Itai Chipinda

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. doi request reprint Zinc diethyldithiocarbamate allergenicity: potential haptenation mechanisms
    Itai Chipinda
    Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, USA
    Contact Dermatitis 59:79-89. 2008
  2. doi request reprint Increased cell proliferation in spleen and lymph nodes peripheral to contact allergen application site
    Itai Chipinda
    Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505 2888, United States
    Toxicology 257:113-6. 2009
  3. pmc Rapid and simple kinetics screening assay for electrophilic dermal sensitizers using nitrobenzenethiol
    Itai Chipinda
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 2888, USA
    Chem Res Toxicol 23:918-25. 2010
  4. doi request reprint Use of the human monocytic leukemia THP-1 cell line and co-incubation with microsomes to identify and differentiate hapten and prohapten sensitizers
    Itai Chipinda
    Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505 2888, USA
    Toxicology 280:135-43. 2011
  5. doi request reprint Discrimination of haptens from prohaptens using the metabolically deficient Cpr(low/low) mouse
    Itai Chipinda
    Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505 2888, USA
    Toxicol Appl Pharmacol 252:268-72. 2011
  6. ncbi request reprint Oxidation of 2-mercaptobenzothiazole in latex gloves and its possible haptenation pathway
    Itai Chipinda
    Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505 2888, USA
    Chem Res Toxicol 20:1084-92. 2007
  7. doi request reprint Mercaptobenzothiazole allergenicity-role of the thiol group
    Itai Chipinda
    Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 2888, USA
    Cutan Ocul Toxicol 27:103-16. 2008
  8. doi request reprint Pyridoxylamine reactivity kinetics as an amine based nucleophile for screening electrophilic dermal sensitizers
    Itai Chipinda
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, United States
    Toxicology 315:102-9. 2014
  9. pmc Characterization of methylene diphenyl diisocyanate-haptenated human serum albumin and hemoglobin
    Morgen Mhike
    Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Anal Biochem 440:197-204. 2013
  10. ncbi request reprint Kinetics and mechanistic studies of the hydrolysis of diisocyanate-derived bis-thiocarbamates of cysteine methyl ester
    Itai Chipinda
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505 2888, USA
    Chem Res Toxicol 19:341-50. 2006

Collaborators

Detail Information

Publications12

  1. doi request reprint Zinc diethyldithiocarbamate allergenicity: potential haptenation mechanisms
    Itai Chipinda
    Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, USA
    Contact Dermatitis 59:79-89. 2008
    ..Zinc diethyldithiocarbamate (ZDEC) and its disulfide, tetraethylthiuram disulfide (TETD), are rubber accelerators and contact allergens that cross-react in some individuals...
  2. doi request reprint Increased cell proliferation in spleen and lymph nodes peripheral to contact allergen application site
    Itai Chipinda
    Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505 2888, United States
    Toxicology 257:113-6. 2009
    ..Thus the contra-lateral draining superficial parotid node cannot be used as a control for application of contact allergen to a single ear in a modified LLNA...
  3. pmc Rapid and simple kinetics screening assay for electrophilic dermal sensitizers using nitrobenzenethiol
    Itai Chipinda
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 2888, USA
    Chem Res Toxicol 23:918-25. 2010
    ..This simple, rapid, and inexpensive absorbance-based method has great potential for use as a preliminary screening tool for skin allergens...
  4. doi request reprint Use of the human monocytic leukemia THP-1 cell line and co-incubation with microsomes to identify and differentiate hapten and prohapten sensitizers
    Itai Chipinda
    Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505 2888, USA
    Toxicology 280:135-43. 2011
    ..In conclusion, modification of in vitro cell culture assays to include co-incubation with microsomes enhances identification of prohaptens and allows them to be clearly distinguished from direct-binding haptens...
  5. doi request reprint Discrimination of haptens from prohaptens using the metabolically deficient Cpr(low/low) mouse
    Itai Chipinda
    Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505 2888, USA
    Toxicol Appl Pharmacol 252:268-72. 2011
    ..Results of the present study suggest potential utility of the Cpr(low/low) mice in the LLNA to differentiate prohaptens from direct acting haptens...
  6. ncbi request reprint Oxidation of 2-mercaptobenzothiazole in latex gloves and its possible haptenation pathway
    Itai Chipinda
    Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505 2888, USA
    Chem Res Toxicol 20:1084-92. 2007
    ..The data suggest that the critical functional group on MBT is the thiol, and haptenation is via the formation of mixed disulfides between the thiol group on MBT and a protein sulfhydryl group...
  7. doi request reprint Mercaptobenzothiazole allergenicity-role of the thiol group
    Itai Chipinda
    Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 2888, USA
    Cutan Ocul Toxicol 27:103-16. 2008
    ..It is concluded that the probable haptenation mechanism of MBT is through initial oxidation to MBTS with subsequent reduction to form mixed disulfides with proteins...
  8. doi request reprint Pyridoxylamine reactivity kinetics as an amine based nucleophile for screening electrophilic dermal sensitizers
    Itai Chipinda
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, United States
    Toxicology 315:102-9. 2014
    ..76). The use of PDA serves as a simple, inexpensive amine based method that shows promise as a preliminary screening tool for electrophilic, amine-selective skin sensitizers. ..
  9. pmc Characterization of methylene diphenyl diisocyanate-haptenated human serum albumin and hemoglobin
    Morgen Mhike
    Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Anal Biochem 440:197-204. 2013
    ....
  10. ncbi request reprint Kinetics and mechanistic studies of the hydrolysis of diisocyanate-derived bis-thiocarbamates of cysteine methyl ester
    Itai Chipinda
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505 2888, USA
    Chem Res Toxicol 19:341-50. 2006
    ..Thiocarbamate dissociation rates and type of products formed may potentially influence antigenicity and subsequent hypersensitivity/toxic reactions following dNCO exposures...
  11. pmc Haptenation: chemical reactivity and protein binding
    Itai Chipinda
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, MS L 2040, 1095 Willowdale Road, Morgantown, WV 26505, USA
    J Allergy (Cairo) 2011:839682. 2011
    ..Chemical aspects related to both reactivity and protein-specific binding are discussed...
  12. doi request reprint Fungal pigments inhibit the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis of darkly pigmented fungi
    Amanda D Buskirk
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Anal Biochem 411:122-8. 2011
    ..The addition of tricyclazole to the fungal growth media blocks fungal melanin synthesis and results in less melanized fungi that may be analyzed by MALDI-TOF MS...