vaccines seem to be at least partially accounted for by health care utilization or information bias...- MMR vaccine and autism: an update of the scientific evidenceFrank Destefano
National Immunization Program, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop E61, Atlanta, Georgia 30333, USA
Expert Rev Vaccines 3:19-22. 2004..The evidence now is convincing that the measles-mumps-rubella vaccine does not cause autism or any particular subtypes of autistic spectrum disorder... 
Factors associated with social contacts in four communities during the 2007-2008 influenza seasonF DeStefano
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Epidemiol Infect 139:1181-90. 2011..These results should be useful for modelling influenza epidemics and pandemics and in planning mitigation and response strategies...- Hepatitis B vaccine and risk of multiple sclerosisFrank Destefano
Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
Expert Rev Vaccines 1:461-6. 2002..The US Institute of Medicine and other review panels have concluded that the evidence favors rejection of a causal association between hepatitis B vaccine and multiple sclerosis... - Vaccinations and risk of central nervous system demyelinating diseases in adultsFrank Destefano
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Arch Neurol 60:504-9. 2003..Several case reports of the onset or exacerbation of multiple sclerosis or other demyelinating conditions shortly after vaccination have suggested that vaccines may increase the risk of demyelinating diseases... - Childhood vaccinations, vaccination timing, and risk of type 1 diabetes mellitusF DeStefano
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
Pediatrics 108:E112. 2001..To evaluate suggested associations between childhood vaccinations, particularly against hepatitis B and Haemophilus influenzae type b, and risk of developing type 1 diabetes; and to determine whether timing of vaccination influences risk... - Autism and measles-mumps-rubella vaccination: controversy laid to rest?F DeStefano
National Center on Birth Defects and Developmental Disabilities, Atlanta, Georgia 30341 3724, USA
CNS Drugs 15:831-7. 2001..Currently, the weight of the available epidemiological and related evidence does not support a causal association between MMR vaccine, or any other vaccine or vaccine constituent, and autism... - Influenza vaccination in children with asthma in health maintenance organizations. Vaccine Safety Datalink TeamP Kramarz
Centers for Disease Control and Prevention, 1600 Clifton Road, MS E61, Atlanta, GA 30333, USA
Vaccine 18:2288-94. 2000..Vaccination coverage could be increased by taking advantage of all opportunities to vaccinate children with asthma whenever they make clinic visits in the fall and early winter... - Does influenza vaccination exacerbate asthma? Analysis of a large cohort of children with asthma. Vaccine Safety Datalink TeamP Kramarz
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Arch Fam Med 9:617-23. 2000..One reason for low influenza vaccine coverage among children with asthma may be concern that influenza vaccination may induce an exacerbation of asthma... - Challenges and controversies in immunization safetyR T Chen
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Infect Dis Clin North Am 15:21-39, viii. 2001..It also provides information on how various safety research is conducted, some of the concurrent challenges, and finally, some guidance on communicating with patients on vaccine risks... 
The Vaccine Safety Datalink: immunization research in health maintenance organizations in the USAR T Chen
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Bull World Health Organ 78:186-94. 2000....- The incidence of Kawasaki syndrome in West Coast health maintenance organizationsE D Belay
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Pediatr Infect Dis J 19:828-32. 2000..Kawasaki syndrome (KS) causes an acute vasculitis of unknown etiology. It is a leading cause of acquired heart disease of children in Japan and the United States... - The Vaccine Safety Datalink projectF DeStefano
National Immunization Program MS F34, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Pharmacoepidemiol Drug Saf 10:403-6. 2001..A cohort study was conducted that allowed estimation of incidence rates of intussusception and attributable risks associated with rotavirus vaccine... - Does influenza vaccination prevent asthma exacerbations in children?P Kramarz
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Pediatr 138:306-10. 2001..The effectiveness of influenza vaccine in preventing influenza-related asthma exacerbations, however, is not known. We evaluated influenza vaccine effectiveness in protecting children against influenza-related asthma exacerbations... - Population-based study of rotavirus vaccination and intussusceptionP Kramarz
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA, USA
Pediatr Infect Dis J 20:410-6. 2001..0. The attributable risk was one case of intussusception per 11 073 children vaccinated. CONCLUSIONS: RRV-TV is associated with an increased risk of intussusception. The risk is greatest 3 to 7 days after the first vaccination dose... - Immunity to tetanus is protective against the development of multiple sclerosisT Verstraeten
Epidemic Intelligence Service EIS Program, Epidemiology Program Office, Centers for Disease Control and Prevention, Altanta, GA, USA
Med Hypotheses 65:966-9. 2005..Laboratory evidence could be sought by testing the effect of tetanus toxoid on experimental allergic encephalomyelitis, the experimental animal model of MS... - MMR vaccine and autism: a review of the evidence for a causal associationF DeStefano
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop F34, Atlanta, GA 30341-3724, USA
Mol Psychiatry 7:S51-2. 2002 - Vaccines and autism: evidence does not support a causal associationF DeStefano
Statistics and Epidemiology Unit, RTI International, Atlanta, Georgia, USA
Clin Pharmacol Ther 82:756-9. 2007.... - Epidemiology of autoimmune reactions induced by vaccinationR T Chen
Vaccine Safety and Development Activity, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Autoimmun 16:309-18. 2001..Examples include the possible association of immunization and multiple sclerosis (and other demyelinating diseases), type 1 diabetes mellitus, Guillain-Barre Syndrome, idiopathic thrombocytopenic purpura, and rheumatoid arthritis... - Hepatitis B vaccine and risk of multiple sclerosisFrank Destefano
Pharmacoepidemiol Drug Saf 16:705-7, author reply 707-8. 2007 - Early thimerosal exposure and neuropsychological outcomes at 7 to 10 yearsWilliam W Thompson
National Center for Immunizations and Respiratory Diseases, Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
N Engl J Med 357:1281-92. 2007..It has been hypothesized that early exposure to thimerosal, a mercury-containing preservative used in vaccines and immune globulin preparations, is associated with neuropsychological deficits in children... - Recombinant hepatitis B vaccine and the risk of multiple sclerosis: a prospective studyFrank Destefano
Neurology 64:1317; author reply 1317. 2005 - Guillain-Barré syndrome following influenza vaccinationPenina Haber
Immunization Safety Branch, Epidemiology and Surveillance Division, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
JAMA 292:2478-81. 2004..Guillain-Barre syndrome remains the most frequent neurological condition reported after influenza vaccination to the Vaccine Adverse Events Reporting System (VAERS) since its inception in 1990... - Letter to the editor. The safety of thimerosal in newborn and infant vaccinesWilliam W Thompson
Vaccine 23:281-2. 2004 - Understanding vaccine safety information from the Vaccine Adverse Event Reporting SystemFrederick Varricchio
Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration/NIH/DHHS, Rockville MD, USA
Pediatr Infect Dis J 23:287-94. 2004..Confirmation in a controlled study is usually required. An understanding of the system's defined objectives and inherent drawbacks is vital to the effective use of VAERS data in vaccine safety investigations... - Age at first measles-mumps-rubella vaccination in children with autism and school-matched control subjects: a population-based study in metropolitan atlantaFrank Destefano
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Pediatrics 113:259-66. 2004..To compare ages at first measles-mumps-rubella (MMR) vaccination between children with autism and children who did not have autism in the total population and in selected subgroups, including children with regression in development... - Hepatitis B vaccination among adolescents in 3 large health maintenance organizationsIdalia M Gonzalez
Epidemiology Program Office, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Pediatrics 110:929-34. 2002..Little is known about the implementation of these recommendations in a managed care setting. The objective of this study was to determine the impact of ACIP recommendations on HB vaccination among adolescents in 3 managed care settings... - Safety of thimerosal-containing vaccines: a two-phased study of computerized health maintenance organization databasesThomas Verstraeten
Epidemic Intelligence Service Program, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Pediatrics 112:1039-48. 2003..Conflicting results were found at different HMOs for certain outcomes. For resolving the conflicting findings, studies with uniform neurodevelopmental assessments of children with a range of cumulative thimerosal exposures are needed... - Vaccine safety surveillance using large linked databases: opportunities, hazards and proposed guidelinesThomas Verstraeten
GlaxoSmithKline Biologicals, Rixensart, Belgium
Expert Rev Vaccines 2:21-9. 2003..We also offer our opinion on the future use of large linked databases for vaccine safety surveillance purposes... - Wheezing lower respiratory disease and vaccination of full-term infantsJohn P Mullooly
Center for Health Research, 3800 N Interstate Ave, Portland, OR 97227, USA
Pharmacoepidemiol Drug Saf 11:21-30. 2002..There have been speculations that increases in vaccinations have caused recent increases in wheezing lower respiratory disease during infancy. We assess possible associations between vaccines and incidence of wheezing in full-term infants... - Risk of anaphylaxis after vaccination of children and adolescentsKari Bohlke
Center for Health Studies, Group Health Cooperative, Seattle, Washington 98101 1448, USA
Pediatrics 112:815-20. 2003..To quantify the risk of anaphylaxis after vaccination of children and adolescents... - Safety of trivalent inactivated influenza vaccine in children 6 to 23 months oldSimon J Hambidge
Clinical Research Unit, Kaiser Permanente Colorado, Denver, CO 80237 8066, USA
JAMA 296:1990-7. 2006..Beginning with the winter season of 2004-2005, influenza vaccination has been recommended for all children 6 to 23 months old in the United States. However, its safety in young children has not been adequately studied in large populations... - Influenza vaccination and Guillain Barré syndromePenina Haber
Clin Immunol 109:359; author reply 360-1. 2003 - A potential signal of Bell's palsy after parenteral inactivated influenza vaccines: reports to the Vaccine Adverse Event Reporting System (VAERS)--United States, 1991-2001Weigong Zhou
Epidemic Intelligence Service, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Pharmacoepidemiol Drug Saf 13:505-10. 2004..A population-based controlled study is needed to determine whether this association could be causal and to quantify the risk... - Infant vaccinations and childhood asthma among full-term infantsJulie E Maher
Center for Health Research, Kaiser Permanente Northwest, 3800 N Interstate, Portland, OR 97227 1110, USA
Pharmacoepidemiol Drug Saf 13:1-9. 2004..To determine if infant vaccinations are associated with childhood asthma among full-term infants. The secondary objective was to describe relationships between characteristics of infant wheezing and childhood asthma... - Epidemiology of anaphylaxis among children and adolescents enrolled in a health maintenance organizationKari Bohlke
Center for Health Studies, Group Health Cooperative, Seattle, WA 98101-1448, USA
J Allergy Clin Immunol 113:536-42. 2004..Anaphylaxis in this population was frequently diagnosed as another related condition, and the basis and implications of diagnostic practices in this disorder warrant further exploration... - Compliance with the recommendations for 2 doses of trivalent inactivated influenza vaccine in children less than 9 years of age receiving influenza vaccine for the first time: a Vaccine Safety Datalink studyLisa A Jackson
Group Health Center for Health Studies, Seattle, Washington, USA
Pediatrics 118:2032-7. 2006..We conducted a population-based retrospective cohort study to evaluate compliance with the 2-dose trivalent inactivated influenza vaccine recommendations... - A retrospective cohort study of the association of varicella vaccine failure with asthma, steroid use, age at vaccination, and measles-mumps-rubella vaccinationThomas Verstraeten
Epidemic Intelligence Service Program, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Pediatrics 112:e98-103. 2003..We assessed the association of varicella breakthrough with asthma, steroids, age at varicella vaccination, and timing of measles-mumps-rubella (MMR) vaccination... - Immunogenicity and reactogenicity of 1 versus 2 doses of trivalent inactivated influenza vaccine in vaccine-naive 5-8-year-old childrenKathleen M Neuzil
Program for Appropriate Technology in Health, School of Medicine, University of Washington, Seattle, Seattle, WA 98107, USA
J Infect Dis 194:1032-9. 2006..This study assessed the need for a second dose of TIV in this age group... - Lack of association between hepatitis B birth immunization and neonatal death: a population-based study from the vaccine safety datalink projectEileen M Eriksen
UCLA Center for Vaccine Research, Harbor-UCLA Medical Center, Torrance, CA 90502, USA
Pediatr Infect Dis J 23:656-62. 2004..CONCLUSIONS: A relationship between HBV and neonatal death was not identified... - Trends in diagnosis rates for autism and ADHD at hospital discharge in the context of other psychiatric diagnosesDavid S Mandell
Center for Mental Health Policy and Services Research, University of Pennsylvania, 3535 Market Street, Philadelphia, PA 19104, USA
Psychiatr Serv 56:56-62. 2005.... - MMR vaccination and autism: is there a link?Frank Destefano
Expert Opin Drug Saf 1:115-20. 2002..Currently, the weight of the available epidemiological and related evidence does not support a causal link between MMR vaccine and autism...